Connection

OLIVIER LICHTARGE to Humans

This is a "connection" page, showing publications OLIVIER LICHTARGE has written about Humans.
Connection Strength

0.787
  1. Meta-EA: a gene-specific combination of available computational tools for predicting missense variant effects. Nat Commun. 2025 01 02; 16(1):159.
    View in: PubMed
    Score: 0.026
  2. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Nat Commun. 2023 05 13; 14(1):2765.
    View in: PubMed
    Score: 0.023
  3. EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants. Nucleic Acids Res. 2022 07 08; 50(12):e70.
    View in: PubMed
    Score: 0.022
  4. Genome interpretation using in silico predictors of variant impact. Hum Genet. 2022 Oct; 141(10):1549-1577.
    View in: PubMed
    Score: 0.021
  5. A general calculus of fitness landscapes finds genes under selection in cancers. Genome Res. 2022 05; 32(5):916-929.
    View in: PubMed
    Score: 0.021
  6. Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).
    View in: PubMed
    Score: 0.021
  7. Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family. Bioinformatics. 2021 11 18; 37(22):4033-4040.
    View in: PubMed
    Score: 0.021
  8. A method to delineate de novo missense variants across pathways prioritizes genes linked to autism. Sci Transl Med. 2021 05 19; 13(594).
    View in: PubMed
    Score: 0.020
  9. Harnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease. Alzheimers Dement. 2021 05; 17(5):831-846.
    View in: PubMed
    Score: 0.019
  10. An Evolutionary Trace method defines functionally important bases and sites common to RNA families. PLoS Comput Biol. 2020 03; 16(3):e1007583.
    View in: PubMed
    Score: 0.018
  11. Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks. Pac Symp Biocomput. 2020; 25:439-450.
    View in: PubMed
    Score: 0.018
  12. CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. Hum Mutat. 2019 09; 40(9):1436-1454.
    View in: PubMed
    Score: 0.018
  13. Multimodal network diffusion predicts future disease-gene-chemical associations. Bioinformatics. 2019 05 01; 35(9):1536-1543.
    View in: PubMed
    Score: 0.017
  14. Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10666-10671.
    View in: PubMed
    Score: 0.017
  15. Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests. Hum Mutat. 2017 09; 38(9):1072-1084.
    View in: PubMed
    Score: 0.015
  16. Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction. PLoS One. 2017; 12(3):e0174766.
    View in: PubMed
    Score: 0.015
  17. DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS. Pac Symp Biocomput. 2017; 22:336-347.
    View in: PubMed
    Score: 0.015
  18. Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3539-44.
    View in: PubMed
    Score: 0.014
  19. COMPUTING THERAPY FOR PRECISION MEDICINE: COLLABORATIVE FILTERING INTEGRATES AND PREDICTS MULTI-ENTITY INTERACTIONS. Pac Symp Biocomput. 2016; 21:21-32.
    View in: PubMed
    Score: 0.014
  20. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36.
    View in: PubMed
    Score: 0.013
  21. Single nucleotide variations: biological impact and theoretical interpretation. Protein Sci. 2014 Dec; 23(12):1650-66.
    View in: PubMed
    Score: 0.013
  22. A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness. Genome Res. 2014 Dec; 24(12):2050-8.
    View in: PubMed
    Score: 0.013
  23. Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol. 2014 Nov-Dec; 116(2-3):194-202.
    View in: PubMed
    Score: 0.012
  24. Evolution: a guide to perturb protein function and networks. Curr Opin Struct Biol. 2010 Jun; 20(3):351-9.
    View in: PubMed
    Score: 0.009
  25. Evolutionary trace annotation of protein function in the structural proteome. J Mol Biol. 2010 Mar 12; 396(5):1451-73.
    View in: PubMed
    Score: 0.009
  26. Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors. Proteins. 2006 Sep 01; 64(4):1046-57.
    View in: PubMed
    Score: 0.007
  27. Evolutionary trace report_maker: a new type of service for comparative analysis of proteins. Bioinformatics. 2006 Jul 01; 22(13):1656-7.
    View in: PubMed
    Score: 0.007
  28. Evolutionary and structural feedback on selection of sequences for comparative analysis of proteins. Proteins. 2006 Apr 01; 63(1):87-99.
    View in: PubMed
    Score: 0.007
  29. Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity. J Mol Biol. 2005 Jul 15; 350(3):402-15.
    View in: PubMed
    Score: 0.007
  30. Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A. Hum Genet. 2025 Mar; 144(2-3):295-308.
    View in: PubMed
    Score: 0.007
  31. Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):265-280.
    View in: PubMed
    Score: 0.006
  32. Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers. Hum Genet. 2025 Mar; 144(2-3):127-142.
    View in: PubMed
    Score: 0.006
  33. CAGI6 ID panel challenge: assessment of phenotype and variant predictions in 415 children with neurodevelopmental disorders (NDDs). Hum Genet. 2025 Mar; 144(2-3):227-242.
    View in: PubMed
    Score: 0.006
  34. Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):113-125.
    View in: PubMed
    Score: 0.006
  35. MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discov. 2024 Sep 04; 14(9):1699-1716.
    View in: PubMed
    Score: 0.006
  36. Assessing predictions on fitness effects of missense variants in HMBS in CAGI6. Hum Genet. 2025 Mar; 144(2-3):173-189.
    View in: PubMed
    Score: 0.006
  37. Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms. Blood Cancer J. 2024 06 18; 14(1):99.
    View in: PubMed
    Score: 0.006
  38. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 06; 300(6):107368.
    View in: PubMed
    Score: 0.006
  39. Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project. Hum Genomics. 2024 04 29; 18(1):44.
    View in: PubMed
    Score: 0.006
  40. Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence. Nat Microbiol. 2024 May; 9(5):1382-1392.
    View in: PubMed
    Score: 0.006
  41. A family of evolution-entropy hybrid methods for ranking protein residues by importance. J Mol Biol. 2004 Mar 05; 336(5):1265-82.
    View in: PubMed
    Score: 0.006
  42. Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt. Am J Hum Genet. 2024 03 07; 111(3):487-508.
    View in: PubMed
    Score: 0.006
  43. Predicting the impact of rare variants on RNA splicing in CAGI6. Hum Genet. 2025 Mar; 144(2-3):243-251.
    View in: PubMed
    Score: 0.006
  44. Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity. Nat Metab. 2023 Oct; 5(10):1673-1684.
    View in: PubMed
    Score: 0.006
  45. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 06; 128(11):2013-2024.
    View in: PubMed
    Score: 0.006
  46. Evolutionary predictions of binding surfaces and interactions. Curr Opin Struct Biol. 2002 Feb; 12(1):21-7.
    View in: PubMed
    Score: 0.005
  47. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431.
    View in: PubMed
    Score: 0.005
  48. Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. Genet Med. 2021 08; 23(8):1465-1473.
    View in: PubMed
    Score: 0.005
  49. Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis. Blood Cancer J. 2021 03 06; 11(3):52.
    View in: PubMed
    Score: 0.005
  50. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186.
    View in: PubMed
    Score: 0.005
  51. Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108.
    View in: PubMed
    Score: 0.005
  52. A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1483-8.
    View in: PubMed
    Score: 0.005
  53. The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biol. 2019 11 19; 20(1):244.
    View in: PubMed
    Score: 0.005
  54. Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. J Biol Chem. 2019 12 13; 294(50):19279-19291.
    View in: PubMed
    Score: 0.004
  55. Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nat Commun. 2019 09 09; 10(1):4075.
    View in: PubMed
    Score: 0.004
  56. Assessing predictions on fitness effects of missense variants in calmodulin. Hum Mutat. 2019 09; 40(9):1463-1473.
    View in: PubMed
    Score: 0.004
  57. Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Hum Mutat. 2019 09; 40(9):1530-1545.
    View in: PubMed
    Score: 0.004
  58. CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases. Hum Mutat. 2019 09; 40(9):1373-1391.
    View in: PubMed
    Score: 0.004
  59. Assessment of predicted enzymatic activity of a-N-acetylglucosaminidase variants of unknown significance for CAGI 2016. Hum Mutat. 2019 09; 40(9):1519-1529.
    View in: PubMed
    Score: 0.004
  60. Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants. Hum Mutat. 2019 09; 40(9):1546-1556.
    View in: PubMed
    Score: 0.004
  61. Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Hum Mutat. 2019 09; 40(9):1612-1622.
    View in: PubMed
    Score: 0.004
  62. Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5. Hum Mutat. 2019 09; 40(9):1474-1485.
    View in: PubMed
    Score: 0.004
  63. Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. Cell Rep. 2019 07 30; 28(5):1370-1384.e5.
    View in: PubMed
    Score: 0.004
  64. Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge. Hum Mutat. 2019 09; 40(9):1392-1399.
    View in: PubMed
    Score: 0.004
  65. Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge. Hum Mutat. 2019 09; 40(9):1330-1345.
    View in: PubMed
    Score: 0.004
  66. Assessment of methods for predicting the effects of PTEN and TPMT protein variants. Hum Mutat. 2019 09; 40(9):1495-1506.
    View in: PubMed
    Score: 0.004
  67. Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Hum Mutat. 2019 09; 40(9):1314-1320.
    View in: PubMed
    Score: 0.004
  68. Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases. Ann Surg. 2019 05; 269(5):917-923.
    View in: PubMed
    Score: 0.004
  69. Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci Signal. 2018 08 28; 11(545).
    View in: PubMed
    Score: 0.004
  70. FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance. Mol Genet Metab. 2018 11; 125(3):281-291.
    View in: PubMed
    Score: 0.004
  71. Pathogenic Germline Variants in 10,389 Adult Cancers. Cell. 2018 04 05; 173(2):355-370.e14.
    View in: PubMed
    Score: 0.004
  72. Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H109-H121.
    View in: PubMed
    Score: 0.004
  73. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med. 2018 05; 24(4):505-511.
    View in: PubMed
    Score: 0.004
  74. A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 2018 02 22; 172(5):924-936.e11.
    View in: PubMed
    Score: 0.004
  75. Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action. Int J Parasitol Drugs Drug Resist. 2018 04; 8(1):31-35.
    View in: PubMed
    Score: 0.004
  76. Evolutionary action and structural basis of the allosteric switch controlling ?2AR functional selectivity. Nat Commun. 2017 12 18; 8(1):2169.
    View in: PubMed
    Score: 0.004
  77. Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone. 2018 02; 107:161-171.
    View in: PubMed
    Score: 0.004
  78. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 09; 38(9):1042-1050.
    View in: PubMed
    Score: 0.004
  79. Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
    View in: PubMed
    Score: 0.004
  80. ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017 06 16; 292(24):9967-9974.
    View in: PubMed
    Score: 0.004
  81. Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling. Hum Mutat. 2017 05; 38(5):569-580.
    View in: PubMed
    Score: 0.004
  82. HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER. Pac Symp Biocomput. 2017; 22:414-425.
    View in: PubMed
    Score: 0.004
  83. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 12 29; 128(26):3061-3072.
    View in: PubMed
    Score: 0.004
  84. Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. 2016 10; 240(2):224-34.
    View in: PubMed
    Score: 0.004
  85. An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol. 1996 Mar 29; 257(2):342-58.
    View in: PubMed
    Score: 0.004
  86. REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING. Pac Symp Biocomput. 2016; 21:207-18.
    View in: PubMed
    Score: 0.003
  87. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia. 2015 Oct; 17(10):789-803.
    View in: PubMed
    Score: 0.003
  88. Elucidation of G-protein and ?-arrestin functional selectivity at the dopamine D2 receptor. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):7097-102.
    View in: PubMed
    Score: 0.003
  89. Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients. Cancer Res. 2015 Apr 01; 75(7):1205-15.
    View in: PubMed
    Score: 0.003
  90. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30; 290(5):2870-8.
    View in: PubMed
    Score: 0.003
  91. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19.
    View in: PubMed
    Score: 0.003
  92. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24; 289(43):29961-74.
    View in: PubMed
    Score: 0.003
  93. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol. 2014 Feb; 34(3):374-85.
    View in: PubMed
    Score: 0.003
  94. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88.
    View in: PubMed
    Score: 0.003
  95. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013 Feb 14; 494(7436):201-6.
    View in: PubMed
    Score: 0.003
  96. A large-scale evaluation of computational protein function prediction. Nat Methods. 2013 Mar; 10(3):221-7.
    View in: PubMed
    Score: 0.003
  97. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. Am J Med Genet A. 2011 Jul; 155A(7):1597-604.
    View in: PubMed
    Score: 0.003
  98. Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations. Hum Mutat. 2011 Jun; 32(6):579-89.
    View in: PubMed
    Score: 0.002
  99. Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7787-92.
    View in: PubMed
    Score: 0.002
  100. Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol Pharmacol. 2010 Mar; 77(3):405-15.
    View in: PubMed
    Score: 0.002
  101. Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B. Arch Neurol. 2009 Aug; 66(8):1028-32.
    View in: PubMed
    Score: 0.002
  102. Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones. Traffic. 2009 Aug; 10(8):1019-33.
    View in: PubMed
    Score: 0.002
  103. Secondary structure determination of human beta-endorphin by 1H NMR spectroscopy. Biochemistry. 1987 Sep 08; 26(18):5916-25.
    View in: PubMed
    Score: 0.002
  104. Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. Nat Struct Mol Biol. 2007 Apr; 14(4):301-7.
    View in: PubMed
    Score: 0.002
  105. Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. J Neurosci. 2006 Dec 06; 26(49):12727-34.
    View in: PubMed
    Score: 0.002
  106. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006 Jan 13; 281(2):1261-73.
    View in: PubMed
    Score: 0.002
  107. Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. J Mol Biol. 2004 Nov 19; 344(2):303-10.
    View in: PubMed
    Score: 0.002
  108. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78.
    View in: PubMed
    Score: 0.001
  109. Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function. J Biol Chem. 2000 Nov 10; 275(45):35393-401.
    View in: PubMed
    Score: 0.001
  110. Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes. Ann Neurol. 2000 May; 47(5):670-9.
    View in: PubMed
    Score: 0.001
  111. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem. 1999 Jun 11; 274(24):17033-41.
    View in: PubMed
    Score: 0.001
  112. C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. J Biol Chem. 1999 May 28; 274(22):15757-65.
    View in: PubMed
    Score: 0.001
  113. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. Genomics. 1998 Nov 15; 54(1):79-88.
    View in: PubMed
    Score: 0.001
  114. Some model experiments in hemodynamics: VI. Two-body collisions between blood cells. Biorheology. 1981; 18(3-6):531-55.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.