OLIVIER LICHTARGE to Humans
This is a "connection" page, showing publications OLIVIER LICHTARGE has written about Humans.
Connection Strength
0.782
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Meta-EA: a gene-specific combination of available computational tools for predicting missense variant effects. Nat Commun. 2025 01 02; 16(1):159.
Score: 0.026
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Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Nat Commun. 2023 05 13; 14(1):2765.
Score: 0.023
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EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants. Nucleic Acids Res. 2022 07 08; 50(12):e70.
Score: 0.022
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Genome interpretation using in silico predictors of variant impact. Hum Genet. 2022 Oct; 141(10):1549-1577.
Score: 0.021
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A general calculus of fitness landscapes finds genes under selection in cancers. Genome Res. 2022 05; 32(5):916-929.
Score: 0.021
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Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).
Score: 0.021
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Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family. Bioinformatics. 2021 11 18; 37(22):4033-4040.
Score: 0.021
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A method to delineate de novo missense variants across pathways prioritizes genes linked to autism. Sci Transl Med. 2021 05 19; 13(594).
Score: 0.020
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Harnessing the paradoxical phenotypes of APOE ?2 and APOE ?4 to identify genetic modifiers in Alzheimer's disease. Alzheimers Dement. 2021 05; 17(5):831-846.
Score: 0.019
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An Evolutionary Trace method defines functionally important bases and sites common to RNA families. PLoS Comput Biol. 2020 03; 16(3):e1007583.
Score: 0.018
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Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks. Pac Symp Biocomput. 2020; 25:439-450.
Score: 0.018
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CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. Hum Mutat. 2019 09; 40(9):1436-1454.
Score: 0.018
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Multimodal network diffusion predicts future disease-gene-chemical associations. Bioinformatics. 2019 05 01; 35(9):1536-1543.
Score: 0.017
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Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10666-10671.
Score: 0.017
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Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests. Hum Mutat. 2017 09; 38(9):1072-1084.
Score: 0.015
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Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction. PLoS One. 2017; 12(3):e0174766.
Score: 0.015
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DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS. Pac Symp Biocomput. 2017; 22:336-347.
Score: 0.015
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Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3539-44.
Score: 0.014
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COMPUTING THERAPY FOR PRECISION MEDICINE: COLLABORATIVE FILTERING INTEGRATES AND PREDICTS MULTI-ENTITY INTERACTIONS. Pac Symp Biocomput. 2016; 21:21-32.
Score: 0.014
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Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36.
Score: 0.013
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Single nucleotide variations: biological impact and theoretical interpretation. Protein Sci. 2014 Dec; 23(12):1650-66.
Score: 0.013
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A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness. Genome Res. 2014 Dec; 24(12):2050-8.
Score: 0.013
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Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol. 2014 Nov-Dec; 116(2-3):194-202.
Score: 0.012
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Evolution: a guide to perturb protein function and networks. Curr Opin Struct Biol. 2010 Jun; 20(3):351-9.
Score: 0.009
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Evolutionary trace annotation of protein function in the structural proteome. J Mol Biol. 2010 Mar 12; 396(5):1451-73.
Score: 0.009
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Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors. Proteins. 2006 Sep 01; 64(4):1046-57.
Score: 0.007
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Evolutionary trace report_maker: a new type of service for comparative analysis of proteins. Bioinformatics. 2006 Jul 01; 22(13):1656-7.
Score: 0.007
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Evolutionary and structural feedback on selection of sequences for comparative analysis of proteins. Proteins. 2006 Apr 01; 63(1):87-99.
Score: 0.007
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Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity. J Mol Biol. 2005 Jul 15; 350(3):402-15.
Score: 0.007
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Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A. Hum Genet. 2025 Mar; 144(2-3):295-308.
Score: 0.006
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Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):265-280.
Score: 0.006
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Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers. Hum Genet. 2025 Mar; 144(2-3):127-142.
Score: 0.006
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CAGI6 ID panel challenge: assessment of phenotype and variant predictions in 415 children with neurodevelopmental disorders (NDDs). Hum Genet. 2025 Mar; 144(2-3):227-242.
Score: 0.006
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Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges. Hum Genet. 2025 Mar; 144(2-3):113-125.
Score: 0.006
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MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discov. 2024 Sep 04; 14(9):1699-1716.
Score: 0.006
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Assessing predictions on fitness effects of missense variants in HMBS in CAGI6. Hum Genet. 2025 Mar; 144(2-3):173-189.
Score: 0.006
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Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms. Blood Cancer J. 2024 06 18; 14(1):99.
Score: 0.006
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ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 06; 300(6):107368.
Score: 0.006
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Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project. Hum Genomics. 2024 04 29; 18(1):44.
Score: 0.006
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Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence. Nat Microbiol. 2024 May; 9(5):1382-1392.
Score: 0.006
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A family of evolution-entropy hybrid methods for ranking protein residues by importance. J Mol Biol. 2004 Mar 05; 336(5):1265-82.
Score: 0.006
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Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt. Am J Hum Genet. 2024 03 07; 111(3):487-508.
Score: 0.006
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Predicting the impact of rare variants on RNA splicing in CAGI6. Hum Genet. 2025 Mar; 144(2-3):243-251.
Score: 0.006
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Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity. Nat Metab. 2023 Oct; 5(10):1673-1684.
Score: 0.006
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Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 06; 128(11):2013-2024.
Score: 0.006
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Evolutionary predictions of binding surfaces and interactions. Curr Opin Struct Biol. 2002 Feb; 12(1):21-7.
Score: 0.005
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431.
Score: 0.005
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Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. Genet Med. 2021 08; 23(8):1465-1473.
Score: 0.005
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Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis. Blood Cancer J. 2021 03 06; 11(3):52.
Score: 0.005
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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186.
Score: 0.005
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108.
Score: 0.005
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A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1483-8.
Score: 0.005
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biol. 2019 11 19; 20(1):244.
Score: 0.004
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Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. J Biol Chem. 2019 12 13; 294(50):19279-19291.
Score: 0.004
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Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nat Commun. 2019 09 09; 10(1):4075.
Score: 0.004
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Assessing predictions on fitness effects of missense variants in calmodulin. Hum Mutat. 2019 09; 40(9):1463-1473.
Score: 0.004
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Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Hum Mutat. 2019 09; 40(9):1530-1545.
Score: 0.004
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CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases. Hum Mutat. 2019 09; 40(9):1373-1391.
Score: 0.004
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Assessment of predicted enzymatic activity of a-N-acetylglucosaminidase variants of unknown significance for CAGI 2016. Hum Mutat. 2019 09; 40(9):1519-1529.
Score: 0.004
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Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants. Hum Mutat. 2019 09; 40(9):1546-1556.
Score: 0.004
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Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Hum Mutat. 2019 09; 40(9):1612-1622.
Score: 0.004
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Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5. Hum Mutat. 2019 09; 40(9):1474-1485.
Score: 0.004
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Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. Cell Rep. 2019 07 30; 28(5):1370-1384.e5.
Score: 0.004
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Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge. Hum Mutat. 2019 09; 40(9):1392-1399.
Score: 0.004
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Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge. Hum Mutat. 2019 09; 40(9):1330-1345.
Score: 0.004
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Assessment of methods for predicting the effects of PTEN and TPMT protein variants. Hum Mutat. 2019 09; 40(9):1495-1506.
Score: 0.004
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Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Hum Mutat. 2019 09; 40(9):1314-1320.
Score: 0.004
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Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases. Ann Surg. 2019 05; 269(5):917-923.
Score: 0.004
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Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci Signal. 2018 08 28; 11(545).
Score: 0.004
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FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance. Mol Genet Metab. 2018 11; 125(3):281-291.
Score: 0.004
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Pathogenic Germline Variants in 10,389 Adult Cancers. Cell. 2018 04 05; 173(2):355-370.e14.
Score: 0.004
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Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H109-H121.
Score: 0.004
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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med. 2018 05; 24(4):505-511.
Score: 0.004
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A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 2018 02 22; 172(5):924-936.e11.
Score: 0.004
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Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action. Int J Parasitol Drugs Drug Resist. 2018 04; 8(1):31-35.
Score: 0.004
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Evolutionary action and structural basis of the allosteric switch controlling ?2AR functional selectivity. Nat Commun. 2017 12 18; 8(1):2169.
Score: 0.004
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Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone. 2018 02; 107:161-171.
Score: 0.004
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Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 09; 38(9):1042-1050.
Score: 0.004
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Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
Score: 0.004
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?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017 06 16; 292(24):9967-9974.
Score: 0.004
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Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling. Hum Mutat. 2017 05; 38(5):569-580.
Score: 0.004
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HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER. Pac Symp Biocomput. 2017; 22:414-425.
Score: 0.004
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Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 12 29; 128(26):3061-3072.
Score: 0.004
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Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. 2016 10; 240(2):224-34.
Score: 0.004
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An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol. 1996 Mar 29; 257(2):342-58.
Score: 0.003
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REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING. Pac Symp Biocomput. 2016; 21:207-18.
Score: 0.003
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Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia. 2015 Oct; 17(10):789-803.
Score: 0.003
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Elucidation of G-protein and ?-arrestin functional selectivity at the dopamine D2 receptor. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):7097-102.
Score: 0.003
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Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients. Cancer Res. 2015 Apr 01; 75(7):1205-15.
Score: 0.003
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Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30; 290(5):2870-8.
Score: 0.003
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Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19.
Score: 0.003
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Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24; 289(43):29961-74.
Score: 0.003
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Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol. 2014 Feb; 34(3):374-85.
Score: 0.003
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Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88.
Score: 0.003
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Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013 Feb 14; 494(7436):201-6.
Score: 0.003
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A large-scale evaluation of computational protein function prediction. Nat Methods. 2013 Mar; 10(3):221-7.
Score: 0.003
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Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. Am J Med Genet A. 2011 Jul; 155A(7):1597-604.
Score: 0.002
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Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations. Hum Mutat. 2011 Jun; 32(6):579-89.
Score: 0.002
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Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7787-92.
Score: 0.002
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Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol Pharmacol. 2010 Mar; 77(3):405-15.
Score: 0.002
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Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B. Arch Neurol. 2009 Aug; 66(8):1028-32.
Score: 0.002
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Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones. Traffic. 2009 Aug; 10(8):1019-33.
Score: 0.002
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Secondary structure determination of human beta-endorphin by 1H NMR spectroscopy. Biochemistry. 1987 Sep 08; 26(18):5916-25.
Score: 0.002
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Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. Nat Struct Mol Biol. 2007 Apr; 14(4):301-7.
Score: 0.002
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Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. J Neurosci. 2006 Dec 06; 26(49):12727-34.
Score: 0.002
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006 Jan 13; 281(2):1261-73.
Score: 0.002
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Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. J Mol Biol. 2004 Nov 19; 344(2):303-10.
Score: 0.002
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Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78.
Score: 0.001
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Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function. J Biol Chem. 2000 Nov 10; 275(45):35393-401.
Score: 0.001
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Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes. Ann Neurol. 2000 May; 47(5):670-9.
Score: 0.001
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Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem. 1999 Jun 11; 274(24):17033-41.
Score: 0.001
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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. J Biol Chem. 1999 May 28; 274(22):15757-65.
Score: 0.001
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The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. Genomics. 1998 Nov 15; 54(1):79-88.
Score: 0.001
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Some model experiments in hemodynamics: VI. Two-body collisions between blood cells. Biorheology. 1981; 18(3-6):531-55.
Score: 0.000