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DOUGLAS C. EIKENBURG

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address542G Science and Research Building 2
Houston TX 77204-5037
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    1. Taneja M, Salim S, Saha K, Happe HK, Qutna N, Petty F, Bylund DB, Eikenburg DC. Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience. Behav Brain Res. 2011 Aug 1; 221(1):25-33. PMID: 21333691; PMCID: PMC3108052.
    2. Salim S, Desai AN, Taneja M, Eikenburg DC. Chronic adrenaline treatment fails to down-regulate the Del301-303-alpha2B-adrenoceptor in neuronal cells. Br J Pharmacol. 2009 Sep; 158(1):314-27. PMID: 19719784; PMCID: PMC2795243.
    3. Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007; 7:16. PMID: 18096057; PMCID: PMC2234403.
    4. Salim S, Hite B, Eikenburg DC. Activation of the CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells. FEBS Lett. 2007 Jul 10; 581(17):3204-10. PMID: 17583697.
      View in: PubMed
    5. Salim S, Standifer KM, Eikenburg DC. Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells. J Pharmacol Exp Ther. 2007 Apr; 321(1):51-9. PMID: 17255468.
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    6. Salim S, Eikenburg DC. Role of 90-kDa heat shock protein (Hsp 90) and protein degradation in regulating neuronal levels of G protein-coupled receptor kinase 3. J Pharmacol Exp Ther. 2007 Mar; 320(3):1106-12. PMID: 17179467.
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    7. Desai AN, Salim S, Standifer KM, Eikenburg DC. Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor. J Pharmacol Exp Ther. 2006 Jun; 317(3):1027-35. PMID: 16533872.
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    8. Desai AN, Standifer KM, Eikenburg DC. Cellular G protein-coupled receptor kinase levels regulate sensitivity of the {alpha}2b-adrenergic receptor to undergo agonist-induced down-regulation. J Pharmacol Exp Ther. 2005 Feb; 312(2):767-73. PMID: 15456839.
      View in: PubMed
    9. Desai AN, Standifer KM, Eikenburg DC. Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):794-802. PMID: 15192083.
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    10. Bawa T, Altememi GF, Eikenburg DC, Standifer KM. Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. Br J Pharmacol. 2003 Mar; 138(5):921-31. PMID: 12642394; PMCID: PMC1573738.
    11. Shivachar AC, Eikenburg DC. Differential effects of epinephrine and norepinephrine on cAMP response and g(i3)alpha protein expression in cultured sympathetic neurons. J Pharmacol Exp Ther. 1999 Oct; 291(1):258-64. PMID: 10490912.
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    12. Apparsundaram S, Eikenburg DC. Prejunctional alpha adrenoceptor desensitization in rat heart after chronic epinephrine treatment. J Pharmacol Exp Ther. 1996 Aug; 278(2):862-70. PMID: 8768741.
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    13. Lakhlani PP, Amenta F, Napoleone P, Felici L, Eikenburg DC. Pharmacological characterization and anatomical localization of prejunctional beta-adrenoceptors in the rat kidney. Br J Pharmacol. 1994 Apr; 111(4):1296-308. PMID: 8032617; PMCID: PMC1910169.
    14. Sadeghi HM, Eikenburg DC. Is sympathetic neurotransmission in the rat mesentery modulated by prejunctional beta adrenoceptors? J Pharmacol Exp Ther. 1993 May; 265(2):657-63. PMID: 8388457.
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    15. Lakhlani PP, Eikenburg DC. Dependence of prejunctional beta-adrenoceptor facilitation of sympathetic neurotransmission on stimulus train length and agonist exposure time. Eur J Pharmacol. 1993 Jan 5; 230(1):107-10. PMID: 8094053.
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    16. Sadeghi HM, Eikenburg DC. Chronic epinephrine treatment fails to alter prejunctional adrenoceptor modulation of sympathetic neurotransmission in the rat mesentery. J Pharmacol Exp Ther. 1992 Jun; 261(3):924-30. PMID: 1602397.
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    17. Eikenburg DC. Effects of immobilization stress on renal sympathetic neurotransmission. Clin Exp Hypertens A. 1992; 14(3):435-51. PMID: 1318175.
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    18. Eikenburg DC. Age-related changes in vascular sympathetic neurotransmission in the rat kidney. J Pharmacol Exp Ther. 1991 Oct; 259(1):176-81. PMID: 1681084.
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    19. Schwartz DD, Eikenburg DC. Effects of synthetic ANF (rANF(3-28)) on sympathetic neurotransmission in the isolated perfused rat kidney. Life Sci. 1991; 48(8):781-7. PMID: 1847231.
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    20. Eikenburg DC. Effects of chronic norepinephrine administration on sympathetic neurotransmission in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1990 Dec; 255(3):1053-9. PMID: 1979810.
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    21. Schwartz DD, Eikenburg DC. Acute epinephrine treatment fails to facilitate stimulus-induced neurotransmitter overflow in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1989 Apr; 249(1):177-83. PMID: 2565387.
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    22. Schwartz DD, Eikenburg DC. Enhanced endogenous neurotransmitter overflow in the isolated perfused rat kidney after chronic epinephrine administration: lack of a prejunctional beta adrenoceptor influence. J Pharmacol Exp Ther. 1988 Jan; 244(1):11-8. PMID: 2891841.
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    23. Eikenburg DC, Schwartz DD. Enhanced stimulus-induced neurotransmitter overflow in epinephrine-induced hypertensive rats is not mediated by prejunctional beta-adrenoceptor activation. J Hypertens Suppl. 1986 Dec; 4(6):S226-9. PMID: 2886572.
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    24. Eikenburg DC, Lokhandwala MF. Calcium antagonists and sympathetic neuroeffector function. J Auton Pharmacol. 1986 Sep; 6(3):237-55. PMID: 2876996.
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    25. Schwartz DD, Eikenburg DC. Cardiovascular responsiveness to sympathetic activation after chronic epinephrine administration. J Pharmacol Exp Ther. 1986 Jul; 238(1):148-54. PMID: 2873235.
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    26. Peter EJ, Steenberg ML, Lokhandwala MF, Jandhyala BS, Eikenburg DC. Influence of felodipine and verapamil on the sympathetic transmitter release and on the pre- and post-junctional effects of exogenous noradrenaline in the perfused rat kidney. Drugs. 1985; 29 Suppl 2:198-204. PMID: 2859187.
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    27. Eikenburg DC. Functional characterization of the pre- and postjunctional alpha-adrenoceptors in the in situ perfused rat mesenteric vascular bed. Eur J Pharmacol. 1984 Oct 1; 105(1-2):161-5. PMID: 6092113.
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    28. Eikenburg DC. Effects of captopril on vascular noradrenergic transmission in SHR. Hypertension. 1984 Sep-Oct; 6(5):660-5. PMID: 6094342.
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    29. Lokhandwala MF, Eikenburg DC. Minireview. Presynaptic receptors and alterations in norepinephrine release in spontaneously hypertensive rats. Life Sci. 1983 Oct 17; 33(16):1527-42. PMID: 6314074.
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    30. Peter EJ, Eikenburg DC, Lokhandwala MF. Influence of the autonomic nervous system in the hypotensive action of calcium antagonists in rats. Proc West Pharmacol Soc. 1983; 26:329-31. PMID: 6889361.
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    31. Eikenburg DC, Ekas RD, Lokhandwala MF. Alterations in prejunctional responsiveness to angiotensin II during the development of 2-kidney, 1-clip Goldblatt hypertension in rats. J Pharmacol Exp Ther. 1982 Dec; 223(3):766-73. PMID: 6292400.
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    32. Ekas RD, Steenberg ML, Eikenburg DC, Lokhandwala MF. Presynaptic inhibition of sympathetic neurotransmission by adenosine in the rat kidney. Eur J Pharmacol. 1981 Dec 17; 76(4):301-7. PMID: 6276189.
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    33. Stickney JL, Eikenburg DC. Peripheral sympatholytic effects of 1-alpha-acetylmethadol. J Cardiovasc Pharmacol. 1981 Mar-Apr; 3(2):369-80. PMID: 6166807.
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    34. Eikenburg DC, Ekas RD, Lokhandwala MF. Strain differences in the facilitatory action of angiotensin on noradrenergic transmission in the rat mesentery. Clin Exp Hypertens. 1981; 3(5):1039-51. PMID: 7285721.
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    35. Stickney JL, Eikenburg DC, Keedy JD. l-alpha-Acetylmethadol (LAAM) attenuates sympathetic function by a peripheral mechanism. Proc West Pharmacol Soc. 1981; 24:237-9. PMID: 7255458.
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    36. Eikenburg DC, Stickney JL. Cardiac effects of 1-alpha-acetylmethadol. V. Possible involvement of the autonomic nervous system. Toxicol Appl Pharmacol. 1979 Oct; 51(1):91-100. PMID: 524375.
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    37. Eikenburg DC, Stickney JL. Anti-cholinesterase activity of 1-alpha-acetylmethadol: relationship to bradycardia. Gen Pharmacol. 1979; 10(3):195-200. PMID: 467958.
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    38. Eikenburg DC, Stickney JL. Inhibition of sympathetic neuronal transport and ouabain-induced cardiac arrhythmias. Res Commun Chem Pathol Pharmacol. 1977 Dec; 18(4):587-99. PMID: 928958.
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    39. Eikenburg DC, Ravitz AJ, Gudelsky GA, Moore KE. Effects of estrogen on prolactin and tuberoinfundibular dopaminergic neurons. J Neural Transm. 1977; 40(4):235-44. PMID: 881623.
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