MELANIE BERNHARDT

TitleAdjunct Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics - Oncology AICT
AddressPediatrics - Oncology
Houston, 77030
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    Collapse Biography 
    Collapse education and training
    University of Houston, Houston, TXM.S.05/2013Pharmacy Administration, Pharmacoepidemiology
    University of Georgia, Athens, GAPharm.D.05/2003Pharmacy
    Collapse awards and honors
    2008 - 2009Pediatric House Staff Award of Appreciation, Baylor College of Medicine
    2009 - 2010Houston/Galveston Region Outstanding Clinical Preceptor, University of Texas College of Pharmacy

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Taylor ZL, Miller TP, Poweleit EA, DeGroote NP, Pommert L, Awoniyi O, Board SG, Ugboh N, Joshi V, Ambrosino N, Chavana A, Bernhardt MB, Schafer ES, O'Brien MM, Castellino SM, Ramsey LB. Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org. Clin Transl Sci. 2023 Nov; 16(11):2130-2143. PMID: 37503924; PMCID: PMC10651646.
      Citations: 1     Fields:    Translation:Humans
    2. Schoon S, Makamo N, Uittenboogaard A, Bernhardt MB, Ozuah NW, Kaspers GJL, Huibers MHW. Impact of undernutrition on the pharmacokinetics of chemotherapy in children with cancer: A systematic review. Pediatr Blood Cancer. 2023 Jul 01; e30531. PMID: 37393425.
      Citations:    Fields:    
    3. Hogan LE, Brown PA, Ji L, Xu X, Devidas M, Bhatla T, Borowitz MJ, Raetz EA, Carroll A, Heerema NA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Hunger SP, Loh ML. Children's Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse. J Clin Oncol. 2023 09 01; 41(25):4118-4129. PMID: 37257143; PMCID: PMC10852366.
      Citations:    
    4. Stevens AM, Schafer ES, Li M, Terrell M, Rashid R, Paek H, Bernhardt MB, Weisnicht A, Smith WT, Keogh NJ, Alozie MC, Oviedo HH, Gonzalez AK, Ilangovan T, Mangubat-Medina A, Wang H, Jo E, Rabik CA, Bocchini C, Hilsenbeck S, Ball ZT, Cooper TM, Redell MS. Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated. Cancers (Basel). 2023 Feb 20; 15(4). PMID: 36831684; PMCID: PMC9954468.
      Citations:    
    5. Unguru Y, Bernhardt MB, Berg SL, Marie-Johnson L, Grimm KP, Woodman C, Fernandez CV. Essential medicines for childhood cancer in Europe. Lancet Oncol. 2023 02; 24(2):e67. PMID: 36725147.
      Citations: 1     Fields:    Translation:Humans
    6. Harris RD, Bernhardt MB, Zobeck MC, Taylor OA, Gramatges MM, Schafer ES, Lupo PJ, Rabin KR, Scheurer ME, Brown AL. Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate. Cancer. 2023 04 15; 129(8):1287-1294. PMID: 36692972; PMCID: PMC10625847.
      Citations:    Fields:    Translation:Humans
    7. Dong EE, Bruno MA, Kim JJ, Bernhardt MB, Brown AL, Gramatges MM. Distribution and frequency of tyrosine kinase inhibitor-associated long-term complications in children with chronic myeloid leukemia. Pediatr Blood Cancer. 2022 09; 69(9):e29786. PMID: 35593027.
      Citations:    Fields:    Translation:Humans
    8. Russell HV, Chi YY, Okcu MF, Bernhardt MB, Rodriguez-Galindo C, Gupta AA, Hawkins DS. Rising drug cost impacts on cost-effectiveness of 2 chemotherapy regimens for intermediate-risk rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer. 2022 Jan 15; 128(2):317-325. PMID: 34623638; PMCID: PMC8738099.
      Citations:    Fields:    Translation:Humans
    9. Schraw JM, Woodhouse JP, Bernhardt MB, Taylor OA, Horton TM, Scheurer ME, Okcu MF, Rabin KR, Lupo PJ, Brown AL. Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia. Sci Rep. 2021 10 04; 11(1):19613. PMID: 34608220; PMCID: PMC8490393.
      Citations:    Fields:    Translation:Humans
    10. Holle LM, Bilse T, Alabelewe RM, Kintzel PE, Kandemir EA, Tan CJ, Weru I, Chambers CR, Dobish R, Handel E, Tewthanom K, Saeteaw M, Dewi LKM, Schwartz R, Bernhardt B, Garg M, Chatterjee A, Manyau P, Chan A, Bayraktar-Ekincioglu A, Aras-Atik E, Harvey RD, Goldspiel BR. International Society of Oncology Pharmacy Practitioners (ISOPP) position statement: Role of the oncology pharmacy team in cancer care. J Oncol Pharm Pract. 2021 Jun; 27(4):785-801. PMID: 34024179.
      Citations:    Fields:    Translation:Humans
    11. Kirk SE, Scheurer ME, Bernhardt MB, Mahoney DH, Powers JM. Phosphorus levels in children treated with intravenous ferric carboxymaltose. Am J Hematol. 2021 06 01; 96(6):E215-E218. PMID: 33735470; PMCID: PMC8113159.
      Citations: 1     Fields:    Translation:Humans
    12. Zobeck MC, Bernhardt MB, Kamdar KY, Rabin KR, Lupo PJ, Scheurer ME. Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene. Pediatr Blood Cancer. 2021 08; 68(8):e29036. PMID: 33788417; PMCID: PMC8238882.
      Citations:    Fields:    Translation:Humans
    13. Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML. Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2021 03 02; 325(9):833-842. PMID: 33651090; PMCID: PMC7926290.
      Citations: 37     Fields:    Translation:HumansCTClinical Trials
    14. McAtee CL, Lubega J, Underbrink K, Curry K, Msaouel P, Barrow M, Muscal E, Lotze T, Srivaths P, Forbes LR, Allen C, Bernhardt MB. Association of Rituximab Use With Adverse Events in Children, Adolescents, and Young Adults. JAMA Netw Open. 2021 02 01; 4(2):e2036321. PMID: 33533931; PMCID: PMC7859842.
      Citations: 7     Fields:    Translation:HumansCells
    15. Bernhardt MB, Lindsay H, Allen-Rhoades W, Foster JH. The Best Pharmaceuticals for Children Act and Pediatric Research Equity Act reach the age of majority-An oncology perspective. Pediatr Blood Cancer. 2021 03; 68(3):e28871. PMID: 33381908.
      Citations:    Fields:    Translation:Humans
    16. Bernhardt MB, Militano O, Honeyford L, Zupanec S. Blinatumomab use in pediatric ALL: Taking a BiTE out of preparation, administration and toxicity challenges. J Oncol Pharm Pract. 2021 Mar; 27(2):376-388. PMID: 33334253.
      Citations: 1     Fields:    Translation:Humans
    17. Brown AL, Raghubar KP, Taylor OA, Bernhardt MB, Kahalley LS, Pan W, Lupo PJ, Hockenberry MJ, Scheurer ME. Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse. Support Care Cancer. 2021 May; 29(5):2455-2464. PMID: 32929538; PMCID: PMC8011637.
      Citations: 1     Fields:    Translation:Humans
    18. Brown AL, Sok P, Taylor O, Woodhouse JP, Bernhardt MB, Raghubar KP, Kahalley LS, Lupo PJ, Hockenberry MJ, Scheurer ME. Cerebrospinal Fluid Metabolomic Profiles Associated With Fatigue During Treatment for Pediatric Acute Lymphoblastic Leukemia. J Pain Symptom Manage. 2021 03; 61(3):464-473. PMID: 32889041; PMCID: PMC7914130.
      Citations: 5     Fields:    Translation:Humans
    19. Whittle SB, Smith V, Silverstein A, Parmeter M, Minard CG, Bernhardt MB, Zage PE, Venkatramani R, Nuchtern JG, Heczey A, Russell HV, Shohet JM, Foster JH. Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoietic growth factors. Pediatr Blood Cancer. 2020 10; 67(10):e28417. PMID: 32729196; PMCID: PMC7722106.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    20. Mangum R, Bernhardt MB, Cheng WS, Schafer ES, Berg SL, Foster JH. Do intravenous fluid substitutions influence methotrexate clearance? An unanticipated impact of an intravenous sodium bicarbonate drug shortage. Pediatr Blood Cancer. 2020 09; 67(9):e28334. PMID: 32608575.
      Citations: 1     Fields:    Translation:Humans
    21. Wiernikowski JT, Bernhardt MB. Review of nutritional status, body composition, and effects of antineoplastic drug disposition. Pediatr Blood Cancer. 2020 06; 67 Suppl 3:e28207. PMID: 32083372.
      Citations:    Fields:    Translation:Humans
    22. Young EP, Cheng WS, Bernhardt MB, Wang LL, Rainusso N, Foster JH. Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma. Pediatr Blood Cancer. 2020 04; 67(4):e28123. PMID: 31867853.
      Citations: 1     Fields:    Translation:Humans
    23. Stuckert AJ, Schafer ES, Bernhardt MB, Baxter P, Brackett J. Use of allopurinol to reduce hepatotoxicity from 6-mercaptopurine (6-MP) in patients with acute lymphoblastic leukemia (ALL). Leuk Lymphoma. 2020 05; 61(5):1246-1249. PMID: 31842647.
      Citations: 2     Fields:    Translation:Humans
    24. Rees CA, Bernhardt MB, Camp EA, Lin JS, Chumpitazi CE. Race and ethnicity: Not factors in the prescribing of hydrocodone and codeine-containing products in two pediatric emergency departments. J Opioid Manag. 2019 May/Jun; 15(3):229-233. PMID: 31343724.
      Citations: 1     Fields:    Translation:Humans
    25. Unguru Y, Bernhardt MB, Berg SL, Johnson LM, Pyke-Grimm K, Woodman C, Fernandez CV. Chemotherapy and Supportive Care Agents as Essential Medicines for Children With Cancer. JAMA Pediatr. 2019 05 01; 173(5):477-484. PMID: 30830204.
      Citations: 8     Fields:    Translation:Humans
    26. Adamson PC, Veal GJ, Womer RB, Meany HJ, Bernhardt MB, Frazier AL, Balis FM. Fundamental problems with pediatric adaptive dosing of carboplatin using nuclear-medicine-based estimates of renal function. Pediatr Blood Cancer. 2019 06; 66(6):e27672. PMID: 30767382.
      Citations: 1     Fields:    Translation:Humans
    27. Foster JH, Thompson PA, Bernhardt MB, Margolin JF, Hilsenbeck SG, Jo E, Marquez-Do DA, Scheurer ME, Schafer ES. A prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities. Cancer Chemother Pharmacol. 2019 02; 83(2):349-360. PMID: 30488179.
      Citations: 1     Fields:    Translation:Humans
    28. Cloyd C, Moffett BS, Bernhardt MB, Monico EM, Patel N, Hanson D. Efficacy of liposomal bupivacaine in pediatric patients undergoing spine surgery. Paediatr Anaesth. 2018 11; 28(11):982-986. PMID: 30207019.
      Citations: 2     Fields:    Translation:Humans
    29. Chuk MK, Widemann BC, Minard CG, Liu X, Kim A, Bernhardt MB, Kudgus RA, Reid JM, Voss SD, Blaney S, Fox E, Weigel BJ. A phase 1 study of cabozantinib in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1211, a report from the Children's Oncology Group. Pediatr Blood Cancer. 2018 08; 65(8):e27077. PMID: 29693796; PMCID: PMC6082380.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    30. Bernhardt MB, Taylor RS, Hagan JL, Patel N, Chumpitazi CE, Fox KA, Glover C. Evaluation of opioid prescribing after rescheduling of hydrocodone-containing products. Am J Health Syst Pharm. 2017 Dec 15; 74(24):2046-2053. PMID: 29222361.
      Citations: 3     Fields:    Translation:Humans
    31. Schafer ES, Bernhardt MB, Reichert KE, Haworth TE, Shah MD. Hispanic ethnicity as a risk factor for requiring glucarpidase rescue in pediatric patients receiving high-dose methotrexate. Am J Hematol. 2018 02; 93(2):E40-E42. PMID: 29119597.
      Citations: 1     Fields:    Translation:Humans
    32. McAtee CL, Schneller N, Brackett J, Bernhardt MB, Schafer ES. Treatment-related sinusoidal obstruction syndrome in children with de novo acute lymphoblastic leukemia during intensification. Cancer Chemother Pharmacol. 2017 Dec; 80(6):1261-1264. PMID: 29051993.
      Citations: 3     Fields:    Translation:Humans
    33. Felix-Ukwu F, Reichert K, Bernhardt MB, Schafer ES, Berger A. Evaluation of aprepitant for acute chemotherapy-induced nausea and vomiting in children and adolescents with acute lymphoblastic leukemia receiving high-dose methotrexate. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 29031010.
      Citations: 1     Fields:    Translation:Humans
    34. Bernhardt MB, De Guzman MM, Grimes A, Kirk S, Nelson S, Bergsbaken J, Minard CG, Despotovic JM. Rapid infusion of rituximab is well tolerated in children with hematologic, oncologic, and rheumatologic disorders. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28792663.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    35. Bernhardt MB. Nausea and vomiting: Therapeutic orphans of pediatric oncology. Pediatr Blood Cancer. 2017 10; 64(10). PMID: 28561924.
      Citations: 1     Fields:    Translation:Humans
    36. McClain CA, Bernhardt MB, Berger A, Bernini JC, Marquez-Do D, Winslow R, Scheurer ME, Schafer ES. Pharmacogenetic association with neurotoxicity in Hispanic children with acute lymphoblastic leukaemia. Br J Haematol. 2018 06; 181(5):684-687. PMID: 28419449.
      Citations: 6     Fields:    Translation:Humans
    37. Marquez L, Jones KN, Whaley EM, Koy TH, Revell PA, Taylor RS, Bernhardt MB, Wagner JL, Dunn JJ, LiPuma JJ, Campbell JR. An Outbreak of Burkholderia cepacia Complex Infections Associated with Contaminated Liquid Docusate. Infect Control Hosp Epidemiol. 2017 05; 38(5):567-573. PMID: 28166854.
      Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
    38. Bernhardt MB, Thompson PA, Smith EO, Schafer ES, Foster JH. Using a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity. J Pediatr Hematol Oncol. 2017 01; 39(1):72-76. PMID: 27820134.
      Citations: 2     Fields:    Translation:Humans
    39. Russell HV, Bernhardt MB, Berg S. Using decision modeling to guide drug allocation during a shortage. Pediatr Blood Cancer. 2017 Jul; 64(7). PMID: 27862980.
      Citations: 2     Fields:    Translation:Humans
    40. Chumpitazi CE, Rees CA, Camp EA, Bernhardt MB. Decreased Opioid Prescribing in a Pediatric Emergency Department After the Rescheduling of Hydrocodone. J Emerg Med. 2017 Apr; 52(4):547-553. PMID: 27727038.
      Citations: 5     Fields:    Translation:Humans
    41. Russell H, Bernhardt MB. Bending the Cost Curve in Childhood Cancer. Curr Hematol Malig Rep. 2016 08; 11(4):295-302. PMID: 27193602.
      Citations: 5     Fields:    Translation:Humans
    42. Unguru Y, Fernandez CV, Bernhardt B, Berg S, Pyke-Grimm K, Woodman C, Joffe S. An Ethical Framework for Allocating Scarce Life-Saving Chemotherapy and Supportive Care Drugs for Childhood Cancer. J Natl Cancer Inst. 2016 Jun; 108(6):djv392. PMID: 26825103.
      Citations: 6     Fields:    Translation:Humans
    43. Beaty RS, Bernhardt MB, Berger AH, Hesselgrave JE, Russell HV, Okcu MF. Inpatient versus outpatient vincristine, dactinomycin, and cyclophosphamide for pediatric cancers: Quality and cost implications. Pediatr Blood Cancer. 2015 Nov; 62(11):1925-8. PMID: 26152314.
      Citations: 4     Fields:    Translation:Humans
    44. Bernhardt MB, Thompson PA. Reply to: No correlation between estimated and actual glomerular filtration rates in pediatric oncology patients. Pediatr Blood Cancer. 2015 Jul; 62(7):1300. PMID: 25777466.
      Citations:    Fields:    Translation:Humans
    45. G Salazar E, Bernhardt MB, Li Y, Aplenc R, Adamson PC. The impact of chemotherapy shortages on COG and local clinical trials: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Jun; 62(6):940-4. PMID: 25704486; PMCID: PMC4670038.
      Citations: 6     Fields:    Translation:Humans
    46. Burke MJ, Ahern C, Weigel BJ, Poirier JT, Rudin CM, Chen Y, Cripe TP, Bernhardt MB, Blaney SM. Phase I trial of Seneca Valley Virus (NTX-010) in children with relapsed/refractory solid tumors: a report of the Children's Oncology Group. Pediatr Blood Cancer. 2015 May; 62(5):743-50. PMID: 25307519; PMCID: PMC4376652.
      Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
    47. Bernhardt MB, Moffett BS, Johnson M, Tam VH, Thompson P, Garey KW. Agreement among measurements and estimations of glomerular filtration in children with cancer. Pediatr Blood Cancer. 2015 Jan; 62(1):80-4. PMID: 25263332.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    48. Brackett J, Schafer ES, Leung DH, Bernhardt MB. Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism. Pediatr Blood Cancer. 2014 Jun; 61(6):1114-7. PMID: 24376133.
      Citations: 9     Fields:    Translation:Humans
    49. Siden R, Kem R, Ostrenga A, Nicksy D, Bernhardt B, Bartholomew J. Templates of patient brochures for the preparation, administration and safe-handling of oral chemotherapy. J Oncol Pharm Pract. 2014 Jun; 20(3):217-24. PMID: 23748870.
      Citations:    Fields:    Translation:Humans
    50. Parsons K, Bernhardt B, Strickland B. Targeted immunotherapy for high-risk neuroblastoma--the role of monoclonal antibodies. Ann Pharmacother. 2013 Feb; 47(2):210-8. PMID: 23386066.
      Citations: 17     Fields:    Translation:HumansAnimals
    51. Hockenberry MJ, McCarthy KS, Taylor OA, Hesselgrave J, Bernhardt MB, Daves M, Kamdar K. Using improvement science to promote evidence-based practice in a childhood cancer and hematology center. J Pediatr Oncol Nurs. 2012 Jan-Feb; 29(1):5-13. PMID: 22367765.
      Citations: 1     Fields:    Translation:Humans
    52. Bernhardt MB, Hicks MJ, Pappo AS. Administration of high-dose interleukin-2 in a 2-year-old with metastatic melanoma. Pediatr Blood Cancer. 2009 Dec 15; 53(7):1346-8. PMID: 19731326.
      Citations:    Fields:    Translation:Humans
    53. Raphael JL, Bernhardt MB, Mahoney DH, Mueller BU. Oral iron chelation and the treatment of iron overload in a pediatric hematology center. Pediatr Blood Cancer. 2009 May; 52(5):616-20. PMID: 19148949.
      Citations: 8     Fields:    Translation:Humans
    54. Raphael JL, Kamdar A, Beavers MB, Mahoney DH, Mueller BU. Treatment of uncomplicated vaso-occlusive crises in children with sickle cell disease in a day hospital. Pediatr Blood Cancer. 2008 Jul; 51(1):82-5. PMID: 18383165.
      Citations: 13     Fields:    Translation:Humans
    55. Beavers MB. Specializing in pediatric hematology and oncology. Am J Health Syst Pharm. 2007 Apr 15; 64(8):812-3. PMID: 17420194.
      Citations: 4     Fields:    Translation:Humans
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