TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Houston, TX 77030
ORCID ORCID Icon0000-0001-5793-4398 Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience

    Collapse Biography 
    Collapse awards and honors
    2014MNSS Career Transition Fellowship, National Multiple Sclerosis Society
    2016Petrello Endowed Scholar , NRI/TCH
    2021Young Investigator Award, BCM
    2021Research Mentor Award, BCM

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01NS126287     (LEE, HYUN KYOUNG)Jan 1, 2023 - Dec 31, 2028
    Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke
    Role: PI

    Research Grant     (LEE, HYUN KYOUNG)Jul 1, 2021 - Jun 30, 2024
    Does Brain Injury Provoke Gliomagenesis? Novel discovery and validation approach for stroke-brain cancer
    Role: PI

    Mark A. Wallace Endowment Award     (LEE, HYUN KYOUNG)Jul 1, 2021 - Jun 30, 2022
    Texas Children’s Hospital
    Deciphering Mechanisms of Perinatal White Matter Injury-Induced Neuropsychiatric Disease
    Role: PI

    Research Grant & Supplement     (LEE, HYUN KYOUNG)Apr 1, 2020 - Mar 21, 2024
    National Multiple Sclerosis Society
    Role: PI

    R01NS110859     (LEE, HYUN KYOUNG)Feb 1, 2019 - Jan 31, 2024
    Deciphering the Daam2-VHL signaling axis in oligodendrocyte development and white matter injury
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chung HL, Ye Q, Park YJ, Zuo Z, Mok JW, Kanca O, Tattikota SG, Lu S, Perrimon N, Lee HK, Bellen HJ. Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell Metab. 2023 05 02; 35(5):855-874.e5. PMID: 37084732; PMCID: PMC10160010.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Cristobal CD, Lee HK. Development of myelinating glia: An overview. Glia. 2022 12; 70(12):2237-2259. PMID: 35785432; PMCID: PMC9561084.
      Citations:    Fields:    
    3. Lai CSE, Leyva-Aranda V, Kong VH, Lopez-Silva TL, Farsheed AC, Cristobal CD, Swain JWR, Lee HK, Hartgerink JD. A Combined Conduit-Bioactive Hydrogel Approach for Regeneration of Transected Sciatic Nerves. ACS Appl Bio Mater. 2022 Apr 21. PMID: 35446025; PMCID: PMC11097895.
      Citations:    Fields:    
    4. Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X, Lee HK, Yoo JY, Yoo SH, Chen Z. ROR activation by Nobiletin enhances antitumor efficacy via suppression of I?B/NF-?B signaling in triple-negative breast cancer. Cell Death Dis. 2022 04 19; 13(4):374. PMID: 35440077; PMCID: PMC9018867.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Wirianto M, Wang CY, Kim E, Koike N, Gomez-Gutierrez R, Nohara K, Escobedo G, Choi JM, Han C, Yagita K, Jung SY, Soto C, Lee HK, Morales R, Yoo SH, Chen Z. The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model. FASEB J. 2022 03; 36(3):e22186. PMID: 35120261; PMCID: PMC8887996.
      Citations: 3     Fields:    Translation:Animals
    6. Cristobal CD, Wang CY, Zuo Z, Smith JA, Lindeke-Myers A, Bellen HJ, Lee HK. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. J Neurosci. 2022 03 02; 42(9):1679-1691. PMID: 35101966; PMCID: PMC8896627.
      Citations:    Fields:    Translation:AnimalsCells
    7. Jo J, Woo J, Cristobal CD, Choi JM, Wang CY, Ye Q, Smith JA, Ung K, Liu G, Cortes D, Jung SY, Arenkiel BR, Lee HK. Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function. EMBO Rep. 2021 12 06; 22(12):e53200. PMID: 34633730; PMCID: PMC8647146.
      Citations: 1     Fields:    Translation:Cells
    8. Cristobal CD, Ye Q, Jo J, Ding X, Wang CY, Cortes D, Chen Z, Lee HK. Daam2 couples translocation and clustering of Wnt receptor signalosomes through Rac1. J Cell Sci. 2021 01 25; 134(2). PMID: 33310913; PMCID: PMC7860116.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 01; 35(1):e21225. PMID: 33337568.
      Citations:    Fields:    Translation:AnimalsCells
    10. Lopez-Silva TL, Cristobal CD, Edwin Lai CS, Leyva-Aranda V, Lee HK, Hartgerink JD. Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury. Biomaterials. 2021 01; 265:120401. PMID: 33002786; PMCID: PMC7669633.
      Citations: 14     Fields:    Translation:HumansAnimals
    11. Wirianto M, Yang J, Kim E, Gao S, Paudel KR, Choi JM, Choe J, Gloston GF, Ademoji P, Parakramaweera R, Jin J, Esser KA, Jung SY, Geng YJ, Lee HK, Chen Z, Yoo SH. The GSK-3?-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Cell Rep. 2020 09 15; 32(11):108140. PMID: 32937135; PMCID: PMC8299398.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    12. Kim HK, Lee SY, Koike N, Kim E, Wirianto M, Burish MJ, Yagita K, Lee HK, Chen Z, Chung JM, Abdi S, Yoo SH. Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape. Sci Rep. 2020 08 14; 10(1):13844. PMID: 32796949; PMCID: PMC7427990.
      Citations: 7     Fields:    Translation:Animals
    13. Ding X, Jo J, Wang CY, Cristobal CD, Zuo Z, Ye Q, Wirianto M, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen HJ, Yoo SH, Lee HK. The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Genes Dev. 2020 09 01; 34(17-18):1177-1189. PMID: 32792353; PMCID: PMC7462057.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Members of Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Neuron. 2020 05 20; 106(4):589-606.e6. PMID: 32169171; PMCID: PMC7289150.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    15. Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 10 01; 129(10):4408-4418. PMID: 31498149; PMCID: PMC6763246.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    16. Liu G, Froudarakis E, Patel JM, Kochukov MY, Pekarek B, Hunt PJ, Patel M, Ung K, Fu CH, Jo J, Lee HK, Tolias AS, Arenkiel BR. Target specific functions of EPL interneurons in olfactory circuits. Nat Commun. 2019 07 29; 10(1):3369. PMID: 31358754; PMCID: PMC6662826.
      Citations: 6     Fields:    Translation:AnimalsCells
    17. Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL. Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. J Biol Chem. 2017 12 29; 292(52):21643-21652. PMID: 29127200; PMCID: PMC5766961.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 10 20; 6. PMID: 29053101; PMCID: PMC5650470.
      Citations: 10     Fields:    Translation:HumansCells
    19. Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Mohila CA, Deneen B, Clovis YM, Lee SK. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov; 20(11):1520-1528. PMID: 28892058; PMCID: PMC5919190.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219; PMCID: PMC5824716.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    21. Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917. PMID: 27881777; PMCID: PMC5125245.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct; 63(10):1840-9. PMID: 25946682; PMCID: PMC4534334.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18; 85(6):1227-43. PMID: 25754822; PMCID: PMC4402944.
      Citations: 40     Fields:    Translation:AnimalsCells
    24. Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12; 74(1):79-94. PMID: 22500632; PMCID: PMC3543821.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    25. Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17; 22(1):183-96. PMID: 22227309; PMCID: PMC3264735.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    26. Jung J, Cai W, Lee HK, Pellegatta M, Shin YK, Jang SY, Suh DJ, Wrabetz L, Feltri ML, Park HT. Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. J Neurosci. 2011 Feb 09; 31(6):2009-15. PMID: 21307239; PMCID: PMC3071261.
      Citations: 49     Fields:    Translation:AnimalsCells
    27. Shin YK, Jang SY, Lee HK, Jung J, Suh DJ, Seo SY, Park HT. Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy. Glia. 2010 Dec; 58(16):1961-76. PMID: 20830808.
      Citations: 25     Fields:    Translation:AnimalsCells
    28. Lee HK, Shin YK, Jung J, Seo SY, Baek SY, Park HT. Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo. Glia. 2009 Dec; 57(16):1825-34. PMID: 19455715.
      Citations: 27     Fields:    Translation:AnimalsCells
    29. Lee HK, Seo IA, Suh DJ, Park HT. Nidogen plays a role in the regenerative axon growth of adult sensory neurons through Schwann cells. J Korean Med Sci. 2009 Aug; 24(4):654-9. PMID: 19654948; PMCID: PMC2719197.
      Citations: 6     Fields:    Translation:AnimalsCells
    30. Lee HK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT. Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo. Korean J Physiol Pharmacol. 2009 Jun; 13(3):161-8. PMID: 19885032; PMCID: PMC2766727.
      Citations: 6     
    31. Wang L, Lee HK, Seo IA, Shin YK, Lee KY, Park HT. Cell type-specific STAT3 activation by gp130-related cytokines in the peripheral nerves. Neuroreport. 2009 May 06; 20(7):663-8. PMID: 19349921.
      Citations: 11     Fields:    Translation:AnimalsCells
    32. Seo IA, Lee HK, Shin YK, Lee SH, Seo SY, Park JW, Park HT. Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130. Korean J Physiol Pharmacol. 2009 Apr; 13(2):131-8. PMID: 19885008; PMCID: PMC2766696.
      Citations: 7     
    33. Lee HK, Seo IA, Shin YK, Park JW, Suh DJ, Park HT. Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem Biophys Res Commun. 2009 May 01; 382(2):445-50. PMID: 19285962.
      Citations: 8     Fields:    Translation:AnimalsCells
    34. Lee HK, Wang L, Shin YK, Lee KY, Suh DJ, Park HT. Interleukin-6 induces proinflammatory signaling in Schwann cells: a high-throughput analysis. Biochem Biophys Res Commun. 2009 May 01; 382(2):410-4. PMID: 19285039.
      Citations: 3     Fields:    Translation:AnimalsCells
    35. Lee HK, Seo IA, Suh DJ, Hong JI, Yoo YH, Park HT. Interleukin-6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration. J Neurochem. 2009 Feb; 108(3):776-86. PMID: 19187095.
      Citations: 23     Fields:    Translation:AnimalsCells
    36. Lee HK, Seo IA, Suh DJ, Lee HJ, Park HT. A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells. J Neurochem. 2009 Jan; 108(1):273-84. PMID: 19012752.
      Citations: 9     Fields:    Translation:AnimalsCells
    37. Lee HK, Seo IA, Lee SH, Seo SY, Kim KS, Park HT. Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling. Korean J Physiol Pharmacol. 2008 Oct; 12(5):281-6. PMID: 19967068; PMCID: PMC2788648.
      Citations: 3     
    38. Lee HK, Seo IA, Shin YK, Lee SH, Seo SY, Suh DJ, Park HT. Netrin-1 specifically enhances cell spreading on fibronectin in human glioblastoma cells. Korean J Physiol Pharmacol. 2008 Oct; 12(5):225-30. PMID: 19967060; PMCID: PMC2788640.
      Citations: 1     
    39. Lee HK, Seo IA, Seo E, Seo SY, Lee HJ, Park HT. Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. Biochem Biophys Res Commun. 2007 Nov 03; 362(4):1057-62. PMID: 17825258.
      Citations: 15     Fields:    Translation:AnimalsCells
    40. Park JI, Seo IA, Lee HK, Park HT, Shin SW, Park YM, Ahn KJ. Netrin inhibits regenerative axon growth of adult dorsal root ganglion neurons in vitro. J Korean Med Sci. 2007 Aug; 22(4):641-5. PMID: 17728502; PMCID: PMC2693812.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Ae Seo I, Kyoung Lee H, Mi Park Y, Jin Ahn K, Tae Park H. Acute changes of nidogen immunoreactivity in the basal lamina of the spinal cord vessels following dorsal hemisection without correlative changes of nidogen gene expression. Acta Histochem. 2007; 109(6):446-53. PMID: 17570475.
      Citations: 1     Fields:    Translation:Animals
    42. Lee HK, Seo IA, Park HK, Park YM, Ahn KJ, Yoo YH, Park HT. Nidogen is a prosurvival and promigratory factor for adult Schwann cells. J Neurochem. 2007 Aug; 102(3):686-98. PMID: 17437540.
      Citations: 22     Fields:    Translation:AnimalsCells
    43. Ahn KJ, Seo IA, Lee HK, Choi EJ, Seo EH, Lee HJ, Park HT. Down-regulation of UNC5 homologue expression after the spinal cord injury in the adult rat. Neurosci Lett. 2007 May 23; 419(1):43-8. PMID: 17452076.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Lee HK, Kang DS, Seo IA, Choi EJ, Park HT, Park JI. Expression of tumor endothelial marker 7 mRNA and protein in the dorsal root ganglion neurons of the rat. Neurosci Lett. 2006 Jul 10; 402(1-2):71-5. PMID: 16707219.
      Citations: 1     Fields:    Translation:AnimalsCells
    45. Lee HK, Seo IA, Park HK, Park HT. Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. FEBS Lett. 2006 Apr 17; 580(9):2253-7. PMID: 16574105.
      Citations: 14     Fields:    Translation:HumansCells
    46. Kim TH, Lee HK, Seo IA, Bae HR, Suh DJ, Wu J, Rao Y, Hwang KG, Park HT. Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem. 2005 Oct; 95(1):1-8. PMID: 16181408; PMCID: PMC2683579.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    47. Lee HK, Bae HR, Park HK, Seo IA, Lee EY, Suh DJ, Park HT. Cloning, characterization and neuronal expression profiles of tumor endothelial marker 7 in the rat brain. Brain Res Mol Brain Res. 2005 May 20; 136(1-2):189-98. PMID: 15893603.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
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