Header Logo

BETTY SLAGLE

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
vCardDownload vCard

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R21AI163439     (SLAGLE, BETTY L)Jul 15, 2021 - Jun 30, 2023
    NIH
    Small molecule inhibitors of HBx that decrease hepatitis B virus replication
    Role: Principal Investigator
    R21CA177951     (SLAGLE, BETTY L)Jul 1, 2013 - Jun 30, 2016
    NIH
    Hepatitis B virus replication and DDB1
    Role: Principal Investigator
    R01CA095388     (SLAGLE, BETTY L)Jul 1, 2003 - Jun 30, 2009
    NIH
    Hepatitis HBx-Mediated Pathogenesis
    Role: Principal Investigator
    R56CA095388     (SLAGLE, BETTY L)Jul 1, 2002 - Jun 30, 2011
    NIH
    Hepatitis HBx-Mediated Pathogenesis
    Role: Principal Investigator
    R13AI050045     (SLAGLE, BETTY L)Jul 1, 2001 - Jun 30, 2002
    NIH
    International Conference on Hepatitis B Viruses
    Role: Principal Investigator
    R01CA054557     (SLAGLE, BETTY L)Mar 15, 1991 - Mar 31, 2001
    NIH
    HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig KD. A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. JHEP Rep. 2021 Apr; 3(2):100252. PMID: 33733079; PMCID: PMC7940981.
      Citations: 1     
    2. Liang Y, Yu L, Zhang D, Zhao X, Gao H, Slagle BL, Goss JA, Wang X, Li K, Lin SY. BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K. Am J Cancer Res. 2020; 10(6):1900-1918. PMID: 32642299; PMCID: PMC7339272.
      Citations: 2     
    3. Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL. Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020 03 30; 9(4). PMID: 32235678; PMCID: PMC7226812.
      Citations: 9     Fields:    Translation:HumansCells
    4. Freitas N, Lukash T, Gunewardena S, Chappell B, Slagle BL, Gudima SO. Relative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus Carriers. J Virol. 2018 05 15; 92(10). PMID: 29491161; PMCID: PMC5923063.
      Citations: 9     Fields:    Translation:HumansCells
    5. Slagle BL, Bouchard MJ. Role of HBx in hepatitis B virus persistence and its therapeutic implications. Curr Opin Virol. 2018 06; 30:32-38. PMID: 29454995; PMCID: PMC5988931.
      Citations: 33     Fields:    Translation:HumansCells
    6. Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 03; 65(3):893-906. PMID: 28102638; PMCID: PMC5319891.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    7. Slagle BL, Bouchard MJ. Hepatitis B Virus X and Regulation of Viral Gene Expression. Cold Spring Harb Perspect Med. 2016 Jan 08; 6(3):a021402. PMID: 26747833; PMCID: PMC4772081.
      Citations: 49     Fields:    Translation:HumansCells
    8. Chung W, Kim M, de la Monte S, Longato L, Carlson R, Slagle BL, Dong X, Wands JR. Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett. 2016 Jan 01; 370(1):1-9. PMID: 26433160; PMCID: PMC4684747.
      Citations: 28     Fields:    Translation:AnimalsCells
    9. Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui A. Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. PMID: 25099228; PMCID: PMC4320676.
      Citations: 39     Fields:    Translation:HumansCells
    10. Minor MM, Slagle BL. Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system. Viruses. 2014 Nov 24; 6(11):4683-702. PMID: 25421893; PMCID: PMC4246244.
      Citations: 30     Fields:    Translation:HumansCells
    11. Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014 Dec; 46(12):1267-73. PMID: 25362482.
      Citations: 319     Fields:    Translation:HumansCells
    12. Luo N, Cai Y, Zhang J, Tang W, Slagle BL, Wu X, He S. The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes. Virus Res. 2012 May; 165(2):170-8. PMID: 22387566.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Hodgson AJ, Hyser JM, Keasler VV, Cang Y, Slagle BL. Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012 Apr 25; 426(1):73-82. PMID: 22342275; PMCID: PMC3294142.
      Citations: 36     Fields:    Translation:HumansCells
    14. Kumar M, Jung SY, Hodgson AJ, Madden CR, Qin J, Slagle BL. Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol. 2011 Jan; 85(2):987-95. PMID: 21068253; PMCID: PMC3020017.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    15. Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JR. Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology. 2009 Jun; 49(6):1935-43. PMID: 19475691; PMCID: PMC2754284.
      Citations: 30     Fields:    Translation:Animals
    16. Keasler VV, Hodgson AJ, Madden CR, Slagle BL. Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology. 2009 Jul 20; 390(1):122-9. PMID: 19464721; PMCID: PMC2749295.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Hodgson AJ, Keasler VV, Slagle BL. Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res. 2008 Dec 15; 68(24):10341-8. PMID: 19074903; PMCID: PMC2730779.
      Citations: 18     Fields:    Translation:AnimalsCells
    18. Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CE. Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 2008 Sep; 173(3):856-64. PMID: 18688024; PMCID: PMC2527078.
      Citations: 111     Fields:    Translation:HumansAnimals
    19. Keasler VV, Hodgson AJ, Madden CR, Slagle BL. Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol. 2007 Mar; 81(6):2656-62. PMID: 17182675; PMCID: PMC1865975.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    20. Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75. PMID: 16427673.
      Citations: 17     Fields:    Translation:AnimalsCells
    SLAGLE's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (117)
    Explore
    _
    Co-Authors (12)
    Explore
    _
    Similar People (58)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _