NICHOLAS RIDER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    JMF Translational Award     (Nicholas L. Rider, D.O.)Aug 1, 2019 - Jul 30, 2022
    Jeffrey Modell Foundation
    Longitudinal Validation & Optimization of the SPIRIT Analyzer
    Role Description: We will evaluate use of a computational tool for predictive analytics towards risk of primary immunodeficiency within the TCH Health Plan. We will also utilize data mined from the analyzed cohort to design, test and validate a machine learning algorithm for predictive analytics.
    Role: PI

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rider NL, Srinivasan R, Khoury P. Artificial intelligence and the hunt for immunological disorders. Curr Opin Allergy Clin Immunol. 2020 Dec; 20(6):565-573. PMID: 33002894.
      Citations:    Fields:    
    2. Rider NL. Digital systems for improving outcomes in patients with primary immune defects. Curr Opin Pediatr. 2020 Dec; 32(6):772-779. PMID: 33060445.
      Citations:    Fields:    
    3. Pickett G, Motazedi T, Kutac C, Cahill G, Cunnigham-Rundles C, Fuleihan RL, Sullivan KE, Rider NL. Infection Phenotypes Among Patients with Primary Antibody Deficiency Mined from a US Patient Registry. J Clin Immunol. 2020 Nov 17. PMID: 33205244.
      Citations:    
    4. Joseph M, Chew WT, Seeborg F, Satter LF, Anvari S, Chinn IK, Davis CM, Gupta MR, Nicholas S, Noroski LM, James M, Deniskin R, Diaz VC, Lowe J, Lee GL, Craddock MF, Chan AJ, Rider NL. Intralesional Corticosteroids as Adjunctive Therapy for Refractory Cutaneous Lesions in Chronic Granulomatous Disease. J Allergy Clin Immunol Pract. 2020 Sep; 8(8):2769-2770. PMID: 32600996.
      Citations:    Fields:    
    5. Searing DA, Dutmer CM, Fleischer DM, Shaker MS, Oppenheimer J, Grayson MH, Stukus D, Hartog N, Hsieh EWY, Rider NL, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Abrams EM, Bansal P, Lang DM, Lieberman J, Golden DB, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services. J Allergy Clin Immunol Pract. 2020 Jul - Aug; 8(7):2125-2134. PMID: 32450236.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    6. Shaker MS, Oppenheimer J, Grayson M, Stukus D, Hartog N, Hsieh EWY, Rider N, Dutmer CM, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Lang D, Lieberman J, Fleischer D, Golden DBK, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. Reply to "Subcutaneous terbutaline as an alternative to aerosolized albuterol". J Allergy Clin Immunol Pract. 2020 Jul - Aug; 8(7):2450-2452. PMID: 32340824.
      Citations:    Fields:    
    7. Shaker MS, Oppenheimer J, Grayson M, Stukus D, Hartog N, Hsieh EWY, Rider N, Dutmer CM, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Lang D, Lieberman J, Fleischer D, Golden DBK, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic. J Allergy Clin Immunol Pract. 2020 05; 8(5):1477-1488.e5. PMID: 32224232.
      Citations: 23     Fields:    Translation:HumansPHPublic Health
    8. Hartono S, Ippoliti MR, Mastroianni M, Torres R, Rider NL. Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases. Clin Rev Allergy Immunol. 2019 Oct; 57(2):145-165. PMID: 29754192.
      Citations: 2     Fields:    Translation:Humans
    9. Wright TE, Shah MD, Rider NL, Porea TJ, Musick MA, Miller J, Daves M, Foster JH, Anvari S. A case series of pediatric oncology patients undergoing successful rapid etoposide desensitization. Pediatr Allergy Immunol. 2019 08; 30(5):579-582. PMID: 30963632.
      Citations:    Fields:    Translation:Humans
    10. Rider NL, Miao D, Dodds M, Modell V, Modell F, Quinn J, Schwarzwald H, Orange JS. Calculation of a Primary Immunodeficiency "Risk Vital Sign" via Population-Wide Analysis of Claims Data to Aid in Clinical Decision Support. Front Pediatr. 2019; 7:70. PMID: 30937298.
      Citations:    
    11. Deniskin R, Sasa GS, Nandiwada SL, Rider NL. Lymphopenia With Clinical and Laboratory Features of Combined Immune Deficiency in an 11-Year-Old Female With FANCD2 Variants and Fanconi Anemia. Front Pediatr. 2018; 6:390. PMID: 30713837.
      Citations:    
    12. Webster L, Rider NL, Archambault ME. Evaluating and managing chronic idiopathic urticaria in adults. JAAPA. 2018 Jul; 31(7):22-26. PMID: 29889715.
      Citations:    Fields:    Translation:Humans
    13. Rider NL, Jameson MB, Creech CB. Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease. J Pediatric Infect Dis Soc. 2018 May 09; 7(suppl_1):S2-S5. PMID: 29746675.
      Citations: 6     Fields:    Translation:Humans
    14. Yanir AD, Hanson IC, Shearer WT, Noroski LM, Forbes LR, Seeborg FO, Nicholas S, Chinn I, Orange JS, Rider NL, Leung KS, Naik S, Carrum G, Sasa G, Hegde M, Omer BA, Ahmed N, Allen CE, Khaled Y, Wu MF, Liu H, Gottschalk SM, Heslop HE, Brenner MK, Krance RA, Martinez CA. High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease. Biol Blood Marrow Transplant. 2018 08; 24(8):1643-1650. PMID: 29630926.
      Citations: 6     Fields:    Translation:Humans
    15. Ngwube A, Hanson IC, Orange J, Rider NL, Seeborg F, Shearer W, Noroski L, Nicholas S, Forbes L, Leung K, Sasa G, Naik S, Hegde M, Omer B, Ahmed N, Allen C, Gottschalk S, Wu MF, Liu H, Brenner M, Heslop H, Krance R, Martinez C. Outcomes after Allogeneic Transplant in Patients with Wiskott-Aldrich Syndrome. Biol Blood Marrow Transplant. 2018 03; 24(3):537-541. PMID: 29196075.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    16. Vargas-Hernández A, Mace EM, Zimmerman O, Zerbe CS, Freeman AF, Rosenzweig S, Leiding JW, Torgerson T, Altman MC, Schussler E, Cunningham-Rundles C, Chinn IK, Carisey AF, Hanson IC, Rider NL, Holland SM, Orange JS, Forbes LR. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018 06; 141(6):2142-2155.e5. PMID: 29111217.
      Citations: 17     Fields:    Translation:HumansCells
    17. Li E, Grimes AB, Rider NL, Mahoney DH, Fleisher TA, Shearer WT. Diagnostic dilemma: ALPS versus Evans syndrome. Clin Immunol. 2017 10; 183:247-248. PMID: 28802957.
      Citations:    Fields:    Translation:Humans
    18. Rios X, Chinn IK, Orange JS, Hanson CI, Rider NL. T-Cell Lymphopenia Detected by Newborn Screening in Two Siblings with an Xq13.1 Duplication. Front Pediatr. 2017; 5:156. PMID: 28770187.
      Citations:    
    19. Rider NL, Kutac C, Hajjar J, Scalchunes C, Seeborg FO, Boyle M, Orange JS. Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment. J Clin Immunol. 2017 Jul; 37(5):461-475. PMID: 28536745.
      Citations: 12     Fields:    Translation:Humans
    20. Patel DR, Yu H, Wong LC, Lupski JR, Seeborg FO, Rider NL, Martinez CA, Orange JS, Hanson C. Linking newborn severe combined immunodeficiency screening with targeted exome sequencing: A case report. J Allergy Clin Immunol Pract. 2017 Sep - Oct; 5(5):1442-1444. PMID: 28438538.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    21. Aubert G, Strauss KA, Lansdorp PM, Rider NL. Defects in lymphocyte telomere homeostasis contribute to cellular immune phenotype in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 2017 Oct; 140(4):1120-1129.e1. PMID: 28126377.
      Citations: 6     Fields:    Translation:HumansCells
    22. Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LTN, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. J Allergy Clin Immunol. 2017 01; 139(1):232-245. PMID: 27577878.
      Citations: 50     Fields:    Translation:Humans
    23. Wu S, Orange JS, Chiou EH, Nicholas SK, Seeborg F, Gwalani LA, Kearney D, Rider NL, Rasalingam S, Hanson IC. Use of enteral immunoglobulin in NEMO syndrome for eradication of persistent symptomatic norovirus enteritis. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):539-541.e1. PMID: 26795245.
      Citations:    Fields:    Translation:Humans
    24. Rider NL, Boisson B, Jyonouchi S, Hanson EP, Rosenzweig SD, Casanova JL, Orange JS. Corrigendum: Novel TTC37 Mutations in a Patient with Immunodeficiency without Diarrhea: Extending the Phenotype of Trichohepatoenteric Syndrome. Front Pediatr. 2015; 3:28. PMID: 25932458.
      Citations:    
    25. Rider NL, Boisson B, Jyonouchi S, Hanson EP, Rosenzweig SD, Cassanova JL, Orange JS. Novel TTC37 Mutations in a Patient with Immunodeficiency without Diarrhea: Extending the Phenotype of Trichohepatoenteric Syndrome. Front Pediatr. 2015; 3:2. PMID: 25688341.
      Citations:    
    26. Ng J, Zhen J, Meyer E, Erreger K, Li Y, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider NL, Morton DH, Strauss KA, Puffenberger EG, D'Agnano D, Anikster Y, Carducci C, Hyland K, Rotstein M, Leuzzi V, Borck G, Reith ME, Kurian MA. Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood. Brain. 2014 Apr; 137(Pt 4):1107-19. PMID: 24613933.
      Citations: 40     Fields:    Translation:Humans
    27. Archambault ME, Rider NL. Sublingual immunotherapy for aeroallergen desensitization. JAAPA. 2013 Jun; 26(6):55-6. PMID: 23805596.
      Citations:    Fields:    Translation:Humans
    28. Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA. Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012; 7(1):e28936. PMID: 22279524.
      Citations: 96     Fields:    Translation:Humans
    29. Rider NL, Strauss KA, Brown K, Finkenstedt A, Puffenberger EG, Hendrickson CL, Robinson DL, Muenke N, Tselepis C, Saunders L, Zoller H, Morton DH. Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: longitudinal risk and disease management. Am J Hematol. 2011 Oct; 86(10):827-34. PMID: 21815188.
      Citations: 5     Fields:    Translation:HumansCells
    30. Strauss KA, Brumbaugh J, Duffy A, Wardley B, Robinson D, Hendrickson C, Tortorelli S, Moser AB, Puffenberger EG, Rider NL, Morton DH. Safety, efficacy and physiological actions of a lysine-free, arginine-rich formula to treat glutaryl-CoA dehydrogenase deficiency: focus on cerebral amino acid influx. Mol Genet Metab. 2011 Sep-Oct; 104(1-2):93-106. PMID: 21820344.
      Citations: 17     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    31. de la Fuente MA, Recher M, Rider NL, Strauss KA, Morton DH, Adair M, Bonilla FA, Ochs HD, Gelfand EW, Pessach IM, Walter JE, King A, Giliani S, Pai SY, Notarangelo LD. Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 2011 Jul; 128(1):139-146. PMID: 21570718.
      Citations: 10     Fields:    Translation:HumansCells
    32. O'Connor MJ, Rider NL, Thomas Collins R, Hanna BD, Holmes Morton D, Strauss KA. Contemporary management of congenital malformations of the heart in infants with Ellis - van Creveld syndrome: a report of nine cases. Cardiol Young. 2011 Apr; 21(2):145-52. PMID: 21070693.
      Citations: 6     Fields:    Translation:Humans
    33. Lohr NJ, Molleston JP, Strauss KA, Torres-Martinez W, Sherman EA, Squires RH, Rider NL, Chikwava KR, Cummings OW, Morton DH, Puffenberger EG. Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. Am J Hum Genet. 2010 Mar 12; 86(3):447-53. PMID: 20170897.
      Citations: 65     Fields:    Translation:HumansCells
    34. Strauss KA, Wardley B, Robinson D, Hendrickson C, Rider NL, Puffenberger EG, Shellmer D, Shelmer D, Moser AB, Morton DH. Classical maple syrup urine disease and brain development: principles of management and formula design. Mol Genet Metab. 2010 Apr; 99(4):333-45. PMID: 20061171.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    35. Rider NL, Morton DH, Puffenberger E, Hendrickson CL, Robinson DL, Strauss KA. Immunologic and clinical features of 25 Amish patients with RMRP 70 A-->G cartilage hair hypoplasia. Clin Immunol. 2009 Apr; 131(1):119-28. PMID: 19150606.
      Citations: 16     Fields:    Translation:Humans
    36. Rider NL, Craig TJ. Liver enzyme elevation and normal pulmonary function in an adult with a declining forced expiratory volume in 1 second. Allergy Asthma Proc. 2008 May-Jun; 29(3):345-8. PMID: 18534093.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    37. Strauss KA, Puffenberger EG, Bunin N, Rider NL, Morton MC, Eastman JT, Morton DH. Clinical application of DNA microarrays: molecular diagnosis and HLA matching of an Amish child with severe combined immune deficiency. Clin Immunol. 2008 Jul; 128(1):31-8. PMID: 18442948.
      Citations: 8     Fields:    Translation:Humans
    38. Rider NL, Craig TJ. A safety review of long-acting beta2-agonists in patients with asthma. J Am Osteopath Assoc. 2006 Sep; 106(9):562-7. PMID: 17079526.
      Citations: 3     Fields:    Translation:Humans
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