LIYA HU

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hu L, Salmen W, Sankaran B, Lasanajak Y, Smith DF, Crawford SE, Estes MK, Prasad BVV. Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Commun Biol. 2022 05 05; 5(1):419. PMID: 35513489.
      Citations:    Translation:HumansCells
    2. Choi KJ, Quan MD, Qi C, Lee JH, Tsoi PS, Zahabiyon M, Bajic A, Hu L, Prasad BVV, Liao SJ, Li W, Ferreon ACM, Ferreon JC. NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency. Nat Cell Biol. 2022 05; 24(5):737-747. PMID: 35484250.
      Citations:    Fields:    Translation:HumansCells
    3. Hu L, Salmen W, Chen R, Zhou Y, Neill F, Crowe JE, Atmar RL, Estes MK, Prasad BVV. Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity. Nat Commun. 2022 03 10; 13(1):1241. PMID: 35273142.
      Citations: 1     Fields:    Translation:HumansCells
    4. Taylor DM, Anglin J, Hu L, Wang L, Sankaran B, Wang J, Matzuk MM, Prasad BVV, Palzkill T. Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. ACS Infect Dis. 2021 12 10; 7(12):3345-3354. PMID: 34817169.
      Citations: 1     Fields:    Translation:Cells
    5. Zhao B, Hu L, Song Y, Patil K, Ramani S, Atmar RL, Estes MK, Prasad BVV. Norovirus Protease Structure and Antivirals Development. Viruses. 2021 10 14; 13(10). PMID: 34696498.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Tenge VR, Hu L, Prasad BVV, Larson G, Atmar RL, Estes MK, Ramani S. Glycan Recognition in Human Norovirus Infections. Viruses. 2021 10 14; 13(10). PMID: 34696500.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Furey IM, Mehta SC, Sankaran B, Hu L, Prasad BVV, Palzkill T. Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ß-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799. PMID: 34022225.
      Citations: 4     Fields:    Translation:HumansCells
    8. Huang W, Soeung V, Boragine DM, Hu L, Prasad BVV, Estes MK, Atmar RL, Palzkill T. High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. J Virol. 2020 12 09; 95(1). PMID: 33055250.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Soeung V, Lu S, Hu L, Judge A, Sankaran B, Prasad BVV, Palzkill T. A drug-resistant ß-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255. PMID: 33109613.
      Citations: 3     Fields:    Translation:Cells
    10. Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 05; 581(7808):329-332. PMID: 32433610.
      Citations: 13     Fields:    Translation:HumansCells
    11. Brown CA, Hu L, Sun Z, Patel MP, Singh S, Porter JR, Sankaran B, Prasad BVV, Bowman GR, Palzkill T. Antagonism between substitutions in ß-lactamase explains a path not taken in the evolution of bacterial drug resistance. J Biol Chem. 2020 05 22; 295(21):7376-7390. PMID: 32299911.
      Citations: 7     Fields:    Translation:Cells
    12. Kumar D, Yu X, Crawford SE, Moreno R, Jakana J, Sankaran B, Anish R, Kaundal S, Hu L, Estes MK, Wang Z, Prasad BVV. 2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. Sci Adv. 2020 04; 6(16):eaay6410. PMID: 32494598.
      Citations: 1     Fields:    Translation:Cells
    13. Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS Infect Dis. 2020 05 08; 6(5):1214-1227. PMID: 32182432.
      Citations: 10     Fields:    Translation:Cells
    14. Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M. TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun. 2020 Jan 28; 11(1):547. PMID: 31992706.
      Citations: 6     Fields:    Translation:Cells
    15. Mitra S, Kumar D, Hu L, Sankaran B, Moosa MM, Rice AP, Ferreon JC, Ferreon ACM, Prasad BVV. Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity. J Virol. 2019 11 01; 93(21). PMID: 31375595.
      Citations: 7     Fields:    Translation:Cells
    16. Viskovska MA, Zhao B, Shanker S, Choi JM, Deng L, Song Y, Palzkill T, Hu L, Estes MK, Venkataram Prasad BV. GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site. J Virol. 2019 03 15; 93(6). PMID: 30626675.
      Citations: 6     Fields:    Translation:HumansCells
    17. Criglar JM, Anish R, Hu L, Crawford SE, Sankaran B, Prasad BVV, Estes MK. Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12015-E12023. PMID: 30509975.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    18. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, Shinge D, Rani S, Anandan S, Hu L, Ferreon JC, Kuruvilla KA, Petrosino JF, Venkataram Prasad BV, Bode L, Kang G, Estes MK. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nat Commun. 2018 11 27; 9(1):5010. PMID: 30479342.
      Citations: 59     Fields:    Translation:HumansCells
    19. Sun Z, Hu L, Sankaran B, Prasad BVV, Palzkill T. Differential active site requirements for NDM-1 ß-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics. Nat Commun. 2018 10 30; 9(1):4524. PMID: 30375382.
      Citations: 20     Fields:    Translation:Cells
    20. Patel MP, Hu L, Brown CA, Sun Z, Adamski CJ, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T. Synergistic effects of functionally distinct substitutions in ß-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984. PMID: 30275013.
      Citations: 8     Fields:    Translation:Cells
    21. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    22. Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M. Structure of an EIIC sugar transporter trapped in an inward-facing conformation. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):5962-5967. PMID: 29784777.
      Citations: 6     Fields:    Translation:Cells
    23. Shanker S, Hu L, Ramani S, Atmar RL, Estes MK, Venkataram Prasad BV. Structural features of glycan recognition among viral pathogens. Curr Opin Struct Biol. 2017 06; 44:211-218. PMID: 28591681.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Ramani S, Hu L, Venkataram Prasad BV, Estes MK. Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):263-273. PMID: 28090561.
      Citations: 33     Fields:    
    25. Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015 Sep 30; 6:8346. PMID: 26420502.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    26. Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T. A triple mutant in the O-loop of TEM-1 ß-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94. PMID: 25713062.
      Citations: 20     Fields:    Translation:Cells
    27. Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV. Probing the sites of interactions of rotaviral proteins involved in replication. J Virol. 2014 Nov; 88(21):12866-81. PMID: 25165107.
      Citations: 12     Fields:    Translation:Cells
    28. Venkataram Prasad BV, Shanker S, Hu L, Choi JM, Crawford SE, Ramani S, Czako R, Atmar RL, Estes MK. Structural basis of glycan interaction in gastroenteric viral pathogens. Curr Opin Virol. 2014 Aug; 7:119-27. PMID: 25073118.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    29. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    30. Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans. J Virol. 2013 Jul; 87(13):7255-64. PMID: 23616650.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    31. Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV. Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57. PMID: 22811529.
      Citations: 15     Fields:    Translation:Cells
    32. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    33. Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV. Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature. 2012 Apr 15; 485(7397):256-9. PMID: 22504179.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
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