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BENNY ABRAHAM KAIPPARETTU

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
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    R03CA150027     (KAIPPARETTU, BENNY ABRAHAM)Jan 7, 2011 - Dec 31, 2013
    NIH/NCI
    Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Role: Principal Investigator

    R21CA179720     (KAIPPARETTU, BENNY ABRAHAM)Jul 24, 2013 - Jun 30, 2016
    NIH/NCI
    Mitochondria-nuclear crosstalk in triple negative breast cancer racial disparity
    Role: Principal Investigator

    R21CA173150     (KAIPPARETTU, BENNY ABRAHAM)Sep 17, 2013 - Aug 31, 2015
    NIH/NCI
    Mitochondria specific metabolomic signature in triple negative breast cancer meta
    Role: Principal Investigator

    R03CA212816     (KAIPPARETTU, BENNY ABRAHAM)Sep 19, 2017 - Aug 31, 2019
    NIH/NCI
    Mitochondrial DNA copy number and fat metabolism in triple negative breast cancer
    Role: Principal Investigator

    R03CA235113     (KAIPPARETTU, BENNY ABRAHAM)Jan 1, 2019 - Dec 31, 2020
    NIH/NCI
    High-fat diet-mediated activation of Src oncopathway in triple negative breast cancer
    Role: Principal Investigator

    R01CA234479     (KAIPPARETTU, BENNY ABRAHAM)Jan 1, 2019 - Dec 31, 2023
    NIH/NCI
    Energy reprogramming-regulated oncopathways and drug resistance in triple negative breast cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun Z, Brunetti L, Hyoung Park J, Kaipparettu BA, Putluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal DT. Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss. Cell Metab. 2019 Aug 06; 30(2):261-273.e6. PMID: 31279675.
      View in: PubMed
    2. Mukhopadhyay UK, Oturkar CC, Adams C, Wickramasekera N, Bansal S, Medisetty R, Miller A, Swetzig WM, Silwal-Pandit L, Borresen-Dale AL, Creighton CJ, Park JH, Konduri SD, Mukhopadhyay A, Caradori A, Omilian A, Bshara W, Kaipparettu BA, Das GM. TP53 Status as a Determinant of Pro- versus Anti-tumorigenic Effects of Estrogen Receptor-beta in Breast Cancer. J Natl Cancer Inst. 2019 Apr 16. PMID: 30990221.
      View in: PubMed
    3. Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells. 2019 04 11; 8(4). PMID: 30978984.
      View in: PubMed
    4. Jia D, Lu M, Jung KH, Park JH, Yu L, Onuchic JN, Kaipparettu BA, Levine H. Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3909-3918. PMID: 30733294.
      View in: PubMed
    5. Jia D, Park JH, Jung KH, Levine H, Kaipparettu BA. Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States. Cells. 2018 Mar 13; 7(3). PMID: 29534029.
      View in: PubMed
    6. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 Apr 02; 128(4):1283-1299. PMID: 29480818.
      View in: PubMed
    7. White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer. 2018 04; 25(4):453-469. PMID: 29431615.
      View in: PubMed
    8. Jin F, Thaiparambil J, Donepudi SR, Vantaku V, Piyarathna DWB, Maity S, Krishnapuram R, Putluri V, Gu F, Purwaha P, Bhowmik SK, Ambati CR, von Rundstedt FC, Roghmann F, Berg S, Noldus J, Rajapakshe K, Gödde D, Roth S, Störkel S, Degener S, Michailidis G, Kaipparettu BA, Karanam B, Terris MK, Kavuri SM, Lerner SP, Kheradmand F, Coarfa C, Sreekumar A, Lotan Y, El-Zein R, Putluri N. Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila). 2017 Oct; 10(10):588-597. PMID: 28851690.
      View in: PubMed
    9. Vangapandu HV, Havranek O, Ayres ML, Kaipparettu BA, Balakrishnan K, Wierda WG, Keating MJ, Davis RE, Stellrecht CM, Gandhi V. B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia. Mol Cancer Res. 2017 12; 15(12):1692-1703. PMID: 28835371.
      View in: PubMed
    10. Yu L, Lu M, Jia D, Ma J, Ben-Jacob E, Levine H, Kaipparettu BA, Onuchic JN. Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation. Cancer Res. 2017 04 01; 77(7):1564-1574. PMID: 28202516.
      View in: PubMed
    11. Gupta BK, Singh S, Kumar P, Lee Y, Kedawat G, Narayanan TN, Vithayathil SA, Ge L, Zhan X, Gupta S, Martí AA, Vajtai R, Ajayan PM, Kaipparettu BA. Bifunctional Luminomagnetic Rare-Earth Nanorods for High-Contrast Bioimaging Nanoprobes. Sci Rep. 2016 09 02; 6:32401. PMID: 27585638.
      View in: PubMed
    12. Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 05 19; 7:11612. PMID: 27194471.
      View in: PubMed
    13. Singh S, Kumar P, Kaipparettu BA, Gupta BK. Eu3+ doped a-sodium gadolinium fluoride luminomagnetic nanophosphor as a bimodal nanoprobe for high-contrast in vitro bioimaging and external magnetic field tracking applications. RSC Adv. 2016; 6(50):44606-44615. PMID: 27668077.
      View in: PubMed
    14. Liang DH, Choi DS, Ensor JE, Kaipparettu BA, Bass BL, Chang JC. The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett. 2016 07 01; 376(2):249-58. PMID: 27060208.
      View in: PubMed
    15. Chen F, Zhang Y, Senbabaoglu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Rep. 2016 Mar 15; 14(10):2476-89. PMID: 26947078.
      View in: PubMed
    16. Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Sreekumar A, Lewis MT, Creighton CJ, Wong LC, Kaipparettu BA. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep. 2016 Mar 08; 14(9):2154-2165. PMID: 26923594.
      View in: PubMed
    17. Saraf M, Kumar P, Kedawat G, Dwivedi J, Vithayathil SA, Jaiswal N, Kaipparettu BA, Gupta BK. Probing highly luminescent europium-doped lanthanum orthophosphate nanorods for strategic applications. Inorg Chem. 2015 Mar 16; 54(6):2616-25. PMID: 25732726.
      View in: PubMed
    18. Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014 Sep 08; 26(3):319-330. PMID: 25155756.
      View in: PubMed
    19. Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJ. Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One. 2013; 8(5):e61747. PMID: 23671572.
      View in: PubMed
    20. Gupta BK, Narayanan TN, Vithayathil SA, Lee Y, Koshy S, Reddy AL, Saha A, Shanker V, Singh VN, Kaipparettu BA, Martí AA, Ajayan PM. Highly luminescent-paramagnetic nanophosphor probes for in vitro high-contrast imaging of human breast cancer cells. Small. 2012 Oct 08; 8(19):3028-34. PMID: 22807340.
      View in: PubMed
    21. Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani SA, Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM. Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging. Adv Mater. 2012 Jun 12; 24(22):2992-8. PMID: 22573478.
      View in: PubMed
    22. Peng J, Gao W, Gupta BK, Liu Z, Romero-Aburto R, Ge L, Song L, Alemany LB, Zhan X, Gao G, Vithayathil SA, Kaipparettu BA, Marti AA, Hayashi T, Zhu JJ, Ajayan PM. Graphene quantum dots derived from carbon fibers. Nano Lett. 2012 Feb 08; 12(2):844-9. PMID: 22216895.
      View in: PubMed
    23. Vithayathil SA, Ma Y, Kaipparettu BA. Transmitochondrial cybrids: tools for functional studies of mutant mitochondria. Methods Mol Biol. 2012; 837:219-30. PMID: 22215551.
      View in: PubMed
    24. Tu YF, Kaipparettu BA, Ma Y, Wong LJ. Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties. Biochim Biophys Acta. 2011 Sep; 1807(9):1125-32. PMID: 21570379.
      View in: PubMed
    25. Konduri SD, Medisetty R, Liu W, Kaipparettu BA, Srivastava P, Brauch H, Fritz P, Swetzig WM, Gardner AE, Khan SA, Das GM. Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15081-6. PMID: 20696891.
      View in: PubMed
    26. Kaipparettu BA, Ma Y, Wong LJ. Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids. Ann N Y Acad Sci. 2010 Jul; 1201:137-46. PMID: 20649550.
      View in: PubMed
    27. Hammerich-Hille S, Kaipparettu BA, Tsimelzon A, Creighton CJ, Jiang S, Polo JM, Melnick A, Meyer R, Oesterreich S. SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. J Biol Chem. 2010 Feb 05; 285(6):3608-16. PMID: 19901029.
      View in: PubMed
    28. Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009 Mar 06; 8:15. PMID: 19267898.
      View in: PubMed
    29. Kaipparettu BA, Kuiatse I, Tak-Yee Chan B, Benny Kaipparettu M, Lee AV, Oesterreich S. Novel egg white-based 3-D cell culture system. Biotechniques. 2008 Aug; 45(2):165-8, 170-1. PMID: 18687065.
      View in: PubMed
    30. Kaipparettu BA, Malik S, Konduri SD, Liu W, Rokavec M, van der Kuip H, Hoppe R, Hammerich-Hille S, Fritz P, Schroth W, Abele I, Das GM, Oesterreich S, Brauch H. Estrogen-mediated downregulation of CD24 in breast cancer cells. Int J Cancer. 2008 Jul 01; 123(1):66-72. PMID: 18404683.
      View in: PubMed
    31. Jaremko M, Justenhoven C, Schroth W, Abraham BK, Fritz P, Vollmert C, Illig T, Simon W, Schwab M, Brauch H. Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer. Pharmacogenet Genomics. 2007 Jul; 17(7):529-38. PMID: 17558308.
      View in: PubMed
    32. Abraham BK, Justenhoven C, Pesch B, Harth V, Weirich G, Baisch C, Rabstein S, Ko YD, Brüning T, Fischer HP, Haas S, Brod S, Oberkanins C, Hamann U, Brauch H. Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer. Cancer Epidemiol Biomarkers Prev. 2005 May; 14(5):1102-7. PMID: 15894659.
      View in: PubMed
    33. Jaremko M, Justenhoven C, Abraham BK, Schroth W, Fritz P, Brod S, Vollmert C, Illig T, Brauch H. MALDI-TOF MS and TaqMan assisted SNP genotyping of DNA isolated from formalin-fixed and paraffin-embedded tissues (FFPET). Hum Mutat. 2005 Mar; 25(3):232-8. PMID: 15706592.
      View in: PubMed
    34. Jose R, Chandrasekaran A, Sam SS, Gerard N, Chanolean S, Abraham BK, Satyanarayanamoorthy K, Peter A, Rajagopal K. CYP2C9 and CYP2C19 genetic polymorphisms: frequencies in the south Indian population. Fundam Clin Pharmacol. 2005 Feb; 19(1):101-5. PMID: 15660966.
      View in: PubMed
    35. Abraham BK, Fritz P, McClellan M, Hauptvogel P, Athelogou M, Brauch H. Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res. 2005 Feb 01; 11(3):1154-9. PMID: 15709183.
      View in: PubMed
    36. Naveen AT, Adithan C, Padmaja N, Shashindran CH, Abraham BK, Satyanarayanamoorthy K, Anitha P, Gerard N, Krishnamoorthy R. Glutathione S-transferase M1 and T1 null genotype distribution in South Indians. Eur J Clin Pharmacol. 2004 Aug; 60(6):403-6. PMID: 15197518.
      View in: PubMed
    37. Koumaravelou K, Adithan C, Shashindran CH, Asad M, Abraham BK. Influence of honey on orally and intravenously administered diltiazem kinetics in rabbits. Indian J Exp Biol. 2002 Oct; 40(10):1164-8. PMID: 12693698.
      View in: PubMed
    38. Koumaravelou K, Adithan C, Shashindran CH, Asad M, Abraham BK. Effect of honey on carbamazepine kinetics in rabbits. Indian J Exp Biol. 2002 May; 40(5):560-3. PMID: 12622202.
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    39. Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S. Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life Sci. 2001 Nov 21; 70(1):17-24. PMID: 11764003.
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    40. Asad M, Shewade DG, Koumaravelou K, Abraham BK, Balasinor N, Ramaswamy S. Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats. J Pharm Pharmacol. 2001 Nov; 53(11):1541-7. PMID: 11732757.
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    41. Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S. Effect of centrally administered prolactin on gastric and duodenal ulcers in rats. Fundam Clin Pharmacol. 2001 Jun; 15(3):175-9. PMID: 11468028.
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    42. Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S. Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats. Acta Pharmacol Sin. 2001 Jun; 22(6):488-92. PMID: 11747752.
      View in: PubMed
    43. Abraham BK, Adithan C, Mohanasundaram J, Shashindran CH, Koumaravelou K, Asad M. Genetic polymorphism of CYP2D6 in Tamil population. Eur J Clin Pharmacol. 2001 Jan-Feb; 56(11):849-50. PMID: 11294377.
      View in: PubMed
    44. Abraham BK, Adithan C, Kiran PU, Asad M, Koumaravelou K. Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India. Acta Pharmacol Sin. 2000 Jun; 21(6):494-8. PMID: 11360682.
      View in: PubMed
    45. Abraham BK, Adithan C, Shashindran CH, Vasu S, Alekutty NA. Genetic polymorphism of CYP2D6 in a keralite (South India) population. Br J Clin Pharmacol. 2000 Mar; 49(3):285-6. PMID: 10718787.
      View in: PubMed
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