GRETCHEN DIEHL

TitleAdjunct Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAdjunct Assistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology


    Collapse Research 
    Collapse research activities and funding
    R21AI123945     (DIEHL, GRETCHEN E)Dec 1, 2016 - Nov 30, 2018
    NIH
    Commensal-dependent induction of protective immunity
    Role: Principal Investigator

    R01AI125264     (DIEHL, GRETCHEN E)Mar 2, 2017 - Feb 28, 2022
    NIH
    Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu WH, Kim M, Chang LC, Assie A, Saldana-Morales FB, Zegarra-Ruiz DF, Norwood K, Samuel BS, Diehl GE. Interleukin-1ß secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair. Gut Microbes. 2022 Jan-Dec; 14(1):2014772. PMID: 34989321.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Chen A, Diehl GE. T cells in harmony: Aligning the TCR repertoire pool to identify microbiota recognizing T cells. Immunity. 2021 11 09; 54(11):2437-2439. PMID: 34758332.
      Citations:    Fields:    Translation:AnimalsCells
    3. Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE. Thymic development of gut-microbiota-specific T cells. Nature. 2021 06; 594(7863):413-417. PMID: 33981034.
      Citations: 20     Fields:    Translation:AnimalsCells
    4. Viladomiu M, Metz ML, Lima SF, Jin WB, Chou L, Guo CJ, Diehl GE, Simpson KW, Scherl EJ, Longman RS. Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation. Cell Host Microbe. 2021 04 14; 29(4):607-619.e8. PMID: 33539767.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Saldana-Morales FB, Kim DV, Tsai MT, Diehl GE. Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses. Gut Microbes. 2021 Jan-Dec; 13(1):1-14. PMID: 33929291.
      Citations: 2     Fields:    Translation:Humans
    6. Wu WH, Zegarra-Ruiz DF, Diehl GE. Intestinal Microbes in Autoimmune and Inflammatory Disease. Front Immunol. 2020; 11:597966. PMID: 33424846.
      Citations: 8     Fields:    Translation:HumansAnimals
    7. Yuan X, Chang CY, You R, Shan M, Gu BH, Madison MC, Diehl G, Perusich S, Song LZ, Cornwell L, Rossen RD, Wetsel R, Kimal R, Coarfa C, Eltzschig HK, Corry DB, Kheradmand F. Cigarette smoke-induced reduction of C1q promotes emphysema. JCI Insight. 2019 05 21; 5. PMID: 31112138.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    8. Zegarra-Ruiz DF, Diehl GE. Skin IL-17-Producing T Cells Support Repair 2! Trends Immunol. 2019 03; 40(3):177-179. PMID: 30718047.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Kim M, Gu B, Madison MC, Song HW, Norwood K, Hill AA, Wu WJ, Corry D, Kheradmand F, Diehl GE. Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis. Front Immunol. 2019; 10:75. PMID: 30761142.
      Citations: 14     Fields:    Translation:AnimalsCells
    10. Kim M, Hill AA, Wu WJ, Diehl GE. Intestinal microbes direct CX3CR1+ cells to balance intestinal immunity. Gut Microbes. 2019 Jul 04; 10(4):540-546. PMID: 33970784.
      Citations: 1     Fields:    
    11. Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS. Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. 2018 12 18; 49(6):1077-1089.e5. PMID: 30552020.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    12. Hill AA, Diehl GE. Identifying the Patterns of Pattern Recognition Receptors. Immunity. 2018 09 18; 49(3):389-391. PMID: 30231979.
      Citations: 3     Fields:    
    13. Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE. Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. 2018 07 17; 49(1):151-163.e5. PMID: 29980437.
      Citations: 63     Fields:    Translation:AnimalsCells
    14. You R, DeMayo FJ, Liu J, Cho SN, Burt BM, Creighton CJ, Casal RF, Lazarus DR, Lu W, Tung HY, Yuan X, Hill-McAlester A, Kim M, Perusich S, Cornwell L, Rosen D, Song LZ, Paust S, Diehl G, Corry D, Kheradmand F. IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer. Cancer Immunol Res. 2018 06; 6(6):645-657. PMID: 29653981.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    15. Viladomiu M, Kivolowitz C, Abdulhamid A, Dogan B, Victorio D, Castellanos JG, Woo V, Teng F, Tran NL, Sczesnak A, Chai C, Kim M, Diehl GE, Ajami NJ, Petrosino JF, Zhou XK, Schwartzman S, Mandl LA, Abramowitz M, Jacob V, Bosworth B, Steinlauf A, Scherl EJ, Wu HJ, Simpson KW, Longman RS. IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation. Sci Transl Med. 2017 02 08; 9(376). PMID: 28179509.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    16. Hill AA, Diehl GE. The Infectious Cause of the Chronic Effect. Cell Host Microbe. 2015 Oct 14; 18(4):383-5. PMID: 26468738.
      Citations:    Fields:    Translation:HumansCells
    17. Derebe MG, Zlatkov CM, Gattu S, Ruhn KA, Vaishnava S, Diehl GE, MacMillan JB, Williams NS, Hooper LV. Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection. Elife. 2014 Jul 29; 3:e03206. PMID: 25073702.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    18. Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR. CX3CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014 Jul 28; 211(8):1571-83. PMID: 25024136.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    19. Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity. Cold Spring Harb Symp Quant Biol. 2013; 78:193-201. PMID: 24913313.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    20. Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature. 2013 Feb 07; 494(7435):116-20. PMID: 23334413.
      Citations: 200     Fields:    Translation:AnimalsCells
    21. Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Feb 24; 36(2):276-87. PMID: 22306017.
      Citations: 234     Fields:    Translation:AnimalsCells
    22. Zhang JX, Diehl GE, Littman DR. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. PLoS One. 2008 Apr 30; 3(4):e2035. PMID: 18446227.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    23. Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB. Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Cell Microbiol. 2008 Aug; 10(8):1646-61. PMID: 18397382.
      Citations: 22     Fields:    Translation:AnimalsCells
    24. Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A. TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 2004 Dec; 21(6):877-89. PMID: 15589175.
      Citations: 94     Fields:    Translation:AnimalsCells
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