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STUART DRYER

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Nephrology
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    F32NS007776     (DRYER, STUART E.)Nov 13, 1985
    NIH/NINDS
    SYNAPTIC CHANNELS IN THE VERTEBRATE NEURVOUS SYSTEM
    Role: Principal Investigator

    R29NS027013     (DRYER, STUART E.)Apr 1, 1989 - Mar 31, 1995
    NIH/NINDS
    PROPERTIES OF SODIUM-ACTIVATED POTASSIUM CHANNELS
    Role: Principal Investigator

    R01NS032748     (DRYER, STUART E.)Mar 15, 1995 - Jan 31, 2007
    NIH/NINDS
    DEVELOPMENT OF IONIC CHANNELS
    Role: Principal Investigator

    R01EY011973     (DRYER, STUART E.)Aug 1, 1998 - Jul 31, 2007
    NIH/NEI
    CIRCADIAN REGULATION OF VERTEBRATE PHOTORECEPTORS
    Role: Principal Investigator

    R01DC004857     (DRYER, STUART E.)Mar 1, 2001 - Feb 28, 2006
    NIH/NIDCD
    Circadian Regulation of Olfaction
    Role: Principal Investigator

    R01DK082529     (DRYER, STUART E.)Sep 17, 2009 - Jun 30, 2012
    NIH/NIDDK
    Cellular Physiology of Podocytes
    Role: Principal Investigator

    R01DK104708     (DRYER, STUART E.)Dec 15, 2015 - Nov 30, 2019
    NIH/NIDDK
    Pathophysiology of FSGS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hassanzadeh Khayyat N, Kim EY, Dryer SE. TRPC6 inactivation does not protect against diabetic kidney disease in streptozotocin (STZ)-treated Sprague-Dawley rats. FASEB Bioadv. 2019 Dec; 1(12):773-782. PMID: 32123821.
      View in: PubMed
    2. Dryer SE, Roshanravan H, Kim EY. TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1041-1066. PMID: 30953689.
      View in: PubMed
    3. Kim EY, Shotorbani PY, Dryer SE. TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions. Biochem Biophys Rep. 2019 Mar; 17:139-150. PMID: 30662960.
      View in: PubMed
    4. Kim EY, Hassanzadeh Khayyat N, Dryer SE. Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3527-3536. PMID: 30293571.
      View in: PubMed
    5. Dryer SE, Kim EY. Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels. Front Physiol. 2018; 9:1055. PMID: 30123138.
      View in: PubMed
    6. Kim EY, Yazdizadeh Shotorbani P, Dryer SE. Trpc6 inactivation confers protection in a model of severe nephrosis in rats. J Mol Med (Berl). 2018 07; 96(7):631-644. PMID: 29785489.
      View in: PubMed
    7. Kim EY, Roshanravan H, Dryer SE. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2342-2354. PMID: 28629718.
      View in: PubMed
    8. Roshanravan H, Kim EY, Dryer SE. 20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes. Front Physiol. 2016; 7:351. PMID: 27630573.
      View in: PubMed
    9. Roshanravan H, Kim EY, Dryer SE. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016 10; 65(10):3139-50. PMID: 27388219.
      View in: PubMed
    10. Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J. Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319. PMID: 27020855.
      View in: PubMed
    11. Bouron A, Chauvet S, Dryer S, Rosado JA. Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016; 898:201-49. PMID: 27161231.
      View in: PubMed
    12. Kim EY, Roshanravan H, Dryer SE. Corrigendum to "Syndecan-4 ectocdomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling". Biochim Biophys Acta. 2015 Dec; 1853(12):3294. PMID: 26668845.
      View in: PubMed
    13. Kim EY, Roshanravan H, Dryer SE. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20. PMID: 26193076.
      View in: PubMed
    14. Abkhezr M, Kim EY, Roshanravan H, Nikolos F, Thomas C, Hagmann H, Benzing T, Dryer SE. Pleiotropic signaling evoked by tumor necrosis factor in podocytes. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F98-108. PMID: 26017975.
      View in: PubMed
    15. Dryer SE. Glutamate receptors in the kidney. Nephrol Dial Transplant. 2015 Oct; 30(10):1630-8. PMID: 25829324.
      View in: PubMed
    16. Lin J, Shi Y, Peng H, Shen X, Thomas S, Wang Y, Truong LD, Dryer SE, Hu Z, Xu J. Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Pathol. 2015 May; 236(1):30-40. PMID: 25641678.
      View in: PubMed
    17. Abkhezr M, Dryer SE. STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes. Mol Pharmacol. 2015 Feb; 87(2):231-9. PMID: 25425624.
      View in: PubMed
    18. Abkhezr M, Dryer SE. Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes. Mol Pharmacol. 2014 Aug; 86(2):150-8. PMID: 24850910.
      View in: PubMed
    19. Anderson M, Roshanravan H, Khine J, Dryer SE. Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol. 2014 Apr; 229(4):434-42. PMID: 24037962.
      View in: PubMed
    20. Wilson C, Dryer SE. A mutation in TRPC6 channels abolishes their activation by hypoosmotic stretch but does not affect activation by diacylglycerol or G protein signaling cascades. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1018-25. PMID: 24598806.
      View in: PubMed
    21. Roshanravan H, Dryer SE. ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1088-97. PMID: 24553432.
      View in: PubMed
    22. Rinschen MM, Wu X, K├Ânig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T. Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 2014 Jul; 25(7):1509-22. PMID: 24511133.
      View in: PubMed
    23. Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Brinkkoetter PT. Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 2014 Apr; 28(4):1769-79. PMID: 24421402.
      View in: PubMed
    24. Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J. Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. J Biol Chem. 2013 Dec 20; 288(51):36598-609. PMID: 24194522.
      View in: PubMed
    25. Kim EY, Anderson M, Wilson C, Hagmann H, Benzing T, Dryer SE. NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex. Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C960-71. PMID: 23948707.
      View in: PubMed
    26. Anderson M, Kim EY, Hagmann H, Benzing T, Dryer SE. Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. 2013 Aug 01; 305(3):C276-89. PMID: 23657570.
      View in: PubMed
    27. Kim EY, Anderson M, Dryer SE. Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death. Mol Pharmacol. 2012 Oct; 82(4):728-37. PMID: 22828802.
      View in: PubMed
    28. Kim EY, Anderson M, Dryer SE. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J Physiol Renal Physiol. 2012 Feb 01; 302(3):F298-307. PMID: 22031853.
      View in: PubMed
    29. Kim EY, Dryer SE. Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes. J Cell Physiol. 2011 Sep; 226(9):2307-15. PMID: 21660954.
      View in: PubMed
    30. Alvarez-Baron CP, Jonsson P, Thomas C, Dryer SE, Williams C. The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells. Mol Endocrinol. 2011 Aug; 25(8):1326-36. PMID: 21680658.
      View in: PubMed
    31. Anderson M, Suh JM, Kim EY, Dryer SE. Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C22-32. PMID: 20739624.
      View in: PubMed
    32. Dryer SE, Reiser J. TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F689-701. PMID: 20685822.
      View in: PubMed
    33. Kim EY, Suh JM, Chiu YH, Dryer SE. Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments. Am J Physiol Renal Physiol. 2010 Sep; 299(3):F594-604. PMID: 20630939.
      View in: PubMed
    34. Chiu YH, Alvarez-Baron C, Kim EY, Dryer SE. Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant. Mol Pharmacol. 2010 Apr; 77(4):497-507. PMID: 20051533.
      View in: PubMed
    35. Reisenauer MR, Anderson M, Huang L, Zhang Z, Zhou Q, Kone BC, Morris AP, Lesage GD, Dryer SE, Zhang W. AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. J Biol Chem. 2009 Dec 18; 284(51):35659-69. PMID: 19864429.
      View in: PubMed
    36. Kim EY, Chiu YH, Dryer SE. Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1379-88. PMID: 19794150.
      View in: PubMed
    37. Jha S, Dryer SE. The beta1 subunit of Na+/K+-ATPase interacts with BKCa channels and affects their steady-state expression on the cell surface. FEBS Lett. 2009 Oct 06; 583(19):3109-14. PMID: 19729011.
      View in: PubMed
    38. Ridgway LD, Kim EY, Dryer SE. MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C55-65. PMID: 19403801.
      View in: PubMed
    39. Kim EY, Alvarez-Baron CP, Dryer SE. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol Pharmacol. 2009 Mar; 75(3):466-77. PMID: 19052171.
      View in: PubMed
    40. Kim EY, Choi KJ, Dryer SE. Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F235-46. PMID: 18480178.
      View in: PubMed
    41. Chen SK, Ko GY, Dryer SE. Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination. J Neurosci. 2007 Nov 07; 27(45):12168-75. PMID: 17989283.
      View in: PubMed
    42. Zou S, Jha S, Kim EY, Dryer SE. The beta 1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channels. Mol Pharmacol. 2008 Feb; 73(2):369-78. PMID: 17989350.
      View in: PubMed
    43. Zou S, Jha S, Kim EY, Dryer SE. A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane. Mol Pharmacol. 2008 Feb; 73(2):359-68. PMID: 17989352.
      View in: PubMed
    44. Ko ML, Liu Y, Dryer SE, Ko GY. The expression of L-type voltage-gated calcium channels in retinal photoreceptors is under circadian control. J Neurochem. 2007 Oct; 103(2):784-92. PMID: 17683482.
      View in: PubMed
    45. Scott SP, Shea PW, Dryer SE. Mapping ligand interactions with the hyperpolarization activated cyclic nucleotide modulated (HCN) ion channel binding domain using a soluble construct. Biochemistry. 2007 Aug 21; 46(33):9417-31. PMID: 17655202.
      View in: PubMed
    46. Kim EY, Ridgway LD, Dryer SE. Interactions with filamin A stimulate surface expression of large-conductance Ca2+-activated K+ channels in the absence of direct actin binding. Mol Pharmacol. 2007 Sep; 72(3):622-30. PMID: 17586600.
      View in: PubMed
    47. Kim EY, Zou S, Ridgway LD, Dryer SE. Beta1-subunits increase surface expression of a large-conductance Ca2+-activated K+ channel isoform. J Neurophysiol. 2007 May; 97(5):3508-16. PMID: 17329633.
      View in: PubMed
    48. Chae KS, Ko GY, Dryer SE. Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors. Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):901-6. PMID: 17251493.
      View in: PubMed
    49. Bryan RM, You J, Phillips SC, Andresen JJ, Lloyd EE, Rogers PA, Dryer SE, Marrelli SP. Evidence for two-pore domain potassium channels in rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H770-80. PMID: 16565299.
      View in: PubMed
    50. Chae KS, Dryer SE. The p38 mitogen-activated protein kinase pathway negatively regulates Ca2+-activated K+ channel trafficking in developing parasympathetic neurons. J Neurochem. 2005 Jul; 94(2):367-79. PMID: 15998288.
      View in: PubMed
    51. Chae KS, Oh KS, Dryer SE. Growth factors mobilize multiple pools of KCa channels in developing parasympathetic neurons: role of ADP-ribosylation factors and related proteins. J Neurophysiol. 2005 Aug; 94(2):1597-605. PMID: 15843480.
      View in: PubMed
    52. Krishnan P, Dryer SE, Hardin PE. Measuring circadian rhythms in olfaction using electroantennograms. Methods Enzymol. 2005; 393:495-508. PMID: 15817308.
      View in: PubMed
    53. Chae KS, Martin-Caraballo M, Anderson M, Dryer SE. Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol. 2005 Mar; 93(3):1174-82. PMID: 15509648.
      View in: PubMed
    54. Ko GY, Ko M, Dryer SE. Circadian and cAMP-dependent modulation of retinal cone cGMP-gated channels does not require protein synthesis or calcium influx through L-type channels. Brain Res. 2004 Sep 24; 1021(2):277-80. PMID: 15342277.
      View in: PubMed
    55. Casavant RH, Colbert CM, Dryer SE. A-current expression is regulated by activity but not by target tissues in developing lumbar motoneurons of the chick embryo. J Neurophysiol. 2004 Nov; 92(5):2644-51. PMID: 15163671.
      View in: PubMed
    56. Tanoue S, Krishnan P, Krishnan B, Dryer SE, Hardin PE. Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Curr Biol. 2004 Apr 20; 14(8):638-49. PMID: 15084278.
      View in: PubMed
    57. Ko GY, Ko ML, Dryer SE. Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras. J Neurosci. 2004 Feb 11; 24(6):1296-304. PMID: 14960600.
      View in: PubMed
    58. Lhuillier L, Dryer SE. Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons. Brain Res. 2003 Aug 22; 982(1):119-24. PMID: 12915246.
      View in: PubMed
    59. Ko GY, Ko ML, Dryer SE. Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist. J Neurosci. 2003 Apr 15; 23(8):3145-53. PMID: 12716922.
      View in: PubMed
    60. Dryer SE. Molecular identification of the Na+-activated K+ channel. Neuron. 2003 Mar 06; 37(5):727-8. PMID: 12628162.
      View in: PubMed
    61. Hardin PE, Krishnan B, Houl JH, Zheng H, Ng FS, Dryer SE, Glossop NR. Central and peripheral circadian oscillators in Drosophila. Novartis Found Symp. 2003; 253:140-50; discussion 150-60. PMID: 14712919.
      View in: PubMed
    62. Dryer SE, Lhuillier L, Cameron JS, Martin-Caraballo M. Expression of K(Ca) channels in identified populations of developing vertebrate neurons: role of neurotrophic factors and activity. J Physiol Paris. 2003 Jan; 97(1):49-58. PMID: 14706690.
      View in: PubMed
    63. Martin-Caraballo M, Dryer SE. Glial cell line-derived neurotrophic factor and target-dependent regulation of large-conductance KCa channels in developing chick lumbar motoneurons. J Neurosci. 2002 Dec 01; 22(23):10201-8. PMID: 12451121.
      View in: PubMed
    64. Lhuillier L, Dryer SE. Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion. J Neurophysiol. 2002 Aug; 88(2):954-64. PMID: 12163544.
      View in: PubMed
    65. Martin-Caraballo M, Dryer SE. Activity- and target-dependent regulation of large-conductance Ca2+-activated K+ channels in developing chick lumbar motoneurons. J Neurosci. 2002 Jan 01; 22(1):73-81. PMID: 11756490.
      View in: PubMed
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