TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
Address7200 Cambridge Street, M.S. Bcm609
Houston, TX 77030
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    R01NS025884     (HRACHOVY, RICHARD)Apr 1, 1988 - Mar 31, 1994
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frost JD, Le JT, Lee CL, Ballester-Rosado C, Hrachovy RA, Swann JW. Vigabatrin therapy implicates neocortical high frequency oscillations in an animal model of infantile spasms. Neurobiol Dis. 2015 Oct; 82:1-11. PMID: 26026423; PMCID: PMC4640943.
      Citations: 11     Fields:    Translation:HumansAnimals
    2. Chen DK, Maheshwari A, Franks R, Trolley GC, Robinson JS, Hrachovy RA. Brief group psychoeducation for psychogenic nonepileptic seizures: a neurologist-initiated program in an epilepsy center. Epilepsia. 2014 Jan; 55(1):156-66. PMID: 24446955.
      Citations: 16     Fields:    Translation:Humans
    3. Hrachovy RA, Frost JD. Infantile spasms. Handb Clin Neurol. 2013; 111:611-8. PMID: 23622208.
      Citations: 15     Fields:    Translation:HumansAnimals
    4. Chen DK, Izadyar S, Wisdom NM, Collins RL, Franks R, Hrachovy RA. Intact vs. impaired ictal sensorium: does it affect outcome of psychogenic nonepileptic events following disclosure of diagnosis? Epilepsy Behav. 2012 May; 24(1):30-5. PMID: 22503467.
      Citations:    Fields:    Translation:Humans
    5. Frost JD, Lee CL, Le JT, Hrachovy RA, Swann JW. Interictal high frequency oscillations in an animal model of infantile spasms. Neurobiol Dis. 2012 May; 46(2):377-88. PMID: 22342513; PMCID: PMC3323746.
      Citations: 15     Fields:    Translation:Animals
    6. Chen DK, Izadyar S, Collins RL, Benge JF, Lemaire AW, Hrachovy RA. Induction of psychogenic nonepileptic events: success rate influenced by prior induction exposure, ictal semiology, and psychological profiles. Epilepsia. 2011 Jun; 52(6):1063-70. PMID: 21371022.
      Citations: 1     Fields:    Translation:Humans
    7. Frost JD, Lee CL, Hrachovy RA, Swann JW. High frequency EEG activity associated with ictal events in an animal model of infantile spasms. Epilepsia. 2011 Jan; 52(1):53-62. PMID: 21204817; PMCID: PMC3233379.
      Citations: 21     Fields:    Translation:HumansAnimals
    8. Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: a U.S. consensus report. Epilepsia. 2010 Oct; 51(10):2175-89. PMID: 20608959.
      Citations: 119     Fields:    Translation:Humans
    9. Andropoulos DB, Mizrahi EM, Hrachovy RA, Stayer SA, Stark AR, Heinle JS, McKenzie ED, Dickerson HA, Meador MR, Fraser CD. Electroencephalographic seizures after neonatal cardiac surgery with high-flow cardiopulmonary bypass. Anesth Analg. 2010 Jun 01; 110(6):1680-5. PMID: 20435942.
      Citations: 12     Fields:    Translation:Humans
    10. Mitra J, Glover JR, Ktonas PY, Thitai Kumar A, Mukherjee A, Karayiannis NB, Frost JD, Hrachovy RA, Mizrahi EM. A multistage system for the automated detection of epileptic seizures in neonatal electroencephalography. J Clin Neurophysiol. 2009 Aug; 26(4):218-26. PMID: 19602985; PMCID: PMC2760540.
      Citations: 21     Fields:    Translation:Humans
    11. Price MG, Yoo JW, Burgess DL, Deng F, Hrachovy RA, Frost JD, Noebels JL. A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci. 2009 Jul 08; 29(27):8752-63. PMID: 19587282; PMCID: PMC2782569.
      Citations: 73     Fields:    Translation:AnimalsCells
    12. Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SJ, Hrachovy RA, Anderson AE. Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. 2009 Jul; 50(7):1741-51. PMID: 19453702; PMCID: PMC2925051.
      Citations: 37     Fields:    Translation:AnimalsCells
    13. Friedman DE, Kung DH, Laowattana S, Kass JS, Hrachovy RA, Levin HS. Identifying depression in epilepsy in a busy clinical setting is enhanced with systematic screening. Seizure. 2009 Jul; 18(6):429-33. PMID: 19409813.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    14. Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE. Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. J Neurochem. 2008 Aug; 106(4):1929-40. PMID: 18513371; PMCID: PMC2678944.
      Citations: 51     Fields:    Translation:AnimalsCells
    15. Guggenheim MA, Frost JD, Hrachovy RA. Time interval from a brain insult to the onset of infantile spasms. Pediatr Neurol. 2008 Jan; 38(1):34-7. PMID: 18054690.
      Citations: 5     Fields:    Translation:Humans
    16. Kawai M, Hrachovy RA, Franklin PJ, Foreman PJ. Video-EEG monitoring in a geriatric veteran population. J Clin Neurophysiol. 2007 Dec; 24(6):429-32. PMID: 18090522.
      Citations: 2     Fields:    Translation:Humans
    17. Lee CL, Frost JD, Swann JW, Hrachovy RA. A new animal model of infantile spasms with unprovoked persistent seizures. Epilepsia. 2008 Feb; 49(2):298-307. PMID: 17941850.
      Citations: 34     Fields:    Translation:HumansAnimals
    18. Guerra MP, Hrachovy RA, Lugli L, Mizrahi EM, Ferrari F. A new lethal case of joint contractures, facial abnormalities, pachygyria plus early-onset encephalopathy with a suppression-burst EEG pattern. Eur J Paediatr Neurol. 2007 Sep; 11(5):318-21. PMID: 17412623.
      Citations: 1     Fields:    Translation:Humans
    19. Karayiannis NB, Xiong Y, Frost JD, Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion tracking methods. J Clin Neurophysiol. 2006 Dec; 23(6):521-31. PMID: 17143140.
      Citations: 2     Fields:    Translation:Humans
    20. Hrachovy RA, Frost JD. The EEG in selected generalized seizures. J Clin Neurophysiol. 2006 Aug; 23(4):312-32. PMID: 16885706.
      Citations: 4     Fields:    Translation:Humans
    21. Karayiannis NB, Xiong Y, Tao G, Frost JD, Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures of epileptic origin. Epilepsia. 2006 Jun; 47(6):966-80. PMID: 16822243.
      Citations: 3     Fields:    Translation:Humans
    22. Karayiannis NB, Tao G, Frost JD, Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion segmentation methods. Clin Neurophysiol. 2006 Jul; 117(7):1585-94. PMID: 16684619.
      Citations: 5     Fields:    Translation:Humans
    23. Karayiannis NB, Mukherjee A, Glover JR, Ktonas PY, Frost JD, Hrachovy RA, Mizrahi EM. Detection of pseudosinusoidal epileptic seizure segments in the neonatal EEG by cascading a rule-based algorithm with a neural network. IEEE Trans Biomed Eng. 2006 Apr; 53(4):633-41. PMID: 16602569.
      Citations: 5     Fields:    Translation:Humans
    24. Mitra J, Glover J, Ktonas P, Frost J, Hrachovy R, Mizrahi E. Rule-enhanced Clustering in the Detection of Neonatal Seizures. Conf Proc IEEE Eng Med Biol Soc. 2005; 2006:948-51. PMID: 17282341.
      Citations:    Fields:    
    25. Frost JD, Hrachovy RA. Pathogenesis of infantile spasms: a model based on developmental desynchronization. J Clin Neurophysiol. 2005 Jan-Feb; 22(1):25-36. PMID: 15689710.
      Citations: 33     Fields:    Translation:HumansCells
    26. Mitra J, Glover JR, Frost JD, Ktonas PA, Hrachovy RA, Mizrahi EM. Enhanced spatio-temporal clustering in the detection of neonatal seizures using context-based rules. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4717-20. PMID: 17271362.
      Citations:    Fields:    
    27. Karayiannis NB, Mukherjee A, Glover JR, Ktonas PY, Frost JD, Hrachovy RA, Mizrahi EM. Quantifying and visualizing uncertainty in EEG data of neonatal seizures. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:423-6. PMID: 17271702.
      Citations:    Fields:    
    28. Hrachovy RA, Frost JD. Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome). J Clin Neurophysiol. 2003 Nov-Dec; 20(6):408-25. PMID: 14734931.
      Citations: 36     Fields:    Translation:Humans
    29. Hrachovy RA. West's syndrome (infantile spasms). Clinical description and diagnosis. Adv Exp Med Biol. 2002; 497:33-50. PMID: 11993738.
      Citations: 6     Fields:    Translation:Humans
    30. Lee CL, Hannay J, Hrachovy R, Rashid S, Antalffy B, Swann JW. Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy. Neuroscience. 2001; 107(1):71-84. PMID: 11744248.
      Citations: 25     Fields:    Translation:HumansAnimals
    31. Swann JW, Lee CL, Smith KL, Hrachovy RA. Developmental neuroplasticity and epilepsy. Epilepsia. 2000 Aug; 41(8):1078-9. PMID: 10961649.
      Citations:    Fields:    Translation:HumansAnimalsCells
    32. Galvan CD, Hrachovy RA, Smith KL, Swann JW. Blockade of neuronal activity during hippocampal development produces a chronic focal epilepsy in the rat. J Neurosci. 2000 Apr 15; 20(8):2904-16. PMID: 10751443; PMCID: PMC6772221.
      Citations: 36     Fields:    Translation:AnimalsCells
    33. Rashid S, Lee I, Anderson AE, Hrachovy RA, Swann JW. Insights into the tetanus toxin model of early-onset epilepsy from long-term video monitoring during anticonvulsant therapy. Brain Res Dev Brain Res. 1999 Dec 10; 118(1-2):221-5. PMID: 10611523.
      Citations:    Fields:    Translation:Animals
    34. Hrachovy RA, O'Donnell DM. The significance of excessive rhythmic alpha and/or theta frequency activity in the EEG of the neonate. Clin Neurophysiol. 1999 Mar; 110(3):438-44. PMID: 10363767.
      Citations: 1     Fields:    Translation:Humans
    35. Anderson AE, Hrachovy RA, Antalffy BA, Armstrong DL, Swann JW. A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. Neuroscience. 1999; 92(1):73-82. PMID: 10392831.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Anderson AE, Hrachovy RA, Swann JW. Increased susceptibility to tetanus toxin-induced seizures in immature rats. Epilepsy Res. 1997 Mar; 26(3):433-42. PMID: 9127724.
      Citations: 6     Fields:    Translation:Animals
    37. Lee CL, Hrachovy RA, Smith KL, Frost JD, Swann JW. Tetanus toxin-induced seizures in infant rats and their effects on hippocampal excitability in adulthood. Brain Res. 1995 Apr 17; 677(1):97-109. PMID: 7606473.
      Citations: 12     Fields:    Translation:Animals
    38. Frost JD, Hrachovy RA, Glaze DG, Rettig GM. Alpha rhythm slowing during initiation of carbamazepine therapy: implications for future cognitive performance. J Clin Neurophysiol. 1995 Jan; 12(1):57-63. PMID: 7896910.
      Citations: 5     Fields:    Translation:Humans
    39. Hrachovy RA, Frost JD, Glaze DG. Coupling of focal electrical seizure discharges with infantile spasms: incidence during long-term monitoring in newly diagnosed patients. J Clin Neurophysiol. 1994 Jul; 11(4):461-4. PMID: 7962492.
      Citations:    Fields:    Translation:Humans
    40. Hrachovy RA, Frost JD, Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr. 1994 May; 124(5 Pt 1):803-6. PMID: 8176573.
      Citations: 42     Fields:    Translation:HumansCTClinical Trials
    41. Smith Doody R, Hrachovy RA, Feher EP. Recurrent fluent aphasia associated with a seizure focus. Brain Lang. 1992 May; 42(4):419-30. PMID: 1611466.
      Citations:    Fields:    Translation:Humans
    42. Frost JD, Hrachovy RA, Glaze DG. Spike morphology in childhood focal epilepsy: relationship to syndromic classification. Epilepsia. 1992 May-Jun; 33(3):531-6. PMID: 1592033.
      Citations: 2     Fields:    Translation:Humans
    43. Frost JD, Hrachovy RA, Glaze DG, McCully MI. Sleep modulation of interictal spike configuration in untreated children with partial seizures. Epilepsia. 1991 May-Jun; 32(3):341-6. PMID: 1904344.
      Citations: 2     Fields:    Translation:Humans
    44. Hrachovy RA, Glaze DG, Frost JD. A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia. 1991 Mar-Apr; 32(2):212-4. PMID: 1848513.
      Citations: 14     Fields:    Translation:Humans
    45. Hrachovy RA, Frost JD, Glaze DG, Kellaway P. Surgical treatment for infantile spasms? Ann Neurol. 1991 Jan; 29(1):110-2. PMID: 1996874.
      Citations: 2     Fields:    Translation:Humans
    46. Hrachovy RA, Frost JD, Glaze DG, Rose D. Treatment of infantile spasms with methysergide and alpha-methylparatyrosine. Epilepsia. 1989 Sep-Oct; 30(5):607-10. PMID: 2571497.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    47. Hrachovy RA, Frost JD. Infantile spasms. Pediatr Clin North Am. 1989 Apr; 36(2):311-29. PMID: 2538796.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    48. Hrachovy RA, Frost JD. Infantile spasms. Cleve Clin J Med. 1989; 56 Suppl Pt 1:S10-6; dicussion S40-2. PMID: 2541944.
      Citations: 1     Fields:    Translation:Humans
    49. Hrachovy RA, Frost JD, Pollack MS, Glaze DG. Serologic HLA typing in infantile spasms. Epilepsia. 1988 Nov-Dec; 29(6):817-9. PMID: 3191897.
      Citations: 1     Fields:    Translation:Humans
    50. Hrachovy RA, Frost JD, Glaze DG. Treatment of infantile spasms with tetrabenazine. Epilepsia. 1988 Sep-Oct; 29(5):561-3. PMID: 3409841.
      Citations: 1     Fields:    Translation:Humans
    51. Glaze DG, Hrachovy RA, Frost JD, Kellaway P, Zion TE. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr. 1988 Mar; 112(3):389-96. PMID: 2450190.
      Citations: 9     Fields:    Translation:Humans
    52. Hrachovy RA, Frost JD, Gospe SM, Glaze DG. Infantile spasms following near-drowning: a report of two cases. Epilepsia. 1987 Jan-Feb; 28(1):45-8. PMID: 3792289.
      Citations: 1     Fields:    Translation:Humans
    53. Frost JD, Kellaway P, Hrachovy RA, Glaze DG, Mizrahi EM. Changes in epileptic spike configuration associated with attainment of seizure control. Ann Neurol. 1986 Dec; 20(6):723-6. PMID: 3101580.
      Citations: 4     Fields:    Translation:Humans
    54. Glaze DG, Hrachovy RA, Frost JD, Zion TE, Bryan RN. Computed tomography in infantile spasms: effects of hormonal therapy. Pediatr Neurol. 1986 Jan-Feb; 2(1):23-7. PMID: 2854738.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    55. Hrachovy RA, Frost JD, Kellaway P. Hypsarrhythmia: variations on the theme. Epilepsia. 1984 Jun; 25(3):317-25. PMID: 6539199.
      Citations: 29     Fields:    Translation:Humans
    56. Strickbine-Van Reet P, Glaze DG, Hrachovy RA. A preliminary prospective neurophysiological study of coma in children. Am J Dis Child. 1984 May; 138(5):492-5. PMID: 6711506.
      Citations: 2     Fields:    Translation:Humans
    57. Hrachovy RA, Frost JD, Glaze DG. What have we learned about sudden infant death? N Engl J Med. 1984 Mar 22; 310(12):787-8. PMID: 6700660.
      Citations:    Fields:    Translation:Humans
    58. Hrachovy RA, Frost JD, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr. 1983 Oct; 103(4):641-5. PMID: 6312008.
      Citations: 53     Fields:    Translation:HumansCTClinical Trials
    59. Kellaway P, Hrachovy RA. Status epilepticus in newborns: a perspective on neonatal seizures. Adv Neurol. 1983; 34:93-9. PMID: 6829364.
      Citations: 1     Fields:    Translation:Humans
    60. Hrachovy RA. Drug-induced alpha coma. Neurology. 1982 Nov; 32(11):1319. PMID: 6890173.
      Citations:    Fields:    Translation:Humans
    61. Hrachovy RA, Frost JD, Kellaway P. Sleep characteristics in infantile spasms. Neurology. 1981 Jun; 31(6):688-93. PMID: 6264348.
      Citations: 8     Fields:    Translation:Humans
    62. Hrachovy RA, Frost JD, Kellaway P, Zion T. A controlled study of ACTH therapy in infantile spasms. Epilepsia. 1980 Dec; 21(6):631-6. PMID: 6254755.
      Citations: 11     Fields:    Translation:Humans
    63. Kellaway P, Hrachovy RA, Frost JD, Zion T. Precise characterization and quantification of infantile spasms. Ann Neurol. 1979 Sep; 6(3):214-8. PMID: 534418.
      Citations: 32     Fields:    Translation:Humans
    64. Hrachovy RA, Frost JD, Kellaway P, Zion T. A controlled study of prednisone therapy in infantile spasms. Epilepsia. 1979 Aug; 20(4):403-7. PMID: 157873.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    65. Frost JD, Hrachovy RA, Kellaway P, Zion T. Quantitative analysis and characterization of infantile spasms. Epilepsia. 1978 Jun; 19(3):273-82. PMID: 679895.
      Citations: 1     Fields:    Translation:Humans
    66. Bruhn JG, Hrachovy RA. Black college students' attitudes toward opportunities in the health professions. J Med Educ. 1977 Oct; 52(10):847-9. PMID: 903951.
      Citations: 2     Fields:    Translation:Humans
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