TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine

    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience

    InstitutionBaylor College of Medicine
    DepartmentDepartment of Obstetrics & Gynecology
    DivisionObstetrics and Gynecology

    Collapse Research 
    Collapse research activities and funding
    R41CA217561     (LONARD, DAVID M)Sep 1, 2018 - Aug 31, 2019
    Small molecule Inhibitors of steroid receptor coactivator to treat breast cancer
    Role: Co-Principal Investigator

    P01DK113954     (O'MALLEY, BERT W)Jul 1, 2018 - Jun 30, 2023
    Nuclear receptors and their Coactivators as Mediators of Systems Metabolism
    Role: Principal Investigator

    R01HD082786     (O'MALLEY, BERT W)Apr 14, 2014 - Mar 31, 2020
    The ERbeta/SRC-1 isoform complex drives endometriosis progression
    Role: Principal Investigator

    U01HD082786     (O'MALLEY, BERT W)Apr 14, 2014 - Mar 31, 2019
    The ERbeta/SRC-1 isoform complex drives endometriosis progression
    Role: Principal Investigator

    R01ES023206     (WALKER, CHERYL L)Sep 1, 2013 - May 31, 2018
    Epigenetic Programmers Targeted During Developmental Reprogramming
    Role: Co-Principal Investigator

    U24DK097748     (O'MALLEY, BERT W)Sep 17, 2012 - Aug 31, 2019
    A Hub for the Nuclear Receptor Signaling Atlas1
    Role: Principal Investigator

    U19DK062434     (O'MALLEY, BERT W)Aug 15, 2002 - Jul 31, 2012
    Nuclear Receptors and Coregulators in Health and Disease
    Role: Principal Investigator

    P01DK059820     (O'MALLEY, BERT W)Jul 1, 2001 - Jun 30, 2018
    Genetic and Metabolic Fingerprints of Coativators Program Project
    Role: Principal Investigator

    R01DK048896     (O'MALLEY, BERT W)Sep 30, 1994 - Aug 31, 1999
    Role: Principal Investigator

    T32HD007165     (O'MALLEY, BERT W)Jul 1, 1979 - Apr 30, 2017
    Reproductive Biology: Regulatory Mechanisms
    Role: Principal Investigator

    U54HD007495     (DEMAYO, FRANCESCO JOHN)Jun 1, 1978 - Mar 31, 2015
    Center for Reproductive Biological Research
    Role: Co-Principal Investigator

    P30HD007495     (O'MALLEY, BERT W)Jun 1, 1978 - Mar 31, 1998
    Role: Principal Investigator

    R01HD007857     (O'MALLEY, BERT W)May 1, 1977 - Feb 28, 2022
    Sex Hormone Receptor Components and the Cell Genome
    Role: Principal Investigator

    R01HD008188     (O'MALLEY, BERT W)Sep 1, 1974 - Mar 31, 2024
    Reproductive Hormones - Biological and Molecular Actions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O'Malley BW, Yi P. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2218229120. PMID: 37155905; PMCID: PMC10193960.
    2. Han SJ, Jain P, Gilad Y, Xia Y, Sung N, Park MJ, Dean AM, Lanz RB, Xu J, Dacso CC, Lonard DM, O'Malley BW. Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion. bioRxiv. 2023 Mar 29. PMID: 37034717; PMCID: PMC10081245.
    3. Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. Res Sq. 2023 Mar 10. PMID: 36945511; PMCID: PMC10029087.
    4. Panigrahi AK, Lonard DM, O'Malley BW. Enhancer-promoter entanglement explains their transcriptional interdependence. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2216436120. PMID: 36656865; PMCID: PMC9942820.
      Citations:    Fields:    Translation:HumansCells
    5. Miranda SP, Blue R, Parasher AK, Lerner DK, Glicksman JT, Detchou D, Dimentberg R, Thurlow J, Lebold D, Hudgins J, Ebesutani D, Lee JYK, Storm PB, O'Malley BW, Palmer JN, Yoshor D, Adappa ND, Grady MS. Implementation of a Streamlined Care Pathway to Reduce Cost and Length of Stay for Patients Undergoing Endoscopic Transsphenoidal Pituitary Surgery. World Neurosurg. 2023 Apr; 172:e357-e363. PMID: 36640831.
      Citations:    Fields:    Translation:Humans
    6. Gilad Y, Lonard DM, O'Malley BW. Steroid receptor coactivators - their role in immunity. Front Immunol. 2022; 13:1079011. PMID: 36582250; PMCID: PMC9793089.
      Citations:    Fields:    
    7. McClendon LK, Garcia RL, Lazaro T, Robledo A, Vasandani V, Luna ZAE, Rao AS, Srivatsan A, Lonard DM, Dacso CC, Kan P, O'Malley BW. A steroid receptor coactivator small molecule "stimulator" attenuates post-stroke ischemic brain injury. Front Mol Neurosci. 2022; 15:1055295. PMID: 36533127; PMCID: PMC9751323.
      Citations: 1     
    8. Maurya VK, Szwarc MM, Lonard DM, Gibbons WE, Wu SP, O'Malley BW, DeMayo FJ, Lydon JP. Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3. Front Reprod Health. 2022; 4:1033581. PMID: 36505394; PMCID: PMC9730893.
    9. Park Y, Cho YJ, Sung N, Park MJ, Guan X, Gibbons WE, O'Malley BW, Han SJ. Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis. J Biomed Sci. 2022 Nov 22; 29(1):100. PMID: 36419064; PMCID: PMC9682776.
    10. Han SJ, Sung N, Wang J, O'Malley BW, Lonard DM. Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 10 31; 24(1):73. PMID: 36316775; PMCID: PMC9620627.
    11. Generotti C, Cox BC, Singh J, Hamilton D, McKenzie E, O'Malley BW, Li D. Subclinical diagnosis of cisplatin-induced ototoxicity with biomarkers. Sci Rep. 2022 Oct 27; 12(1):18032. PMID: 36302835; PMCID: PMC9613680.
    12. Yu X, Yi P, Panigrahi AK, Lumahan LEV, Lydon JP, Lonard DM, Lutdke SJ, Wang Z, O'Malley BW. Spatial definition of the human progesterone receptor-B transcriptional complex. iScience. 2022 Nov 18; 25(11):105321. PMID: 36325049; PMCID: PMC9618773.
    13. Tu J, Zhang H, Yang T, Liu Y, Kibreab S, Zhang Y, Gao L, Moses RE, O'Malley BW, Xiao J, Li X. Aging-associated REG? proteasome decline predisposes to tauopathy. J Biol Chem. 2022 11; 298(11):102571. PMID: 36209822; PMCID: PMC9647549.
    14. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. Reply to: Target expression is a relevant factor in synthetic lethal screens. Commun Biol. 2022 08 19; 5(1):836. PMID: 35986082; PMCID: PMC9391391.
    15. Yver CM, Chao TN, Thaler ER, Ruckenstein MJ, Chalian AA, Weinstein GS, O'Malley BW, Cannady SB. Financial impact of the COVID-19 pandemic on an academic otolaryngology department. World J Otorhinolaryngol Head Neck Surg. 2022 Jul 21. PMID: 35942327; PMCID: PMC9349602.
    16. Anagnos VJ, Brody RM, Carey RM, De Ravin E, Tasche KK, Newman JG, Shanti RM, Chalian AA, Rassekh CH, Weinstein GS, O'Malley BW, Cannady Md SB. Post-operative Monitoring for Head and Neck Microvascular Reconstruction in the Era of Resident Duty Hour Restrictions: A Retrospective Cohort Study Comparing 2 Monitoring Protocols. Ann Otol Rhinol Laryngol. 2023 Mar; 132(3):310-316. PMID: 35473389.
      Citations:    Fields:    
    17. Meng H, Gonzales NM, Jung SY, Lu Y, Putluri N, Zhu B, Dacso CC, Lonard DM, O'Malley BW. Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Rep. 2022 03 08; 38(10):110491. PMID: 35263593; PMCID: PMC8958721.
      Citations:    Fields:    Translation:Animals
    18. Brody RM, Shimunov D, Cohen RB, Lin A, Lukens JN, Hartner L, Aggarwal C, Duvvuri U, Montone KT, Jalaly JB, LiVolsi VA, Carey RM, Shanti RM, Rajasekaran K, Chalian AA, Rassekh CH, Cannady SB, Newman JG, O'Malley BW, Weinstein GS, Gimotty PA, Basu D. A benchmark for oncologic outcomes and model for lethal recurrence risk after transoral robotic resection of HPV-related oropharyngeal cancers. Oral Oncol. 2022 04; 127:105798. PMID: 35245888; PMCID: PMC9288202.
      Citations:    Fields:    Translation:Humans
    19. Yi P, Yu X, Wang Z, O'Malley BW. Steroid receptor-coregulator transcriptional complexes: new insights from CryoEM. Essays Biochem. 2021 12 17; 65(6):857-866. PMID: 34061186; PMCID: PMC8845409.
      Citations: 1     Fields:    Translation:Cells
    20. Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Rep. 2021 12 07; 37(10):110075. PMID: 34879284; PMCID: PMC8715676.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Della-Flora Nunes G, Wilson ER, Hurley E, He B, O'Malley BW, Poitelon Y, Wrabetz L, Feltri ML. Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination. Elife. 2021 09 14; 10. PMID: 34519641; PMCID: PMC8478418.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Tong CCL, Koptyra M, Raman P, Rathi KS, Choudhari N, Lin X, Seckar T, Wei Z, Kohanski MA, O'Malley BW, Cohen NA, Kennedy DW, Adappa ND, Robertson ES, Baranov E, Kuan EC, Papagiannopoulos P, Jalaly JB, Feldman MD, Storm PB, Resnick AC, Palmer JN. Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma. Int Forum Allergy Rhinol. 2022 02; 12(2):200-209. PMID: 34510780.
      Citations:    Fields:    Translation:Humans
    23. Qin L, Chen J, Lu D, Jain P, Yu Y, Cardenas D, Peng X, Yu X, Xu J, Wang J, O'Malley BW, Lonard DM. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670. PMID: 34310341; PMCID: PMC8404148.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Parhar HS, Weinstein GS, O'Malley BW, Shimunov D, Rassekh CH, Chalian AA, Newman JG, Basu D, Cannady SB, Rajasekaran K, Lin A, Lukens JN, Swisher-McClure S, Cohen RB, Bauml JM, Aggrawal C, Brody RM. Oncologic outcomes of transoral robotic surgery for HPV-negative oropharyngeal carcinomas. Head Neck. 2021 10; 43(10):2923-2934. PMID: 34101290.
      Citations:    Fields:    Translation:Humans
    25. Carey RM, Brody RM, Shimunov D, Shinn JR, Mady LJ, Rajasekaran K, Cannady SB, Lin A, Lukens JN, Bauml JM, Cohen RB, Basu D, O'Malley BW, Weinstein GS, Newman JG. Locoregional Recurrence in p16-Positive Oropharyngeal Squamous Cell Carcinoma After TORS. Laryngoscope. 2021 12; 131(12):E2865-E2873. PMID: 34076275.
      Citations:    Fields:    Translation:HumansCells
    26. Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O'Malley BW, Beirowski B, Poitelon Y, Wrabetz L, Feltri ML. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021 06 02; 12(1):3285. PMID: 34078899; PMCID: PMC8172551.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Ding Y, Liu Y, Lee DK, Tong Z, Yu X, Li Y, Xu Y, Lanz RB, O'Malley BW, Xu J. Cell lineage tracing links ERa loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). PMID: 34006643; PMCID: PMC8166171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Yu W, Singh R, Wang Z, O'Malley BW, Yi P. The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1. J Biol Chem. 2021 Jan-Jun; 296:100739. PMID: 33991522; PMCID: PMC8191236.
      Citations: 2     Fields:    Translation:HumansCells
    29. Yver CM, Shimunov D, Weinstein GS, Rajasekaran K, Cannady SB, Lukens JN, Lin A, Swisher-McClure S, Cohen RB, Aggarwal C, Bauml JM, Loevner LA, Newman JG, Chalian AA, Rassekh CH, Basu D, O'Malley BW, Brody RM. Oncologic and survival outcomes for resectable locally-advanced HPV-related oropharyngeal cancer treated with transoral robotic surgery. Oral Oncol. 2021 07; 118:105307. PMID: 33932874.
      Citations:    Fields:    Translation:HumansCells
    30. Rajasekaran K, Carey RM, Lin X, Seckar TD, Wei Z, Chorath K, Newman JG, O'Malley BW, Weinstein GS, Feldman MD, Robertson E. The microbiome of HPV-positive tonsil squamous cell carcinoma and neck metastasis. Oral Oncol. 2021 06; 117:105305. PMID: 33905914.
      Citations: 4     Fields:    Translation:HumansCells
    31. Panigrahi A, O'Malley BW. Mechanisms of enhancer action: the known and the unknown. Genome Biol. 2021 04 15; 22(1):108. PMID: 33858480; PMCID: PMC8051032.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    32. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399. PMID: 33767353; PMCID: PMC7994904.
      Citations:    Translation:HumansCells
    33. Rhoades D, Rheingold AL, O'Malley BW, Wang J. Expedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators. J Am Chem Soc. 2021 04 07; 143(13):4915-4920. PMID: 33755462.
      Citations: 1     Fields:    Translation:Cells
    34. Bankoti K, Generotti C, Hwa T, Wang L, O'Malley BW, Li D. Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:209-236. PMID: 33850952; PMCID: PMC8010215.
      Citations: 1     
    35. Mullany LK, Lonard DM, O'Malley BW. Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3). PMID: 33340403; PMCID: PMC7814297.
      Citations:    Fields:    Translation:HumansAnimalsCells
    36. Liu J, Xie Y, Guo J, Li X, Wang J, Jiang H, Peng Z, Wang J, Wang S, Li Q, Ye L, Zhong Y, Zhang Q, Liu X, Lonard DM, Wang J, O'Malley BW, Liu Z. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022. PMID: 33589584; PMCID: PMC7884723.
      Citations: 8     Fields:    Translation:HumansCells
    37. Nikolai BC, Jain P, Cardenas DL, York B, Feng Q, McKenna NJ, Dasgupta S, Lonard DM, O'Malley BW. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441. PMID: 33564037; PMCID: PMC7873281.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    38. Gilad Y, Gellerman G, Lonard DM, O'Malley BW. Drug Combination in Cancer Treatment-From Cocktails to Conjugated Combinations. Cancers (Basel). 2021 Feb 07; 13(4). PMID: 33562300; PMCID: PMC7915944.
      Citations: 4     
    39. Rohira AD, Lonard DM, O'Malley BW. Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50. PMID: 33337343; PMCID: PMC7925431.
      Citations:    Fields:    Translation:HumansAnimalsCells
    40. Carey RM, Shimunov D, Weinstein GS, Cannady SB, Lukens JN, Lin A, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Newman JG, Chalian AA, Rassekh CH, Basu D, O'Malley BW, Rajasekaran K, Brody RM. Increased rate of recurrence and high rate of salvage in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma with adverse features treated with primary surgery without recommended adjuvant therapy. Head Neck. 2021 04; 43(4):1128-1141. PMID: 33325579.
      Citations: 2     Fields:    Translation:HumansCells
    41. Meng H, Gonzales NM, Lonard DM, Putluri N, Zhu B, Dacso CC, York B, O'Malley BW. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215. PMID: 33277471; PMCID: PMC7718229.
      Citations: 9     Fields:    Translation:HumansAnimals
    42. Mullany LK, Rohira AD, Leach JP, Kim JH, Monroe TO, Ortiz AR, Stork B, Gaber MW, Sarkar P, Sikora AG, Rosengart TK, York B, Song Y, Dacso CC, Lonard DM, Martin JF, O'Malley BW. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31353-31364. PMID: 33229578; PMCID: PMC7733826.
      Citations: 5     Fields:    Translation:AnimalsCells
    43. Parhar HS, Shimunov D, Brody RM, Cannady SB, Newman JG, O'Malley BW, Chalian AA, Rassekh CH, Weinstein GS, Rajasekaran K. Revisiting the Recommendation for Contralateral Tonsillectomy in HPV-Associated Tonsillar Carcinoma. Otolaryngol Head Neck Surg. 2021 06; 164(6):1222-1229. PMID: 33138700.
      Citations:    Fields:    Translation:Humans
    44. Sawant Dessai A, Dominguez MP, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, Dasgupta S. Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 01 01; 81(1):50-63. PMID: 33115805; PMCID: PMC7878313.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Parasher AK, Lerner DK, Glicksman JT, Miranda SP, Dimentberg R, Ebesutani D, Kohanski M, Lee JYK, Storm PB, O'Malley BW, Palmer JN, Grady MS, Adappa ND. Drivers of In-Hospital Costs Following Endoscopic Transphenoidal Pituitary Surgery. Laryngoscope. 2021 04; 131(4):760-764. PMID: 32830866.
      Citations: 2     Fields:    Translation:Humans
    46. Reny DC, Ranasinghe VJ, Magana LC, Kaufman AC, Chalian AA, O'Malley BW, Weinstein GS, Brody RM. Predictors of Nodal Metastasis in Mucoepidermoid Carcinoma of the Oral Cavity and Oropharynx. ORL J Otorhinolaryngol Relat Spec. 2020; 82(6):327-334. PMID: 32810854.
      Citations: 1     Fields:    Translation:Humans
    47. Yu X, Yi P, Hamilton RA, Shen H, Chen M, Foulds CE, Mancini MA, Ludtke SJ, Wang Z, O'Malley BW. Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. Mol Cell. 2020 09 03; 79(5):812-823.e4. PMID: 32668201; PMCID: PMC7483370.
      Citations: 23     Fields:    Translation:HumansCells
    48. Parhar HS, Brody RM, Shimunov D, Rajasekaran K, Rassekh CH, Basu D, O'Malley BW, Chalian AA, Newman JG, Loevner L, Lazor JW, Weinstein GS, Cannady SB. Retropharyngeal Internal Carotid Artery Management in TORS Using Microvascular Reconstruction. Laryngoscope. 2021 03; 131(3):E821-E827. PMID: 32621638.
      Citations: 2     Fields:    Translation:Humans
    49. O'Malley BW. 90 YEARS OF PROGESTERONE: Reminiscing on the origins of the field of progesterone and estrogen receptor action. J Mol Endocrinol. 2020 07; 65(1):C1-C4. PMID: 32599564.
      Citations: 4     Fields:    Translation:HumansAnimals
    50. Ali S, Balachandran K, O'Malley B. 90 Years of progesterone: Ninety years of progesterone: the 'other' ovarian hormone. J Mol Endocrinol. 2020 07; 65(1):E1-E4. PMID: 32580155; PMCID: PMC7354701.
      Citations: 1     Fields:    Translation:Humans
    51. Weinstein GS, Cohen R, Lin A, O'Malley BW, Lukens J, Swisher-McClure S, Shanti RM, Newman JG, Parhar HS, Tasche K, Brody RM, Chalian A, Cannady S, Palmer JN, Adappa ND, Kohanski MA, Bauml J, Aggarwal C, Montone K, Livolsi V, Baloch ZW, Jalaly JB, Cooper K, Rajasekaran K, Loevner L, Rassekh C. Penn Medicine Head and Neck Cancer Service Line COVID-19 management guidelines. Head Neck. 2020 Jul; 42(7):1507-1515. PMID: 32584447; PMCID: PMC7362039.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    52. Shanti RM, Stoopler ET, Weinstein GS, Newman JG, Cannady SB, Rajasekaran K, Tanaka TI, O'Malley BW, Le AD, Sollecito TP. Considerations in the evaluation and management of oral potentially malignant disorders during the COVID-19 pandemic. Head Neck. 2020 Jul; 42(7):1497-1502. PMID: 32415891; PMCID: PMC7276902.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    53. O'Malley BW. SRC-2 Coactivator: a role in human metabolic evolution and disease. Mol Med. 2020 05 14; 26(1):45. PMID: 32410572; PMCID: PMC7227291.
      Citations: 2     Fields:    Translation:Humans
    54. Parhar HS, Tasche K, Brody RM, Weinstein GS, O'Malley BW, Shanti RM, Newman JG. Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery. Head Neck. 2020 06; 42(6):1268-1272. PMID: 32333619; PMCID: PMC7267296.
      Citations: 32     Fields:    Translation:HumansCellsPHPublic Health
    55. Rassekh CH, Jenks CM, Ochroch EA, Douglas JE, O'Malley BW, Weinstein GS. Management of the difficult airway in the COVID-19 pandemic: Illustrative complex head and neck cancer scenario. Head Neck. 2020 06; 42(6):1273-1277. PMID: 32298017; PMCID: PMC7262249.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    56. Lee WK, Kim WG, Fozzatti L, Park S, Zhao L, Willingham MC, Lonard D, O'Malley BW, Cheng SY. Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220. PMID: 31977311; PMCID: PMC7326649.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    57. Gilad Y, Eliaz Y, Yu Y, Han SJ, O'Malley BW, Lonard DM. Author Correction: Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2020 Mar 05; 10(1):4463. PMID: 32132607; PMCID: PMC7056712.
      Citations: 2     Fields:    
    58. Shah RR, Maina IW, Patel NN, Triantafillou V, Workman AD, Kuan EC, Tong CCL, Kohanski MA, O'Malley BW, Adappa ND, Palmer JN. Incidence, risk factors, and outcomes of endoscopic sinus surgery after endoscopic skull-base surgery. Int Forum Allergy Rhinol. 2020 04; 10(4):521-525. PMID: 32104979.
      Citations:    Fields:    Translation:Humans
    59. Chao TN, Kuan EC, Tong CCL, Kohanski MA, Grady MS, Palmer JN, Adappa ND, O'Malley BW. Surgical Treatment of Sinonasal Mucosal Melanoma in Patients Treated with Systemic Immunotherapy. J Neurol Surg B Skull Base. 2021 Jul; 82(Suppl 3):e148-e154. PMID: 34306930; PMCID: PMC8289530.
    60. Carey RM, Rajasekaran K, Seckar T, Lin X, Wei Z, Tong CCL, Ranasinghe VJ, Newman JG, O'Malley BW, Weinstein GS, Feldman MD, Robertson ES. The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis. Oncotarget. 2020 Jan 21; 11(3):282-293. PMID: 32076488; PMCID: PMC6980631.
      Citations: 2     Fields:    
    61. Pan Y, Ballance H, Meng H, Gonzalez N, Kim SM, Abdurehman L, York B, Chen X, Schnytzer Y, Levy O, Dacso CC, McClung CA, O'Malley BW, Liu S, Zhu B. 12-h clock regulation of genetic information flow by XBP1s. PLoS Biol. 2020 01; 18(1):e3000580. PMID: 31935211; PMCID: PMC6959563.
      Citations: 13     Fields:    Translation:AnimalsCells
    62. Shen B, Huang D, Ramsey AJ, Ig-Izevbekhai K, Zhang K, Lajud SA, O'Malley BW, Li D. PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinoma. Br J Cancer. 2020 03; 122(5):640-647. PMID: 31853007; PMCID: PMC7054324.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    63. Fu X, Pereira R, De Angelis C, Veeraraghavan J, Nanda S, Qin L, Cataldo ML, Sethunath V, Mehravaran S, Gutierrez C, Chamness GC, Feng Q, O'Malley BW, Selenica P, Weigelt B, Reis-Filho JS, Cohen O, Wagle N, Nardone A, Jeselsohn R, Brown M, Rimawi MF, Osborne CK, Schiff R. FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26823-26834. PMID: 31826955; PMCID: PMC6936436.
      Citations: 34     Fields:    
    64. Han SJ, Lee JE, Cho YJ, Park MJ, O'Malley BW. Genomic Function of Estrogen Receptor ? in Endometriosis. Endocrinology. 2019 11 01; 160(11):2495-2516. PMID: 31504401; PMCID: PMC6773435.
      Citations: 12     Fields:    Translation:HumansAnimals
    65. Gilad Y, Eliaz Y, Yu Y, Han SJ, O'Malley BW, Lonard DM. Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2019 10 22; 9(1):15099. PMID: 31641154; PMCID: PMC6805932.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    66. Gershowitz J, Chao HH, Doucette A, Lukens JN, Swisher-McClure S, Weinstein GS, O'Malley BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A. Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. Br J Radiol. 2019 Dec; 92(1104):20190466. PMID: 31600090; PMCID: PMC6913358.
      Citations:    Fields:    Translation:HumansCells
    67. Fathy R, Kuan E, Lee JYK, Grady MS, Alonso-Basanta M, Palmer JN, Adappa ND, O'Malley BW, Brant J. Factors Associated with and Temporal Trends in the Use of Radiation Therapy for the Treatment of Pituitary Adenoma in the National Cancer Database. J Neurol Surg B Skull Base. 2021 Jun; 82(3):285-294. PMID: 34026404; PMCID: PMC8133815.
      Citations: 2     
    68. Chao HH, Schonewolf CA, Tan EX, Swisher-McClure S, Ghiam AF, Weinstein GS, O'Malley BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A, Lukens JN. The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation. Head Neck. 2019 11; 41(11):3858-3868. PMID: 31411356.
      Citations: 1     Fields:    Translation:Humans
    69. Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K Consortium, O'Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 04 12; 10(1):1718. PMID: 30979869; PMCID: PMC6461669.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    70. Henry LE, Haugen TW, Rassekh CH, Adappa ND, Weinstein GS, O'Malley BW. A novel transpalatal-transoral robotic surgery approach to clival chordomas extending into the nasopharynx. Head Neck. 2019 08; 41(8):E133-E140. PMID: 30969009.
      Citations: 4     Fields:    Translation:Humans
    71. Gomez ED, Thaler ER, O'Malley BW, Rassekh CH, Weinstein GS, Newman JG, Brody RM. Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral robotic surgery (TORS). J Robot Surg. 2019 Aug; 13(4):581-584. PMID: 30945096.
      Citations: 1     Fields:    Translation:Humans
    72. Petrov D, Spadola M, Berger C, Glauser G, Mahmoud AF, O'Malley B, Malhotra NR. Novel approach using ultrasonic bone curettage and transoral robotic surgery for en bloc resection of cervical spine chordoma: case report. J Neurosurg Spine. 2019 Mar 01; 1-6. PMID: 30835711.
      Citations: 1     Fields:    
    73. Kumar R, Murad F, Bogler O, O'Malley BW, Hortobagyi GN. John Mendelsohn: A visionary scientist, oncologist and leader. Genes Cancer. 2019; 10(5-6):109-118. PMID: 31798764; PMCID: PMC6872667.
      Citations: 1     
    74. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85. PMID: 31198906; PMCID: PMC6563330.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    75. Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang J. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319. PMID: 30423406; PMCID: PMC6311429.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    76. Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O'Malley BW, Lydon JP. Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics Reproduction. 2018 10 16; 156(5):387-395. PMID: 30325183; PMCID: PMC6208442.
      Citations: 7     Fields:    Translation:HumansCells
    77. Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT, Trevi?o LS. CARM1 methylates MED12 to regulate its RNA-binding ability. Life Sci Alliance. 2018 Oct; 1(5):e201800117. PMID: 30456381; PMCID: PMC6238599.
      Citations: 19     Fields:    
    78. Antoulas AC, Zhu B, Zhang Q, York B, O'Malley BW, Dacso CC. A novel mathematical method for disclosing oscillations in gene transcription: A comparative study. PLoS One. 2018; 13(9):e0198503. PMID: 30231032; PMCID: PMC6145530.
      Citations: 7     Fields:    Translation:AnimalsCells
    79. Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW. Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 09 03; 8(1):13134. PMID: 30177747; PMCID: PMC6120906.
      Citations: 1     Fields:    Translation:HumansCells
    80. Workman AD, Brody RM, Kuan EC, Baranov E, Brooks SG, Alonso-Basanta M, Newman JG, Rassekh CH, Chalian AA, Chiu AG, Weinstein GS, Feldman MD, Adappa ND, O'Malley BW, Palmer JN. Sinonasal Undifferentiated Carcinoma: A 15-Year Single Institution Experience. J Neurol Surg B Skull Base. 2019 Feb; 80(1):88-95. PMID: 30733906; PMCID: PMC6365239.
    81. Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018 07 02; 128(7):3129-3143. PMID: 29715200; PMCID: PMC6026011.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    82. Zhu B, Dacso CC, O'Malley BW. Unveiling "Musica Universalis" of the Cell: A Brief History of Biological 12-Hour Rhythms. J Endocr Soc. 2018 Jul 01; 2(7):727-752. PMID: 29978151; PMCID: PMC6025213.
      Citations: 9     
    83. Tanaka K, Martinez GJ, Yan X, Long W, Ichiyama K, Chi X, Kim BS, Reynolds JM, Chung Y, Tanaka S, Liao L, Nakanishi Y, Yoshimura A, Zheng P, Wang X, Tian Q, Xu J, O'Malley BW, Dong C. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. Cell Rep. 2018 05 22; 23(8):2318-2329. PMID: 29791844.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    84. Panigrahi AK, Foulds CE, Lanz RB, Hamilton RA, Yi P, Lonard DM, Tsai MJ, Tsai SY, O'Malley BW. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7. PMID: 29775582; PMCID: PMC5966282.
      Citations: 17     Fields:    Translation:HumansCells
    85. Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598. PMID: 29748621; PMCID: PMC6095836.
      Citations: 28     Fields:    Translation:HumansCells
    86. Kayyali MN, Wooltorton JRA, Ramsey AJ, Lin M, Chao TN, Tsourkas A, O'Malley BW, Li D. A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss. J Control Release. 2018 06 10; 279:243-250. PMID: 29673641; PMCID: PMC6344933.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    87. Cho YJ, Lee JE, Park MJ, O'Malley BW, Han SJ. Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis. J Endocrinol. 2018 06; 237(3):255-269. PMID: 29636364; PMCID: PMC5943165.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    88. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254. PMID: 29615789; PMCID: PMC5895503.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    89. Padmanabhan A, Candelaria N, Wong KK, Nikolai BC, Lonard DM, O'Malley BW, Richards JS. USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270. PMID: 29593334; PMCID: PMC5871815.
      Citations: 32     Fields:    Translation:HumansCells
    90. Chandra R, Fisher EW, Jones TM, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW, Piccirillo JF, Ruben R, Sataloff RT, Schwartz S, Sindwani R, Smith RJ, Stewart MG, Weber PC, Welling DB, Youngs R. Open Access: Is There a Predator at the Door? Otol Neurotol. 2018 03; 39(3):271-272. PMID: 29424818.
      Citations:    Fields:    
    91. Kayyali MN, Ramsey AJ, Higbee-Dempsey EM, Yan L, O'Malley BW, Tsourkas A, Li D. The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity. J Assoc Res Otolaryngol. 2018 04; 19(2):123-132. PMID: 29349595; PMCID: PMC5878149.
      Citations: 2     Fields:    Translation:Animals
    92. Gates LA, Foulds CE, O'Malley BW. Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle. Trends Biochem Sci. 2017 12; 42(12):977-989. PMID: 29122461; PMCID: PMC5701853.
      Citations: 51     Fields:    Translation:HumansCells
    93. Ahn PH, Finlay JC, Gallagher-Colombo SM, Quon H, O'Malley BW, Weinstein GS, Chalian A, Malloy K, Sollecito T, Greenberg M, Simone CB, McNulty S, Lin A, Zhu TC, Livolsi V, Feldman M, Mick R, Cengel KA, Busch TM. Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy. Photodiagnosis Photodyn Ther. 2018 Mar; 21:28-35. PMID: 29113960; PMCID: PMC5866751.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    94. Kayyali MN, Wright AC, Ramsey AJ, Brant JA, Stein JM, O'Malley BW, Li D. Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss. Nanomedicine. 2018 02; 14(2):397-404. PMID: 29074310; PMCID: PMC5844828.
      Citations: 2     Fields:    Translation:HumansAnimals
    95. Shanti RM, O'Malley BW. Surgical Management of Oral Cancer. Dent Clin North Am. 2018 01; 62(1):77-86. PMID: 29126495.
      Citations: 8     Fields:    Translation:Humans
    96. Zhang Z, Nikolai BC, Gates LA, Jung SY, Siwak EB, He B, Rice AP, O'Malley BW, Feng Q. Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency. Nucleic Acids Res. 2017 Sep 19; 45(16):9348-9360. PMID: 28637181; PMCID: PMC5766202.
      Citations: 24     Fields:    Translation:HumansCells
    97. Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017 09 01; 23(9):646-653. PMID: 28911214; PMCID: PMC5909854.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    98. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863; PMCID: PMC5657569.
      Citations: 33     Fields:    Translation:HumansCells
    99. Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation. J Biol Chem. 2017 09 01; 292(35):14456-14472. PMID: 28717009; PMCID: PMC5582839.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    100. Gomez ED, Newman JG, Weinstein GS, O'Malley BW, Rassekh CH, Kuchenbecker KJ, Bur AM. Evaluation of high-fidelity simulation as a training tool in transoral robotic surgery. Laryngoscope. 2017 12; 127(12):2790-2795. PMID: 28657696.
      Citations: 5     Fields:    Translation:Animals
    101. Banerjee S, Tian T, Wei Z, Peck KN, Shih N, Chalian AA, O'Malley BW, Weinstein GS, Feldman MD, Alwine J, Robertson ES. Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas. Sci Rep. 2017 06 22; 7(1):4036. PMID: 28642609; PMCID: PMC5481414.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    102. Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304. PMID: 28611048; PMCID: PMC5559321.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    103. Zhu B, Zhang Q, Pan Y, Mace EM, York B, Antoulas AC, Dacso CC, O'Malley BW. A Cell-Autonomous Mammalian 12?hr Clock Coordinates Metabolic and Stress Rhythms. Cell Metab. 2017 Jun 06; 25(6):1305-1319.e9. PMID: 28591634; PMCID: PMC5526350.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    104. Hatten KM, O'Malley BW, Bur AM, Patel MR, Rassekh CH, Newman JG, Cannady SB, Chalian AA, Hodnett BL, Lin A, Lukens JN, Cohen RB, Bauml JM, Montone KT, Livolsi VA, Weinstein GS. Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries. JAMA Otolaryngol Head Neck Surg. 2017 03 01; 143(3):267-273. PMID: 27930761.
      Citations: 7     Fields:    Translation:Humans
    105. Xu Y, O'Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. J Clin Invest. 2017 Apr 03; 127(4):1172-1180. PMID: 28218618; PMCID: PMC5373860.
      Citations: 12     Fields:    Translation:HumansAnimals
    106. Xu Q, Shanti RM, Zhang Q, Cannady SB, O'Malley BW, Le AD. A Gingiva-Derived Mesenchymal Stem Cell-Laden Porcine Small Intestinal Submucosa Extracellular Matrix Construct Promotes Myomucosal Regeneration of the Tongue. Tissue Eng Part A. 2017 04; 23(7-8):301-312. PMID: 27923325; PMCID: PMC5397215.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    107. O'Malley BW. Origins of the Field of Molecular Endocrinology: A Personal Perspective. Mol Endocrinol. 2016 10; 30(10):1015-1018. PMID: 27690769; PMCID: PMC5414606.
      Citations: 1     Fields:    Translation:HumansAnimals
    108. Lonard DM, O'Malley BW. Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407. PMID: 27654711; PMCID: PMC5290137.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    109. Fleet T, Stashi E, Zhu B, Rajapakshe K, Marcelo KL, Kettner NM, Gorman BK, Coarfa C, Fu L, O'Malley BW, York B. Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms. 2016 10; 31(5):443-60. PMID: 27432117; PMCID: PMC5248931.
      Citations: 8     Fields:    Translation:HumansAnimals
    110. Brody RM, Pandey NC, O'Malley BW, Rassekh CH, Weinstein GS, Chalian AA, Newman JG, Cannady SB, Bur AM. Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap. Head Neck. 2016 12; 38(12):1788-1793. PMID: 27310816.
      Citations: 3     Fields:    Translation:Humans
    111. Wang Q, Trevino LS, Wong RL, Medvedovic M, Chen J, Ho SM, Shen J, Foulds CE, Coarfa C, O'Malley BW, Shilatifard A, Walker CL. Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk. Mol Endocrinol. 2016 Aug; 30(8):856-71. PMID: 27219490; PMCID: PMC4965842.
      Citations: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    112. Khalili S, Worrall DM, Brooks S, Morris SM, Farquhar D, Newman JG, Learned KO, Ahn PH, Craig J, Kennedy DW, O'Malley BW, Palmer JN, Adappa ND. Endoscopy versus imaging: Analysis of surveillance methods in sinonasal malignancy. Head Neck. 2016 08; 38(8):1229-33. PMID: 27142811.
      Citations: 3     Fields:    Translation:Humans
    113. Wang L, Lonard DM, O'Malley BW. The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35. PMID: 27125199; PMCID: PMC4930410.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    114. Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5. PMID: 27084884; PMCID: PMC4983835.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    115. Rassekh CH, O'Malley BW, Bewley AF, Montone KT, Livolsi VA, Weinstein GS. Feasibility and relevance of level I substation node counts in oropharyngeal carcinoma. Head Neck. 2016 08; 38(8):1194-200. PMID: 27028011.
      Citations: 2     Fields:    Translation:Humans
    116. Farquhar D, Kim L, Worrall D, Chiu A, Lee JY, Khalili S, Grady S, O'Malley BW, Kennedy DW, Newman JG, Palmer JN, Adappa ND. Propensity score analysis of endoscopic and open approaches to malignant paranasal and anterior skull base tumor outcomes. Laryngoscope. 2016 08; 126(8):1724-9. PMID: 26972568.
      Citations: 9     Fields:    Translation:Humans
    117. Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X. The REG?-proteasome forms a regulatory circuit with I?B? and NF?B in experimental colitis. Nat Commun. 2016 Feb 22; 7:10761. PMID: 26899380; PMCID: PMC4764899.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    118. Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75. PMID: 26833126; PMCID: PMC4794399.
      Citations: 17     Fields:    Translation:HumansCells
    119. Li L, Chao T, Brant J, O'Malley B, Tsourkas A, Li D. Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss. Adv Drug Deliv Rev. 2017 01 01; 108:2-12. PMID: 26796230; PMCID: PMC4940320.
      Citations: 31     Fields:    Translation:Humans
    120. Foulds CE, Panigrahi AK, Coarfa C, Lanz RB, O'Malley BW. Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors. Curr Top Microbiol Immunol. 2016; 394:143-76. PMID: 26362934.
      Citations: 6     Fields:    Translation:HumansCells
    121. Zhang Z, Brown JC, O'Malley BW, Troxel AB, Bauml JM, Rubnitz KR, Grosso CM, Weinstein GS, Schmitz KH. Post-treatment weight change in oral cavity and oropharyngeal squamous cell carcinoma. Support Care Cancer. 2016 May; 24(5):2333-2340. PMID: 26619995; PMCID: PMC5126730.
      Citations: 2     Fields:    Translation:Humans
    122. Zhu B, Gates LA, Stashi E, Dasgupta S, Gonzales N, Dean A, Dacso CC, York B, O'Malley BW. Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell. 2015 Dec 03; 60(5):769-783. PMID: 26611104; PMCID: PMC4671835.
      Citations: 37     Fields:    Translation:AnimalsCells
    123. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function. PLoS One. 2015; 10(11):e0143652. PMID: 26580555; PMCID: PMC4651323.
      Citations:    Fields:    
    124. Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 05; 163(4):960-74. PMID: 26544941; PMCID: PMC4640214.
      Citations: 100     Fields:    Translation:HumansAnimals
    125. Han SJ, Begum K, Foulds CE, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J, O'Malley BW. The Dual Estrogen Receptor a Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol. 2016 Jan; 89(1):14-26. PMID: 26487511; PMCID: PMC4702103.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    126. Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York B. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E6068-77. PMID: 26487680; PMCID: PMC4640775.
      Citations: 5     Fields:    Translation:AnimalsCells
    127. Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011. PMID: 26431029; PMCID: PMC4592245.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    128. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS Genet. 2015 Sep; 11(9):e1005515. PMID: 26418340; PMCID: PMC4587844.
      Citations: 1     Fields:    
    129. Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X. Upregulation of GSK3? Contributes to Brain Disorders in Elderly REG?-knockout Mice. Neuropsychopharmacology. 2016 Apr; 41(5):1340-9. PMID: 26370326; PMCID: PMC4793118.
      Citations: 3     Fields:    Translation:AnimalsCells
    130. Tanaka N, Lajud SA, Ramsey A, Szymanowski AR, Ruffner R, O'Malley BW, Li D. Application of infrared-based molecular imaging to a mouse model with head and neck cancer. Head Neck. 2016 04; 38 Suppl 1:E1351-7. PMID: 26348614.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    131. Jin F, Bhowmik SK, Putluri V, Gu F, Gohlke J, Von Rundstedt FC, Dasgupta S, Krishnapuram R, O'Malley BW, Sreekumar A, Putluri N. A Novel [15N] Glutamine Flux using LC-MS/MS-SRM for Determination of Nucleosides and Nucleobases. J Anal Bioanal Tech. 2015 Oct; 6(5). PMID: 27158554; PMCID: PMC4857768.
      Citations: 1     
    132. Szwarc MM, Lydon JP, O'Malley BW. Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system". J Steroid Biochem Mol Biol. 2015 Sep; 153:144-50. PMID: 26291832.
      Citations:    Fields:    
    133. Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52. PMID: 26267537; PMCID: PMC4536575.
      Citations: 46     Fields:    Translation:HumansCells
    134. Thaler ER, Rassekh CH, Lee JM, Weinstein GS, O'Malley BW. Outcomes for multilevel surgery for sleep apnea: Obstructive sleep apnea, transoral robotic surgery, and uvulopalatopharyngoplasty. Laryngoscope. 2016 Jan; 126(1):266-9. PMID: 26153069.
      Citations: 12     Fields:    Translation:Humans
    135. Szwarc MM, Lydon JP, O'Malley BW. Steroid receptor coactivators as therapeutic targets in the female reproductive system. J Steroid Biochem Mol Biol. 2015 Nov; 154:32-8. PMID: 26151740; PMCID: PMC5201167.
      Citations: 5     Fields:    Translation:HumansAnimals
    136. Gallagher-Colombo SM, Quon H, Malloy KM, Ahn PH, Cengel KA, Simone CB, Chalian AA, O'Malley BW, Weinstein GS, Zhu TC, Putt ME, Finlay JC, Busch TM. Measuring the Physiologic Properties of Oral Lesions Receiving Fractionated Photodynamic Therapy. Photochem Photobiol. 2015 Sep-Oct; 91(5):1210-8. PMID: 26037487; PMCID: PMC4560604.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    137. Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest. 2015 Jul 01; 125(7):2808-24. PMID: 26098214; PMCID: PMC4563678.
      Citations: 43     Fields:    Translation:AnimalsCells
    138. Eedunuri VK, Rajapakshe K, Fiskus W, Geng C, Chew SA, Foley C, Shah SS, Shou J, Mohamed JS, Coarfa C, O'Malley BW, Mitsiades N. miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation. Mol Endocrinol. 2015 Aug; 29(8):1170-83. PMID: 26066330; PMCID: PMC4518002.
      Citations: 18     Fields:    Translation:HumansCells
    139. Kovatch KJ, Purkey MT, Martinez-Lage M, Gausas RE, Loevner LA, Grady MS, O'Malley BW, Rassekh CH. Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach. Laryngoscope. 2015 Nov; 125(11):2457-60. PMID: 25960281.
      Citations:    Fields:    Translation:Humans
    140. Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116. PMID: 25830341; PMCID: PMC4382186.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    141. Lonard DM, Xu J, O'Malley BW. Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157. PMID: 25736684; PMCID: PMC5523467.
      Citations: 2     Fields:    Translation:HumansAnimals
    142. Yi P, Feng Q, Foulds CE, Lanz RB, O'Malley BW, Wang Z, Pintilie GD, Ludtke SJ, Schmid MF, Chiu W. Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell. 2015 Mar 19; 57(6):1047-1058. PMID: 25728767; PMCID: PMC4369429.
      Citations: 61     Fields:    Translation:HumansCells
    143. Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015 Mar 02; 125(3):1174-88. PMID: 25664849; PMCID: PMC4362260.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    144. Nagda DA, Qiao P, Tanaka N, Civantos A, Gu R, Cheng Z, Tsourkas A, O'Malley BW, Li D, Lajud SA. A novel chitosan-hydrogel-based nanoparticle delivery system for local inner ear application. Otol Neurotol. 2015 Feb; 36(2):341-7. PMID: 25587675; PMCID: PMC4365436.
      Citations: 18     Fields:    Translation:Animals
    145. McKenna NJ, Evans RM, O'Malley BW. Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research. Nucl Recept Signal. 2014; 12:e006. PMID: 25614732; PMCID: PMC4303009.
      Citations: 7     Fields:    Translation:Cells
    146. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. PMID: 25489091; PMCID: PMC4280633.
      Citations: 55     Fields:    Translation:HumansCells
    147. Weinstein GS, O'Malley BW, Rinaldo A, Silver CE, Werner JA, Ferlito A. Understanding contraindications for transoral robotic surgery (TORS) for oropharyngeal cancer. Eur Arch Otorhinolaryngol. 2015 Jul; 272(7):1551-2. PMID: 25327689.
      Citations: 17     Fields:    
    148. Lajud SA, Nagda DA, Yamashita T, Zheng J, Tanaka N, Abuzeid WM, Civantos A, Bezpalko O, O'Malley BW, Li D. Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer. Clin Cancer Res. 2014 Dec 15; 20(24):6465-78. PMID: 25324139.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    149. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
      Citations: 1     Fields:    Translation:Humans
    150. Wang W, Bian K, Vallabhaneni S, Zhang B, Wu RC, O'Malley BW, Long W. ERK3 promotes endothelial cell functions by upregulating SRC-3/SP1-mediated VEGFR2 expression. J Cell Physiol. 2014 Oct; 229(10):1529-37. PMID: 24585635; PMCID: PMC4078721.
      Citations: 22     Fields:    Translation:HumansCells
    151. Rechoum Y, Rovito D, Iacopetta D, Barone I, Weigel NL, O'Malley BW, Brown PH, Fuqua SA, And? S. AR collaborates with ERa in aromatase inhibitor-resistant breast cancer. Breast Cancer Res Treat. 2014 Oct; 147(3):473-85. PMID: 25178514; PMCID: PMC4337991.
      Citations: 40     Fields:    Translation:HumansCells
    152. York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF, Tannour-Louet M. Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. Mol Endocrinol. 2014 Oct; 28(10):1707-18. PMID: 25148457; PMCID: PMC4179626.
      Citations: 3     Fields:    Translation:AnimalsCells
    153. Dasgupta S, O'Malley BW. Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology. J Mol Endocrinol. 2014 Oct; 53(2):R47-59. PMID: 25024406; PMCID: PMC4152414.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    154. Hays T, Ma'ayan A, Clark NR, Tan CM, Teixeira A, Teixeira A, Choi JW, Burdis N, Jung SY, Bajaj AO, O'Malley BW, He JC, Hyink DP, Klotman PE. Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte. PLoS One. 2014; 9(6):e100660. PMID: 24949636; PMCID: PMC4065073.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    155. Stashi E, York B, O'Malley BW. Steroid receptor coactivators: servants and masters for control of systems metabolism. Trends Endocrinol Metab. 2014 Jul; 25(7):337-47. PMID: 24953190; PMCID: PMC4108168.
      Citations: 41     Fields:    Translation:HumansAnimals
    156. Feng Q, O'Malley BW. Nuclear receptor modulation--role of coregulators in selective estrogen receptor modulator (SERM) actions. Steroids. 2014 Nov; 90:39-43. PMID: 24945111; PMCID: PMC4192004.
      Citations: 13     Fields:    Translation:HumansAnimals
    157. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PLoS One. 2014; 9(6):e98664. PMID: 24905738; PMCID: PMC4048228.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    158. O'Malley BW, Owen RP, Rinaldo A, Silver CE, Ferlito A, B?ck LJ, M?kitie AA. When is radiofrequency ablation not indicated in head and neck squamous cell carcinoma management? Eur Arch Otorhinolaryngol. 2015 May; 272(5):1045-6. PMID: 24880470.
      Citations:    Fields:    Translation:Humans
    159. Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19. PMID: 24874954; PMCID: PMC4085766.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    160. Reineke EL, Benham A, Soibam B, Stashi E, Taegtmeyer H, Entman ML, Schwartz RJ, O'Malley BW. Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function. J Biol Chem. 2014 Jun 20; 289(25):17721-31. PMID: 24811170; PMCID: PMC4067206.
      Citations: 10     Fields:    Translation:Animals
    161. Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May; 16(5):390-402. PMID: 25016594; PMCID: PMC4198742.
      Citations: 37     Fields:    Translation:HumansCells
    162. Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O'Malley BW, Lonard DM. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243. PMID: 24743578; PMCID: PMC3990629.
      Citations: 21     Fields:    Translation:HumansCells
    163. Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JP. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biol Reprod. 2014 Apr; 90(4):75. PMID: 24571987; PMCID: PMC4076383.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    164. Han SJ, O'Malley BW. The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis. Hum Reprod Update. 2014 Jul-Aug; 20(4):467-84. PMID: 24634322; PMCID: PMC4063700.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    165. Kang YK, Jung SY, Qin J, Li C, Tsai SY, Tsai MJ, O'Malley BW. E2/Estrogen receptor/sjogren syndrome-associated autoantigen relieves coactivator activator-induced G1/S arrest to promote breast tumorigenicity. Mol Cell Biol. 2014 May; 34(9):1670-81. PMID: 24567374; PMCID: PMC3993604.
      Citations: 2     Fields:    Translation:HumansCells
    166. Stashi E, Lanz RB, Mao J, Michailidis G, Zhu B, Kettner NM, Putluri N, Reineke EL, Reineke LC, Dasgupta S, Dean A, Stevenson CR, Sivasubramanian N, Sreekumar A, Demayo F, York B, Fu L, O'Malley BW. SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27; 6(4):633-45. PMID: 24529706; PMCID: PMC4096300.
      Citations: 41     Fields:    Translation:AnimalsCells
    167. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340; PMCID: PMC3938540.
      Citations: 8     Fields:    Translation:HumansCells
    168. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517. PMID: 24390736; PMCID: PMC3947477.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    169. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900. PMID: 24204309; PMCID: PMC3812085.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    170. Savulescu D, Feng J, Ping YS, Mai O, Boehm U, He B, O'Malley BW, Melamed P. Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Mol Endocrinol. 2013 Nov; 27(11):1856-70. PMID: 24085822; PMCID: PMC5427832.
      Citations: 12     Fields:    Translation:AnimalsCells
    171. Owen RP, Lee JS, Silver CE, Beitler JJ, Rinaldo A, O'Malley BW, Haigentz M, Ferlito A, B?ck L. Radiofrequency ablation in advanced head and neck cancer. Eur Arch Otorhinolaryngol. 2014 Feb; 271(2):207-10. PMID: 24061569.
      Citations: 1     Fields:    Translation:Humans
    172. Dasgupta S, Lonard DM, O'Malley BW. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014; 65:279-92. PMID: 24111892; PMCID: PMC4327818.
      Citations: 86     Fields:    Translation:HumansCells
    173. Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. The REG? proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab. 2013 Sep 03; 18(3):380-91. PMID: 24011073; PMCID: PMC3813599.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    174. Stashi E, Wang L, Mani SK, York B, O'Malley BW. Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences. Mol Endocrinol. 2013 Oct; 27(10):1776-87. PMID: 23927929; PMCID: PMC3787127.
      Citations: 11     Fields:    Translation:Animals
    175. Ramakrishnan VR, Lee JY, O'Malley BW, Palmer JN, Chiu AG. 18-FDG-PET in the initial staging of sinonasal malignancy. Laryngoscope. 2013 Dec; 123(12):2962-6. PMID: 23877974.
      Citations: 6     Fields:    Translation:Humans
    176. Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99. PMID: 23850489; PMCID: PMC3900250.
      Citations: 73     Fields:    Translation:HumansCells
    177. Swisher-McClure S, Mitra N, Lin A, Ahn P, Wan F, O'Malley B, Weinstein GS, Bekelman JE. Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer. Head Neck. 2014 May; 36(5):611-6. PMID: 23595858; PMCID: PMC3795979.
      Citations: 21     Fields:    Translation:Humans
    178. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X. REG? deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11005-10. PMID: 23766372; PMCID: PMC3703992.
      Citations: 35     Fields:    Translation:Animals
    179. Bhat-Nakshatri P, Song EK, Collins NR, Uversky VN, Dunker AK, O'Malley BW, Geistlinger TR, Carroll JS, Brown M, Nakshatri H. Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing. BMC Med Genomics. 2013 Jun 11; 6:21. PMID: 23758675; PMCID: PMC3687557.
      Citations: 13     Fields:    Translation:HumansCells
    180. Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002. PMID: 23559371; PMCID: PMC3637757.
      Citations: 124     Fields:    Translation:HumansCells
    181. Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ, Ramsay K, Kobelke SJ, Li X, Hatchell EC, Payne C, Giles KM, Messineo A, Gatignol A, Lanz RB, O'Malley BW, Leedman PJ. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6536-41. PMID: 23550157; PMCID: PMC3631673.
      Citations: 49     Fields:    Translation:HumansCells
    182. O'Malley BW, Khan S. Elwood V. Jensen (1920-2012): father of the nuclear receptors. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):3707-8. PMID: 23471960; PMCID: PMC3593867.
      Citations: 5     Fields:    Translation:HumansAnimals
    183. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87. PMID: 23388826; PMCID: PMC3576513.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    184. York B, Tsimelzon A, Louet JF, Chopra AR, Reineke EL, Zhou S, Stevens RD, Wenner BR, Ilkayeva O, Bain JR, Xu J, Hilsenbeck SG, Newgard CB, O'Malley BW, Sagen JV. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Mol Endocrinol. 2013 Feb; 27(2):366-80. PMID: 23315938; PMCID: PMC3683811.
      Citations: 16     Fields:    Translation:Animals
    185. Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW. SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. PLoS One. 2012; 7(12):e53395. PMID: 23300926; PMCID: PMC3534027.
      Citations: 17     Fields:    Translation:AnimalsCells
    186. Bigaud E, He B, O'Malley BW, Corrales FJ, S?nchez-Quiles V, Segura V, Santamar?a E, Prieto J. Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury. J Proteomics. 2012 Oct 22; 75(18):5783-92. PMID: 22951295.
      Citations: 10     Fields:    Translation:AnimalsCells
    187. Liu SH, Rao DD, Nemunaitis J, Senzer N, Zhou G, Dawson D, Gingras MC, Wang Z, Gibbs R, Norman M, Templeton NS, Demayo FJ, O'Malley B, Sanchez R, Fisher WE, Brunicardi FC. PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform. PLoS One. 2012; 7(8):e40452. PMID: 22905092; PMCID: PMC3414490.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    188. Han SJ, Hawkins SM, Begum K, Jung SY, Kovanci E, Qin J, Lydon JP, DeMayo FJ, O'Malley BW. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012 Jul; 18(7):1102-11. PMID: 22660634; PMCID: PMC3541027.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    189. O'Malley BW, Malovannaya A, Qin J. Minireview: nuclear receptor and coregulator proteomics--2012 and beyond. Mol Endocrinol. 2012 Oct; 26(10):1646-50. PMID: 22745194; PMCID: PMC3458220.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    190. Lonard DM, O'Malley BW. Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol. 2012 Oct; 8(10):598-604. PMID: 22733267; PMCID: PMC3564250.
      Citations: 117     Fields:    Translation:HumansAnimals
    191. Margaill I, Zhang S, Labombarda F, Delespierre B, Liere P, Marchand-Leroux C, O'Malley BW, Lydon JP, De Nicola AF, Sitruk-Ware R, Mattern C, Plotkine M, Schumacher M, Guennoun R, Liu A, Coqueran B. Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology. 2012 Aug; 153(8):3747-57. PMID: 22635678; PMCID: PMC3979171.
      Citations: 41     Fields:    Translation:AnimalsCells
    192. Moses RE, O'Malley BW. DNA transcription and repair: a confluence. J Biol Chem. 2012 Jul 06; 287(28):23266-70. PMID: 22605334; PMCID: PMC3390605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    193. Park S, Yoon S, Zhao Y, Park SE, Liao L, Xu J, Lydon JP, DeMayo FJ, O'Malley BW, Bagchi MK, Katzenellenbogen BS. Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA. Endocrinology. 2012 Aug; 153(8):3982-94. PMID: 22585830; PMCID: PMC3404350.
      Citations: 13     Fields:    Translation:AnimalsCells
    194. O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, Silverstein KA, Schrum CT, Xie WR, Mularoni L, Wheelan SJ, Torbenson MS, O'Malley BW, Largaespada DA, Boeke JD. A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1377-86. PMID: 22556267; PMCID: PMC3361419.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    195. York B, Reineke EL, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW, Sagen JV. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012 May 02; 15(5):752-63. PMID: 22560224; PMCID: PMC3349072.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    196. Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Tsai SY, Tsai MJ, O'Malley BW. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80. PMID: 22505454; PMCID: PMC3336992.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    197. Wu MY, Fu J, Xu J, O'Malley BW, Wu RC. Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor. Cell Res. 2012 Jun; 22(6):1003-21. PMID: 22430150; PMCID: PMC3367527.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    198. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, O'Malley BW. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53. PMID: 22053001; PMCID: PMC3231837.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    199. Park S, Zhao Y, Yoon S, Xu J, Liao L, Lydon J, DeMayo F, O'Malley BW, Katzenellenbogen BS. Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. Endocrinology. 2011 Nov; 152(11):4336-49. PMID: 21862609; PMCID: PMC3199013.
      Citations: 14     Fields:    Translation:AnimalsCells
    200. Johnson AB, O'Malley BW. ERasing breast cancer resistance through the kinome. Nat Med. 2011 Jun; 17(6):660-1. PMID: 21647142.
      Citations: 9     Fields:    Translation:Humans
    201. Johnson AB, O'Malley BW. Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy. Mol Cell Endocrinol. 2012 Jan 30; 348(2):430-9. PMID: 21664237; PMCID: PMC3202666.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    202. Malovannaya A, Lanz RB, Jung SY, Bulynko Y, Le NT, Chan DW, Ding C, Shi Y, Yucer N, Krenciute G, Kim BJ, Li C, Chen R, Li W, Wang Y, O'Malley BW, Qin J. Analysis of the human endogenous coregulator complexome. Cell. 2011 May 27; 145(5):787-99. PMID: 21620140; PMCID: PMC3131083.
      Citations: 207     Fields:    Translation:HumansCells
    203. Reddy SD, Rayala SK, Ohshiro K, Pakala SB, Kobori N, Dash P, Yun S, Qin J, O'Malley BW, Kumar R. Multiple coregulatory control of tyrosine hydroxylase gene transcription. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4200-5. PMID: 21368136; PMCID: PMC3054001.
      Citations: 19     Fields:    Translation:AnimalsCells
    204. Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011 Jan 05; 13(1):35-43. PMID: 21195347; PMCID: PMC3072049.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    205. He B, Kim TH, Kommagani R, Feng Q, Lanz RB, Jeong JW, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology. 2011 Mar; 152(3):1047-56. PMID: 21209023; PMCID: PMC3040048.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    206. O'Malley BW. Cellular proteome, coregulators, endocrine system and the human brain: the Regulatory biology of humanism. Aging (Albany NY). 2011 Jan; 3(1):22-5. PMID: 21258135; PMCID: PMC3047135.
      Citations:    Fields:    Translation:HumansAnimals
    207. Bulynko YA, O'Malley BW. Nuclear receptor coactivators: structural and functional biochemistry. Biochemistry. 2011 Jan 25; 50(3):313-28. PMID: 21141906; PMCID: PMC3647688.
      Citations: 41     Fields:    Translation:HumansAnimals
    208. Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 2010 Dec 01; 12(6):606-18. PMID: 21109193; PMCID: PMC3024581.
      Citations: 37     Fields:    Translation:AnimalsCells
    209. Lydon JP, O'Malley BW. Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis. Endocrinology. 2011 Jan; 152(1):19-25. PMID: 21047941; PMCID: PMC3219052.
      Citations: 24     Fields:    Translation:HumansCells
    210. York B, O'Malley BW. Steroid receptor coactivator (SRC) family: masters of systems biology. J Biol Chem. 2010 Dec 10; 285(50):38743-50. PMID: 20956538; PMCID: PMC2998129.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    211. McKenna NJ, O'Malley BW. SnapShot: NR coregulators. Cell. 2010 Oct 01; 143(1):172-172.e1. PMID: 20887900.
      Citations: 7     Fields:    Translation:HumansAnimals
    212. McKenna NJ, O'Malley BW. SnapShot: Nuclear receptors II. Cell. 2010 Sep 17; 142(6):986.e1. PMID: 20850017.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    213. McKenna NJ, O'Malley BW. SnapShot: Nuclear receptors I. Cell. 2010 Sep 03; 142(5):822-822.e1. PMID: 20813267.
      Citations: 7     Fields:    Translation:HumansAnimals
    214. O'Malley B, Brisken C. Hormone action in the mammary gland. Cold Spring Harb Perspect Biol. 2010 Dec; 2(12):a003178. PMID: 20739412; PMCID: PMC2982168.
      Citations: 165     Fields:    Translation:Animals
    215. Long W, O'Malley BW. Crosstalk among nuclear receptor coactivators and a membrane receptor promotes tumor cell growth and migration. Cell Cycle. 2010 Jun 15; 9(12):2269-70. PMID: 20519947.
      Citations: 1     Fields:    
    216. York B, Yu C, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J, O'Malley BW, Sagen JV. Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11122-7. PMID: 20534466; PMCID: PMC2890746.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    217. O'Malley BW. Masters of the genome. Nat Rev Mol Cell Biol. 2010 May; 11(5):311. PMID: 20422740.
      Citations: 6     Fields:    
    218. Foulds CE, Tsimelzon A, Long W, Le A, Tsai SY, Tsai MJ, O'Malley BW. Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene. Mol Endocrinol. 2010 May; 24(5):1090-105. PMID: 20219889; PMCID: PMC2870939.
      Citations: 30     Fields:    Translation:HumansCells
    219. Lanz RB, Bulynko Y, Malovannaya A, Labhart P, Wang L, Li W, Qin J, Harper M, O'Malley BW. Global characterization of transcriptional impact of the SRC-3 coregulator. Mol Endocrinol. 2010 Apr; 24(4):859-72. PMID: 20181721; PMCID: PMC2852354.
      Citations: 36     Fields:    Translation:HumansCells
    220. Fu X, Yucer N, Liu S, Li M, Yi P, Mu JJ, Yang T, Chu J, Jung SY, O'Malley BW, Gu W, Qin J, Wang Y. RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4579-84. PMID: 20173098; PMCID: PMC2842028.
      Citations: 37     Fields:    Translation:HumansCells
    221. Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY, Tsai MJ, O'Malley BW. SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration. Mol Cell. 2010 Feb 12; 37(3):321-32. PMID: 20159552; PMCID: PMC2824333.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    222. Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2431-6. PMID: 20133760; PMCID: PMC2823922.
      Citations: 68     Fields:    Translation:HumansCells
    223. Lonard DM, O'Malley BW, Stani?ic V. Estrogen receptor-a: molecular mechanisms and interactions with the ubiquitin proteasome system. Horm Mol Biol Clin Investig. 2010 Jan; 1(1):1-9. PMID: 25961966.
      Citations: 1     Fields:    
    224. Stanisic V, Lonard DM, O'Malley BW. Modulation of steroid hormone receptor activity. Prog Brain Res. 2010; 181:153-76. PMID: 20478437.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    225. Han SJ, O'Malley BW, DeMayo FJ. An estrogen receptor alpha activity indicator model in mice. Genesis. 2009 Dec; 47(12):815-24. PMID: 19882671; PMCID: PMC2794894.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    226. Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O'Malley BW, Zhang M, Belaguli NS, Oesterreich S. Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol. 2010 Jan; 30(2):399-412. PMID: 19917725; PMCID: PMC2798473.
      Citations: 44     Fields:    Translation:HumansCells
    227. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, Minami Y, O'Malley BW, Kato S. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009 Oct 23; 36(2):340-7. PMID: 19854141.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    228. Lonard DM, Kumar R, O'Malley BW. Minireview: the SRC family of coactivators: an entr?e to understanding a subset of polygenic diseases? Mol Endocrinol. 2010 Feb; 24(2):279-85. PMID: 19846539; PMCID: PMC2817609.
      Citations: 21     Fields:    Translation:HumansAnimals
    229. O'Malley BW, Kumar R. Nuclear receptor coregulators in cancer biology. Cancer Res. 2009 Nov 01; 69(21):8217-22. PMID: 19843848; PMCID: PMC2783444.
      Citations: 55     Fields:    Translation:HumansAnimals
    230. Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25; 284(52):36167-36174. PMID: 19843527; PMCID: PMC2794732.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    231. Lonard DM, O'Malley BW. Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling. Prog Mol Biol Transl Sci. 2009; 87:117-35. PMID: 20374703.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    232. Xu J, Wu RC, O'Malley BW. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer. 2009 Sep; 9(9):615-30. PMID: 19701241; PMCID: PMC2908510.
      Citations: 256     Fields:    Translation:HumansAnimalsCells
    233. Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Chambon P, O'Malley BW, Khosla S, M?dder UI, G?hin M. Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2. J Biol Chem. 2009 Jul 10; 284(28):18767-77. PMID: 19423703; PMCID: PMC2707192.
      Citations: 15     Fields:    Translation:AnimalsCells
    234. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009 Jun; 23(6):740-6. PMID: 19423650; PMCID: PMC2691684.
      Citations: 61     Fields:    Translation:Cells
    235. Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH. Foxa2-dependent hepatic gene regulatory networks depend on physiological state. Physiol Genomics. 2009 Jul 09; 38(2):186-95. PMID: 19417011; PMCID: PMC2712224.
      Citations: 12     Fields:    Translation:AnimalsCells
    236. Malovannaya A, Qin J, Lonard DM, O'Malley BW, Stani?ic V. OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem. 2009 Jun 12; 284(24):16135-16145. PMID: 19383985; PMCID: PMC2713518.
      Citations: 35     Fields:    Translation:HumansCells
    237. O'Malley BW. The "fourth dimension" of gene transcription. Mol Endocrinol. 2009 May; 23(5):587-9. PMID: 19221049; PMCID: PMC2675955.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    238. Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):151-6. PMID: 19109434; PMCID: PMC2629242.
      Citations: 66     Fields:    Translation:Animals
    239. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140; PMCID: PMC2668604.
      Citations: 96     Fields:    Translation:AnimalsCells
    240. Han SJ, Lonard DM, O'Malley BW. Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab. 2009 Jan; 20(1):8-15. PMID: 19019695; PMCID: PMC3642869.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    241. Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J, Coste A. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17187-92. PMID: 18957541; PMCID: PMC2579399.
      Citations: 93     Fields:    Translation:AnimalsCells
    242. O'Malley B. The Year in Basic Science: nuclear receptors and coregulators. Mol Endocrinol. 2008 Dec; 22(12):2751-8. PMID: 18845672; PMCID: PMC5419400.
      Citations: 12     Fields:    Translation:HumansAnimals
    243. Kang YK, Schiff R, Ko L, Wang T, Tsai SY, Tsai MJ, O'Malley BW. Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. Cancer Res. 2008 Oct 01; 68(19):7887-96. PMID: 18829545; PMCID: PMC2597518.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    244. Li C, Liang YY, Feng XH, Tsai SY, Tsai MJ, O'Malley BW. Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell. 2008 Sep 26; 31(6):835-49. PMID: 18922467; PMCID: PMC2597059.
      Citations: 39     Fields:    Translation:HumansCells
    245. O'Malley BW, McKenna NJ. Coactivators and corepressors: what's in a name? Mol Endocrinol. 2008 Oct; 22(10):2213-4. PMID: 18701638; PMCID: PMC2582534.
      Citations: 17     Fields:    Translation:Humans
    246. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008 Oct; 28(19):5937-50. PMID: 18644862; PMCID: PMC2547002.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    247. O'Malley BW, Qin J, Lanz RB. Cracking the coregulator codes. Curr Opin Cell Biol. 2008 Jun; 20(3):310-5. PMID: 18499426; PMCID: PMC3647352.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    248. Fereshteh MP, Tilli MT, Kim SE, Xu J, O'Malley BW, Wellstein A, Furth PA, Riegel AT. The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res. 2008 May 15; 68(10):3697-706. PMID: 18483252; PMCID: PMC3641830.
      Citations: 61     Fields:    Translation:AnimalsCells
    249. Lonard DM, O'Malley BW. Gene transcription: two worlds merged. Nature. 2008 Apr 24; 452(7190):946-7. PMID: 18432236.
      Citations: 3     Fields:    Translation:Cells
    250. Lonard DM, O'Malley BW. SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells? Sci Signal. 2008 Apr 01; 1(13):pe16. PMID: 18385039.
      Citations: 22     Fields:    Translation:HumansCells
    251. Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76. PMID: 18313384; PMCID: PMC2293272.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    252. Rickard DJ, Iwaniec UT, Evans G, Hefferan TE, Hunter JC, Waters KM, Lydon JP, O'Malley BW, Khosla S, Spelsberg TC, Turner RT. Bone growth and turnover in progesterone receptor knockout mice. Endocrinology. 2008 May; 149(5):2383-90. PMID: 18276762; PMCID: PMC2329269.
      Citations: 20     Fields:    Translation:AnimalsCells
    253. Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res. 2007 Dec 15; 67(24):12026-33. PMID: 18089834.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    254. He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60. PMID: 17932104; PMCID: PMC2234581.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    255. Jordan VC, O'Malley BW. Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. J Clin Oncol. 2007 Dec 20; 25(36):5815-24. PMID: 17893378.
      Citations: 130     Fields:    Translation:Humans
    256. Lonard DM, O'malley BW. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell. 2007 Sep 07; 27(5):691-700. PMID: 17803935.
      Citations: 208     Fields:    Translation:HumansCells
    257. Amazit L, Pasini L, Szafran AT, Berno V, Wu RC, Mielke M, Jones ED, Mancini MG, Hinojos CA, O'Malley BW, Mancini MA. Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation. Mol Cell Biol. 2007 Oct; 27(19):6913-32. PMID: 17646391; PMCID: PMC2099228.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    258. Louet JF, O'Malley BW. Coregulators in adipogenesis: what could we learn from the SRC (p160) coactivator family? Cell Cycle. 2007 Oct 15; 6(20):2448-52. PMID: 17704643.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    259. Lonard DM, Lanz RB, O'Malley BW. Nuclear receptor coregulators and human disease. Endocr Rev. 2007 Aug; 28(5):575-87. PMID: 17609497.
      Citations: 135     Fields:    Translation:HumansAnimals
    260. Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007 Jun 22; 26(6):831-42. PMID: 17588518.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    261. Wu RC, Feng Q, Lonard DM, O'Malley BW. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007 Jun 15; 129(6):1125-40. PMID: 17574025.
      Citations: 124     Fields:    Translation:HumansCells
    262. Jeong JW, Lee KY, Han SJ, Aronow BJ, Lydon JP, O'Malley BW, DeMayo FJ. The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology. 2007 Sep; 148(9):4238-50. PMID: 17556502.
      Citations: 32     Fields:    Translation:Animals
    263. Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T, Akimoto C, Yamamoto Y, Katagiri T, Foulds C, Takezawa S, Kitagawa H, Takeyama K, O'Malley BW, Kato S. DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol. 2007 May; 9(5):604-11. PMID: 17435748.
      Citations: 199     Fields:    Translation:AnimalsCells
    264. Meng Q, Rayala SK, Gururaj AE, Talukder AH, O'Malley BW, Kumar R. Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5866-71. PMID: 17389360; PMCID: PMC1851583.
      Citations: 50     Fields:    Translation:HumansCells
    265. Yu C, York B, Wang S, Feng Q, Xu J, O'Malley BW. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell. 2007 Mar 09; 25(5):765-78. PMID: 17349961; PMCID: PMC1864954.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    266. Dutertre M, Muchardt C, O'Malley BW, Auboeuf D, Batsch? E. Coregulators: transducing signal from transcription to alternative splicing. Trends Endocrinol Metab. 2007 Apr; 18(3):122-9. PMID: 17320409.
      Citations: 26     Fields:    Translation:HumansCells
    267. Han SJ, Tsai SY, Tsai MJ, O'Malley BW. Distinct temporal and spatial activities of RU486 on progesterone receptor function in reproductive organs of ovariectomized mice. Endocrinology. 2007 May; 148(5):2471-86. PMID: 17303655.
      Citations: 12     Fields:    Translation:AnimalsCells
    268. O'Malley BW. Coregulators: from whence came these "master genes". Mol Endocrinol. 2007 May; 21(5):1009-13. PMID: 17284664.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    269. Li C, Wu RC, Amazit L, Tsai SY, Tsai MJ, O'Malley BW. Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover. Mol Cell Biol. 2007 Feb; 27(4):1296-308. PMID: 17158932; PMCID: PMC1800725.
      Citations: 28     Fields:    Translation:HumansCells
    270. Louet JF, Amazit L, Tannour-Louet M, Wu RC, Tsai SY, Tsai MJ, Auwerx J, O'Malley BW, Coste A. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17868-73. PMID: 17098861; PMCID: PMC1693839.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    271. Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW. Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16716-21. PMID: 17065319; PMCID: PMC1636521.
      Citations: 25     Fields:    Translation:AnimalsCells
    272. Mukherjee A, Amato P, Allred DC, Fernandez-Valdivia R, Nguyen J, O'Malley BW, DeMayo FJ, Lydon JP. Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human. J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):22-31. PMID: 17045797.
      Citations: 11     Fields:    Translation:HumansAnimals
    273. O'Malley BW. Molecular biology. Little molecules with big goals. Science. 2006 Sep 22; 313(5794):1749-50. PMID: 16990541.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    274. Mukherjee A, Soyal SM, Fernandez-Valdivia R, Gehin M, Chambon P, Demayo FJ, Lydon JP, O'Malley BW. Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Mol Cell Biol. 2006 Sep; 26(17):6571-83. PMID: 16914740; PMCID: PMC1592830.
      Citations: 62     Fields:    Translation:AnimalsCells
    275. Feng Q, Yi P, Wong J, O'Malley BW. Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol. 2006 Nov; 26(21):7846-57. PMID: 16923966; PMCID: PMC1636757.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    276. Mussi P, Yu C, O'Malley BW, Xu J. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3. Mol Endocrinol. 2006 Dec; 20(12):3105-19. PMID: 16916939.
      Citations: 37     Fields:    Translation:HumansCells
    277. Han SJ, Jung SY, Malovannaya A, Kim T, Lanz RB, Qin J, O'Malley BW. A scoring system for the follow up study of nuclear receptor coactivator complexes. Nucl Recept Signal. 2006; 4:e014. PMID: 16862220; PMCID: PMC1513068.
      Citations: 5     Fields:    
    278. Dhananjayan SC, Ramamoorthy S, Khan OY, Ismail A, Sun J, Slingerland J, O'Malley BW, Nawaz Z. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol. 2006 Oct; 20(10):2343-54. PMID: 16772533.
      Citations: 42     Fields:    Translation:HumansCells
    279. Hatchell EC, Colley SM, Beveridge DJ, Epis MR, Stuart LM, Giles KM, Redfern AD, Miles LE, Barker A, MacDonald LM, Arthur PG, Lui JC, Golding JL, McCulloch RK, Metcalf CB, Wilce JA, Wilce MC, Lanz RB, O'Malley BW, Leedman PJ. SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. Mol Cell. 2006 Jun 09; 22(5):657-68. PMID: 16762838.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    280. Lonard DM, O'Malley BW. The expanding cosmos of nuclear receptor coactivators. Cell. 2006 May 05; 125(3):411-4. PMID: 16678083.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    281. Antal MC, Chan S, Kastner P, Mark M, O'Malley BW, Auwerx J, Coste A. Absence of the steroid receptor coactivator-3 induces B-cell lymphoma. EMBO J. 2006 Jun 07; 25(11):2453-64. PMID: 16675958; PMCID: PMC1478181.
      Citations: 34     Fields:    Translation:AnimalsCells
    282. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK. Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells. J Cell Biochem. 2006 Apr 01; 97(5):1036-51. PMID: 16294321.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    283. Woolley SC, O'Malley B, Lydon J, Crews D. Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice. Behav Brain Res. 2006 Feb 28; 167(2):197-204. PMID: 16413068.
      Citations: 6     Fields:    Translation:Animals
    284. Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92. PMID: 16439211.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    285. Jeong JW, Kwak I, Lee KY, White LD, Wang XP, Brunicardi FC, O'Malley BW, DeMayo FJ. The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism. Mol Endocrinol. 2006 May; 20(5):1138-52. PMID: 16423883.
      Citations: 37     Fields:    Translation:Animals
    286. Winnay JN, Xu J, O'Malley BW, Hammer GD. Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function. Endocrinology. 2006 Mar; 147(3):1322-32. PMID: 16339206.
      Citations: 24     Fields:    Translation:AnimalsCells
    287. Yi P, Wu RC, Sandquist J, Wong J, Tsai SY, Tsai MJ, Means AR, O'Malley BW. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005 Nov; 25(21):9687-99. PMID: 16227615; PMCID: PMC1265806.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    288. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK. Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer. J Immunol. 2005 Oct 15; 175(8):5541-50. PMID: 16210663.
      Citations: 64     Fields:    Translation:AnimalsCells
    289. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
      Citations: 22     Fields:    Translation:AnimalsCells
    290. Hockstein NG, Weinstein GS, O'malley BW. Maintenance of hemostasis in transoral robotic surgery. ORL J Otorhinolaryngol Relat Spec. 2005; 67(4):220-4. PMID: 16145284.
      Citations: 9     Fields:    Translation:Animals
    291. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 01; 65(17):7993-8002. PMID: 16140972.
      Citations: 57     Fields:    Translation:AnimalsCells
    292. Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 2006 Jan; 20(1):45-55. PMID: 16141356.
      Citations: 43     Fields:    Translation:AnimalsCells
    293. Han SJ, Jeong J, Demayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol. 2005 Sep; 25(18):8150-65. PMID: 16135805; PMCID: PMC1234322.
      Citations: 18     Fields:    Translation:AnimalsCells
    294. Zheng FF, Wu RC, Smith CL, O'Malley BW. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005 Sep; 25(18):8273-84. PMID: 16135815; PMCID: PMC1234335.
      Citations: 39     Fields:    Translation:HumansCells
    295. Ying H, Furuya F, Willingham MC, Xu J, O'Malley BW, Cheng SY. Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone. Mol Cell Biol. 2005 Sep; 25(17):7687-95. PMID: 16107715; PMCID: PMC1190271.
      Citations: 11     Fields:    Translation:Cells
    296. McKenna NJ, O'Malley BW. Teaching resources. An interactive course in nuclear receptor signaling: concepts and models. Sci STKE. 2005 Aug 30; 2005(299):tr22. PMID: 16131668.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    297. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK. Recombinant vaccinia virus expressing interleukin-2 invokes anti-tumor cellular immunity in an orthotopic murine model of head and neck squamous cell carcinoma. Mol Ther. 2006 Jan; 13(1):183-93. PMID: 16125469.
      Citations: 10     Fields:    Translation:AnimalsCells
    298. Margolis RN, Evans RM, O'Malley BW, NURSA Atlas Consortium. The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. Mol Endocrinol. 2005 Oct; 19(10):2433-6. PMID: 16051673.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    299. Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct; 19(10):2451-65. PMID: 16051665.
      Citations: 63     Fields:    Translation:HumansCells
    300. Schneider JS, Burgess C, Sleiter NC, DonCarlos LL, Lydon JP, O'Malley B, Levine JE. Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse. Endocrinology. 2005 Oct; 146(10):4340-8. PMID: 16002522.
      Citations: 24     Fields:    Translation:Animals
    301. Dowhan DH, Dutertre M, Martin N, Berget SM, O'Malley BW, Auboeuf D. A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts. Mol Cell Biol. 2005 Jul; 25(13):5307-16. PMID: 15964789; PMCID: PMC1156981.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    302. Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai MJ, O'Malley BW. Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9487-92. PMID: 15983373; PMCID: PMC1172261.
      Citations: 20     Fields:    Translation:Animals
    303. Apostolakis EM, Riherd DN, O'Malley BW. PAC1 receptors mediate pituitary adenylate cyclase-activating polypeptide- and progesterone-facilitated receptivity in female rats. Mol Endocrinol. 2005 Nov; 19(11):2798-811. PMID: 15976009.
      Citations: 11     Fields:    Translation:Animals
    304. O'Malley BW. A life-long search for the molecular pathways of steroid hormone action. Mol Endocrinol. 2005 Jun; 19(6):1402-11. PMID: 15914709.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    305. Masuhiro Y, Mezaki Y, Sakari M, Takeyama K, Yoshida T, Inoue K, Yanagisawa J, Hanazawa S, O'malley BW, Kato S. Splicing potentiation by growth factor signals via estrogen receptor phosphorylation. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8126-31. PMID: 15919818; PMCID: PMC1149443.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    306. Wu RC, Smith CL, O'Malley BW. Transcriptional regulation by steroid receptor coactivator phosphorylation. Endocr Rev. 2005 May; 26(3):393-9. PMID: 15814849.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    307. Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB. Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell. 2005 Apr 01; 18(1):71-82. PMID: 15808510.
      Citations: 82     Fields:    Translation:HumansCells
    308. Lonard DM, O'Malley BW. Expanding functional diversity of the coactivators. Trends Biochem Sci. 2005 Mar; 30(3):126-32. PMID: 15752984.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    309. Dennis AP, Lonard DM, Nawaz Z, O'Malley BW. Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol. 2005 Mar; 94(4):337-46. PMID: 15857753.
      Citations: 29     Fields:    Translation:HumansCells
    310. Park SE, Xu J, Frolova A, Liao L, O'Malley BW, Katzenellenbogen BS. Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol. 2005 Mar; 25(5):1989-99. PMID: 15713652; PMCID: PMC549370.
      Citations: 46     Fields:    Translation:AnimalsCells
    311. Dennis AP, O'Malley BW. Rush hour at the promoter: how the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):139-51. PMID: 15860256.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    312. Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. Mol Cell. 2005 Feb 04; 17(3):429-39. PMID: 15694343.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    313. Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL. Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1339-44. PMID: 15677324; PMCID: PMC547886.
      Citations: 62     Fields:    Translation:HumansCells
    314. Reddy DS, O'Malley BW, Rogawski MA. Anxiolytic activity of progesterone in progesterone receptor knockout mice. Neuropharmacology. 2005 Jan; 48(1):14-24. PMID: 15617723.
      Citations: 57     Fields:    Translation:Animals
    315. Nishihara E, O'Malley BW, Xu J. Nuclear receptor coregulators are new players in nervous system development and function. Mol Neurobiol. 2004 Dec; 30(3):307-25. PMID: 15655254.
      Citations: 10     Fields:    Translation:HumansAnimals
    316. O'Malley BW. Results of a search for the mechanisms of steroid receptor regulation of gene expression. Ann N Y Acad Sci. 2004 Dec; 1038:80-7. PMID: 15838100.
      Citations: 2     Fields:    Translation:AnimalsCells
    317. Wu HY, Hamamori Y, Xu J, Chang SC, Saluna T, Chang MF, O'Malley BW, Kedes L. Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD. J Biol Chem. 2005 Feb 04; 280(5):3129-37. PMID: 15563453.
      Citations: 10     Fields:    Translation:AnimalsCells
    318. Li X, Lonard DM, O'Malley BW. A contemporary understanding of progesterone receptor function. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11):669-78. PMID: 15541762.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    319. Verma S, Ismail A, Gao X, Fu G, Li X, O'Malley BW, Nawaz Z. The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. Mol Cell Biol. 2004 Oct; 24(19):8716-26. PMID: 15367689; PMCID: PMC516762.
      Citations: 31     Fields:    Translation:HumansCells
    320. Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24; 15(6):937-49. PMID: 15383283.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    321. Mark M, Yoshida-Komiya H, Gehin M, Liao L, Tsai MJ, O'Malley BW, Chambon P, Xu J. Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4453-8. PMID: 15070739; PMCID: PMC384768.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    322. Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Olsson J, Otto HF, O'Malley B, Poustka A, M?ller H, Carl?n A. Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Genes Chromosomes Cancer. 2004 Mar; 39(3):185-94. PMID: 14732920.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    323. Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004 Mar 01; 64(5):1875-85. PMID: 14996752.
      Citations: 86     Fields:    Translation:AnimalsCells
    324. Auboeuf D, Dowhan DH, Kang YK, Larkin K, Lee JW, Berget SM, O'Malley BW. Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2270-4. PMID: 14982999; PMCID: PMC356940.
      Citations: 48     Fields:    Translation:Cells
    325. Smith CL, O'Malley BW. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev. 2004 Feb; 25(1):45-71. PMID: 14769827.
      Citations: 260     Fields:    Translation:HumansAnimals
    326. Auboeuf D, Dowhan DH, Li X, Larkin K, Ko L, Berget SM, O'Malley BW. CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing. Mol Cell Biol. 2004 Jan; 24(1):442-53. PMID: 14673176; PMCID: PMC303353.
      Citations: 73     Fields:    Translation:HumansCells
    327. Lonard DM, Tsai SY, O'Malley BW. Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol. 2004 Jan; 24(1):14-24. PMID: 14673139; PMCID: PMC303341.
      Citations: 28     Fields:    Translation:HumansCells
    328. Nawaz Z, O'Malley BW. Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription? Mol Endocrinol. 2004 Mar; 18(3):493-9. PMID: 14673136.
      Citations: 39     Fields:    Translation:Cells
    329. Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, Lydon JP. Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models. Steroids. 2003 Nov; 68(10-13):779-87. PMID: 14667968.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    330. Apostolakis EM, Lanz R, O'Malley BW. Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents. Mol Endocrinol. 2004 Jan; 18(1):173-83. PMID: 14593074.
      Citations: 16     Fields:    Translation:Animals
    331. O'Malley BW. Sequentiality and processivity of nuclear receptor coregulators in regulation of target gene expression. Nucl Recept Signal. 2003; 1:e010. PMID: 16604182; PMCID: PMC1402223.
      Citations: 7     Fields:    
    332. Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S, M?dder UI. Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology. 2004 Feb; 145(2):913-21. PMID: 14563705.
      Citations: 36     Fields:    Translation:Animals
    333. Lanz RB, Chua SS, Barron N, DeMayo F, O'Malley BW, S?der BM. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol. 2003 Oct; 23(20):7163-76. PMID: 14517287; PMCID: PMC230309.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    334. Kamiya Y, Zhang XY, Ying H, Kato Y, Willingham MC, Xu J, O'Malley BW, Cheng SY. Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone. Endocrinology. 2003 Sep; 144(9):4144-53. PMID: 12933689.
      Citations: 17     Fields:    Translation:Animals
    335. Lan ZJ, Gu P, Xu X, Jackson KJ, DeMayo FJ, O'Malley BW, Cooney AJ. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J. 2003 Aug 15; 22(16):4070-81. PMID: 12912906; PMCID: PMC175795.
      Citations: 30     Fields:    Translation:AnimalsCells
    336. Dasgupta S, Tripathi PK, Bhattacharya-Chatterjee M, O'Malley B, Chatterjee SK. Recombinant vaccinia virus expressing IL-2 generates effective anti-tumor responses in an orthotopic murine model of head and neck carcinoma. Mol Ther. 2003 Aug; 8(2):238-48. PMID: 12907146.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    337. Li X, O'Malley BW. Unfolding the action of progesterone receptors. J Biol Chem. 2003 Oct 10; 278(41):39261-4. PMID: 12893816.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    338. Monks DA, Xu J, O'Malley BW, Jordan CL. Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons. Neuroendocrinology. 2003 Jul; 78(1):45-51. PMID: 12869799.
      Citations: 9     Fields:    Translation:AnimalsCells
    339. Li X, Wong J, Tsai SY, Tsai MJ, O'Malley BW. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol. 2003 Jun; 23(11):3763-73. PMID: 12748280; PMCID: PMC155204.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    340. Sadow PM, Chassande O, Koo EK, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE. Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone. Mol Cell Endocrinol. 2003 May 30; 203(1-2):65-75. PMID: 12782404.
      Citations: 12     Fields:    Translation:Animals
    341. Schneider JS, Stone MK, Wynne-Edwards KE, Horton TH, Lydon J, O'Malley B, Levine JE. Progesterone receptors mediate male aggression toward infants. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2951-6. PMID: 12601162; PMCID: PMC151447.
      Citations: 35     Fields:    Translation:Animals
    342. Sadow PM, Koo E, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Seo H, Murata Y, Weiss RE. Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary. Mol Endocrinol. 2003 May; 17(5):882-94. PMID: 12576486.
      Citations: 9     Fields:    Translation:AnimalsCells
    343. Cheskis BJ, McKenna NJ, Wong CW, Wong J, Komm B, Lyttle CR, O'Malley BW. Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members. J Biol Chem. 2003 Apr 11; 278(15):13271-7. PMID: 12540843.
      Citations: 7     Fields:    Translation:AnimalsCells
    344. Nishihara E, Yoshida-Komiya H, Chan CS, Liao L, Davis RL, O'Malley BW, Xu J. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci. 2003 Jan 01; 23(1):213-22. PMID: 12514218; PMCID: PMC6742154.
      Citations: 50     Fields:    Translation:AnimalsCells
    345. Champy MF, O'Malley BW, Chambon P, Auwerx J, Picard F, G?hin M, Annicotte J, Rocchi S. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell. 2002 Dec 27; 111(7):931-41. PMID: 12507421.
      Citations: 185     Fields:    Translation:AnimalsCells
    346. Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):3-14. PMID: 12650696.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    347. Sadow PM, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE. Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E36-46. PMID: 12388168.
      Citations: 12     Fields:    Translation:AnimalsCells
    348. Xu J, O'Malley BW. Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function. Rev Endocr Metab Disord. 2002 Sep; 3(3):185-92. PMID: 12215713.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    349. Auboeuf D, Parker MM, O'Malley BW, Berget SM, H?nig A. Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. Mol Cell Biol. 2002 Aug; 22(16):5698-707. PMID: 12138182; PMCID: PMC133985.
      Citations: 56     Fields:    Translation:HumansCells
    350. Apostolakis EM, Ramamurphy M, Zhou D, O'Malley BW, O?ate S. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Mol Endocrinol. 2002 Jul; 16(7):1511-23. PMID: 12089347.
      Citations: 38     Fields:    Translation:AnimalsCells
    351. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
      Citations: 6     Fields:    Translation:AnimalsCells
    352. Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002 May; 22(10):3549-61. PMID: 11971985; PMCID: PMC133790.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    353. Weiss RE, Gehin M, Xu J, Sadow PM, O'Malley BW, Chambon P, Refetoff S. Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency. Endocrinology. 2002 Apr; 143(4):1554-7. PMID: 11897715.
      Citations: 9     Fields:    Translation:Animals
    354. Takeuchi Y, Murata Y, Sadow P, Hayashi Y, Seo H, Xu J, O'Malley BW, Weiss RE, Refetoff S. Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo. Endocrinology. 2002 Apr; 143(4):1346-52. PMID: 11897691.
      Citations: 19     Fields:    Translation:Animals
    355. McKenna NJ, O'Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell. 2002 Feb 22; 108(4):465-74. PMID: 11909518.
      Citations: 470     Fields:    Translation:HumansAnimalsCells
    356. Cavarretta IT, Mukopadhyay R, Lonard DM, Cowsert LM, Bennett CF, O'Malley BW, Smith CL. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002 Feb; 16(2):253-70. PMID: 11818499.
      Citations: 24     Fields:    Translation:HumansCells
    357. Ye X, Schillinger K, Burcin MM, Tsai SY, O'Malley BW. Ligand-inducible transgene regulation for gene therapy. Methods Enzymol. 2002; 346:551-61. PMID: 11883090.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    358. Smith CL, DeVera DG, Lamb DJ, Nawaz Z, Jiang YH, Beaudet AL, O'Malley BW. Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol Cell Biol. 2002 Jan; 22(2):525-35. PMID: 11756548; PMCID: PMC139730.
      Citations: 28     Fields:    Translation:Animals
    359. Conneely OM, Mulac-Jericevic B, DeMayo F, Lydon JP, O'Malley BW. Reproductive functions of progesterone receptors. Recent Prog Horm Res. 2002; 57:339-55. PMID: 12017551.
      Citations: 95     Fields:    Translation:HumansAnimals
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