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ALI MARIAN

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Cardiology
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    R01HL068884     (MARIAN, ALI J.)Sep 30, 2001 - Jul 31, 2007
    NIH/NHLBI
    Modifier Genes of Familial Hypertrophic Cardiomyopathy
    Role: Principal Investigator

    R01HL088498     (MARIAN, ALI J)Jan 1, 2007 - Mar 31, 2018
    NIH/NHLBI
    Canonical Wnt Signaling in Pathogenesis and Rescue of ARVC
    Role: Principal Investigator

    R21AG038597     (MARIAN, ALI J)Apr 1, 2011 - Mar 31, 2013
    NIH/NIA
    Mouse Models of Non-Syndromic Cardiac Progeria
    Role: Principal Investigator

    R34HL105563     (MARIAN, ALI J)Jan 1, 2012 - Dec 31, 2014
    NIH/NHLBI
    Hypertrophy Regression with N-Acetylcysteine in Hypertrophic Cardiomyopathy
    Role: Principal Investigator

    S10OD018135     (MARIAN, ALI J)Apr 1, 2015 - Mar 31, 2016
    NIH
    Cardiovascular Ultrasonography Unit
    Role: Principal Investigator

    R01HL132401     (MARIAN, ALI J)Mar 15, 2016 - Feb 28, 2020
    NIH/NHLBI
    Pathogenic Role of Selected Cardiac Myocyte- and Fibroblast-Specific Epigenetic Changes in Laminopathies
    Role: Principal Investigator

    R01HL151737     (MARIAN, ALI J)Apr 10, 2020 - Mar 31, 2024
    NIH/NHLBI
    Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D, Lakdawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2020 Jun 02; 75(21):2649-2660. PMID: 32466879.
      View in: PubMed
    2. Auguste G, Rouhi L, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Gurha P, Marian AJ. BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific Lamin A/C-deficient mice. J Clin Invest. 2020 Jun 02. PMID: 32484798.
      View in: PubMed
    3. Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Campbell H, Wehrens X, Gurha P, Marian AJ. Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 May 01; 116(6):1199-1213. PMID: 31350552.
      View in: PubMed
    4. Marian AJ. Editorial: Overcoming current limitations of genetic testing in cardiovascular medicine. Curr Opin Cardiol. 2020 May; 35(3):187-190. PMID: 32175937.
      View in: PubMed
    5. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Kreutz R, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes IB. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res. 2020 Apr 30. PMID: 32352535.
      View in: PubMed
    6. Marian AJ, Asatryan B, Wehrens XHT. Genetic Basis and Molecular Biology of Cardiac Arrhythmias in Cardiomyopathies. Cardiovasc Res. 2020 Apr 29. PMID: 32348453.
      View in: PubMed
    7. Puzzi L, Borin D, Gurha P, Lombardi R, Martinelli V, Weiss M, Andolfi L, Lazzarino M, Mestroni L, Marian AJ, Sbaizero O. Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells. Cells. 2019 12 14; 8(12). PMID: 31847412.
      View in: PubMed
    8. Hall CL, Gurha P, Sabater-Molina M, Asimaki A, Futema M, Lovering RC, Suárez MP, Aguilera B, Molina P, Zorio E, Coarfa C, Robertson MJ, Cheedipudi SM, Ng KE, Delaney P, Hernández JP, Pastor F, Gimeno JR, McKenna WJ, Marian AJ, Syrris P. RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. Int J Cardiol. 2020 03 01; 302:124-130. PMID: 31843279.
      View in: PubMed
    9. Marian AJ. Role of the Extracellular Matrix in the Pathogenesis of Hypertrophic Cardiomyopathy. JACC Basic Transl Sci. 2019 Aug; 4(4):506-508. PMID: 31468005.
      View in: PubMed
    10. Hu J, Yu J, Chen Q, Hu J, Huang Q, Xia Z, Xia Z, Ju Z, Yuan P, Fan S, Xiong Q, Zhu B, Huang L, You C, Bao H, Wu Y, Cheng X, Li J, Marian AJ, Hong K. Efficacy of Nifekalant in Patients With Wolff-Parkinson-White Syndrome and Atrial Fibrillation: Electrophysiological and Clinical Findings. J Am Heart Assoc. 2019 07 02; 8(13):e012511. PMID: 31234695.
      View in: PubMed
    11. Cheedipudi SM, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet M, Taylor M, Mestroni L, Cleveland J, Willerson JT, Gurha P, Marian AJ. Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 04 12; 124(8):1198-1213. PMID: 30739589.
      View in: PubMed
    12. Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 03 15; 124(6):856-873. PMID: 30696354.
      View in: PubMed
    13. Mcginnigle E, Marian AJ. Scientists on the Spot: A brief word with Ali J. Marian on cardiovascular genetics. Cardiovasc Res. 2018 10 01; 114(12):e91-e92. PMID: 31346600.
      View in: PubMed
    14. Marian AJ. Genetic Testing in Cardiovascular Medicine. Tex Heart Inst J. 2018 08; 45(4):231-232. PMID: 30374232.
      View in: PubMed
    15. Chamberlain K, Riyad JM, Garnett T, Kohlbrenner E, Mookerjee A, Elmastour F, Benard L, Chen J, VandenDriessche T, Chuah MK, Marian AJ, Hajjar RJ, Gurha P, Weber T. A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity. Hum Gene Ther. 2018 08; 29(8):927-937. PMID: 29641321.
      View in: PubMed
    16. Marian AJ, Tan Y, Li L, Chang J, Syrris P, Hessabi M, Rahbar MH, Willerson JT, Cheong BY, Liu CY, Kleiman NS, Bluemke DA, Nagueh SF. Hypertrophy Regression With N-Acetylcysteine in Hypertrophic Cardiomyopathy (HALT-HCM): A Randomized, Placebo-Controlled, Double-Blind Pilot Study. Circ Res. 2018 04 13; 122(8):1109-1118. PMID: 29540445.
      View in: PubMed
    17. Auguste G, Gurha P, Lombardi R, Coarfa C, Willerson JT, Marian AJ. Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. Circ Res. 2018 03 02; 122(5):678-692. PMID: 29317431.
      View in: PubMed
    18. Marian AJ. Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene. BMC Med Genet. 2017 10 18; 18(1):116. PMID: 29047356.
      View in: PubMed
    19. Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-Hélaouët M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359. PMID: 29018034.
      View in: PubMed
    20. Marian AJ, Braunwald E. Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. Circ Res. 2017 Sep 15; 121(7):749-770. PMID: 28912181.
      View in: PubMed
    21. Marian AJ. Congenital Heart Disease: The Remarkable Journey From the "Post-Mortem Room" to Adult Clinics. Circ Res. 2017 03 17; 120(6):895-897. PMID: 28302735.
      View in: PubMed
    22. Bainbridge MN, Li L, Tan Y, Cheong BY, Marian AJ. Identification of established arrhythmogenic right ventricular cardiomyopathy mutation in a patient with the contrasting phenotype of hypertrophic cardiomyopathy. BMC Med Genet. 2017 Mar 03; 18(1):24. PMID: 28253841.
      View in: PubMed
    23. Marian AJ. New landscape of cardiovascular genetics and genomics. Curr Opin Cardiol. 2017 Feb 24. PMID: 28240644.
      View in: PubMed
    24. Li L, Bainbridge MN, Tan Y, Willerson JT, Marian AJ. A Potential Oligogenic Etiology of Hypertrophic Cardiomyopathy: A Classic Single-Gene Disorder. Circ Res. 2017 Mar 31; 120(7):1084-1090. PMID: 28223422.
      View in: PubMed
    25. Marian AJ, van Rooij E, Roberts R. Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of Single-Gene Disorders. J Am Coll Cardiol. 2016 Dec 27; 68(25):2831-2849. PMID: 28007145.
      View in: PubMed
    26. Lynch TL, Kuster DWD, Gonzalez B, Balasubramanian N, Nair N, Day S, Calvino JE, Tan Y, Liebetrau C, Troidl C, Hamm CW, Güçlü A, McDonough B, Marian AJ, van der Velden J, Seidman CE, Huggins GS, Sadayappan S. Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC Basic Transl Sci. 2017 Apr; 2(2):122-131. PMID: 28596995.
      View in: PubMed
    27. Marian AJ. Challenges in the Diagnosis of Anderson-Fabry Disease: A Deceptively Simple and Yet Complicated Genetic Disease. J Am Coll Cardiol. 2016 09 06; 68(10):1051-3. PMID: 27585510.
      View in: PubMed
    28. Gurha P, Chen X, Lombardi R, Willerson JT, Marian AJ. Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro. Circ Res. 2016 Sep 02; 119(6):731-50. PMID: 27470638.
      View in: PubMed
    29. Marian AJ. The Case of "Missing Causal Genes" and the Practice of Medicine: A Sherlock Holmes Approach of Deductive Reasoning. Circ Res. 2016 06 24; 119(1):21-4. PMID: 27340268.
      View in: PubMed
    30. Lombardi R, Chen SN, Ruggiero A, Gurha P, Czernuszewicz GZ, Willerson JT, Marian AJ. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016 06 24; 119(1):41-54. PMID: 27121621.
      View in: PubMed
    31. Marian AJ. Clinical applications of molecular genetic discoveries. Transl Res. 2016 Feb; 168:6-14. PMID: 26548329.
      View in: PubMed
    32. Marian AJ. The Bottleneck in Genetic Testing. Circ Res. 2015 Sep 11; 117(7):586-8. PMID: 26358106.
      View in: PubMed
    33. Xiong Q, Cao Q, Zhou Q, Xie J, Shen Y, Wan R, Yu J, Yan S, Marian AJ, Hong K. Arrhythmogenic cardiomyopathy in a patient with a rare loss-of-function KCNQ1 mutation. J Am Heart Assoc. 2015 Jan 23; 4(1):e001526. PMID: 25616976.
      View in: PubMed
    34. Madonna R, Ferdinandy P, De Caterina R, Willerson JT, Marian AJ. Recent developments in cardiovascular stem cells. Circ Res. 2014 Dec 05; 115(12):e71-8. PMID: 25477490.
      View in: PubMed
    35. Marian AJ. Copy number variants and the genetic enigma of congenital heart disease. Circ Res. 2014 Oct 24; 115(10):821-3. PMID: 25342769.
      View in: PubMed
    36. Marian AJ. Recent developments in cardiovascular genetics and genomics. Circ Res. 2014 Sep 12; 115(7):e11-7. PMID: 25214576.
      View in: PubMed
    37. Marian AJ, Williams R. Ali J. Marian: life and science are one. Circ Res. 2014 Aug 29; 115(6):549-51. PMID: 25170092.
      View in: PubMed
    38. Korf BR, Berry AB, Limson M, Marian AJ, Murray MF, O'Rourke PP, Passamani ER, Relling MV, Tooker J, Tsongalis GJ, Rodriguez LL. Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics. Genet Med. 2014 Nov; 16(11):804-9. PMID: 24763287.
      View in: PubMed
    39. Marian AJ. Causality in genetics: the gradient of genetic effects and back to Koch's postulates of causality. Circ Res. 2014 Jan 17; 114(2):e18-21. PMID: 24436434.
      View in: PubMed
    40. Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S. Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury. Am J Physiol Heart Circ Physiol. 2014 Feb 15; 306(4):H547-56. PMID: 24337456.
      View in: PubMed
    41. Gurha P, Marian AJ. Noncoding RNAs in cardiovascular biology and disease. Circ Res. 2013 Dec 06; 113(12):e115-20. PMID: 24311620.
      View in: PubMed
    42. Marian AJ. On the diagnostic utility of junction plakoglobin in arrhythmogenic right ventricular cardiomyopathy. Cardiovasc Pathol. 2013 Sep-Oct; 22(5):309-11. PMID: 23806441.
      View in: PubMed
    43. Marian AJ. Errors in DNA replication and genetic diseases. Curr Opin Cardiol. 2013 May; 28(3):269-71. PMID: 23549234.
      View in: PubMed
    44. Peng X, Shao J, Shen Y, Zhou Y, Cao Q, Hu J, He W, Yu X, Liu X, Marian AJ, Hong K. FAT10 protects cardiac myocytes against apoptosis. J Mol Cell Cardiol. 2013 Jun; 59:1-10. PMID: 23416168.
      View in: PubMed
    45. Ruggiero A, Chen SN, Lombardi R, Rodriguez G, Marian AJ. Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity. Cardiovasc Res. 2013 Jan 01; 97(1):44-54. PMID: 22987565.
      View in: PubMed
    46. Marian AJ. Challenges in medical applications of whole exome/genome sequencing discoveries. Trends Cardiovasc Med. 2012 Nov; 22(8):219-23. PMID: 22921985.
      View in: PubMed
    47. Chen SN, Czernuszewicz G, Tan Y, Lombardi R, Jin J, Willerson JT, Marian AJ. Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2012 Sep 14; 111(7):907-19. PMID: 22821932.
      View in: PubMed
    48. Marian AJ. Elements of 'missing heritability'. Curr Opin Cardiol. 2012 May; 27(3):197-201. PMID: 22450721.
      View in: PubMed
    49. Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012 Feb; 159(2):64-79. PMID: 22243791.
      View in: PubMed
    50. Marian AJ. Modeling human disease phenotype in model organisms: "It's only a model!". Circ Res. 2011 Aug 05; 109(4):356-9. PMID: 21817163.
      View in: PubMed
    51. Rodriguez G, Ueyama T, Ogata T, Czernuszewicz G, Tan Y, Dorn GW, Bogaev R, Amano K, Oh H, Matsubara H, Willerson JT, Marian AJ. Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):349-58. PMID: 21642240.
      View in: PubMed
    52. Marian AJ. Genome-wide association studies complemented with mechanistic biological studies identify sortilin 1 as a novel regulator of cholesterol trafficking. Curr Atheroscler Rep. 2011 Jun; 13(3):190-2. PMID: 21287300.
      View in: PubMed
    53. Rodriguez G, Starr AZ, Czernuszewicz GZ, Manhas A, Alhariri A, Willerson JT, Reist CJ, Pieper K, Mahaffey KW, Marian AJ, Kleiman NS. Determinants of plasma vitamin D levels in patients with acute coronary syndromes. Eur J Clin Invest. 2011 Dec; 41(12):1299-309. PMID: 21615392.
      View in: PubMed
    54. Marian AJ. Medical DNA sequencing. Curr Opin Cardiol. 2011 May; 26(3):175-80. PMID: 21415728.
      View in: PubMed
    55. Alexander D, Lombardi R, Rodriguez G, Mitchell MM, Marian AJ. Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest. 2011 May; 41(5):527-38. PMID: 21155767.
      View in: PubMed
    56. Nagueh SF, Lombardi R, Tan Y, Wang J, Willerson JT, Marian AJ. Atorvastatin and cardiac hypertrophy and function in hypertrophic cardiomyopathy: a pilot study. Eur J Clin Invest. 2010 Nov; 40(11):976-83. PMID: 20629707.
      View in: PubMed
    57. Marian AJ. PCSK9 as a therapeutic target in atherosclerosis. Curr Atheroscler Rep. 2010 May; 12(3):151-4. PMID: 20425252.
      View in: PubMed
    58. Lombardi R, Marian AJ. Arrhythmogenic right ventricular cardiomyopathy is a disease of cardiac stem cells. Curr Opin Cardiol. 2010 May; 25(3):222-8. PMID: 20124997.
      View in: PubMed
    59. Marian AJ. DNA sequence variants and the practice of medicine. Curr Opin Cardiol. 2010 May; 25(3):182-5. PMID: 20224386.
      View in: PubMed
    60. Marian AJ. Hypertrophic cardiomyopathy: from genetics to treatment. Eur J Clin Invest. 2010 Apr; 40(4):360-9. PMID: 20503496.
      View in: PubMed
    61. Marian AJ. Update on hypertrophic cardiomyopathy. Tex Heart Inst J. 2010; 37(3):322-3. PMID: 20548812.
      View in: PubMed
    62. Marian AJ. Nature's genetic gradients and the clinical phenotype. Circ Cardiovasc Genet. 2009 Dec; 2(6):537-9. PMID: 20031631.
      View in: PubMed
    63. Marian AJ. Experimental therapies in hypertrophic cardiomyopathy. J Cardiovasc Transl Res. 2009 Dec; 2(4):483-92. PMID: 20560006.
      View in: PubMed
    64. Marian AJ. Cytochrome p-450 polymorphisms and response to clopidogrel. Curr Atheroscler Rep. 2009 May; 11(3):157-60. PMID: 19361345.
      View in: PubMed
    65. Guo DC, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete SS, Scherer SE, Raman CS, Buja LM, Milewicz DM. Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Hum Genet. 2009 May; 84(5):617-27. PMID: 19409525.
      View in: PubMed
    66. Lombardi R, Dong J, Rodriguez G, Bell A, Leung TK, Schwartz RJ, Willerson JT, Brugada R, Marian AJ. Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res. 2009 May 08; 104(9):1076-84. PMID: 19359597.
      View in: PubMed
    67. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ. Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation. 2009 Mar 17; 119(10):1398-407. PMID: 19255346.
      View in: PubMed
    68. Chen SN, Ballantyne CM, Gotto AM, Marian AJ. The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. BMC Cardiovasc Disord. 2009 Jan 27; 9:3. PMID: 19173706.
      View in: PubMed
    69. Marian AJ. Contemporary treatment of hypertrophic cardiomyopathy. Tex Heart Inst J. 2009; 36(3):194-204. PMID: 19568388.
      View in: PubMed
    70. Marian AJ. Clinical implications of the "personal" genome. Curr Atheroscler Rep. 2008 Oct; 10(5):361-3. PMID: 18706275.
      View in: PubMed
    71. Marian AJ. Genome-wide association study of susceptibility alleles for coronary artery disease. Curr Atheroscler Rep. 2008 Jun; 10(3):183-5. PMID: 18489844.
      View in: PubMed
    72. Marian AJ. Genetic determinants of cardiac hypertrophy. Curr Opin Cardiol. 2008 May; 23(3):199-205. PMID: 18382207.
      View in: PubMed
    73. Lombardi R, Bell A, Senthil V, Sidhu J, Noseda M, Roberts R, Marian AJ. Differential interactions of thin filament proteins in two cardiac troponin T mouse models of hypertrophic and dilated cardiomyopathies. Cardiovasc Res. 2008 Jul 01; 79(1):109-17. PMID: 18349139.
      View in: PubMed
    74. Marian AJ. Surprises of the genome and "personalized" medicine. J Am Coll Cardiol. 2008 Jan 29; 51(4):456-8. PMID: 18222356.
      View in: PubMed
    75. Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR. Enhanced transmural fiber rotation and connexin 43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res. 2007 Nov 09; 101(10):1049-57. PMID: 17885214.
      View in: PubMed
    76. Marian AJ. A novel genetic risk factor for myocardial infarction. Curr Atheroscler Rep. 2007 Sep; 9(3):176-8. PMID: 18241610.
      View in: PubMed
    77. Marian AJ. Clinical significance of single nucleotide polymorphisms in PCSK9. Curr Atheroscler Rep. 2007 Sep; 9(3):175-6. PMID: 18241609.
      View in: PubMed
    78. Daw EW, Chen SN, Czernuszewicz G, Lombardi R, Lu Y, Ma J, Roberts R, Shete S, Marian AJ. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. Hum Mol Genet. 2007 Oct 15; 16(20):2463-71. PMID: 17652099.
      View in: PubMed
    79. Marian AJ. Phenotypic plasticity of sarcomeric protein mutations. J Am Coll Cardiol. 2007 Jun 26; 49(25):2427-9. PMID: 17599606.
      View in: PubMed
    80. Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT, Marian AJ. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2007 Mar 30; 100(6):766-8. PMID: 17347475.
      View in: PubMed
    81. Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJ. Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest. 2006 Jul; 116(7):2012-21. PMID: 16823493.
      View in: PubMed
    82. Marian AJ. Matrix metalloproteinase-I gene variants and risk of myocardial infarction. Curr Atheroscler Rep. 2006 May; 8(3):174-6. PMID: 16767840.
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    83. Marian AJ. Interleukin-18 and cardiovascular events. Curr Atheroscler Rep. 2006 May; 8(3):173-4. PMID: 16767839.
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    84. Marian AJ, Senthil V, Chen SN, Lombardi R. Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation. J Am Coll Cardiol. 2006 Feb 21; 47(4):827-34. PMID: 16487852.
      View in: PubMed
    85. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668.
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    86. Marian AJ. Cholesteryl ester transfer protein TaqIB polymorphism in the cholesterol and recurrent events study. Curr Atheroscler Rep. 2005 May; 7(3):178-9. PMID: 15811250.
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    87. Marian AJ. Pharmacogenetic study of statin therapy and cholesterol reduction. Curr Atheroscler Rep. 2005 May; 7(3):177-8. PMID: 15811249.
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    88. Chen SN, Ballantyne CM, Gotto AM, Tan Y, Willerson JT, Marian AJ. A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol. 2005 May 17; 45(10):1611-9. PMID: 15893176.
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    89. Roberts R, Marian AJ. Can an energy-deficient heart grow bigger and stronger? J Am Coll Cardiol. 2003 May 21; 41(10):1783-5. PMID: 12767665.
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    90. Marian AJ. On predictors of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2003 Mar 19; 41(6):994-6. PMID: 12651047.
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    91. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2748-53. PMID: 12601178.
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