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Massimo Pietropaolo

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Endocrinology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Endocrinology/Metabolism


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    R01DK053456     (PIETROPAOLO, MASSIMO T)May 1, 1999 - Jun 30, 2022
    NIH/NIDDK
    ENHANCEMENT OF BIOMARKERS FOR TYPE 1 DIABETES
    Role: Principal Investigator

    R01DK056200     (PIETROPAOLO, MASSIMO T)Apr 1, 2001 - Aug 31, 2012
    NIH/NIDDK
    Epidemiology of Heterogenity in Type 2 Diabetes
    Role: Principal Investigator

    R21DK073724     (PIETROPAOLO, MASSIMO T)Sep 25, 2005 - Jun 30, 2008
    NIH/NIDDK
    Proteomics of Autoimmune Type 1 Diabetes
    Role: Principal Investigator

    DP3DK101083     (PIETROPAOLO, MASSIMO T)Sep 20, 2013 - Aug 31, 2016
    NIH/NIDDK
    A Novel Approach Applying CGM Metrics to Identify a Prediabetic State
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M. Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 Sep; 68(9):1819-1829. PMID: 31167877.
      View in: PubMed
    2. Mulukutla SN, Acevedo-Calado M, Hampe CS, Pietropaolo M, Balasubramanyam A. Response to Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640. Diabetes Care. 2019 05; 42(5):e82-e83. PMID: 31010950.
      View in: PubMed
    3. Vonberg AD, Acevedo-Calado M, Cox AR, Pietropaolo SL, Gianani R, Lundy SK, Pietropaolo M. CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus. JCI Insight. 2018 12 06; 3(23). PMID: 30518692.
      View in: PubMed
    4. Mulukutla SN, Acevedo-Calado M, Hampe CS, Pietropaolo M, Balasubramanyam A. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care. 2018 12; 41(12):2637-2640. PMID: 30327357.
      View in: PubMed
    5. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 01; 96:50-58. PMID: 30122420.
      View in: PubMed
    6. James EA, Pietropaolo M, Mamula MJ. Immune Recognition of ß-Cells: Neoepitopes as Key Players in the Loss of Tolerance. Diabetes. 2018 06; 67(6):1035-1042. PMID: 29784651.
      View in: PubMed
    7. Menon R, Becker D, Arslanian S, Kordonouri O, Trucco M, Pietropaolo M, Danne T. Editorial Tribute: Mark A. Sperling, MD, Editor-in-Chief, Pediatric Diabetes 2000-2017. Pediatr Diabetes. 2018 05; 19(3):345. PMID: 29695032.
      View in: PubMed
    8. Acevedo-Calado M, James EA, Morran MP, Pietropaolo SL, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Apr; 40(4):561-568. PMID: 28174261.
      View in: PubMed
    9. Mitre TM, Pietropaolo M, Khadra A. The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation. Math Biosci. 2017 05; 287:12-23. PMID: 27765528.
      View in: PubMed
    10. Jaberi-Douraki M, Pietropaolo M, Khadra A. Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes. J Theor Biol. 2015 Oct 21; 383:93-105. PMID: 26271890.
      View in: PubMed
    11. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050.
      View in: PubMed
    12. Hecht Baldauff N, Tfayli H, Dong W, Arena VC, Gurtunca N, Pietropaolo M, Becker DJ, Libman IM. Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study. Pediatr Diabetes. 2016 06; 17(4):249-56. PMID: 25754190.
      View in: PubMed
    13. Arvan P, Bernal-Mizrachi E, Liu M, Pietropaolo M, Satin L, Schnell S, Soleimanpour SA. Molecular aspects of pancreatic beta cell failure and diabetes. Mol Aspects Med. 2015 Apr; 42:1-2. PMID: 25596327.
      View in: PubMed
    14. Morran MP, Vonberg A, Khadra A, Pietropaolo M. Immunogenetics of type 1 diabetes mellitus. Mol Aspects Med. 2015 Apr; 42:42-60. PMID: 25579746.
      View in: PubMed
    15. Cedillo M, Libman IM, Arena VC, Zhou L, Trucco M, Ize-Ludlow D, Pietropaolo M, Becker DJ. Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes. J Clin Endocrinol Metab. 2015 Jan; 100(1):E82-6. PMID: 25250632.
      View in: PubMed
    16. Buryk MA, Dosch HM, Libman I, Arena VC, Huang Y, Cheung RK, Trucco M, Pietropaolo M, Becker DJ. Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes. Diabetes Care. 2015 Jan; 38(1):43-50. PMID: 25414154.
      View in: PubMed
    17. Subauste A, Gianani R, Chang AM, Plunkett C, Pietropaolo SL, Zhang YJ, Barinas-Mitchell E, Kuller LH, Galecki A, Halter JB, Pietropaolo M. Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes. PLoS One. 2014; 9(9):e106537. PMID: 25226365.
      View in: PubMed
    18. Fan Y, Gualtierotti G, Tajima A, Grupillo M, Coppola A, He J, Bertera S, Owens G, Pietropaolo M, Rudert WA, Trucco M. Compromised central tolerance of ICA69 induces multiple organ autoimmunity. J Autoimmun. 2014 Sep; 53:10-25. PMID: 25088457.
      View in: PubMed
    19. Jaberi-Douraki M, Schnell S, Pietropaolo M, Khadra A. Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes. J Theor Biol. 2015 Jun 21; 375:77-87. PMID: 24831415.
      View in: PubMed
    20. Jaberi-Douraki M, Liu SW, Pietropaolo M, Khadra A. Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease. Pediatr Diabetes. 2014 May; 15(3):162-74. PMID: 24827702.
      View in: PubMed
    21. Jaberi-Douraki M, Pietropaolo M, Khadra A. Predictive models of type 1 diabetes progression: understanding T-cell cycles and their implications on autoantibody release. PLoS One. 2014; 9(4):e93326. PMID: 24705439.
      View in: PubMed
    22. Fernando R, Vonberg A, Atkins SJ, Pietropaolo S, Pietropaolo M, Smith TJ. Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases. J Clin Endocrinol Metab. 2014 May; 99(5):E796-803. PMID: 24517144.
      View in: PubMed
    23. Buschur E, Sarma AV, Pietropaolo M, Dunn RL, Braffett BH, Cleary PA, Cowie C, Larkin ME, Wessells H, Nathan DM, Kim C. Self-reported autoimmune disease by sex in the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study. Diabetes Care. 2014 Feb; 37(2):e28-9. PMID: 24459159.
      View in: PubMed
    24. Bodnar TW, Acevedo MJ, Pietropaolo M. Management of non-islet-cell tumor hypoglycemia: a clinical review. J Clin Endocrinol Metab. 2014 Mar; 99(3):713-22. PMID: 24423303.
      View in: PubMed
    25. Pietropaolo M. Persistent C-peptide: what does it mean? Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):279-84. PMID: 23743645.
      View in: PubMed
    26. Schnell S, Pietropaolo M. Autoimmunity treatment using pMHC-NP-based therapy: designing nanoparticle treatment of autoimmunity with quantitative biology. Immunol Cell Biol. 2013 May; 91(5):333-4. PMID: 23609902.
      View in: PubMed
    27. Pietropaolo M, Towns R, Eisenbarth GS. Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). PMID: 23028135.
      View in: PubMed
    28. Arvan P, Pietropaolo M, Ostrov D, Rhodes CJ. Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012 Aug 01; 2(8). PMID: 22908193.
      View in: PubMed
    29. Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M. Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem. 2012 May 18; 287(21):17882-93. PMID: 22447927.
      View in: PubMed
    30. Towns R, Pietropaolo M. GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA). Drugs Future. 2011 Nov; 36(11):847. PMID: 22869930.
      View in: PubMed
    31. Lin MS, Tse HM, Delmastro MM, Bertera S, Wong CT, Lakomy R, He J, Sklavos MM, Coudriet GM, Pietropaolo M, Trucco MM, Piganelli JD. A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice. Immunol Res. 2011 Aug; 50(2-3):213-20. PMID: 21717080.
      View in: PubMed
    32. Khadra A, Pietropaolo M, Nepom GT, Sherman A. Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PLoS One. 2011 May 10; 6(5):e14796. PMID: 21573001.
      View in: PubMed
    33. Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited. Diabetes. 2011 May; 60(5):1370-9. PMID: 21525508.
      View in: PubMed
    34. Gonzalez CD, Lee MS, Marchetti P, Pietropaolo M, Towns R, Vaccaro MI, Watada H, Wiley JW. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy. 2011 Jan; 7(1):2-11. PMID: 20935516.
      View in: PubMed
    35. Thomas IH, Pietropaolo M. Type 1 diabetes: a genetic Pandora's box? Pediatr Diabetes. 2010 Dec; 11(8):511-2. PMID: 21118341.
      View in: PubMed
    36. Tao B, Pietropaolo M, Atkinson M, Schatz D, Taylor D. Estimating the cost of type 1 diabetes in the U.S.: a propensity score matching method. PLoS One. 2010 Jul 09; 5(7):e11501. PMID: 20634976.
      View in: PubMed
    37. Singer K, Pietropaolo M, Menon RK. Improving type 1 diabetes control with leptin--is this a game-changer? Pediatr Diabetes. 2010 Jun; 11(4):216-7. PMID: 20618743.
      View in: PubMed
    38. Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, Pietropaolo M. Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology. 2010 Jun; 151(6):2528-37. PMID: 20382696.
      View in: PubMed
    39. Towns R, Pietropaolo M. AIRE's partnerships: an answer for many questions and new questions in search of answers. Pediatr Diabetes. 2010 Mar; 11(2):85-7. PMID: 20415724.
      View in: PubMed
    40. Nelson P, Smith N, Ciupe S, Zou W, Omenn GS, Pietropaolo M. Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses. Math Biosci Eng. 2009 Oct; 6(4):753-78. PMID: 19835428.
      View in: PubMed
    41. Wiley JW, Pietropaolo M. Autoimmune pancreatitis: the emerging role of serologic biomarkers. Diabetes. 2009 Mar; 58(3):520-2. PMID: 19246601.
      View in: PubMed
    42. Pietropaolo M, Surhigh JM, Nelson PW, Eisenbarth GS. Primer: immunity and autoimmunity. Diabetes. 2008 Nov; 57(11):2872-82. PMID: 18971434.
      View in: PubMed
    43. Morran MP, Omenn GS, Pietropaolo M. Immunology and genetics of type 1 diabetes. Mt Sinai J Med. 2008 Aug; 75(4):314-27. PMID: 18729178.
      View in: PubMed
    44. Towns R, Pietropaolo M, Wiley JW. Stimulation of autophagy by autoantibody-mediated activation of death receptor cascades. Autophagy. 2008 Jul; 4(5):715-6. PMID: 18560272.
      View in: PubMed
    45. Morran MP, McInerney MF, Pietropaolo M. Innate and adaptive autoimmunity in type 1 diabetes. Pediatr Diabetes. 2008 Apr; 9(2):152-61. PMID: 18221432.
      View in: PubMed
    46. Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol. 2008 Apr; 87(4):197-209. PMID: 18187231.
      View in: PubMed
    47. Pietropaolo M, Barinas-Mitchell E, Kuller LH. The heterogeneity of diabetes: unraveling a dispute: is systemic inflammation related to islet autoimmunity? Diabetes. 2007 May; 56(5):1189-97. PMID: 17322478.
      View in: PubMed
    48. Oral EA, Pietropaolo M. Editorial: Metabolism lessons for survival: when adults and children are not alike. J Clin Endocrinol Metab. 2006 Oct; 91(10):3763-5. PMID: 17028291.
      View in: PubMed
    49. Barinas-Mitchell E, Kuller LH, Pietropaolo S, Zhang YJ, Henderson T, Pietropaolo M. The prevalence of the 65-kilodalton isoform of glutamic acid decarboxylase autoantibodies by glucose tolerance status in elderly patients from the cardiovascular health study. J Clin Endocrinol Metab. 2006 Aug; 91(8):2871-7. PMID: 16720660.
      View in: PubMed
    50. Pietropaolo M, Yu S, Libman IM, Pietropaolo SL, Riley K, LaPorte RE, Drash AL, Mazumdar S, Trucco M, Becker DJ. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes. 2005 Dec; 6(4):184-92. PMID: 16390386.
      View in: PubMed
    51. Casu A, Trucco M, Pietropaolo M. A look to the future: prediction, prevention, and cure including islet transplantation and stem cell therapy. Pediatr Clin North Am. 2005 Dec; 52(6):1779-804. PMID: 16301093.
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    52. Pietropaolo M. An 18-year-old patient with type 1 diabetes undergoing surgery. PLoS Med. 2005 May; 2(5):e140. PMID: 15916471.
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    53. Strotmeyer ES, Yang Z, LaPorte RE, Chang YF, Steenkiste AR, Pietropaolo M, Nucci AM, Shen S, Wang L, Wang B, Dorman JS. Infant diet and type 1 diabetes in China. Diabetes Res Clin Pract. 2004 Sep; 65(3):283-92. PMID: 15331209.
      View in: PubMed
    54. McInerney MF, Najjar SM, Brickley D, Lutzke M, Abou-Rjaily GA, Reifsnyder P, Haskell BD, Flurkey K, Zhang YJ, Pietropaolo SL, Pietropaolo M, Byers JP, Leiter EH. Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain. Exp Diabesity Res. 2004 Jul-Sep; 5(3):177-85. PMID: 15512785.
      View in: PubMed
    55. Barinas-Mitchell E, Pietropaolo S, Zhang YJ, Henderson T, Trucco M, Kuller LH, Pietropaolo M. Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey. Diabetes. 2004 May; 53(5):1293-302. PMID: 15111499.
      View in: PubMed
    56. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Evidence for heterogeneous pathogenesis of insulin-treated diabetes in black and white children. Diabetes Care. 2003 Oct; 26(10):2876-82. PMID: 14514595.
      View in: PubMed
    57. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care. 2003 Oct; 26(10):2871-5. PMID: 14514594.
      View in: PubMed
    58. Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M. Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem. 2003 Jul 11; 278(28):26166-73. PMID: 12682071.
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    59. Friday RP, Pietropaolo SL, Profozich J, Trucco M, Pietropaolo M. Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. J Biol Chem. 2003 Jan 10; 278(2):853-63. PMID: 12409289.
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    60. Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD. Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes. 2002 Aug; 51(8):2561-7. PMID: 12145171.
      View in: PubMed
    61. Giannoukakis N, Pietropaolo M, Trucco M. Genes and engineered cells as drugs for type I and type II diabetes mellitus therapy and prevention. Curr Opin Investig Drugs. 2002 May; 3(5):735-51. PMID: 12090547.
      View in: PubMed
    62. Pietropaolo M, Giannoukakis N, Trucco M. Cellular environment and freedom of gene expression. Nat Immunol. 2002 Apr; 3(4):335; author reply 336. PMID: 11919570.
      View in: PubMed
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