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Institute for Clinical and Translational Research

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Betty L. Slagle

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    R01CA054557     (SLAGLE, BETTY L)Mar 15, 1991 - Mar 31, 2001
    NIH/NCI
    HEPATITIS B VIRUS AND HEPATOCELLULAR CARCINOMA
    Role: Principal Investigator
    R13AI050045     (SLAGLE, BETTY L)Jul 1, 2001 - Jun 30, 2002
    NIH/NIAID
    International Conference on Hepatitis B Viruses
    Role: Principal Investigator
    R56CA095388     (SLAGLE, BETTY L)Jul 1, 2002 - Jun 30, 2011
    NIH/NCI
    Hepatitis HBx-Mediated Pathogenesis
    Role: Principal Investigator
    R01CA095388     (SLAGLE, BETTY L)Jul 1, 2003 - Jun 30, 2009
    NIH/NCI
    Hepatitis HBx-Mediated Pathogenesis
    Role: Principal Investigator
    R21CA177951     (SLAGLE, BETTY L)Jul 1, 2013 - Jun 30, 2015
    NIH/NCI
    Hepatitis B virus replication and DDB1
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freitas N, Lukash T, Gunewardena S, Chappell B, Slagle BL, Gudima SO. Relative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus Carriers. J Virol. 2018 05 15; 92(10). PMID: 29491161.
      View in: PubMed
    2. Slagle BL, Bouchard MJ. Role of HBx in hepatitis B virus persistence and its therapeutic implications. Curr Opin Virol. 2018 06; 30:32-38. PMID: 29454995.
      View in: PubMed
    3. Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 03; 65(3):893-906. PMID: 28102638.
      View in: PubMed
    4. Slagle BL, Bouchard MJ. Hepatitis B Virus X and Regulation of Viral Gene Expression. Cold Spring Harb Perspect Med. 2016 Jan 08; 6(3):a021402. PMID: 26747833.
      View in: PubMed
    5. Chung W, Kim M, de la Monte S, Longato L, Carlson R, Slagle BL, Dong X, Wands JR. Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett. 2016 Jan 01; 370(1):1-9. PMID: 26433160.
      View in: PubMed
    6. Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui A. Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. PMID: 25099228.
      View in: PubMed
    7. Minor MM, Slagle BL. Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system. Viruses. 2014 Nov 24; 6(11):4683-702. PMID: 25421893.
      View in: PubMed
    8. Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014 Dec; 46(12):1267-73. PMID: 25362482.
      View in: PubMed
    9. Luo N, Cai Y, Zhang J, Tang W, Slagle BL, Wu X, He S. The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes. Virus Res. 2012 May; 165(2):170-8. PMID: 22387566.
      View in: PubMed
    10. Hodgson AJ, Hyser JM, Keasler VV, Cang Y, Slagle BL. Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012 Apr 25; 426(1):73-82. PMID: 22342275.
      View in: PubMed
    11. Kumar M, Jung SY, Hodgson AJ, Madden CR, Qin J, Slagle BL. Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol. 2011 Jan; 85(2):987-95. PMID: 21068253.
      View in: PubMed
    12. Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JR. Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology. 2009 Jun; 49(6):1935-43. PMID: 19475691.
      View in: PubMed
    13. Keasler VV, Hodgson AJ, Madden CR, Slagle BL. Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology. 2009 Jul 20; 390(1):122-9. PMID: 19464721.
      View in: PubMed
    14. Hodgson AJ, Keasler VV, Slagle BL. Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res. 2008 Dec 15; 68(24):10341-8. PMID: 19074903.
      View in: PubMed
    15. Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CE. Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 2008 Sep; 173(3):856-64. PMID: 18688024.
      View in: PubMed
    16. Keasler VV, Hodgson AJ, Madden CR, Slagle BL. Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol. 2007 Mar; 81(6):2656-62. PMID: 17182675.
      View in: PubMed
    17. Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75. PMID: 16427673.
      View in: PubMed
    18. Madden CR, Finegold MJ, Slagle BL. Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J Virol. 2002 Nov; 76(22):11770-4. PMID: 12388740.
      View in: PubMed
    19. Xu Z, Yen TS, Wu L, Madden CR, Tan W, Slagle BL, Ou JH. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol. 2002 Mar; 76(5):2579-84. PMID: 11836439.
      View in: PubMed
    20. Nag A, Datta A, Yoo K, Bhattacharyya D, Chakrabortty A, Wang X, Slagle BL, Costa RH, Raychaudhuri P. DDB2 induces nuclear accumulation of the hepatitis B virus X protein independently of binding to DDB1. J Virol. 2001 Nov; 75(21):10383-92. PMID: 11581406.
      View in: PubMed
    21. Madden CR, Finegold MJ, Slagle BL. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol. 2001 Apr; 75(8):3851-8. PMID: 11264374.
      View in: PubMed
    22. Jaitovich-Groisman I, Benlimame N, Slagle BL, Perez MH, Alpert L, Song DJ, Fotouhi-Ardakani N, Galipeau J, Alaoui-Jamali MA. Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. J Biol Chem. 2001 Apr 27; 276(17):14124-32. PMID: 11278765.
      View in: PubMed
    23. Madden CR, Slagle BL. Stimulation of cellular proliferation by hepatitis B virus X protein. Dis Markers. 2001; 17(3):153-7. PMID: 11790880.
      View in: PubMed
    24. Wentz MJ, Becker SA, Slagle BL. Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein. Virus Res. 2000 Jun; 68(1):87-92. PMID: 10930665.
      View in: PubMed
    25. Madden CR, Finegold MJ, Slagle BL. Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice. J Virol. 2000 Jun; 74(11):5266-72. PMID: 10799603.
      View in: PubMed
    26. Shiyanov P, Hayes SA, Donepudi M, Nichols AF, Linn S, Slagle BL, Raychaudhuri P. The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. Mol Cell Biol. 1999 Jul; 19(7):4935-43. PMID: 10373543.
      View in: PubMed
    27. Chomarat P, Rice JM, Slagle BL, Wild CP. Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein. Toxicol Lett. 1998 Dec 28; 102-103:595-601. PMID: 10022319.
      View in: PubMed
    28. Slagle BL, Kaufman RH, Reeves WC, Icenogle JP. Expression of ras, c-myc, and p53 proteins in cervical intraepithelial neoplasia. Cancer. 1998 Oct 01; 83(7):1401-8. PMID: 9762942.
      View in: PubMed
    29. Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol. 1998 Jan; 72(1):266-72. PMID: 9420223.
      View in: PubMed
    30. Becker SA, Zhou YZ, Slagle BL. Frequent loss of chromosome 8p in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res. 1996 Nov 01; 56(21):5092-7. PMID: 8895769.
      View in: PubMed
    31. Marriott SJ, Lee TH, Slagle BL, Butel JS. Activation of the HTLV-I long terminal repeat by the hepatitis B virus X protein. Virology. 1996 Oct 01; 224(1):206-13. PMID: 8862415.
      View in: PubMed
    32. Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog. 1996 Apr; 15(4):261-9. PMID: 8634084.
      View in: PubMed
    33. Butel JS, Lee TH, Slagle BL. Is the DNA repair system involved in hepatitis-B-virus-mediated hepatocellular carcinogenesis? Trends Microbiol. 1996 Mar; 4(3):119-24. PMID: 8868091.
      View in: PubMed
    34. Khaoustov VI, Ozer A, Smith JR, Noda A, Mearns M, Krishnan B, Slagle BL, Yoffe B. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin. Lab Invest. 1995 Jul; 73(1):118-27. PMID: 7603034.
      View in: PubMed
    35. Slagle BL. p53 mutations and hepatitis B virus: cofactors in hepatocellular carcinoma. Hepatology. 1995 Feb; 21(2):597-9. PMID: 7843736.
      View in: PubMed
    36. Butel JS, Lee TH, Slagle BL. Viral co-factors in liver cancer: lessons from hepatitis B virus. Princess Takamatsu Symp. 1995; 25:185-98. PMID: 8875624.
      View in: PubMed
    37. Hsu HC, Peng SY, Lai PL, Sheu JC, Chen DS, Lin LI, Slagle BL, Butel JS. Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients. Cancer. 1994 Jan 01; 73(1):42-7. PMID: 7506118.
      View in: PubMed
    38. Slagle BL, Zhou YZ, Birchmeier W, Scorsone KA. Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology. 1993 Oct; 18(4):757-62. PMID: 8104855.
      View in: PubMed
    39. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992 Mar 19; 356(6366):215-21. PMID: 1552940.
      View in: PubMed
    40. Scorsone KA, Zhou YZ, Butel JS, Slagle BL. p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res. 1992 Mar 15; 52(6):1635-8. PMID: 1311638.
      View in: PubMed
    41. Slagle BL, Lee TH, Butel JS. Hepatitis B virus and hepatocellular carcinoma. Prog Med Virol. 1992; 39:167-203. PMID: 1317597.
      View in: PubMed
    42. Slagle BL, Zhou YZ, Butel JS. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. Cancer Res. 1991 Jan 01; 51(1):49-54. PMID: 1670994.
      View in: PubMed
    43. Sepulveda AR, Finegold MJ, Smith B, Slagle BL, DeMayo JL, Shen RF, Woo SL, Butel JS. Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene. Cancer Res. 1989 Nov 01; 49(21):6108-17. PMID: 2551499.
      View in: PubMed
    44. Donehower LA, Slagle BL, Wilde M, Darlington G, Butel JS. Identification of a conserved sequence in the non-coding regions of many human genes. Nucleic Acids Res. 1989 Jan 25; 17(2):699-710. PMID: 2536922.
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    45. Nath A, Slagle B, Wolinsky JS. Anti-idiotypic antibodies to rubella virus. Arch Virol. 1989; 107(1-2):159-67. PMID: 2803003.
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    46. Zhou YZ, Slagle BL, Donehower LA, vanTuinen P, Ledbetter DH, Butel JS. Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma. J Virol. 1988 Nov; 62(11):4224-31. PMID: 2845134.
      View in: PubMed
    47. Slagle BL, Medina D, Butel JS. Mammary cancer stages in BALB/cV mice: mouse mammary tumor virus expression and virus-host interactions. J Natl Cancer Inst. 1987 Aug; 79(2):323-35. PMID: 3037152.
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    48. Slagle BL, Wheeler DA, Hager GL, Medina D, Butel JS. Molecular basis of altered mouse mammary tumor virus expression in the D-2 hyperplastic alveolar nodule line of BALB/c mice. Virology. 1985 May; 143(1):1-15. PMID: 2414907.
      View in: PubMed
    49. Slagle BL, Butel JS. Identification and characterization of a mouse mammary tumor virus protein uniquely expressed on the surface of BALB/cV mammary tumor cells. Virology. 1985 May; 143(1):127-42. PMID: 2997998.
      View in: PubMed
    50. Slagle BL, Lanford RE, Medina D, Butel JS. Expression of mammary tumor virus proteins in preneoplastic outgrowth lines and mammary tumors of BALB/cV mice. Cancer Res. 1984 May; 44(5):2155-62. PMID: 6324998.
      View in: PubMed
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