Header Logo

MICHAEL TAYLOR

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
ORCID ORCID Icon0000-0001-7009-3466 Additional info
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neurosurgery
    DivisionNeurosurgery


    Collapse Biography 
    Collapse education and training
    University of Western Ontario, London, OntarioBSc06/1990 Science
    University of Western Ontario, London, OntarioMD06/1994Medicine
    University of Toronto, Toronto, OntarioResidency (FRCS)06/2003Neurosurgery
    University of Toronto, Toronto, OntarioPhD06/2002Molecular Genetics of Paediatric Brain Tumours
    St Jude Children’s Research Hospital, Memphis, TennesseePost Doc06/2004Cancer Genomics
    University of Toronto, Toronto, OntarioPost Doc07/2005Functional Genomics
    Collapse awards and honors
    2025Elected Corresponding Member , Brazilian Academy of Sciences
    2025Medal of Honor, Spanish Society of Pediatric Neurosurgery (SENEP)
    2024Viking Lecturer Award, Annual Scandinavian Course in Neurosurgery
    202149th Fondation ARC Leopold Griffuel Award , ARC Fondation
    2021AACR Team Science Award , AACR
    2019Fellow and Member, Royal Society of Canada
    2019H. Richard Winn, MD Prize, The Society of Neurological Surgeons
    2019Distinguished Oliver Smithies Lecture, McLaughlin Centre, University of Toronto
    2019Adam Balinsky Lecturer , Hospital for Sick Children, Toronto, Canada
    2019Sutow Award and Lectureship in Pediatric Oncology, M.D. Anderson Cancer Center
    2018Mr. Otto Lien Da Wong Visiting Professor in Neuro-oncology, Department of Surgery, The Chinese University of Hong Kong
    201717th Annual Invited Rosomoff Visiting Professor in Neurosurgery, University of Miami
    2016Lister Prize in Surgery, University of Toronto
    2016Voynick Award in Neuro-Oncology, Yale University
    2016Guha Award in Neuro-Oncology, Society for Neuro-Oncology
    2016Zulch Prize in Basic Neuroscience , Max Planck Society
    2015William E. Rawls Prize , Canadian Cancer Society
    2011George-Armstrong Peters Prize in Surgery, University of Toronto
    2010Gold Medal Award in Surgery, Royal College of Physicians and Surgeons of Canada

    Collapse Overview 
    Collapse overview
    I am a practicing pediatric neurosurgeon/clinician scientist, whose research uses tools from human genetics/genomics and mouse models to further our understanding of the biology of pediatric brain tumors, particularly medulloblastoma and ependymoma. As someone who is comfortable in both the clinic and at the bench, I have a great deal to offer in the development of translational research for brain tumors. I have discovered key genetic events that appear to drive the pathogenesis of medulloblastoma. My laboratory has recently developed functional genomic mouse models of medulloblastoma to facilitate the interpretation of our genomic studies of human medulloblastoma. I am the creator and principal investigator of the Medulloblastoma Advanced Genomics International Consortium (MAGIC), which now has >2200 frozen medulloblastoma samples from >90 high quality pediatric neuro-oncology centers from around the world. My clinical expertise, research experience, and current environment uniquely position me to further advance our knowledge of medulloblastoma and ependymoma biology. My current research is heavily focused on understanding brain tumor metastases and includes investigations that monitor circulating tumor cells over time, as well as studies to evaluate the impact of current therapies and the inflammatory response on the metastatic process. My overarching goal is to drive novel adjuvant therapies into the clinic to effectively treat patients suffering from these devastating malignancies.
    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Richman CM, Rasnitsyn A, Holgado BL, Vladoiu M, Abeysundara N, Majo S, Chabi S, Taunay LJ, Suzuki H, Shibahara I, Haapasalo J, Pallotta JG, Douglas T, Kharas K, Juraschka K, Ocsenas O, Kumar SA, Nordfors K, Guerreiro Stücklin A, Suarez RA, Zhang J, Wu X, Daniels C, Garzia L, Reimand J, Saulnier O, Merchant TE, Pouponnot C, Raleigh DR, Taylor MD, De Antonellis P, Guerreiro St?cklin A, Reimand J, Richman CM, Rasnitsyn A, Holgado BL, Vladoiu M, Abeysundara N, Majo S, Chabi S, Taunay LJ, Suzuki H, Shibahara I, Haapasalo J, Pallotta JG, Douglas T, Kharas K, Juraschka K, Ocsenas O, Kumar SA, Nordfors K, Guerreiro St?cklin A, Suarez RA, Zhang J, Wu X, Daniels C, Garzia L, Reimand J, Saulnier O, Merchant TE, Pouponnot C, Raleigh DR, Taylor MD, De Antonellis P. Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiotherapy. Cancer Res. 2025 Oct 01; 85(19):3737-3751. PMID: 40712054; PMCID: PMC12442109.
      Citations:    Fields:    Translation:HumansAnimals
    2. Hoang TT, Schraw JM, Shumate C, Desrosiers TA, Nembhard WN, Yazdy M, Nestoridi E, Janitz AE, Kirby RS, Salemi JL, Tanner JP, Chambers TM, Taylor MD, Huff CD, Plon SE, Lupo PJ, Scheurer ME, Hoang TT, Schraw JM, Kirby RS, Salemi JL, Tanner JP, Chambers TM, Taylor MD, Huff CD, Plon SE, Lupo PJ, Scheurer ME. Co-occurrence of congenital anomalies and childhood brain tumors in 22 million live births. Neuro Oncol. 2025 Sep 08; 27(7):1910-1922. PMID: 40138258; PMCID: PMC12417818.
      Citations:    Fields:    Translation:Humans
    3. Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR. Retraction Note: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2025 Aug; 644(8075):290. PMID: 40634621.
      Citations:    Fields:    
    4. Li J, Liu H, Wang Z, Zhang J, Chen X, Daniels C, Wu X, Saulnier O, Suzuki H, De Antonellis P, Rasnitsyn A, Ong W, Wang EY, Hendrikse LD, Su Y, Tian Y, Han D, Wang R, Mo J, Liu F, Deng K, Wang D, Feng Z, Jiang Y, Li Y, Ma Y, Liu Z, Li M, Tian P, Shi Y, Jiang Y, Yang T, Li S, Liang J, Wu J, Wang Y, Zou W, Jiang Y, Wang L, Chen F, Jin X, Li S, Qiu X, Li C, Gao Y, Tang Y, Taylor MD, Jiang T, Li J, Liu H, Wang Z, Zhang J, Chen X, Daniels C, Wu X, Saulnier O, Suzuki H, De Antonellis P, Rasnitsyn A, Ong W, Wang EY, Hendrikse LD, Su Y, Tian Y, Han D, Mo J, Liu F, Deng K, Wang D, Feng Z, Jiang Y, Li Y, Ma Y, Liu Z, Li M, Tian P, Shi Y, Jiang Y, Yang T, Li S, Liang J, Wu J, Wang Y, Zou W, Jiang Y, Wang L, Chen F, Jin X, Qiu X, Li C, Gao Y, Tang Y, Taylor MD, Jiang T. Unveiling spatial heterogeneity in medulloblastoma: A multi-omics analysis of cellular state and geographical organization. Neuro Oncol. 2025 Jul 30; 27(6):1611-1627. PMID: 39957311.
      Citations: 1     Fields:    Translation:HumansCells
    5. Masihi MB, Chambers KR, Friedman RA, Pampou S, Gudenas BL, Torrejon J, Lee C, Furnari G, Chau LQ, Gc S, Lin Y, Chapman OS, Skowron P, Garzia L, Taylor MD, Chavez L, Ayrault O, Northcott PA, Karan C, Wechsler-Reya RJ. Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma. bioRxiv. 2025 Jul 21. PMID: 40777316; PMCID: PMC12330759.
      Citations:    
    6. Nör C, Kharas K, Rasnitsyn A, Vladoiu MC, Cho NW, Young JS, Nör F, Mankahla N, Haapasalo J, Nordfors K, Rapic S, Skowron P, Suárez RA, Bahcheli AT, Ocsenas O, Chen X, Bahrampour S, Momin A, Sundaresan L, Ong W, Hendrikse LD, Abeysundara N, Juraschka K, Ly M, Pallota JG, Douglas T, Huang N, Wang H, Mak E, Qin L, Liu J, Shen L, Luu B, Manno A, Kumar SA, Donovan LK, Fong V, Richman C, Daniels C, Garzia L, Rich JN, Hawkins C, Wu X, DaCosta R, Reimand J, Huang X, Ramaswamy V, Raleigh DR, Taylor MD, N?r C, N?r F, Su?rez RA, Reimand J. Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. Dev Cell. 2025 Nov 03; 60(21):2880-2896.e7. PMID: 40609543.
      Citations: 2     Fields:    Translation:HumansAnimals
    7. Santhana Kumar K, Neve A, Guerreiro Stücklin AS, Kuzan-Fischer CM, Rushing EJ, Taylor MD, Tripolitsioti D, Behrmann L, Kirschenbaum D, Grotzer MA, Baumgartner M, Guerreiro St?cklin AS. TGF-? Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma. Cell Rep. 2025 Jul 22; 44(7):115996. PMID: 40722255.
      Citations:    Fields:    
    8. Jassim A, Nimmervoll BV, Terranova S, Nathan E, Hu L, Taylor JT, Masih KE, Ruff L, Duarte M, Cooper E, Katyal G, Akhbari M, Gilbertson RJ, Coleman JC, Toker JS, Terhune C, Balmus G, Jackson SP, Liu H, Jiang T, Taylor MD, Hua K, Abraham JE, Filbin MG, Hill A, Patrizi A, Dani N, Regev A, Lehtinen MK, Gilbertson RJ. Gene context drift identifies drug targets to mitigate cancer treatment resistance. Cancer Cell. 2025 Sep 08; 43(9):1608-1621.e9. PMID: 40578362.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Abeysundara N, Rasnitsyn A, Fong V, Bahcheli A, Van Ommeren R, Juraschka K, Vladoiu M, Ong W, Livingston B, de Antonellis P, Ly M, Holgado BL, Sirbu O, Bahrampour S, Min HK, Fan J, Nor C, Visvanathan A, Zhang J, Wang H, Qin L, Huang N, Pallotta J, Douglas T, Mak E, Su H, Ng K, Zhang KY, Daniels C, Lucas CG, Eberhart CG, Liu H, Jiang T, Notta F, Ramaswamy V, Reimand J, Gallo M, Rich JN, Wu X, Huang X, Taylor MD, Holgado BL, Reimand J. Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth. Nat Cell Biol. 2025 May; 27(5):863-874. PMID: 40263572; PMCID: PMC12081294.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    10. Fan JJ, Erickson AW, Carrillo-Garcia J, Wang X, Skowron P, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Suárez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadiñanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD, Huang X, Su?rez RA, Cadi?anos J. A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance. Dev Cell. 2025 Jun 09; 60(11):1532-1549.e7. PMID: 39862856.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Wang S, Curry RN, McDonald MF, Koh HY, Erickson AW, Kleinman CL, Taylor MD, Rao G, Deneen B, Harmanci AO, Serin Harmanci A. Inferred developmental origins of brain tumors from single-cell RNA-sequencing data. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf016. PMID: 40321621; PMCID: PMC12046312.
      Citations:    
    12. Freire NH, Herlinger AL, Vanini J, Dalmolin M, Fernandes MAC, Nör C, Ramaswamy V, de Farias CB, Brunetto AT, Brunetto AL, Gregianin LJ, Jaeger MDC, Taylor MD, Roesler R, Freire NH, N?r C, Brunetto AT, Gregianin LJ. Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres. Cells. 2025 01 07; 14(2). PMID: 39851500; PMCID: PMC11763699.
      Citations: 3     Fields:    Translation:HumansCells
    13. Lee JJY, Tao R, You Z, Haldipur P, Erickson AW, Farooq H, Hendriske LD, Abeysundara N, Richman CM, Wang EY, Das Gupta N, Hadley J, Batts M, Mount CW, Wu X, Rasnitsyn A, Bailey S, Cavalli FMG, Morrissy S, Garzia L, Michealraj KA, Visvanathan A, Fong V, Palotta J, Suarez R, Livingston BG, Liu M, Luu B, Daniels C, Loukides J, Bendel A, French PJ, Kros JM, Korshunov A, Kool M, Chico Ponce de Le?n F, Perezpe?a-Diazconti M, Lach B, Singh SK, Leary SES, Cho BK, Kim SK, Wang KC, Lee JY, Tominaga T, Weiss WA, Phillips JJ, Dai S, Zadeh G, Saad AG, Bogn?r L, Klekner A, Pollack IF, Hamilton RL, Ra YS, Grajkowska WA, Perek-Polnik M, Thompson RC, Kenney AM, Cooper MK, Mack SC, Jabado N, Lupien M, Gallo M, Ramaswamy V, Suva ML, Suzuki H, Millen KJ, Huang LF, Northcott PA, Taylor MD. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip. Nat Genet. 2025 Jan; 57(1):88-102. PMID: 39753768; PMCID: PMC11735403.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Purzner J, Brown AS, Purzner T, Ellis L, Broski S, Litzenburger U, Andrews K, Sharma A, Wang X, Taylor MD, Cho YJ, Fuller MT, Scott MP. Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma. bioRxiv. 2024 Nov 25. PMID: 39605517; PMCID: PMC11601632.
      Citations:    
    15. Lee JJY, Johnston MJ, Farooq H, Chen HM, Younes ST, Suarez R, Zwaig M, Juretic N, Weiss WA, Ragoussis J, Jabado N, Taylor MD, Gallo M. 3D genome topology distinguishes molecular subgroups of medulloblastoma. Am J Hum Genet. 2024 Dec 05; 111(12):2720-2734. PMID: 39481374; PMCID: PMC11639096.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY. A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 08 19; 59(16):2171-2188.e7. PMID: 39106860; PMCID: PMC12374751.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE, Coudi?re-Morrison L, Richard S. A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 08; 26(8):1233-1246. PMID: 39025928; PMCID: PMC11321995.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    18. Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M, Ellezam B, Weil A. TULIPs decorate the three-dimensional genome of PFA ependymoma. Cell. 2024 Sep 05; 187(18):4926-4945.e22. PMID: 38986619.
      Citations: 7     Fields:    Translation:Humans
    19. Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse LD, Patil V, Bashardanesh Z, Golser J, Livingston BG, Nakashima T, Funakoshi Y, Ong W, Rasnitsyn A, Aldinger KA, Richman CM, Van Ommeren R, Lee JJY, Ly M, Vladoiu MC, Kharas K, Balin P, Erickson AW, Fong V, Zhang J, Su?rez RA, Wang H, Huang N, Pallota JG, Douglas T, Haapasalo J, Razavi F, Silvestri E, Sirbu O, Worme S, Kameda-Smith MM, Wu X, Daniels C, MichaelRaj AK, Bhaduri A, Schramek D, Suzuki H, Garzia L, Ahmed N, Kleinman CL, Stein LD, Dirks P, Dunham C, Jabado N, Rich JN, Li W, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD. Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma. Cell. 2024 Aug 22; 187(17):4733-4750.e26. PMID: 38971152; PMCID: PMC11707800.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Cui H, Maan H, Vladoiu MC, Zhang J, Taylor MD, Wang B. DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics. Genome Biol. 2024 01 19; 25(1):27. PMID: 38243313; PMCID: PMC10799431.
      Citations: 26     Fields:    
    21. Zhao L, Qiu Z, Yang Z, Xu L, Pearce TM, Wu Q, Yang K, Li F, Saulnier O, Fei F, Yu H, Gimple RC, Varadharajan V, Liu J, Hendrikse LD, Fong V, Wang W, Zhang J, Lv D, Lee D, Lehrich BM, Jin C, Ouyang L, Dixit D, Wu H, Wang X, Sloan AE, Wang X, Huan T, Mark Brown J, Goldman SA, Taylor MD, Zhou S, Rich JN. Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nat Cancer. 2024 Jan; 5(1):147-166. PMID: 38172338.
      Citations: 19     Fields:    Translation:HumansCells
    22. Zwaig M, Johnston MJ, Lee JJY, Farooq H, Gallo M, Jabado N, Taylor MD, Ragoussis J. Linked-read based analysis of the medulloblastoma genome. Front Oncol. 2023; 13:1221611. PMID: 37576901; PMCID: PMC10419201.
      Citations: 4     
    23. Zwaig M, Baguette A, Hu B, Johnston M, Lakkis H, Nakada EM, Faury D, Juretic N, Karamchandani J, Majewski J, Taylor MD, Gallo M, Kleinman CL, Jabado N, Ragoussis J, Ellezam B, Weil AG, Blanchette M. Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data. BMC Cancer. 2022 Dec 12; 22(1):1297. PMID: 36503484; PMCID: PMC9743522.
      Citations: 6     Fields:    Translation:Humans
    24. Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Shokouhian M, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia JJ, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang EY, Kumar SA, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Wang YC, Pfister SM, Kim SK, Delattre O, Bourdeaut F, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks P, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Hauser P, Phillips JJ, Ra YS, Li KKW, Ng HK, Poon WS, Pollack IF, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Iolascon A, Ferrucci V, de Antonellis P, Zollo M, Cinalli G, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, Chico F, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Golden JA, Ellison DW, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE, Suzuki H, Millen KJ, Taylor MD, Coudi?re-Morrison L, Mercier AL, Su?rez RA, B?rub? P, Doz F, F?vre-Montange M, Jouvet A, Garami M, de Torres C, Mora J, L?pez-Aguilar E, Carlotti CG, Razavi F, Egu?a P, P?rezpe?a M, Reimand J, Ayrault O. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028. PMID: 36131014; PMCID: PMC10026724.
      Citations: 76     Fields:    Translation:Humans
    25. Hamed AA, Kunz DJ, El-Hamamy I, Trinh QM, Subedar OD, Richards LM, Foltz W, Bullivant G, Ware M, Vladoiu MC, Zhang J, Raj AM, Pugh TJ, Taylor MD, Teichmann SA, Stein LD, Simons BD, Dirks PB. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nat Commun. 2022 07 19; 13(1):4178. PMID: 35853870; PMCID: PMC9296666.
      Citations: 19     Fields:    Translation:HumansAnimals
    26. Skowron P, Farooq H, Cavalli FMG, Morrissy AS, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Dai S, Stucklin ASG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-Rabbo D, Wang YC, Luu B, Suarez RA, Rastan A, Gillmor AH, Lee JJY, Zhang XY, Daniels C, Dirks P, Malkin D, Bouffet E, Tabori U, Loukides J, Bourdeaut F, Delattre OO, Masliah-Planchon J, Kim SK, Meyronet D, Grajkowska WA, Eberhart CG, Van Meir EG, Kumabe T, French PJ, Kros JM, Jabado N, Lach B, Pollack IF, Hamilton RL, Rao AAN, Giannini C, Olson JM, Klekner A, Zitterbart K, Phillips JJ, Thompson RC, Cooper MK, Rubin JB, Liau LM, Hauser P, Li KKW, Ng HK, Poon WS, Yancey Gillespie G, Chan JA, Jung S, McLendon RE, Thompson EM, Zagzag D, Vibhakar R, Ra YS, Garre ML, Shofuda T, Faria CC, Zadeh G, Hui CC, Ramaswamy V, Bailey SD, Jones SJ, Mungall AJ, Moore RA, Calarco JA, Stein LD, Bader GD, Ragoussis J, Weiss WA, Marra MA, Suzuki H, Taylor MD, B?rub? P, Doz FP, Ayrault O, Carlotti CG, de Torres C, Mora J, Bogn?r L, Garami M, Sch?ller U, L?pez-Aguilar E, Reimand J. The transcriptional landscape of Shh medulloblastoma. Nat Commun. 2021 03 19; 12(1):1749. PMID: 33741928; PMCID: PMC7979819.
      Citations: 49     Fields:    Translation:HumansCells
    27. Guilhamon P, Chesnelong C, Kushida MM, Nikolic A, Singhal D, MacLeod G, Madani Tonekaboni SA, Cavalli FM, Arlidge C, Rajakulendran N, Rastegar N, Hao X, Hassam R, Smith LJ, Whetstone H, Coutinho FJ, Nadorp B, Ellestad KI, Luchman HA, Chan JA, Shoichet MS, Taylor MD, Haibe-Kains B, Weiss S, Angers S, Gallo M, Dirks PB, Lupien M. Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival. Elife. 2021 01 11; 10. PMID: 33427645; PMCID: PMC7847307.
      Citations: 55     Fields:    Translation:HumansCells
    28. Quon JL, Bala W, Chen LC, Wright J, Kim LH, Han M, Shpanskaya K, Lee EH, Tong E, Iv M, Seekins J, Lungren MP, Braun KRM, Poussaint TY, Laughlin S, Taylor MD, Lober RM, Vogel H, Fisher PG, Grant GA, Ramaswamy V, Vitanza NA, Ho CY, Edwards MSB, Cheshier SH, Yeom KW. Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study. AJNR Am J Neuroradiol. 2020 09; 41(9):1718-1725. PMID: 32816765; PMCID: PMC7583118.
      Citations: 40     Fields:    Translation:Humans
    29. Zagozewski J, Shahriary GM, Saulnier O, Stromecki M, Fresnoza A, Palidwor G, Porter CJ, Forget A, Ayrault O, Hawkins C, Chan JA, Vladoiu MC, Sundaresan L, Arsenio J, Taylor MD, Ramaswamy V, Werbowetski-Ogilvie TE, Morrison LC. An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate. Nat Commun. 2020 07 20; 11(1):3627. PMID: 32686664; PMCID: PMC7371715.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    30. Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD, Deblois G, Kanshin E, S?nchez-Osuna M, Tyers M. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. 2020 06 11; 181(6):1329-1345.e24. PMID: 32445698; PMCID: PMC10782558.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    31. Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Finch E, Finlay JL, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Rutka J, Sabel M, Salgado D, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U, Cruz O, Faure Conter C, Frappaz D, Lassaletta A, Morales La Madrid A, Quiroga-Cantero E, Solano P. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4. PMID: 32923898; PMCID: PMC7446502.
      Citations: 79     Fields:    
    32. Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD. Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nat Med. 2020 05; 26(5):720-731. PMID: 32341580; PMCID: PMC8815773.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    33. Ocasio JK, Babcock B, Malawsky D, Weir SJ, Loo L, Simon JM, Zylka MJ, Hwang D, Dismuke T, Sokolsky M, Rosen EP, Vibhakar R, Zhang J, Saulnier O, Vladoiu M, El-Hamamy I, Stein LD, Taylor MD, Smith KS, Northcott PA, Colaneri A, Wilhelmsen K, Gershon TR. scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy. Nat Commun. 2019 12 20; 10(1):5829. PMID: 31863004; PMCID: PMC6925218.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    34. Suzuki H, Kumar SA, Shuai S, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Calarco JA, Stein L, Taylor MD, Diaz-Navarro A, Gutierrez-Fernandez A, Jouvet A, F?vre-Montange M, Garr? ML, L?pez-Aguilar E, Bogn?r L, Puente XS. Recurrent noncoding U1?snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711. PMID: 31664194; PMCID: PMC7141958.
      Citations: 107     Fields:    Translation:HumansCells
    35. Zhang L, He X, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Roussel MF, Weiss WA, Lu QR, Remke M. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019 09 16; 36(3):302-318.e7. PMID: 31474569; PMCID: PMC6760242.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    36. Johnston MJ, Nikolic A, Ninkovic N, Guilhamon P, Cavalli FMG, Seaman S, Zemp FJ, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida MM, Coutinho FJ, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Dirks PB, Pugh TJ, Morrissy S, St Croix B, Mahoney DJ, Lupien M, Gallo M. High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma. Genome Res. 2019 08; 29(8):1211-1222. PMID: 31249064; PMCID: PMC6673710.
      Citations:    
    37. Lian H, Daniels C, Han YP, Li QF, Zhao Y, Wang BC, Zhu CB, Mao WW, Taylor MD, Ma J. Incidence of metastatic disease and survival among patients with newly diagnosed primary CNS tumors in the United States from 2004-2013. J Cancer. 2019; 10(13):3037-3045. PMID: 31281481; PMCID: PMC6590036.
      Citations:    
    38. Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019 08; 572(7767):67-73. PMID: 31043743; PMCID: PMC6675628.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    39. Hoffman M, Gillmor AH, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King J, Ellestad K, Dang NH, Cavalli FMG, Kushida MM, Coutinho FJ, Zhu Y, Luu B, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Pugh TJ, Dirks PB, Strother D, Lafay-Cousin L, Resnick AC, Scherer S, Senger DL, Simons BD, Chan JA, Morrissy AS, Gallo M. Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma. Cancer Res. 2019 05 01; 79(9):2111-2123. PMID: 30877103; PMCID: PMC7282886.
      Citations:    
    40. Lee DD, Komosa M, Gallo M, Zhang CH, Lipman T, Heidari A, Nunes NM, Price AJ, De Mello RA, Huntsman D, Vanner R, Zadeh G, Karamchandani J, Das S, Taylor MD, Hawkins CE, Wasserman JD, Figueiredo A, Hamilton RJ, Minden MD, Wani K, Diplas B, Yan H, Aldape K, Akbari MR, Danesh A, Pugh TJ, Dirks PB, Castelo-Branco P, Tabori U, Le?o R, Remke M, Apol?nio JD, Dias JS, Hermanns T, Wild PJ. DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. J Clin Invest. 2019 01 02; 129(1):223-229. PMID: 30358567; PMCID: PMC6307937.
      Citations:    
    41. Liang L, Tatari N, Stromecki M, Fresnoza A, Porter CJ, Del Bigio MR, Hawkins C, Chan JA, Ryken TC, Taylor MD, Ramaswamy V, Werbowetski-Ogilvie TE, Coudi?re-Morrison L. CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma. Cancer Res. 2018 08 15; 78(16):4745-4759. PMID: 29930101.
      Citations:    
    42. Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M, Ferrucci V, de Antonellis P, Pennino FP, Virgilio A, Galeone A, Navas L, Carotenuto M, D'Argenio V, Mastronuzzi A, Giangaspero F, Picard D, Remke M, Delattre O, Salvatore F, Zollo M. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-?-OTX2-SNAIL via PTEN inhibition. Brain. 2018 05 01; 141(5):1300-1319. PMID: 29490009.
      Citations:    
    43. Stromecki M, Tatari N, Kaur R, Zagozewski J, Palidwor G, Ramaswamy V, Skowron P, Milde T, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE, Morrison LC, W?lfl M. Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma. Mol Oncol. 2018 04; 12(4):495-513. PMID: 29377567; PMCID: PMC5891039.
      Citations:    
    44. Wang X, Holgado BL, Ramaswamy V, Mack S, Zayne K, Wu X, Garzia L, Daniels C, Kenney AM, Taylor MD, Remke M. miR miR on the wall, who's the most malignant medulloblastoma miR of them all? Neuro Oncol. 2018 02 19; 20(3):313-323. PMID: 28575493; PMCID: PMC5817951.
      Citations: 10     Fields:    Translation:Humans
    45. Guerreiro Stucklin AS, Ramaswamy V, Daniels C, Taylor MD. Review of molecular classification and treatment implications of pediatric brain tumors. Curr Opin Pediatr. 2018 02; 30(1):3-9. PMID: 29315108.
      Citations:    
    46. Mack SC, Taylor MD. Put away your microscopes: the ependymoma molecular era has begun. Curr Opin Oncol. 2017 Nov; 29(6):443-447. PMID: 28885433; PMCID: PMC6003664.
      Citations: 11     Fields:    Translation:HumansAnimals
    47. Lan X, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, Luu B, Carles A, Moksa M, Rastegar N, Head R, Dolma S, Prinos P, Cusimano MD, Das S, Bernstein M, Arrowsmith CH, Mungall AJ, Moore RA, Ma Y, Gallo M, Lupien M, Pugh TJ, Taylor MD, Hirst M, Eaves CJ, Simons BD, Dirks PB, J?rg DJ. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. 2017 09 14; 549(7671):227-232. PMID: 28854171; PMCID: PMC5608080.
      Citations:    
    48. Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska WA, Perek-Polnik M, Vasiljevic A, Faure-Conter C, Jouvet A, Giannini C, Nageswara Rao AA, Li KKW, Ng HK, Eberhart CG, Pollack IF, Hamilton RL, Gillespie GY, Olson JM, Leary S, Weiss WA, Lach B, Chambless LB, Thompson RC, Cooper MK, Vibhakar R, Hauser P, van Veelen MC, Kros JM, French PJ, Ra YS, Kumabe T, López-Aguilar E, Zitterbart K, Sterba J, Finocchiaro G, Massimino M, Van Meir EG, Osuka S, Shofuda T, Klekner A, Zollo M, Leonard JR, Rubin JB, Jabado N, Albrecht S, Mora J, Van Meter TE, Jung S, Moore AS, Hallahan AR, Chan JA, Tirapelli DPC, Carlotti CG, Fouladi M, Pimentel J, Faria CC, Saad AG, Massimi L, Liau LM, Wheeler H, Nakamura H, Elbabaa SK, Perezpeña-Diazconti M, Chico Ponce de León F, Robinson S, Zapotocky M, Lassaletta A, Huang A, Hawkins CE, Tabori U, Bouffet E, Bartels U, Dirks PB, Rutka JT, Bader GD, Reimand J, Goldenberg A, Ramaswamy V, Taylor MD, Remke M, Jouvet A, L?pez-Aguilar E, Mora J, Tirapelli DPC, Carlotti CG, Pimentel J, Perezpe?a-Diazconti M, Chico Ponce de Le?n F, Reimand J. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2017 06 12; 31(6):737-754.e6. PMID: 28609654; PMCID: PMC6163053.
      Citations:    
    49. Holgado BL, Guerreiro Stucklin A, Garzia L, Daniels C, Taylor MD. Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a Time. Annu Rev Genomics Hum Genet. 2017 08 31; 18:143-166. PMID: 28475368.
      Citations:    
    50. Morrissy AS, Cavalli FMG, Remke M, Ramaswamy V, Shih DJH, Holgado BL, Farooq H, Donovan LK, Garzia L, Agnihotri S, Kiehna EN, Mercier E, Mayoh C, Papillon-Cavanagh S, Nikbakht H, Gayden T, Torchia J, Merino DM, Vladoiu M, Luu B, Wu X, Daniels C, Horswell S, Thompson YY, Hovestadt V, Northcott PA, Jones DTW, Peacock J, Wang X, Mack SC, Albrecht S, Fontebasso AM, Thiessen N, Li Y, Schein JE, Lee D, Carlsen R, Mayo M, Tse K, Tam A, Dhalla N, Ally A, Chuah E, Cheng Y, Plettner P, Li HI, Corbett RD, Wong T, Long W, Loukides J, Buczkowicz P, Hawkins CE, Tabori U, Rood BR, Myseros JS, Packer RJ, Korshunov A, Lichter P, Kool M, Pfister SM, Dirks P, Huang A, Bouffet E, Rutka JT, Bader GD, Swanton C, Ma Y, Moore RA, Mungall AJ, Majewski J, Jones SJM, Das S, Malkin D, Jabado N, Marra MA, Taylor MD, Picard D, Reimand J, Sch?ller U. Spatial heterogeneity in medulloblastoma. Nat Genet. 2017 May; 49(5):780-788. PMID: 28394352; PMCID: PMC5553617.
      Citations: 58     Fields:    Translation:HumansCells
    51. Pajtler KW, Mack SC, Ramaswamy V, Smith CA, Witt H, Smith A, Hansford JR, von Hoff K, Wright KD, Hwang E, Kanemura Y, Massimino M, Modena P, Tabori U, Warren KE, Holland EC, Ichimura K, Giangaspero F, von Deimling A, Kool M, Dirks PB, Grundy RG, Foreman NK, Gajjar A, Korshunov A, Finlay J, Gilbertson RJ, Ellison DW, Aldape KD, Merchant TE, Bouffet E, Pfister SM, Taylor MD, Frappaz D, Faure-Conter C, Castel D. The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants. Acta Neuropathol. 2017 01; 133(1):5-12. PMID: 27858204; PMCID: PMC5209402.
      Citations: 110     Fields:    Translation:HumansAnimals
    52. Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH, Stearns DS, Massimi L, Sterba J, Zitterbart K, Ayrault O, Dunn SE, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD, Remke M, Pimentel J, Nunes S, Sch?ller U, Puget S, Tirapelli DP, Carlotti CG. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Jan 21; 529(7586):351-7. PMID: 26760213; PMCID: PMC4936195.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    53. Mack SC, Hubert CG, Miller TE, Taylor MD, Rich JN. An epigenetic gateway to brain tumor cell identity. Nat Neurosci. 2016 Jan; 19(1):10-9. PMID: 26713744; PMCID: PMC5568053.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    54. Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, Sturm D, Kushida MM, Head R, Cusimano MD, Bernstein M, Clarke ID, Dick JE, Pfister SM, Rich JN, Arrowsmith CH, Taylor MD, Jabado N, Bazett-Jones DP, Lupien M, Dirks PB. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. Cancer Cell. 2015 Dec 14; 28(6):715-729. PMID: 26626085.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    55. Liang L, Aiken C, McClelland R, Morrison LC, Tatari N, Remke M, Ramaswamy V, Issaivanan M, Ryken T, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE, Morrison LC. Characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes. Oncotarget. 2015 Nov 17; 6(36):38881-900. PMID: 26497209; PMCID: PMC4770744.
      Citations:    
    56. Thompson YY, Ramaswamy V, Diamandis P, Daniels C, Taylor MD. Posterior fossa ependymoma: current insights. Childs Nerv Syst. 2015 Oct; 31(10):1699-706. PMID: 26351223.
      Citations:    
    57. Mack SC, Agnihotri S, Bertrand KC, Wang X, Shih DJ, Witt H, Hill N, Zayne K, Barszczyk M, Ramaswamy V, Remke M, Thompson Y, Ryzhova M, Massimi L, Grajkowska W, Lach B, Gupta N, Weiss WA, Guha A, Hawkins C, Croul S, Rutka JT, Pfister SM, Korshunov A, Pekmezci M, Tihan T, Philips JJ, Jabado N, Zadeh G, Taylor MD. Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype. Clin Cancer Res. 2015 Aug 15; 21(16):3750-8. PMID: 25957288; PMCID: PMC4537825.
      Citations: 17     Fields:    Translation:HumansCells
    58. Voisin V, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Clarke ID, Taylor MD, Dirks PB. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 2014 Jul 14; 26(1):33-47. PMID: 24954133; PMCID: PMC4441014.
      Citations:    
    59. Gerges N, Sin-Chan P, Quang DA, Fontebasso AM, Spence T, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes JL, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel PM, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor MD, Chan JA, Huang A, Jabado N, Kleinman CL, Papillon-Cavanagh S, Pramatarova A, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Schwartzentruber J, Staffa A, Montpetit A, Berube P, Sladek R, Pastinen T, Majewski J. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat Genet. 2014 Jan; 46(1):39-44. PMID: 24316981.
      Citations:    
    60. Doucette TA, Yang Y, Pedone C, Kim JY, Dubuc A, Northcott PD, Taylor MD, Fults DW, Rao G. WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma. Neurosurgery. 2012 Apr; 70(4):1003-10; discussion 1010. PMID: 22037313; PMCID: PMC3607499.
      Citations: 13     Fields:    Translation:AnimalsCells
    61. Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature. 2012 Feb 15; 482(7386):529-33. PMID: 22343890; PMCID: PMC3288636.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    62. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012 Apr; 123(4):465-72. PMID: 22134537; PMCID: PMC3306779.
      Citations: 728     Fields:    Translation:HumansCells
    63. Shamszad P, Slesnick TC, Smith EO, Taylor MD, Feig DI. Association between left ventricular mass index and cardiac function in pediatric dialysis patients. Pediatr Nephrol. 2012 May; 27(5):835-41. PMID: 22105968.
      Citations: 12     Fields:    Translation:Humans
    64. Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 2011 Aug 16; 20(2):143-57. PMID: 21840481; PMCID: PMC4154494.
      Citations: 203     Fields:    Translation:Humans
    65. Parsons DW, Li M, Zhang X, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE, Jones S. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9. PMID: 21163964; PMCID: PMC3110744.
      Citations: 402     Fields:    Translation:HumansCells
    66. International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, de Alava E, Ferguson ML, Geary P, Hayes DN, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, van de Vijver M, Futreal PA, Aburatani H, Botwell DD, Campbell PJ, Estivill X, Grimmond SM, Gut I, Hirst M, Majumder P, Marra M, McPherson JD, Ning Z, Puente XS, Ruan Y, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Flicek P, Getz G, Guo G, Haussler D, Heath S, Hubbard TJ, Jiang T, Jones SM, Li Q, Luo R, Muthuswamy L, Ouellette BF, Pearson JV, Quesada V, Raphael BJ, Sander C, Speed TP, Stein LD, Stuart JM, Teague JW, Totoki Y, Tsunoda T, Valencia A, Wheeler DA, Wu H, Zhao S, Zhou G, Lathrop M, Thomas G, Yoshida T, Axton M, Gunter C, Miller LJ, Zhang J, Haider SA, Wang J, Yung CK, Cros A, Cross A, Liang Y, Gnaneshan S, Guberman J, Hsu J, Chalmers DR, Hasel KW, Kaan TS, Lowrance WW, Masui T, Rodriguez LL, Vergely C, Bowtell DD, Cloonan N, deFazio A, Eshleman JR, Etemadmoghadam D, Gardiner BB, Gardiner BA, Kench JG, Sutherland RL, Tempero MA, Waddell NJ, Wilson PJ, Gallinger S, Tsao MS, Shaw PA, Petersen GM, Mukhopadhyay D, DePinho RA, Thayer S, Shazand K, Beck T, Sam M, Timms L, Ballin V, Lu Y, Ji J, Zhang X, Chen F, Hu X, Yang Q, Tian G, Zhang L, Xing X, Li X, Zhu Z, Yu Y, Yu J, Brennan P, Holcatova I, Zaridze D, Brazma A, Egevard L, Prokhortchouk E, Banks RE, Viksna J, Ponten F, Skryabin K, Birney E, Borg A, Caldas C, Foekens JA, Martin S, Reis-Filho JS, Richardson AL, Sotiriou C, Thoms G, van't Veer L, Birnbaum D, Boucher P, Boyault S, Masson-Jacquemier JD, Pivot X, Vincent-Salomon A, Tabone E, Theillet C, Treilleux I, Bioulac-Sage P, Decaens T, Franco D, Gut M, Samuel D, Zucman-Rossi J, Eils R, Brors B, Korbel JO, Korshunov A, Landgraf P, Lehrach H, Pfister S, Radlwimmer B, Reifenberger G, Taylor MD, von Kalle C, Majumder PP, Pederzoli P, Lawlor RA, Delledonne M, Bardelli A, Gress T, Klimstra D, Zamboni G, Nakamura Y, Miyano S, Fujimoto A, Campo E, Montserrat E, Jares P, Himmelbauer H, Himmelbaue H, Bea S, Aparicio S, Easton DF, Collins FS, Compton CC, Lander ES, Burke W, Green AR, Hamilton SR, Kallioniemi OP, Ley TJ, Liu ET, Wainwright BJ, Bernab? RR, Nicol?s P, Cl?ment B, Degos F, Bay?s M, L?pez-Ot?n C, Guig? R, L?pez-Bigas N, Tost J, Uhl?n M, B?rresen-Dale AL, Blanche H, Pauport? I, de Sanjos? S, Gonz?lez-D?az M. International network of cancer genome projects. Nature. 2010 Apr 15; 464(7291):993-8. PMID: 20393554; PMCID: PMC2902243.
      Citations: 1005     Fields:    Translation:HumansCells
    67. Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J, Macdonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell. 2005 Oct; 8(4):323-35. PMID: 16226707.
      Citations: 351     Fields:    Translation:HumansAnimalsCells
    TAYLOR's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (286)
    Explore
    _
    Co-Authors (26)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _