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BHAGAVATULA MOORTHY

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Newborn
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Pulmonary

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01ES009132     (MOORTHY, BHAGAVATULA)Aug 1, 1998 - Sep 30, 2011
    NIH/NIEHS
    Molecular mechanism of cytochrome P4501A1 expression.
    Role: Principal Investigator

    R01HL070921     (MOORTHY, BHAGAVATULA)Aug 1, 2002 - Nov 30, 2008
    NIH/NHLBI
    Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Role: Principal Investigator

    R01HL087174     (MOORTHY, BHAGAVATULA)Jul 16, 2007 - May 31, 2012
    NIH/NHLBI
    Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Role: Principal Investigator

    R01ES019689     (MOORTHY, BHAGAVATULA)Dec 1, 2010 - Nov 30, 2015
    NIH/NIEHS
    Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
    Role: Principal Investigator

    R01HL112516     (MOORTHY, BHAGAVATULA)Jan 1, 2012 - Dec 31, 2016
    NIH/NHLBI
    Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
    Role: Principal Investigator

    R21DA035751     (GHOSE, ROMI)Mar 15, 2014 - Feb 29, 2016
    NIH/NIDA
    Novel in vivo regulatory mechanisms of human CYP3A4
    Role: Co-Principal Investigator

    R01HL129794     (MOORTHY, BHAGAVATULA)Apr 1, 2016 - Mar 31, 2020
    NIH/NHLBI
    Mechanistic roles of Cytochrome P4501A enzymes in hyperoxic lung injury
    Role: Principal Investigator

    R01ES029382     (MOORTHY, BHAGAVATULA)Sep 1, 2018 - May 31, 2023
    NIH/NIEHS
    Mechanistic role of P4501 enzymes in the prevention of PAH carcinogenesis by omega 3 fatty acids
    Role: Principal Investigator

    R56ES030221     (MOORTHY, BHAGAVATULA)Feb 1, 2019 - Jan 31, 2020
    NIH/NIEHS
    Prenatal exposure to PAHs and hyperoxic lung injury: Role of the microbiome
    Role: Principal Investigator

    P42ES027725     (MOORTHY, BHAGAVATULA)Feb 28, 2020 - Jan 31, 2025
    NIH/NIEHS
    POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Althouse MH, Stewart C, Jiang W, Moorthy B, Lingappan K. Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury. Sci Rep. 2019 10 18; 9(1):14992. PMID: 31628395.
      View in: PubMed
    2. Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun. 2019 Aug 20; 516(2):344-349. PMID: 31208719.
      View in: PubMed
    3. Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose R. Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 04 30; 9(1):6663. PMID: 31040347.
      View in: PubMed
    4. Song W, Vidonish JE, Kamath R, Yu P, Chu C, Moorthy B, Gao B, Zygourakis K, Alvarez PJJ. Pilot-Scale Pyrolytic Remediation of Crude-Oil-Contaminated Soil in a Continuously-Fed Reactor: Treatment Intensity Trade-Offs. Environ Sci Technol. 2019 02 19; 53(4):2045-2053. PMID: 30681845.
      View in: PubMed
    5. Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B. Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicol Sci. 2018 10 01; 165(2):462-474. PMID: 29939353.
      View in: PubMed
    6. Taneja G, Chu C, Maturu P, Moorthy B, Ghose R. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 04; 46(4):397-404. PMID: 29440179.
      View in: PubMed
    7. Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI. ß-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicol Appl Pharmacol. 2018 01 15; 339:133-142. PMID: 29180065.
      View in: PubMed
    8. Veith A, Moorthy B. ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES. Curr Opin Toxicol. 2018 Feb; 7:44-51. PMID: 29527583.
      View in: PubMed
    9. Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L991-L1005. PMID: 28818871.
      View in: PubMed
    10. Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI. Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal ß-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicol Sci. 2017 05 01; 157(1):260-271. PMID: 28201809.
      View in: PubMed
    11. Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 04 04; 7(1):642. PMID: 28377578.
      View in: PubMed
    12. Abbas MMK, Patel B, Chen Q, Jiang W, Moorthy B, Barrios R, Puschett JB. Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome. Lung. 2017 06; 195(3):323-332. PMID: 28260175.
      View in: PubMed
    13. Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun; 41:75-82. PMID: 28242239.
      View in: PubMed
    14. Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616. PMID: 28537216.
      View in: PubMed
    15. Shrestha AK, Patel A, Menon RT, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun. 2017 03 25; 485(1):195-200. PMID: 28192119.
      View in: PubMed
    16. Patel A, Zhang S, Shrestha AK, Maturu P, Moorthy B, Shivanna B. Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway. Toxicol Appl Pharmacol. 2016 Nov 15; 311:26-33. PMID: 27725188.
      View in: PubMed
    17. Lingappan K, Jiang W, Wang L, Moorthy B. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 01; 311(2):L481-93. PMID: 27343189.
      View in: PubMed
    18. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 08 05; 476(4):346-351. PMID: 27235555.
      View in: PubMed
    19. Shivanna B, Maity S, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Belmont J, Coarfa C, Moorthy B. Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia. Toxicol Sci. 2016 07; 152(1):155-68. PMID: 27103661.
      View in: PubMed
    20. Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68. PMID: 26910068.
      View in: PubMed
    21. Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ß in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7. PMID: 26470915.
      View in: PubMed
    22. Zhang S, Patel A, Moorthy B, Shivanna B. Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2. Biochem Biophys Res Commun. 2015 Nov 13; 467(2):282-7. PMID: 26441083.
      View in: PubMed
    23. Patel A, Zhang S, Moorthy B, Shivanna B. Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia. Pharm Anal Acta. 2015 Oct; 6(10). PMID: 26779382.
      View in: PubMed
    24. Patel A, Zhang S, Paramahamsa M, Jiang W, Wang L, Moorthy B, Shivanna B. Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos. 2015 Dec; 43(12):1966-70. PMID: 26417045.
      View in: PubMed
    25. Lingappan K, Moorthy B. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1383-6. PMID: 26361877.
      View in: PubMed
    26. Shivanna B, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Moorthy B. Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. Toxicol Sci. 2015 Nov; 148(1):276-87. PMID: 26272953.
      View in: PubMed
    27. Zhang S, Patel A, Moorthy B, Shivanna B. Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1048-1053. PMID: 26196743.
      View in: PubMed
    28. Tiwari KK, Moorthy B, Lingappan K. Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicol In Vitro. 2015 Oct; 29(7):1369-76. PMID: 26004619.
      View in: PubMed
    29. Zhou GD, Moorthy B. Detection of Bulky Endogenous Oxidative DNA Lesions Derived from 8,5'-Cyclo-2'-deoxyadenosine by ³²P-Postlabeling Assay. Curr Protoc Toxicol. 2015 May 04; 64:17.17.1-14. PMID: 26344223.
      View in: PubMed
    30. Moorthy B, Chu C, Carlin DJ. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci. 2015 May; 145(1):5-15. PMID: 25911656.
      View in: PubMed
    31. Zhang S, Patel A, Chu C, Jiang W, Wang L, Welty SE, Moorthy B, Shivanna B. Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB. Toxicol Appl Pharmacol. 2015 Jul 15; 286(2):92-101. PMID: 25831079.
      View in: PubMed
    32. Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 04; 331:14-23. PMID: 25703676.
      View in: PubMed
    33. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282.
      View in: PubMed
    34. Davies J, Karmouty-Quintana H, Le TT, Chen NY, Weng T, Luo F, Molina J, Moorthy B, Blackburn MR. Adenosine promotes vascular barrier function in hyperoxic lung injury. Physiol Rep. 2014 Sep 01; 2(9). PMID: 25263205.
      View in: PubMed
    35. Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581. PMID: 25003466.
      View in: PubMed
    36. Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 08; 450(4):1345-50. PMID: 24997337.
      View in: PubMed
    37. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714.
      View in: PubMed
    38. Phillips TD, Richardson M, Cheng YS, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol. 2015 Jun; 89(6):967-77. PMID: 24888377.
      View in: PubMed
    39. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529.
      View in: PubMed
    40. Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90. PMID: 23792423.
      View in: PubMed
    41. Shivanna B, Zhang W, Jiang W, Welty SE, Couroucli XI, Wang L, Moorthy B. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol. 2013 Mar 15; 267(3):209-17. PMID: 23337360.
      View in: PubMed
    42. Gandhi A, Guo T, Shah P, Moorthy B, Ghose R. Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 01; 266(3):430-8. PMID: 23238562.
      View in: PubMed
    43. Gandhi A, Moorthy B, Ghose R. Drug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44. PMID: 22746301.
      View in: PubMed
    44. Gandhi AS, Guo T, Shah P, Moorthy B, Chow DS, Hu M, Ghose R. CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice. Br J Pharmacol. 2012 Aug; 166(7):2176-87. PMID: 22394353.
      View in: PubMed
    45. Lin Y, Yao Y, Liu S, Wang L, Moorthy B, Xiong D, Cheng T, Ding X, Gu J. Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice. Toxicol Lett. 2012 Jul 20; 212(2):97-105. PMID: 22595614.
      View in: PubMed
    46. Zhou GD, Zhu H, Phillips TD, Wang J, Wang SZ, Wang F, Amendt BA, Couroucli XI, Donnelly KC, Moorthy B. Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10):e26589. PMID: 22066002.
      View in: PubMed
    47. Shivanna B, Chu C, Welty SE, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor. Free Radic Biol Med. 2011 Nov 15; 51(10):1910-7. PMID: 21906671.
      View in: PubMed
    48. Shivanna B, Jiang W, Wang L, Couroucli XI, Moorthy B. Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2011 Oct; 339(1):106-14. PMID: 21768223.
      View in: PubMed
    49. Couroucli XI, Liang YH, Jiang W, Wang L, Barrios R, Yang P, Moorthy B. Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol. 2011 Oct 15; 256(2):83-94. PMID: 21745492.
      View in: PubMed
    50. Jiang W, Couroucli XI, Wang L, Barrios R, Moorthy B. Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo. Biochem Biophys Res Commun. 2011 Apr 01; 407(1):79-85. PMID: 21362406.
      View in: PubMed
    51. Zhou GD, Richardson M, Fazili IS, Wang J, Donnelly KC, Wang F, Amendt B, Moorthy B. Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention. Toxicol Appl Pharmacol. 2010 Dec 15; 249(3):224-30. PMID: 20888851.
      View in: PubMed
    52. Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, Moorthy B. Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther. 2010 Nov; 335(2):369-79. PMID: 20732958.
      View in: PubMed
    53. Fazili IS, Jiang W, Wang L, Felix EA, Khatlani T, Coumoul X, Barouki R, Moorthy B. Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther. 2010 Apr; 333(1):99-109. PMID: 20051482.
      View in: PubMed
    54. Jiang W, Wang L, Zhang W, Coffee R, Fazili IS, Moorthy B. Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1419-24. PMID: 19900403.
      View in: PubMed
    55. Bhakta KY, Jiang W, Couroucli XI, Fazili IS, Muthiah K, Moorthy B. Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury. Toxicol Appl Pharmacol. 2008 Dec 01; 233(2):169-78. PMID: 18824009.
      View in: PubMed
    56. Kondraganti SR, Jiang W, Jaiswal AK, Moorthy B. Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol Sci. 2008 Apr; 102(2):337-44. PMID: 18203689.
      View in: PubMed
    57. Zhou GD, Moorthy B, Bi J, Donnelly KC, Randerath K. DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells. Environ Mol Mutagen. 2007 Dec; 48(9):715-21. PMID: 17948277.
      View in: PubMed
    58. Kommaddi RP, Turman CM, Moorthy B, Wang L, Strobel HW, Ravindranath V. An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites. J Neurochem. 2007 Aug; 102(3):867-77. PMID: 17630984.
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    59. Moorthy B, Muthiah K, Fazili IS, Kondraganti SR, Wang L, Couroucli XI, Jiang W. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1071-7. PMID: 17276403.
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    60. Couroucli XI, Wei YH, Jiang W, Muthiah K, Evey LW, Barrios R, Moorthy B. Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: implications for lung injury. Pediatr Res. 2006 Mar; 59(3):401-6. PMID: 16492979.
      View in: PubMed
    61. Couroucli XI, Liang YW, Jiang W, Barrios R, Moorthy B. Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes. J Pharmacol Exp Ther. 2006 Jun; 317(3):946-54. PMID: 16497785.
      View in: PubMed
    62. Das A, Kole L, Wang L, Barrios R, Moorthy B, Jaiswal AK. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Free Radic Biol Med. 2006 May 15; 40(10):1843-56. PMID: 16678022.
      View in: PubMed
    63. Kondraganti SR, Muthiah K, Jiang W, Barrios R, Moorthy B. Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses. Chem Res Toxicol. 2005 Nov; 18(11):1634-41. PMID: 16300371.
      View in: PubMed
    64. Sinha A, Muthiah K, Jiang W, Couroucli X, Barrios R, Moorthy B. Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Toxicol Sci. 2005 Sep; 87(1):204-12. PMID: 15958656.
      View in: PubMed
    65. Galván N, Teske DE, Zhou G, Moorthy B, MacWilliams PS, Czuprynski CJ, Jefcoate CR. Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Toxicol Appl Pharmacol. 2005 Feb 01; 202(3):244-57. PMID: 15667830.
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    66. Ramos KS, Moorthy B. Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis. Drug Metab Rev. 2005; 37(4):595-610. PMID: 16393887.
      View in: PubMed
    67. Zhang W, Moorthy B, Chen M, Muthiah K, Coffee R, Purchio AF, West DB. A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice. Toxicol Sci. 2004 Nov; 82(1):297-307. PMID: 15329440.
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    68. Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, Yu L, Avery SE, Moorthy B. Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J Pharmacol Exp Ther. 2004 Aug; 310(2):512-9. PMID: 15123765.
      View in: PubMed
    69. Moorthy B, Miller KP, Jiang W, Williams ES, Kondraganti SR, Ramos KS. Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates. J Pharmacol Exp Ther. 2003 Apr; 305(1):394-401. PMID: 12649394.
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    70. Kondraganti SR, Fernandez-Salguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy B. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Int J Cancer. 2003 Jan 01; 103(1):5-11. PMID: 12455047.
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    71. Kondraganti SR, Jiang W, Moorthy B. Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. J Pharmacol Exp Ther. 2002 Dec; 303(3):945-51. PMID: 12438513.
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    72. Couroucli XI, Welty SE, Geske RS, Moorthy B. Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury. Mol Pharmacol. 2002 Mar; 61(3):507-15. PMID: 11854430.
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    73. Moorthy B, Miller KP, Jiang W, Ramos KS. The atherogen 3-methylcholanthrene induces multiple DNA adducts in mouse aortic smooth muscle cells: role of cytochrome P4501B1. Cardiovasc Res. 2002 Mar; 53(4):1002-9. PMID: 11922910.
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    74. Li D, Wang M, Firozi PF, Chang P, Zhang W, Baer-Dubowska W, Moorthy B, Vulimiri SV, Goth-Goldstein R, Weyand EH, DiGiovanni J. Characterization of a major aromatic DNA adduct detected in human breast tissues. Environ Mol Mutagen. 2002; 39(2-3):193-200. PMID: 11921189.
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    75. Moorthy B. 3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene. Redox Rep. 2002; 7(1):9-13. PMID: 11981449.
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    76. Moorthy B. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues. J Pharmacol Exp Ther. 2000 Jul; 294(1):313-22. PMID: 10871328.
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    77. Moorthy B, Parker KM, Smith CV, Bend JR, Welty SE. Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole. J Pharmacol Exp Ther. 2000 Feb; 292(2):553-60. PMID: 10640292.
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    78. Randerath K, Sriram P, Moorthy B, Aston JP, Baan RA, van den Berg PT, Booth ED, Watson WP. Comparison of immunoaffinity chromatography enrichment and nuclease P1 procedures for 32P-postlabelling analysis of PAH-DNA adducts. Chem Biol Interact. 1998 Mar 12; 110(1-2):85-102. PMID: 9566727.
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    79. Rogers LK, Moorthy B, Smith CV. Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses. Chem Res Toxicol. 1997 Apr; 10(4):470-6. PMID: 9114986.
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    80. Moorthy B, Sriram P, Randerath E, Randerath K. Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo. Biochem Pharmacol. 1997 Mar 07; 53(5):663-9. PMID: 9113085.
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    81. Moorthy B, Nguyen UT, Gupta S, Stewart KD, Welty SE, Smith CV. Induction and decline of hepatic cytochromes P4501A1 and 1A2 in rats exposed to hyperoxia are not paralleled by changes in glutathione S-transferase-alpha. Toxicol Lett. 1997 Jan 15; 90(1):67-75. PMID: 9020404.
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    82. Mabon N, Moorthy B, Randerath E, Randerath K. Monophosphate 32P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry. Mutat Res. 1996 Nov 04; 371(1-2):87-104. PMID: 8950354.
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    83. Moorthy B, Randerath K. Pentachlorophenol enhances 9-hydroxybenzo [a] pyrene-induced hepatic DNA adduct formation in vivo and inhibits microsomal epoxide hydrolase and glutathione S-transferase activities in vitro: likely inhibition of epoxide detoxication by pentachlorophenol. Arch Toxicol. 1996; 70(11):696-703. PMID: 8896715.
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    84. Moorthy B, Sriram P, Pathak DN, Bodell WJ, Randerath K. Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo. Cancer Res. 1996 Jan 01; 56(1):53-7. PMID: 8548775.
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    85. Moorthy B, Sriram P, Randerath K. Effects of a single dose of the cytochrome P450 inducer, beta-naphthoflavone, on hepatic and renal covalent DNA modifications (I-compounds). Toxicology. 1995 Dec 15; 104(1-3):165-77. PMID: 8560495.
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    86. Moorthy B, Liehr J, Randerath E, Randerath K. Evidence from 32P-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethylstilbestrol and its dimethyl ether in mouse live: likely alpha-hydroxylation of ethyl group(s) followed by sulfate conjugation. Carcinogenesis. 1995 Nov; 16(11):2643-8. PMID: 7586180.
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    87. Vulimiri SV, Gupta S, Smith CV, Moorthy B, Randerath K. Rapid decreases in indigenous covalent DNA modifications (I-compounds) of male Fischer-344 rat liver DNA by diquat treatment. Chem Biol Interact. 1995 Mar 30; 95(1-2):1-16. PMID: 7697743.
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    88. Randerath K, Moorthy B, Mabon N, Sriram P. Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite. Carcinogenesis. 1994 Oct; 15(10):2087-94. PMID: 7955037.
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    89. Randerath K, Bi J, Mabon N, Sriram P, Moorthy B. Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor and ubiquitous environmental pollutant pentachlorophenol. Carcinogenesis. 1994 May; 15(5):797-800. PMID: 8200078.
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    90. Moorthy B, Sriram P, Randerath K. Chemical structure- and time-dependent effects of polycyclic aromatic hydrocarbon-type inducers on rat liver cytochrome P450, DNA adducts, and I-compounds. Fundam Appl Toxicol. 1994 May; 22(4):549-60. PMID: 8056202.
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    91. Moorthy B, Chen S, Li D, Randerath K. 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds. Carcinogenesis. 1993 May; 14(5):879-86. PMID: 8504481.
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    92. Randerath K, Li D, Moorthy B, Randerath E. I-compounds--endogenous DNA markers of nutritional status, ageing, tumour promotion and carcinogenesis. IARC Sci Publ. 1993; (124):157-65. PMID: 8225479.
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    93. Li D, Moorthy B, Chen S, Randerath K. Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA. Carcinogenesis. 1992 Jul; 13(7):1191-8. PMID: 1638686.
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    94. Moorthy B, van Golen KL, Randerath K. Sex-specific modulation of hepatic covalent DNA modifications (I-compounds) by the cytochrome P450 inducer, pregnenolone-16 alpha-carbonitrile. Toxicol Appl Pharmacol. 1992 Apr; 113(2):218-26. PMID: 1561630.
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