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ANDREW SIKORA

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Otolaryngology-Head and Neck Surgery
DivisionOtolaryngology
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    R03DE021741     (SIKORA, ANDREW GREGORY)Jul 15, 2011 - Jun 30, 2013
    NIH/NIDCR
    Role of Activated EGFR and COX-2 in Metastasis and Escape from Tumor Dormancy
    Role: Principal Investigator

    K08CA154963     (SIKORA, ANDREW GREGORY)Aug 8, 2011 - Jul 31, 2016
    NIH/NCI
    TARGETING INOS TO INHIBIT MYELOID-DERIVED SUPPRESSOR CELLS (MDSC) IN MELANOMA
    Role: Principal Investigator

    R01FD005109     (SIKORA, ANDREW GREGORY)Sep 10, 2015 - Jul 31, 2018
    FDA
    Phase II trial of ADXS11-001 vaccine for HPV-related oropharyngeal cancer
    Role: Principal Investigator

    U01DE028233     (SIKORA, ANDREW GREGORY)Sep 19, 2018 - Aug 31, 2023
    NIH/NIDCR
    Targeting the immunosuppressive tumor microenvironment to enhance efficacy of radiotherapy and immuno-radiotherapy for oral cancer
    Role: Principal Investigator

    I01BX004420     (SIKORA, ANDREW GREGORY)Jul 1, 2019 - Jun 30, 2021
    VA
    Immunogenetic determinants of HPV-related head and neck cancer in Veterans
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gelbard A, Wanjalla C, Wootten CT, Drake WP, Lowery AS, Wheeler DA, Cardenas MF, Sikora AG, Pathak RR, McDonnell W, Mallal S, Pilkinton M. The Proximal Airway Is a Reservoir for Adaptive Immunologic Memory in Idiopathic Subglottic Stenosis. Laryngoscope. 2020 Jun 30. PMID: 32603507.
      View in: PubMed
    2. Krupar R, Watermann C, Idel C, Ribbat-Idel J, Offermann A, Pasternack H, Kirfel J, Sikora AG, Perner S. In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation. Sci Rep. 2020 Jun 10; 10(1):9389. PMID: 32523042.
      View in: PubMed
    3. Annapragada A, Sikora A, Bollard C, Conejo-Garcia J, Cruz CR, Demehri S, Demetriou M, Demirdjian L, Fong L, Horowitz M, Hutson A, Kadash-Edmondson K, Kufe D, Lipkin S, Liu S, McCarthy C, Morgan M, Morris Z, Pan Y, Pasquini M, Schoenberger S, Van Allen E, Vilar E, Xing Y, Zha W, Odunsi A. Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 06; 8(1). PMID: 32554617.
      View in: PubMed
    4. Frederick M, Skinner HD, Kazi SA, Sikora AG, Sandulache VC. High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung. Sci Rep. 2020 Apr 14; 10(1):6380. PMID: 32286489.
      View in: PubMed
    5. Ferrarotto R, Bell D, Rubin ML, Hutcheson KA, Johnson JM, Goepfert RP, Phan J, Elamin YY, Torman DK, Warneke CL, Hessel AC, Garden AS, Myers JN, Johnson FM, Lee JJ, Sikora AG, Gillison ML, Glisson BS, Gross ND. Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results. Clin Cancer Res. 2020 Jul 01; 26(13):3211-3219. PMID: 32269052.
      View in: PubMed
    6. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199.
      View in: PubMed
    7. Porter CE, Rosewell Shaw A, Jung Y, Yip T, Castro PD, Sandulache VC, Sikora A, Gottschalk S, Ittman MM, Brenner MK, Suzuki M. Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors. Mol Ther. 2020 May 06; 28(5):1251-1262. PMID: 32145203.
      View in: PubMed
    8. Gelbard A, Anderson C, Berry LD, Amin MR, Benninger MS, Blumin JH, Bock JM, Bryson PC, Castellanos PF, Chen SC, Clary MS, Cohen SM, Crawley BK, Dailey SH, Daniero JJ, de Alarcon A, Donovan DT, Edell ES, Ekbom DC, Fernandes-Taylor S, Fink DS, Franco RA, Garrett CG, Guardiani EA, Hillel AT, Hoffman HT, Hogikyan ND, Howell RJ, Huang LC, Hussain LK, Johns MM, Kasperbauer JL, Khosla SM, Kinnard C, Kupfer RA, Langerman AJ, Lentz RJ, Lorenz RR, Lott DG, Lowery AS, Makani SS, Maldonado F, Mannion K, Matrka L, McWhorter AJ, Merati AL, Mori MC, Netterville JL, O'Dell K, Ongkasuwan J, Postma GN, Reder LS, Rohde SL, Richardson BE, Rickman OB, Rosen CA, Rutter MJ, Sandhu GS, Schindler JS, Schneider GT, Shah RN, Sikora AG, Sinard RJ, Smith ME, Smith LJ, Soliman AMS, Sveinsdóttir S, Van Daele DJ, Veivers D, Verma SP, Weinberger PM, Weissbrod PA, Wootten CT, Shyr Y, Francis DO. Comparative Treatment Outcomes for Patients With Idiopathic Subglottic Stenosis. JAMA Otolaryngol Head Neck Surg. 2019 Oct 31; 1-10. PMID: 31670805.
      View in: PubMed
    9. Sandulache VC, Wilde DC, Sturgis EM, Chiao EY, Sikora AG. A Hidden Epidemic of "Intermediate Risk" Oropharynx Cancer. Laryngoscope Investig Otolaryngol. 2019 Dec; 4(6):617-623. PMID: 31890879.
      View in: PubMed
    10. Pham N, Ludwig MS, Wang M, Ebrahimpour A, Bonnen MD, Diwan AH, Kim SJ, Bryan J, Newton JM, Sikora AG, Donovan DT, Sandulache V, Ghebre YT. Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis. Radiat Res. 2019 11; 192(5):473-482. PMID: 31415221.
      View in: PubMed
    11. Newton JM, Hanoteau A, Liu HC, Gaspero A, Parikh F, Gartrell-Corrado RD, Hart TD, Laoui D, Van Ginderachter JA, Dharmaraj N, Spanos WC, Saenger Y, Young S, Sikora AG. Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition. J Immunother Cancer. 2019 08 13; 7(1):216. PMID: 31409394.
      View in: PubMed
    12. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2019 Aug 05. PMID: 31383940.
      View in: PubMed
    13. Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). J Immunother Cancer. 2019 07 15; 7(1):184. PMID: 31307547.
      View in: PubMed
    14. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3089-3101. PMID: 31308490.
      View in: PubMed
    15. Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A. ERR1 and PGC1a associated mitochondrial alterations correlate with pan-cancer disparity in African Americans. J Clin Invest. 2019 03 28; 129(6):2351-2356. PMID: 30920960.
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    16. Harms A, Kansara S, Stach C, Richardson PA, Chen G, Lai S, Sikora AG, Parke R, Donovan D, Chiao E, Skinner H, Sandulache VC. Swallowing Function in Survivors of Oropharyngeal Cancer Is Associated With Advanced T Classification. Ann Otol Rhinol Laryngol. 2019 Aug; 128(8):696-703. PMID: 30913911.
      View in: PubMed
    17. Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res. 2019 06 15; 25(12):3689-3701. PMID: 30846479.
      View in: PubMed
    18. Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep. 2019 04; 20(4). PMID: 30787043.
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    19. Badr H, Sobrero M, Chen J, Kotz T, Genden E, Sikora AG, Miles B. Associations between pre-, post-, and peri-operative variables and health resource use following surgery for head and neck cancer. Oral Oncol. 2019 03; 90:102-108. PMID: 30846167.
      View in: PubMed
    20. Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape. Oncoimmunology. 2019; 8(4):e1568809. PMID: 30906661.
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    21. Carrero I, Liu HC, Sikora AG, Milosavljevic A. Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments. Oncogene. 2019 05; 38(19):3551-3568. PMID: 30655605.
      View in: PubMed
    22. Hanoteau A, Newton JM, Krupar R, Huang C, Liu HC, Gaspero A, Gartrell RD, Saenger YM, Hart TD, Santegoets SJ, Laoui D, Spanos C, Parikh F, Jayaraman P, Zhang B, Van der Burg SH, Van Ginderachter JA, Melief CJM, Sikora AG. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy. J Immunother Cancer. 2019 01 15; 7(1):10. PMID: 30646957.
      View in: PubMed
    23. Suk R, Mahale P, Sonawane K, Sikora AG, Chhatwal J, Schmeler KM, Sigel K, Cantor SB, Chiao EY, Deshmukh AA. Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus-Associated Cancers. JAMA Netw Open. 2018 09 07; 1(5):e181999. PMID: 30646145.
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    24. Krishna S, Ulrich P, Wilson E, Parikh F, Narang P, Yang S, Read AK, Kim-Schulze S, Park JG, Posner M, Wilson Sayres MA, Sikora A, Anderson KS. Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer. Cancer Res. 2018 11 01; 78(21):6159-6170. PMID: 30154146.
      View in: PubMed
    25. Richardson PA, Kansara S, Chen GG, Sabichi A, Sikora AG, Parke RB, Donovan DT, Chiao E, Sandulache VC. Treatment Patterns in Veterans with Laryngeal and Oropharyngeal Cancer and Impact on Survival. Laryngoscope Investig Otolaryngol. 2018 Aug; 3(4):275-282. PMID: 30186958.
      View in: PubMed
    26. DeBord LC, Pathak RR, Villaneuva M, Liu HC, Harrington DA, Yu W, Lewis MT, Sikora AG. The chick chorioallantoic membrane (CAM) as a versatile patient-derived xenograft (PDX) platform for precision medicine and preclinical research. Am J Cancer Res. 2018; 8(8):1642-1660. PMID: 30210932.
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    27. Jayaraman P, Parikh F, Newton JM, Hanoteau A, Rivas C, Krupar R, Rajapakshe K, Pathak R, Kanthaswamy K, MacLaren C, Huang S, Coarfa C, Spanos C, Edwards DP, Parihar R, Sikora AG. TGF-ß1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy. Oncoimmunology. 2018; 7(10):e1490853. PMID: 30288358.
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    28. Li L, Mok H, Jhaveri P, Bonnen MD, Sikora AG, Eissa NT, Komaki RU, Ghebre YT. Anticancer therapy and lung injury: molecular mechanisms. Expert Rev Anticancer Ther. 2018 10; 18(10):1041-1057. PMID: 29996062.
      View in: PubMed
    29. Newton JM, Hanoteau A, Sikora AG. Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors. J Vis Exp. 2018 06 07; (136). PMID: 29939180.
      View in: PubMed
    30. Farina M, Chua CYX, Ballerini A, Thekkedath U, Alexander JF, Rhudy JR, Torchio G, Fraga D, Pathak RR, Villanueva M, Shin CS, Niles JA, Sesana R, Demarchi D, Sikora AG, Acharya GS, Gaber AO, Nichols JE, Grattoni A. Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells. Biomaterials. 2018 09; 177:125-138. PMID: 29886385.
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    31. Patel RS, Mohr T, Hartman C, Stach C, Sikora AG, Zevallos JP, Sandulache VC. Tracheoesophageal Prosthesis Use Is Associated With Improved Overall Quality of Life in Veterans With Laryngeal Cancer. Ann Otol Rhinol Laryngol. 2018 Jul; 127(7):421-428. PMID: 29756480.
      View in: PubMed
    32. Newton JM, Flores-Arredondo JH, Suki S, Ware MJ, Krzykawska-Serda M, Agha M, Law JJ, Sikora AG, Curley SA, Corr SJ. Non-Invasive Radiofrequency Field Treatment of 4T1 Breast Tumors Induces T-cell Dependent Inflammatory Response. Sci Rep. 2018 02 22; 8(1):3474. PMID: 29472563.
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    33. Krupar R, Schreiber C, Offermann A, Lengerke C, Sikora AG, Thorns C, Perner S. In silico analysis of anti-leukemia immune response and immune evasion in acute myeloid leukemia. Leuk Lymphoma. 2018 10; 59(10):2493-2496. PMID: 29431550.
      View in: PubMed
    34. Leach DG, Dharmaraj N, Piotrowski SL, Lopez-Silva TL, Lei YL, Sikora AG, Young S, Hartgerink JD. STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy. Biomaterials. 2018 05; 163:67-75. PMID: 29454236.
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    35. Patro A, Guerrini CJ, Huang AT, Sikora AG. The Patient Who Continues to Smoke On-Treatment: An Ethical Dilemma. Otolaryngol Head Neck Surg. 2018 03; 158(3):469-472. PMID: 29337655.
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    36. Krupar R, Hautmann MG, Pathak RR, Varier I, McLaren C, Gaag D, Hellerbrand C, Evert M, Laban S, Idel C, Sandulache V, Perner S, Bosserhoff AK, Sikora AG. Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma. Am J Pathol. 2018 01; 188(1):72-83. PMID: 29107073.
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    37. Sonawane K, Suk R, Chiao EY, Chhatwal J, Qiu P, Wilkin T, Nyitray AG, Sikora AG, Deshmukh AA. Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014. Ann Intern Med. 2017 Nov 21; 167(10):714-724. PMID: 29049523.
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    38. San Martin R, Pathak R, Jain A, Jung SY, Hilsenbeck SG, Piña-Barba MC, Sikora AG, Pienta KJ, Rowley DR. Tenascin-C and Integrin a9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment. Cancer Res. 2017 11 01; 77(21):5977-5988. PMID: 28916657.
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    39. Rosewell Shaw A, Porter CE, Watanabe N, Tanoue K, Sikora A, Gottschalk S, Brenner MK, Suzuki M. Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer. Mol Ther. 2017 11 01; 25(11):2440-2451. PMID: 28974431.
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    40. Montealegre JR, Varier I, Bracamontes CG, Dillon LM, Guillaud M, Sikora AG, Follen M, Adler-Storthz K, Scheurer ME. Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes. Ethn Health. 2019 10; 24(7):804-815. PMID: 28870103.
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    41. Chew EY, Hartman CM, Richardson PA, Zevallos JP, Sikora AG, Kramer JR, Chiao EY. Risk factors for oropharynx cancer in a cohort of HIV-infected veterans. Oral Oncol. 2017 05; 68:60-66. PMID: 28438295.
      View in: PubMed
    42. Laban S, Giebel G, Klümper N, Schröck A, Doescher J, Spagnoli G, Thierauf J, Theodoraki MN, Remark R, Gnjatic S, Krupar R, Sikora AG, Litjens G, Grabe N, Kristiansen G, Bootz F, Schuler PJ, Brunner C, Brägelmann J, Hoffmann TK, Perner S. MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. Oncotarget. 2017 Feb 28; 8(9):14719-14735. PMID: 28146422.
      View in: PubMed
    43. Nelson C, Lee J, Ko K, Sikora AG, Bonnen MD, Enkhbaatar P, Ghebre YT. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017; 8:16. PMID: 28184197.
      View in: PubMed
    44. Liao K, Blumenthal-Barby J, Sikora AG. Factors Influencing Head and Neck Surgical Oncologists' Transition from Curative to Palliative Treatment Goals. Otolaryngol Head Neck Surg. 2017 01; 156(1):46-51. PMID: 27625024.
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    45. Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD. Vascular Aging: Implications for Cardiovascular Disease and Therapy. Transl Med (Sunnyvale). 2016 Dec; 6(4). PMID: 28932625.
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    46. Ramer I, Varier I, Zhang D, Demicco EG, Posner MR, Misiukiewicz K, Genden EM, Miles BA, Teng MS, Sikora AG. Racial disparities in incidence of human papillomavirus-associated oropharyngeal cancer in an urban population. Cancer Epidemiol. 2016 10; 44:91-95. PMID: 27518158.
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    47. Yin W, Duluc D, Joo H, Xue Y, Gu C, Wang Z, Wang L, Ouedraogo R, Oxford L, Clark A, Parikh F, Kim-Schulze S, Thompson-Snipes L, Lee SY, Beauregard C, Woo JH, Zurawski S, Sikora AG, Zurawski G, Oh S. Therapeutic HPV Cancer Vaccine Targeted to CD40 Elicits Effective CD8+ T-cell Immunity. Cancer Immunol Res. 2016 10; 4(10):823-834. PMID: 27485136.
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    48. Varier I, Keeley BR, Krupar R, Patsias A, Dong J, Gupta N, Parasher AK, Genden EM, Miles BA, Teng M, Bakst RL, Gupta V, Misiukiewicz KJ, Chiao EY, Scheurer ME, Laban S, Zhang D, Ye F, Cui M, Demicco EG, Posner MR, Sikora AG. Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non-human papillomavirus16 viral subtypes. Head Neck. 2016 09; 38(9):1330-7. PMID: 27080140.
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    49. Kass JI, Giraldez L, Gooding W, Choby G, Kim S, Miles B, Teng M, Sikora AG, Johnson JT, Myers EN, Duvvuri U, Genden EM, Ferris RL. Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma. Head Neck. 2016 10; 38(10):1467-71. PMID: 27080244.
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    50. Wang J, Peng L, Zhang R, Zheng Z, Chen C, Cheung KL, Cui M, Bian G, Xu F, Chiang D, Hu Y, Chen Y, Lu G, Yang J, Zhang H, Yang J, Zhu H, Chen SH, Liu K, Zhou MM, Sikora AG, Li L, Jiang B, Xiong H. 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation. Oncotarget. 2016 Apr 12; 7(15):19312-26. PMID: 27027355.
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    51. Veit JA, Heine D, Thierauf J, Lennerz J, Shetty S, Schuler PJ, Whiteside T, Beutner D, Meyer M, Grünewald I, Ritter G, Gnjatic S, Sikora AG, Hoffmann TK, Laban S. Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck. 2016 07; 38(7):1008-16. PMID: 26874246.
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    52. Hashemi-Sadraei N, Sikora AG, Brizel DM. Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. Am Soc Clin Oncol Educ Book. 2016; 35:e277-82. PMID: 27249733.
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    53. Li M, Pathak RR, Lopez-Rivera E, Friedman SL, Aguirre-Ghiso JA, Sikora AG. The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma. J Vis Exp. 2015 Oct 09; (104). PMID: 26484588.
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    54. Rettig EM, Wentz A, Posner MR, Gross ND, Haddad RI, Gillison ML, Fakhry C, Quon H, Sikora AG, Stott WJ, Lorch JH, Gourin CG, Guo Y, Xiao W, Miles BA, Richmon JD, Andersen PE, Misiukiewicz KJ, Chung CH, Gerber JE, Rajan SD, D'Souza G. Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus-Related Oropharyngeal Carcinoma. JAMA Oncol. 2015 Oct; 1(7):907-15. PMID: 26226294.
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    55. Parasher AK, Kidwai SM, Schorn VJ, Goljo E, Weinberg AD, Richards-Kortum R, Sikora AG, Iloreta AM, Govindaraj S, Miles BA. High-resolution microendoscope imaging of inverted papilloma and normal sinonasal mucosa: evaluation of interobserver concordance. Int Forum Allergy Rhinol. 2015 Dec; 5(12):1136-40. PMID: 26228817.
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    56. Stucken CL, de Almeida JR, Sikora AG, Tong CC, Genden EM. Impact of human papillomavirus and smoking on survival outcomes after transoral robotic surgery. Head Neck. 2016 Mar; 38(3):380-6. PMID: 25351893.
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    57. de Almeida JR, Moskowitz AJ, Miles BA, Goldstein DP, Teng MS, Sikora AG, Gupta V, Posner M, Genden EM. Cost-effectiveness of transoral robotic surgery versus (chemo)radiotherapy for early T classification oropharyngeal carcinoma: A cost-utility analysis. Head Neck. 2016 Apr; 38(4):589-600. PMID: 25488048.
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    58. Patsias A, Giraldez-Rodriguez L, Polydorides AD, Richards-Kortum R, Anandasabapathy S, Quang T, Sikora AG, Miles B. Feasibility of transoral robotic-assisted high-resolution microendoscopic imaging of oropharyngeal squamous cell carcinoma. Head Neck. 2015 Aug; 37(8):E99-102. PMID: 25327825.
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    59. Miles BA, Patsias A, Quang T, Polydorides AD, Richards-Kortum R, Sikora AG. Operative margin control with high-resolution optical microendoscopy for head and neck squamous cell carcinoma. Laryngoscope. 2015 Oct; 125(10):2308-16. PMID: 26059758.
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    60. Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, Shen K, Wang J, Liu X, Wang W, Zheng Z, Qi CF, Si C, He JC, Liu K, Lira SA, Sikora AG, Li L, Xiong H. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun. 2015 Mar 27; 6:6676. PMID: 25813085.
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    61. Moskalenko M, Pan M, Fu Y, de Moll EH, Hashimoto D, Mortha A, Leboeuf M, Jayaraman P, Bernardo S, Sikora AG, Wolchok J, Bhardwaj N, Merad M, Saenger Y. Requirement for innate immunity and CD90? NK1.1? lymphocytes to treat established melanoma with chemo-immunotherapy. Cancer Immunol Res. 2015 Mar; 3(3):296-304. PMID: 25600438.
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    62. Misiukiewicz K, Camille N, Gupta V, Bakst R, Teng M, Miles B, Genden E, Sikora A, Posner M. The role of HPV status in recurrent/metastatic squamous cell carcinoma of the head and neck. Clin Adv Hematol Oncol. 2014 Dec; 12(12):812-9. PMID: 25674839.
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    63. Cheng J, Kleinberger AJ, Sikora A. Fusobacterium necrophorum in a pediatric retropharyngeal abscess: A case report and review of the literature. Ear Nose Throat J. 2014 Dec; 93(12):E22-4. PMID: 25531849.
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    64. Parikh F, Duluc D, Imai N, Clark A, Misiukiewicz K, Bonomi M, Gupta V, Patsias A, Parides M, Demicco EG, Zhang DY, Kim-Schulze S, Kao J, Gnjatic S, Oh S, Posner MR, Sikora AG. Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer. Cancer Res. 2014 Dec 15; 74(24):7205-16. PMID: 25320012.
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    65. Jayaraman P, Alfarano MG, Svider PF, Parikh F, Lu G, Kidwai S, Xiong H, Sikora AG. iNOS expression in CD4+ T cells limits Treg induction by repressing TGFß1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity. Clin Cancer Res. 2014 Dec 15; 20(24):6439-51. PMID: 25278453.
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    66. Levovitz C, Chen D, Ivansson E, Gyllensten U, Finnigan JP, Alshawish S, Zhang W, Schadt EE, Posner MR, Genden EM, Boffetta P, Sikora AG. TGFß receptor 1: an immune susceptibility gene in HPV-associated cancer. Cancer Res. 2014 Dec 01; 74(23):6833-44. PMID: 25273091.
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    67. Keeley BR, Islami F, Pourshams A, Poustchi H, Pak JS, Brennan P, Khademi H, Genden EM, Abnet CC, Dawsey SM, Boffetta P, Malekzadeh R, Sikora AG. Prediagnostic serum levels of inflammatory biomarkers are correlated with future development of lung and esophageal cancer. Cancer Sci. 2014 Sep; 105(9):1205-11. PMID: 25040886.
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    68. Megwalu UC, Sikora AG. Survival outcomes in advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg. 2014 Sep; 140(9):855-60. PMID: 25144163.
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    69. Badr H, Gupta V, Sikora A, Posner M. Psychological distress in patients and caregivers over the course of radiotherapy for head and neck cancer. Oral Oncol. 2014 Oct; 50(10):1005-11. PMID: 25091150.
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    71. Jiang N, Muhammad C, Ho Y, Del Signore AG, Sikora AG, Malkin BD. Prevalence of severe obstructive sleep apnea in pediatric adenotonsillectomy patients. Laryngoscope. 2014 Aug; 124(8):1975-8. PMID: 24668559.
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    72. Chen W, Ye F, Cui M, Sikora AG, Wang X, Wang P, Cui X, Guo X, Zhu W, Zhang DY. Protein marker profiling in different T classification in laryngeal squamous cell carcinoma. Head Neck. 2015 Mar; 37(3):357-65. PMID: 24753215.
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    73. Finnigan JP, Sikora AG. Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer. Curr Oncol Rep. 2014 Mar; 16(3):375. PMID: 24488548.
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    74. Bradley J, Jiang N, Levy L, Richards-Kortum R, Sikora A, Smouha E. High-resolution microendoscope images of middle ear cholesteatoma and surrounding tissue: evaluation of interobserver concordance. Otolaryngol Head Neck Surg. 2014 Apr; 150(4):654-8. PMID: 24415492.
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    75. Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso J, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res. 2014 Feb 15; 74(4):1067-78. PMID: 24398473.
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    76. Bonomi M, Patsias A, Posner M, Sikora A. The role of inflammation in head and neck cancer. Adv Exp Med Biol. 2014; 816:107-27. PMID: 24818721.
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    77. Vila PM, Stucken CL, Morris LG, Posner MR, Genden EM, Boffetta P, Sikora AG. Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. Eur Arch Otorhinolaryngol. 2014 Sep; 271(9):2523-9. PMID: 24190760.
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    78. Jang DW, Sikora AG, Leytin A. Thyroglossal duct cyst carcinoma: case report and review of the literature. Ear Nose Throat J. 2013 Sep; 92(9):E12-4. PMID: 24057908.
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    79. Grimm EA, Sikora AG, Ekmekcioglu S. Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target. Clin Cancer Res. 2013 Oct 15; 19(20):5557-63. PMID: 23868870.
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    80. Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med. 2013 Jul 01; 210(7):1447-62. PMID: 23797094.
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    81. Svider PF, Mady LJ, Husain Q, Sikora AG, Setzen M, Baredes S, Eloy JA. Geographic differences in academic promotion practices, fellowship training, and scholarly impact. Am J Otolaryngol. 2013 Sep-Oct; 34(5):464-70. PMID: 23702316.
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    82. Morris LG, Sikora AG, Tosteson TD, Davies L. The increasing incidence of thyroid cancer: the influence of access to care. Thyroid. 2013 Jul; 23(7):885-91. PMID: 23517343.
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    83. Villanueva NL, de Almeida JR, Sikora AG, Miles BA, Genden EM. Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck. 2014 Jan; 36(1):28-33. PMID: 23554023.
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    84. Jain KS, Sikora AG, Baxi SS, Morris LG. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Cancer. 2013 May 15; 119(10):1832-7. PMID: 23423883.
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    85. Chu A, Genden E, Posner M, Sikora A. A patient-centered approach to counseling patients with head and neck cancer undergoing human papillomavirus testing: a clinician's guide. Oncologist. 2013; 18(2):180-9. PMID: 23345545.
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    86. Levy LL, Jiang N, Smouha E, Richards-Kortum R, Sikora AG. Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear. Laryngoscope. 2013 Apr; 123(4):1016-20. PMID: 23299781.
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    87. Tong CC, Kao J, Sikora AG. Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer. Immunol Res. 2012 Dec; 54(1-3):266-74. PMID: 22454102.
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    88. Anvekar RA, Asciolla JJ, Lopez-Rivera E, Floros KV, Izadmehr S, Elkholi R, Belbin G, Sikora AG, Chipuk JE. Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens. Cell Death Dis. 2012 Nov 15; 3:e420. PMID: 23152056.
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    89. Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol. 2012 Jun 01; 188(11):5365-76. PMID: 22529296.
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    90. Vila PM, Park CW, Pierce MC, Goldstein GH, Levy L, Gurudutt VV, Polydorides AD, Godbold JH, Teng MS, Genden EM, Miles BA, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer. Ann Surg Oncol. 2012 Oct; 19(11):3534-9. PMID: 22492225.
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    91. Tong CC, Lau KH, Rivera M, Cannan D, Aguirre-Ghiso J, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J. Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy. Oncol Rep. 2012 May; 27(5):1580-6. PMID: 22322320.
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    92. Sikora AG, Hailemichael Y, Overwijk WW. Conference scene: immune effector mechanisms in tumor immunity. Immunotherapy. 2012 Feb; 4(2):141-3. PMID: 22339456.
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    93. Levy LL, Vila PM, Park RW, Schwarz R, Polydorides AD, Teng MS, Gurudutt VV, Genden EM, Miles B, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. High-Resolution Optical Imaging of Benign and Malignant Mucosa in the Upper Aerodigestive Tract: An Atlas for Image-Guided Surgery. ISRN Minim Invasive Surg. 2012; 2012. PMID: 23641314.
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    94. Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS, Aguirre-Ghiso J, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy. J Cell Sci Ther. 2011 Oct 13; 1(2). PMID: 23483082.
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    95. Genden EM, Kotz T, Tong CC, Smith C, Sikora AG, Teng MS, Packer SH, Lawson WL, Kao J. Transoral robotic resection and reconstruction for head and neck cancer. Laryngoscope. 2011 Aug; 121(8):1668-74. PMID: 21792953.
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    96. Jethanamest D, Vila PM, Sikora AG, Morris LG. Predictors of survival in mucosal melanoma of the head and neck. Ann Surg Oncol. 2011 Oct; 18(10):2748-56. PMID: 21476106.
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    97. Morris LG, Sikora AG, Hayes RB, Patel SG, Ganly I. Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer. Cancer Causes Control. 2011 May; 22(5):671-9. PMID: 21327458.
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    98. Morris LG, Sikora AG, Patel SG, Hayes RB, Ganly I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol. 2011 Feb 20; 29(6):739-46. PMID: 21189382.
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    99. Prince A, Aguirre-Ghizo J, Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies. Mt Sinai J Med. 2010 Nov-Dec; 77(6):684-99. PMID: 21105129.
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    100. Kao J, Ko EC, Eisenstein S, Sikora AG, Fu S, Chen SH. Targeting immune suppressing myeloid-derived suppressor cells in oncology. Crit Rev Oncol Hematol. 2011 Jan; 77(1):12-9. PMID: 20304669.
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    101. Sikora AG, Gelbard A, Davies MA, Sano D, Ekmekcioglu S, Kwon J, Hailemichael Y, Jayaraman P, Myers JN, Grimm EA, Overwijk WW. Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy. Clin Cancer Res. 2010 Mar 15; 16(6):1834-44. PMID: 20215556.
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    102. Morris LG, Shaha AR, Tuttle RM, Sikora AG, Ganly I. Tall-cell variant of papillary thyroid carcinoma: a matched-pair analysis of survival. Thyroid. 2010 Feb; 20(2):153-8. PMID: 20151822.
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    103. Levy L, Smith C, Gurudutt V, Teng M, Rivera M, Anadasabapathy S, Genden E, Gillenwater A, Richards-Kortum R, Sikora A. Ex vivo high resolution imaging with a miniaturized microendoscope to discriminate between benign and malignant mucosa in the upper aerodigestive tract. Laryngoscope. 2010; 120 Suppl 4:S162. PMID: 21225760.
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    104. Vu HL, Sikora AG, Fu S, Kao J. HPV-induced oropharyngeal cancer, immune response and response to therapy. Cancer Lett. 2010 Feb 28; 288(2):149-55. PMID: 19628331.
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    105. Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J Immunol. 2009 Jun 15; 182(12):7398-407. PMID: 19494262.
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    106. Sikora AG, Morris LG, Sturgis EM. Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men. Arch Otolaryngol Head Neck Surg. 2009 Apr; 135(4):402-5. PMID: 19380365.
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    107. Sikora AG, Shnayder Y, Yee H, DeLacure MD. Oropharyngeal kaposi sarcoma in related persons negative for human immunodeficiency virus. Ann Otol Rhinol Laryngol. 2008 Mar; 117(3):172-6. PMID: 18444476.
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    108. Liu C, Lou Y, Lizée G, Qin H, Liu S, Rabinovich B, Kim GJ, Wang YH, Ye Y, Sikora AG, Overwijk WW, Liu YJ, Wang G, Hwu P. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest. 2008 Mar; 118(3):1165-75. PMID: 18259609.
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    109. Morris LG, Sikora AG, Myssiorek D, DeLacure MD. The basis of racial differences in the incidence of thyroid cancer. Ann Surg Oncol. 2008 Apr; 15(4):1169-76. PMID: 18246401.
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    110. Morris LG, Miglietta MA, Sikora AG, Okun MN, Roland JT. Emergency parotidectomy for penetrating zone III neck trauma. Arch Surg. 2007 Dec; 142(12):1206-8. PMID: 18086989.
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    111. Morris LG, Sikora AG, Kuriakose MA, DeLacure MD. Tamoxifen therapy for aggressive fibromatosis of the posterior triangle of the neck. Otolaryngol Head Neck Surg. 2007 Apr; 136(4):674-6. PMID: 17418276.
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    112. Jethanamest D, Morris LG, Sikora AG, Kutler DI. Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors. Arch Otolaryngol Head Neck Surg. 2007 Mar; 133(3):276-80. PMID: 17372086.
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    113. Le BT, Setlur J, Sikora AG, Lee KC. Mycosis fungoides: a case of tonsil involvement. Arch Otolaryngol Head Neck Surg. 2006 Jul; 132(7):794-6. PMID: 16847192.
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    114. Liebeskind A, Sikora AG, Komisar A, Slavit D, Fried K. Rates of malignancy in incidentally discovered thyroid nodules evaluated with sonography and fine-needle aspiration. J Ultrasound Med. 2005 May; 24(5):629-34. PMID: 15840794.
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    115. Sikora AG, Toniolo P, DeLacure MD. The changing demographics of head and neck squamous cell carcinoma in the United States. Laryngoscope. 2004 Nov; 114(11):1915-23. PMID: 15510014.
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    116. Kuriakose MA, Chen WT, He ZM, Sikora AG, Zhang P, Zhang ZY, Qiu WL, Hsu DF, McMunn-Coffran C, Brown SM, Elango EM, Delacure MD, Chen FA. Selection and validation of differentially expressed genes in head and neck cancer. Cell Mol Life Sci. 2004 Jun; 61(11):1372-83. PMID: 15170515.
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    117. Sikora AG, Lee KC. Otolaryngologic manifestations of immunodeficiency. Otolaryngol Clin North Am. 2003 Aug; 36(4):647-72. PMID: 14567058.
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    119. Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci. 2000 Jul 15; 20(14):5292-9. PMID: 10884313.
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    120. Sikora A, Liu J, Brosnan C, Buell G, Chessel I, Bloom BR. Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol. 1999 Jul 15; 163(2):558-61. PMID: 10395640.
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    121. Redlich CA, Rockwell S, Chung JS, Sikora AG, Kelley M, Mayne ST. Vitamin A inhibits radiation-induced pneumonitis in rats. J Nutr. 1998 Oct; 128(10):1661-4. PMID: 9772133.
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