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Stuart Corr

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Surgical Research
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    Dr. Corr obtained his BEng (hons) in Electronics with Music from The University of Glasgow. He went on to study an MEng in Electrical Systems majoring in Nano-electronics and Photonics at Dublin City University, Rep. of Ireland. During this period, he was selected for the Irish Government sponsored FÁS Science Challenge, which placed him in Dr. Lon J. Wilson's Nano-materials group at Rice University, Department of Chemistry where he worked on building a prototype to quantify cyclic magnetic field absorption by gadolinium loaded ultrashort carbon nanotubes (Gd3+ US-SWNTs), which are used as superlative MRI contrast agents. Having returned to Dublin to finish his masters he then completed his PhD studies, over a period of two years, in the field of silver nanoparticles and thin-films for surface enhanced raman spectroscopy of strained silicon. He subsequently spent a 3-month period at the International Space University, Strasbourg, France, as part of their MSc. in Space Studies program - a program which he is still affiliated with. With this knowledge and experience he was asked to return to Rice as a postdoctoral fellow, to synthesize and apply silver nanoparticles to non-invasive radio frequency (RF) hyperthermia, which was part of an active collaboration between Prof Wilson and Dr. Steven A. Curley, at MD Anderson Cancer Center. Since working on this project in 2009, Dr. Corr eventually transferred over to MDACC in 2011 and has since been involved in the research and development of nanoparticle-assisted non-invasive RF hyperthermia.

    RF technology is gaining prominence as a powerful new surgical oncology tool in the fight against cancer. Recent work has shown synergy when combining RF therapy with systemic chemotherapy administration. His current studies have also shown enhanced delivery and retention of chemotherapeutics into tumors when exposed to low levels of RF fields. He is currently active in this field and we are currently seeking FDA approval for full human trials.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ogle MM, Smith McWilliams AD, Ware MJ, Curley SA, Corr SJ, Martí AA. Sensing Temperature in Vitro and in Cells Using a BODIPY Molecular Probe. J Phys Chem B. 2019 Aug 29; 123(34):7282-7289. PMID: 31429279.
      View in: PubMed
    2. Serda M, Ware MJ, Newton JM, Sachdeva S, Krzykawska-Serda M, Nguyen L, Law J, Anderson AO, Curley SA, Wilson LJ, Corr SJ. Development of photoactive Sweet-C60 for pancreatic cancer stellate cell therapy. Nanomedicine (Lond). 2018 12; 13(23):2981-2993. PMID: 30501557.
      View in: PubMed
    3. Ho J, Ware M, Law J, Nagaraj A, Jain S, Rios J, Calderon R, Toombs B, Anderson A, Bray C, Curley S, Corr SJ. Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs. Oncology. 2018; 95(6):360-369. PMID: 30269135.
      View in: PubMed
    4. Krzykawska-Serda M, Ho JC, Ware MJ, Law JJ, Newton JM, Nguyen L, Agha M, Curley SA, Corr SJ. Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy. Transl Oncol. 2018 Aug; 11(4):864-872. PMID: 29763773.
      View in: PubMed
    5. Krzykawska-Serda M, Agha MS, Ho JC, Ware MJ, Law JJ, Newton JM, Nguyen L, Curley SA, Corr SJ. Chemotherapy and Radiofrequency-Induced Mild Hyperthermia Combined Treatment of Orthotopic Pancreatic Ductal Adenocarcinoma Xenografts. Transl Oncol. 2018 Jun; 11(3):664-671. PMID: 29621664.
      View in: PubMed
    6. Newton JM, Flores-Arredondo JH, Suki S, Ware MJ, Krzykawska-Serda M, Agha M, Law JJ, Sikora AG, Curley SA, Corr SJ. Non-Invasive Radiofrequency Field Treatment of 4T1 Breast Tumors Induces T-cell Dependent Inflammatory Response. Sci Rep. 2018 02 22; 8(1):3474. PMID: 29472563.
      View in: PubMed
    7. Ware MJ, Nguyen LP, Law JJ, Krzykawska-Serda M, Taylor KM, Cao HST, Anderson AO, Pulikkathara M, Newton JM, Ho JC, Hwang R, Rajapakshe K, Coarfa C, Huang S, Edwards D, Curley SA, Corr SJ. A new mild hyperthermia device to treat vascular involvement in cancer surgery. Sci Rep. 2017 09 12; 7(1):11299. PMID: 28900126.
      View in: PubMed
    8. Ware MJ, Curtis LT, Wu M, Ho JC, Corr SJ, Curley SA, Godin B, Frieboes HB. Pancreatic adenocarcinoma response to chemotherapy enhanced with non-invasive radio frequency evaluated via an integrated experimental/computational approach. Sci Rep. 2017 06 13; 7(1):3437. PMID: 28611425.
      View in: PubMed
    9. Lapin NA, Krzykawska-Serda M, Dilliard S, Mackeyev Y, Serda M, Wilson LJ, Curley SA, Corr SJ. The effects of non-invasive radiofrequency electric field hyperthermia on biotransport and biodistribution of fluorescent [60]fullerene derivative in a murine orthotopic model of breast adenocarcinoma. J Control Release. 2017 08 28; 260:92-99. PMID: 28527736.
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    10. Ho JC, Nguyen L, Law JJ, Ware MJ, Keshishian V, Lara NC, Nguyen T, Curley SA, Corr SJ. Non-Invasive Radiofrequency Field Treatment to Produce Hepatic Hyperthermia: Efficacy and Safety in Swine. IEEE J Transl Eng Health Med. 2017; 5:1500109. PMID: 28507824.
      View in: PubMed
    11. Ware MJ, Krzykawska-Serda M, Chak-Shing Ho J, Newton J, Suki S, Law J, Nguyen L, Keshishian V, Serda M, Taylor K, Curley SA, Corr SJ. Optimizing non-invasive radiofrequency hyperthermia treatment for improving drug delivery in 4T1 mouse breast cancer model. Sci Rep. 2017 03 13; 7:43961. PMID: 28287120.
      View in: PubMed
    12. Lara NC, Haider AA, Wilson LJ, Curley SA, Corr SJ. Unique heating curves generated by radiofrequency electric-field interactions with semi-aqueous solutions. Appl Phys Lett. 2017 Jan 02; 110(1):013701. PMID: 28104923.
      View in: PubMed
    13. Lara NC, Haider AA, Ho JC, Wilson LJ, Barron AR, Curley SA, Corr SJ. Water-structuring molecules and nanomaterials enhance radiofrequency heating in biologically relevant solutions. Chem Commun (Camb). 2016 Oct 18; 52(85):12630-12633. PMID: 27722511.
      View in: PubMed
    14. Ware MJ, Keshishian V, Law JJ, Ho JC, Favela CA, Rees P, Smith B, Mohammad S, Hwang RF, Rajapakshe K, Coarfa C, Huang S, Edwards DP, Corr SJ, Godin B, Curley SA. Generation of an in vitro 3D PDAC stroma rich spheroid model. Biomaterials. 2016 11; 108:129-42. PMID: 27627810.
      View in: PubMed
    15. Lapin NA, Krzykawska-Serda M, Ware MJ, Curley SA, Corr SJ. Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer Nanotechnol. 2016; 7:5. PMID: 27429662.
      View in: PubMed
    16. Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. Conditional knockout of retinal determination genes in differentiating cells in Drosophila. FEBS J. 2016 08; 283(15):2754-66. PMID: 27257739.
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    17. Ware MJ, Colbert K, Keshishian V, Ho J, Corr SJ, Curley SA, Godin B. Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique. Tissue Eng Part C Methods. 2016 Apr; 22(4):312-21. PMID: 26830354.
      View in: PubMed
    18. Corr SJ, Shamsudeen S, Vergara LA, Ho JC, Ware MJ, Keshishian V, Yokoi K, Savage DJ, Meraz IM, Kaluarachchi W, Cisneros BT, Raoof M, Nguyen DT, Zhang Y, Wilson LJ, Summers H, Rees P, Curley SA, Serda RE. A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia. PLoS One. 2015; 10(8):e0136382. PMID: 26308617.
      View in: PubMed
    19. Ware MJ, Tinger S, Colbert KL, Corr SJ, Rees P, Koshkina N, Curley S, Summers HD, Godin B. Radiofrequency treatment alters cancer cell phenotype. Sci Rep. 2015 Jul 13; 5:12083. PMID: 26165830.
      View in: PubMed
    20. Bogdanov AA, Gupta S, Koshkina N, Corr SJ, Zhang S, Curley SA, Han G. Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agent. Bioconjug Chem. 2015 Jan 21; 26(1):39-50. PMID: 25496453.
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    21. Raoof M, Zhu C, Cisneros BT, Liu H, Corr SJ, Wilson LJ, Curley SA. Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 25128695.
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    22. Raoof M, Corr SJ, Zhu C, Cisneros BT, Kaluarachchi WD, Phounsavath S, Wilson LJ, Curley SA. Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma. Nanomedicine. 2014 Aug; 10(6):1121-30. PMID: 24650884.
      View in: PubMed
    23. Corr SJ, Cisneros BT, Green L, Raoof M, Curley SA. Protocols for assessing radiofrequency interactions with gold nanoparticles and biological systems for non-invasive hyperthermia cancer therapy. J Vis Exp. 2013 Aug 28; (78). PMID: 24022384.
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    24. Kaluarachchi WD, Cisneros BT, Corr SJ, Albert ND, Curley SA, Kontoyiannis DP. Aspergillus fumigatus hyphal damage caused by noninvasive radiofrequency field-induced hyperthermia. Antimicrob Agents Chemother. 2013 Sep; 57(9):4444-8. PMID: 23836166.
      View in: PubMed
    25. Raoof M, Cisneros BT, Corr SJ, Palalon F, Curley SA, Koshkina NV. Tumor selective hyperthermia induced by short-wave capacitively-coupled RF electric-fields. PLoS One. 2013; 8(7):e68506. PMID: 23861912.
      View in: PubMed
    26. Corr SJ, Raoof M, Cisneros BT, Kuznetsov O, Massey K, Kaluarachchi WD, Cheney MA, Billups EW, Wilson LJ, Curley SA. Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells. Nanoscale Res Lett. 2013 May 02; 8(1):208. PMID: 23639042.
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    27. Raoof M, Cisneros BT, Guven A, Phounsavath S, Corr SJ, Wilson LJ, Curley SA. Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields. Biomaterials. 2013 Feb; 34(7):1862-9. PMID: 23228421.
      View in: PubMed
    28. Corr SJ, Raoof M, Mackeyev Y, Phounsavath S, Cheney MA, Cisneros BT, Shur M, Gozin M, McNally PJ, Wilson LJ, Curley SA. Citrate-capped gold nanoparticle electrophoretic heat production in response to a time-varying radiofrequency electric-field. J Phys Chem C Nanomater Interfaces. 2012 Nov 15; 116(45):24380-24389. PMID: 23795228.
      View in: PubMed
    29. Raoof M, Corr SJ, Kaluarachchi WD, Massey KL, Briggs K, Zhu C, Cheney MA, Wilson LJ, Curley SA. Stability of antibody-conjugated gold nanoparticles in the endolysosomal nanoenvironment: implications for noninvasive radiofrequency-based cancer therapy. Nanomedicine. 2012 Oct; 8(7):1096-105. PMID: 22349096.
      View in: PubMed
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