Connection

Co-Authors

This is a "connection" page, showing publications co-authored by OLIVIER LICHTARGE and PANAGIOTIS KATSONIS.
Connection Strength

7.667
  1. Genome interpretation using in silico predictors of variant impact. Hum Genet. 2022 Oct; 141(10):1549-1577.
    View in: PubMed
    Score: 0.832
  2. CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. Hum Mutat. 2019 09; 40(9):1436-1454.
    View in: PubMed
    Score: 0.689
  3. Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests. Hum Mutat. 2017 09; 38(9):1072-1084.
    View in: PubMed
    Score: 0.594
  4. Single nucleotide variations: biological impact and theoretical interpretation. Protein Sci. 2014 Dec; 23(12):1650-66.
    View in: PubMed
    Score: 0.494
  5. A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness. Genome Res. 2014 Dec; 24(12):2050-8.
    View in: PubMed
    Score: 0.490
  6. ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis. Bioinformatics. 2023 08 01; 39(8).
    View in: PubMed
    Score: 0.227
  7. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Nat Commun. 2023 05 13; 14(1):2765.
    View in: PubMed
    Score: 0.224
  8. Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli. Nat Commun. 2022 06 09; 13(1):3189.
    View in: PubMed
    Score: 0.210
  9. A general calculus of fitness landscapes finds genes under selection in cancers. Genome Res. 2022 05; 32(5):916-929.
    View in: PubMed
    Score: 0.206
  10. Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family. Bioinformatics. 2021 11 18; 37(22):4033-4040.
    View in: PubMed
    Score: 0.202
  11. A method to delineate de novo missense variants across pathways prioritizes genes linked to autism. Sci Transl Med. 2021 05 19; 13(594).
    View in: PubMed
    Score: 0.195
  12. Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and the greater coronavirus family. Res Sq. 2021 Feb 15.
    View in: PubMed
    Score: 0.191
  13. Comprehensive Genomic Characterization of Parathyroid Cancer Identifies Novel Candidate Driver Mutations and Core Pathways. J Endocr Soc. 2019 Mar 01; 3(3):544-559.
    View in: PubMed
    Score: 0.162
  14. Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction. PLoS One. 2017; 12(3):e0174766.
    View in: PubMed
    Score: 0.146
  15. REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING. Pac Symp Biocomput. 2016; 21:207-18.
    View in: PubMed
    Score: 0.134
  16. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36.
    View in: PubMed
    Score: 0.126
  17. Negative feedback in genetic circuits confers evolutionary resilience and capacitance. Cell Rep. 2014 Jun 26; 7(6):1789-95.
    View in: PubMed
    Score: 0.120
  18. Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol. 2014 Nov-Dec; 116(2-3):194-202.
    View in: PubMed
    Score: 0.120
  19. Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites. PLoS Genet. 2011 Sep; 7(9):e1002244.
    View in: PubMed
    Score: 0.099
  20. MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discov. 2024 Sep 04; 14(9):1699-1716.
    View in: PubMed
    Score: 0.061
  21. Assessing predictions on fitness effects of missense variants in HMBS in CAGI6. Hum Genet. 2024 Aug 07.
    View in: PubMed
    Score: 0.061
  22. Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers. Res Sq. 2024 Jul 02.
    View in: PubMed
    Score: 0.060
  23. Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms. Blood Cancer J. 2024 06 18; 14(1):99.
    View in: PubMed
    Score: 0.060
  24. Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A. bioRxiv. 2024 Jun 17.
    View in: PubMed
    Score: 0.060
  25. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J Biol Chem. 2024 Jun; 300(6):107368.
    View in: PubMed
    Score: 0.060
  26. Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project. Hum Genomics. 2024 04 29; 18(1):44.
    View in: PubMed
    Score: 0.060
  27. Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt. Am J Hum Genet. 2024 03 07; 111(3):487-508.
    View in: PubMed
    Score: 0.059
  28. Predicting the impact of rare variants on RNA splicing in CAGI6. Hum Genet. 2024 Jan 03.
    View in: PubMed
    Score: 0.058
  29. Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity. Nat Metab. 2023 Oct; 5(10):1673-1684.
    View in: PubMed
    Score: 0.057
  30. Critical assessment of variant prioritization methods for rare disease diagnosis within the Rare Genomes Project. medRxiv. 2023 Aug 04.
    View in: PubMed
    Score: 0.057
  31. CAGI6 ID-Challenge: Assessment of phenotype and variant predictions in 415 children with Neurodevelopmental Disorders (NDDs). Res Sq. 2023 Aug 02.
    View in: PubMed
    Score: 0.057
  32. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 06; 128(11):2013-2024.
    View in: PubMed
    Score: 0.055
  33. Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication. Front Mol Biosci. 2021; 8:791792.
    View in: PubMed
    Score: 0.051
  34. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431.
    View in: PubMed
    Score: 0.050
  35. PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPAR?-DNMT1 Interactions in the Genome. Cancers (Basel). 2021 Aug 07; 13(16).
    View in: PubMed
    Score: 0.049
  36. Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase. Comput Struct Biotechnol J. 2021; 19:2307-2317.
    View in: PubMed
    Score: 0.048
  37. Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. Genet Med. 2021 08; 23(8):1465-1473.
    View in: PubMed
    Score: 0.048
  38. Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis. Blood Cancer J. 2021 03 06; 11(3):52.
    View in: PubMed
    Score: 0.048
  39. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186.
    View in: PubMed
    Score: 0.048
  40. Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Prog Biophys Mol Biol. 2021 08; 163:87-108.
    View in: PubMed
    Score: 0.047
  41. Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma. Cancers (Basel). 2019 Oct 19; 11(10).
    View in: PubMed
    Score: 0.044
  42. Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants. Hum Mutat. 2019 09; 40(9):1530-1545.
    View in: PubMed
    Score: 0.043
  43. CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases. Hum Mutat. 2019 09; 40(9):1373-1391.
    View in: PubMed
    Score: 0.043
  44. Assessing predictions on fitness effects of missense variants in calmodulin. Hum Mutat. 2019 09; 40(9):1463-1473.
    View in: PubMed
    Score: 0.043
  45. Assessment of predicted enzymatic activity of a-N-acetylglucosaminidase variants of unknown significance for CAGI 2016. Hum Mutat. 2019 09; 40(9):1519-1529.
    View in: PubMed
    Score: 0.043
  46. Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants. Hum Mutat. 2019 09; 40(9):1546-1556.
    View in: PubMed
    Score: 0.043
  47. Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Hum Mutat. 2019 09; 40(9):1612-1622.
    View in: PubMed
    Score: 0.043
  48. Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5. Hum Mutat. 2019 09; 40(9):1474-1485.
    View in: PubMed
    Score: 0.043
  49. Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge. Hum Mutat. 2019 09; 40(9):1392-1399.
    View in: PubMed
    Score: 0.043
  50. Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge. Hum Mutat. 2019 09; 40(9):1330-1345.
    View in: PubMed
    Score: 0.043
  51. Assessment of methods for predicting the effects of PTEN and TPMT protein variants. Hum Mutat. 2019 09; 40(9):1495-1506.
    View in: PubMed
    Score: 0.043
  52. Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases. Ann Surg. 2019 05; 269(5):917-923.
    View in: PubMed
    Score: 0.042
  53. FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance. Mol Genet Metab. 2018 11; 125(3):281-291.
    View in: PubMed
    Score: 0.040
  54. Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H109-H121.
    View in: PubMed
    Score: 0.039
  55. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nat Med. 2018 05; 24(4):505-511.
    View in: PubMed
    Score: 0.039
  56. Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone. 2018 02; 107:161-171.
    View in: PubMed
    Score: 0.038
  57. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. Hum Mutat. 2017 09; 38(9):1042-1050.
    View in: PubMed
    Score: 0.037
  58. Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4. Hum Mutat. 2017 09; 38(9):1123-1131.
    View in: PubMed
    Score: 0.037
  59. Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling. Hum Mutat. 2017 05; 38(5):569-580.
    View in: PubMed
    Score: 0.036
  60. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 12 29; 128(26):3061-3072.
    View in: PubMed
    Score: 0.036
  61. Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. 2016 10; 240(2):224-34.
    View in: PubMed
    Score: 0.035
  62. Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. Neoplasia. 2015 Oct; 17(10):789-803.
    View in: PubMed
    Score: 0.033
  63. Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients. Cancer Res. 2015 Apr 01; 75(7):1205-15.
    View in: PubMed
    Score: 0.032
  64. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19.
    View in: PubMed
    Score: 0.031
  65. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88.
    View in: PubMed
    Score: 0.028
  66. Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. Am J Med Genet A. 2011 Jul; 155A(7):1597-604.
    View in: PubMed
    Score: 0.024
  67. Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations. Hum Mutat. 2011 Jun; 32(6):579-89.
    View in: PubMed
    Score: 0.024
  68. Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B. Arch Neurol. 2009 Aug; 66(8):1028-32.
    View in: PubMed
    Score: 0.022
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.