TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address18200 KATY FREEWAY
Houston, TX 77094
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    Collapse Biography 
    Collapse awards and honors
    2019Early-Career Faculty Award for Excellence in Patient Care, Baylor College of Medicine
    2019 - 20202020 Top downloaded paper, Pediatric Blood and Cancer. Wiley Publishers
    20202020 Houstonia Top Doctor Recognized for Excellence, Houstonia
    2021Provider Excellence Award, Texas Children's Hospital
    20212021 Houstonia Top Doctor Recognized for Excellence, Houstonia

    Collapse Overview 
    Collapse overview
    Dr. Ionela Iacobas is the medical director of the Texas Children's Hospital Vascular Anomalies Center. Her main interest is to offer children and young adults with vascular anomalies state-of-the-art medical management in a comprehensive approach. Ranging from venous or lymphatic malformations to metastatic vascular tumors, the Vascular Anomalies Center uses anticoagulants (like low molecular weight heparin), immunosupressants (like sirolimus), chemotherapy, etc. to treat a large variety of vascular anomalies.
    Dr. Iacobas believes that children with vascular tumors and malformations need more than just invasive procedures and medications, so her team involves a multidisciplinary approach and the major supportive services (including physical therapy, social work, child life, psychology, pain management, orthotics - compression garments, support groups, etc).
    As education and research in the vascular anomalies field are essential for best patient care, Dr. Iacobas is very active at the national level as the Chair of the Vascular Anomalies Special Interest Group of ASPHO, where she and her team developed educational resources and a curriculum for hematology-oncology physicians who are interested in vascular anomalies.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blei F, Adams D, Brandao LR, Trenor C, Iacobas I, Hammill A. Forward: Welcome to the Special Issue on Vascular Anomalies. Pediatr Blood Cancer. 2022 08; 69 Suppl 3:e29796. PMID: 35686828.
      Citations:    Fields:    
    2. Iacobas I, Singh M, Finger M, Klepper LK, Blei F. . Survey of Adult Patients with Vascular Anomalies Reveals Acute Need of Adult Hematologists-Oncologists to Enter the Field. Journal of Vascular Anomalies. 2022; 3(1):1-6.
    3. Agarwal S, Anderson BK, Mahajan P, Fernandes CJ, Margolin JF, Iacobas I. Sirolimus efficacy in the treatment of critically ill infants with congenital primary chylous effusions. Pediatr Blood Cancer. 2022 02; 69(2):e29510. PMID: 34889518.
      Citations:    Fields:    Translation:Humans
    4. Kessel R, Blei F, Iacobas I. . Lanzkowsky’s Manual of Pediatric Hematology and Oncology. Vascular Anomalies. 2021; 341-356.
    5. Ali K, Dibbs RP, Dougherty C, Iacobas I, Maricevich RS. Treatment Outcomes of Manual Lymphatic Drainage in Pediatric Lymphedema. Ann Vasc Surg. 2022 Jan; 78:263-271. PMID: 34480978.
      Citations:    Fields:    Translation:Humans
    6. Ricci KW, Iacobas I. How we approach the diagnosis and management of complex lymphatic anomalies. Pediatr Blood Cancer. 2022 08; 69 Suppl 3:e28985. PMID: 33844431.
      Citations: 1     Fields:    
    7. Manor J, Patel K, Iacobas I, Margolin JF, Mahajan P. Clinical variability in multifocal lymphangioendotheliomatosis with thrombocytopenia: a review of the literature. Pediatr Hematol Oncol. 2021 May; 38(4):367-377. PMID: 33641614.
      Citations: 1     Fields:    Translation:Humans
    8. Desai SB, Iacobas I, Rockson SG. Lymphatic Development and Implications for Diagnosis and Therapy. Lymphat Res Biol. 2021 02; 19(1):31-35. PMID: 33625891.
      Citations:    Fields:    Translation:Humans
    9. Knadler JJ, Lawrence E, Iacobas I, Justino H, Sheth S. Combination percutaneous and medical management of cardiac rhabdomyomas obstructing tricuspid valve inflow: Case report. J Neonatal Perinatal Med. 2021; 14(1):143-148. PMID: 32333554.
      Citations: 1     Fields:    Translation:Humans
    10. Mansfield SA, Williams RF, Iacobas I. Vascular tumors. Semin Pediatr Surg. 2020 Oct; 29(5):150975. PMID: 33069294.
      Citations: 4     Fields:    Translation:Humans
    11. Desai SB, Sun RC, Johnson BL, Rialon KL, Iacobas I, Kukreja KU, Schady DA, Phung T, Sanvitha S, Naik-Mathuria BJ. Renal Lymphangiectasia in a Pediatric Patient. Lymphat Res Biol. 2020 12; 18(6):572-578. PMID: 32589505.
      Citations:    Fields:    Translation:Humans
    12. Smith RJ, Metry D, Deardorff MA, Heller E, Grand KL, Iacobas I, Rubin AI, Phung TL, Lopez-Terrada D, Steicher J, Cahill AM, Low D, Treat JR. Segmental congenital hemangiomas: Three cases of a rare entity. Pediatr Dermatol. 2020 May; 37(3):548-553. PMID: 32255239.
      Citations:    Fields:    Translation:Humans
    13. Gurunathan A, Ricci K, Iacobas I, Rednam SP, Wusik K, Fei L, Hammilll AM. Impact of vascular anomalies on the PTEN phenotype in children and young adults. Pediatr Blood Cancer. 2020 06; 67(6):e28258. PMID: 32196895.
      Citations:    Fields:    Translation:Humans
    14. Cohen A, Owolabi FS, Dowdell-Smith CP, Laufman J, Iacobas I, Bass L, Foradori D. Weakness, Anemia, and Neutropenia in a 9-Year-Old Girl With Influenza. Pediatrics. 2020 04; 145(4). PMID: 32144121.
      Citations: 1     Fields:    Translation:Humans
    15. Iacobas I, Adams DM, Pimpalwar S, Phung T, Blei F, Burrows P, Lopez-Gutierrez JC, Levine MA, Trenor CC. Multidisciplinary guidelines for initial evaluation of complicated lymphatic anomalies-expert opinion consensus. Pediatr Blood Cancer. 2020 01; 67(1):e28036. PMID: 31617676.
      Citations: 5     Fields:    Translation:Humans
    16. Maynard K, LoPresti M, Iacobas I, Kan P, Lam S. Antiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: case report. J Neurosurg Pediatr. 2019 Oct 04; 1-7. PMID: 31585413.
      Citations: 2     Fields:    
    17. Sinton JW, Iacobas I, Cleveland H, Pimpalwar S. Case Report of Accelerated Idioventricular Rhythm in the Interventional Radiology Suite: A Sticky Situation. A A Pract. 2019 Apr 15; 12(8):273-276. PMID: 30371525.
      Citations:    Fields:    Translation:Humans
    18. Cohen CT, Bergstrom KL, Xiao R, Elghetany MT, Iacobas I, Sasa G. First case of neutropenia and thrombocytopenia in the setting of cerebral cavernous malformation 3. Int J Hematol. 2019 Jul; 110(1):95-101. PMID: 30904992.
      Citations: 2     Fields:    Translation:Humans
    19. Iacobas I, Phung TL, Adams DM, Trenor CC, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ. Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. J Pediatr. 2018 12; 203:294-300.e2. PMID: 30244993.
      Citations: 17     Fields:    Translation:HumansPHPublic Health
    20. Sheena Pimpalwar, Raphael Yoo, Alex Chau, Daniel Ashton, Judith Margolin, Ionela Iacobas. Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome. International Journal of Angiology. 2018; eFirst(2).
    21. Pimpalwar S, Yoo R, Chau A, Ashton D, Margolin J, Iacobas I. Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome. Int J Angiol. 2018 Sep; 27(3):158-164. PMID: 30154635.
      Citations: 1     
    22. Klein M, Chang AK, Vasudevan SA, Blatt J, Iacobas I, Lee S. Clinically significant ascites as an indication for resection of rapidly involuting congenital hepatic hemangiomas. Pediatr Blood Cancer. 2018 08; 65(8):e27222. PMID: 29741223.
      Citations: 1     Fields:    Translation:Humans
    23. Pimpalwar S, Pereira K, Margolin J, Iacobas I, Phan-Tran H, Pimpalwar A. Percutaneous Management of Peritoneovenous Shunt Malfunction in Children. J Vasc Interv Radiol. 2018 03; 29(3):433-435. PMID: 29455881.
      Citations:    Fields:    Translation:Humans
    24. Pimpalwar A, Iacobas I, Margolin J, Phan-Tran H, Pimpalwar S. Innovative Use of Denver Shunt in a Child with Generalized Lymphatic Anomaly. J Laparoendosc Adv Surg Tech A. 2017 Oct; 27(10):1091-1094. PMID: 28876997.
      Citations: 2     Fields:    Translation:Humans
    25. Grassia KL, Peterman CM, Iacobas I, Margolin JF, Bien E, Padhye B, Meyers RL, Adams DM. Clinical case series of pediatric hepatic angiosarcoma. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28521077.
      Citations: 7     Fields:    Translation:Humans
    26. Huho AN, Issaq N, Iacobas I, Elghetany TM, López-Terrada D, Fisher KE, Punia JN. A Rare Case of Pediatric Chronic Myelogenous Leukemia Presenting With Severe Thrombocytosis Without Leukocytosis. Pediatr Dev Pathol. 2018 Jan-Feb; 21(1):100-104. PMID: 29187020.
      Citations: 1     Fields:    Translation:Humans
    27. Mahajan P, Margolin J, Iacobas I. Kasabach-Merritt Phenomenon: Classic Presentation and Management Options. Clin Med Insights Blood Disord. 2017; 10:1179545X17699849. PMID: 28579853.
      Citations: 19     
    28. Iacobas I, Klepper L, Kelly J, Ferry T, Dellinger MT. Meeting Report for the 2016 Conference on GLA and Gorham-Stout Disease. IBMS BoneKEy. 2016; 847(13):1-3.
    29. Huho AN, Issaq N, Iacobas I, Elghetany MT, Lopez-Terrada D, Fisher K, Punia JN. A Rare Case of Pediatric Chronic Myelogenous Leukemia Presenting with Severe Thrombocytosis without Leukocytosis. Pediatr Dev Pathol. 2016 Jul 25. PMID: 27454200.
    30. Iacobas I, Simon ML, Amir T, Gribbin CE, McPartland TG, Kaufman MR, Calderwood S, Nosher JL. Decreased vascularization of retroperitoneal kaposiform hemangioendothelioma induced by treatment with sirolimus explains relief of symptoms. Clin Imaging. 2015 May-Jun; 39(3):529-32. PMID: 25662209.
      Citations: 6     Fields:    Translation:Humans
    31. Sait S, Zaghloul N, Patel A, Shah T, Iacobas I, Calderwood S. Transfusion related iron overload in pediatric oncology patients treated at a tertiary care centre and treatment with chelation therapy. Pediatr Blood Cancer. 2014 Dec; 61(12):2319-20. PMID: 25154390.
      Citations: 2     Fields:    Translation:Humans
    32. Drolet BA, Trenor CC, Brandão LR, Chiu YE, Chun RH, Dasgupta R, Garzon MC, Hammill AM, Johnson CM, Tlougan B, Blei F, David M, Elluru R, Frieden IJ, Friedlander SF, Iacobas I, Jensen JN, King DM, Lee MT, Nelson S, Patel M, Pope E, Powell J, Seefeldt M, Siegel DH, Kelly M, Adams DM. Consensus-derived practice standards plan for complicated Kaposiform hemangioendothelioma. J Pediatr. 2013 Jul; 163(1):285-91. PMID: 23796341.
      Citations: 51     Fields:    Translation:Humans
    33. Iacobas I, Burrows PE. Chapter: Role of PTEN in Vascular Organization and Anomalies. PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation. 2013; 211-233.
    34. Iacobas I, Burrows PE, Adams DM, Sutton VR, Hollier LH, Chintagumpala MM. Oral rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation. Pediatr Blood Cancer. 2011 Aug; 57(2):321-3. PMID: 21360661.
      Citations: 18     Fields:    Translation:Humans
    35. Iacobas I, Burrows PE, Frieden IJ, Liang MG, Mulliken JB, Mancini AJ, Kramer D, Paller AS, Silverman R, Wagner AM, Metry DW. LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. J Pediatr. 2010 Nov; 157(5):795-801.e1-7. PMID: 20598318.
      Citations: 18     Fields:    Translation:Humans
    36. Iacobas I, Vats A, Hirschi KK. Vascular potential of human pluripotent stem cells. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1110-7. PMID: 20453170.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    37. Duffy HS, Iacobas I, Hotchkiss K, Hirst-Jensen BJ, Bosco A, Dandachi N, Dermietzel R, Sorgen PL, Spray DC. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem. 2007 Mar 30; 282(13):9789-9796. PMID: 17284442.
      Citations: 24     Fields:    Translation:AnimalsCells
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