Institute for Clinical and Translational Research

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LAWRENCE C B CHAN

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressONE BAYLOR PLAZA
HOUSTON TX 77030
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wei Q, Lee JH, Wang H, Bongmba OYN, Wu CS, Pradhan G, Sun Z, Chew L, Bajaj M, Chan L, Chapkin RS, Chen MH, Sun Y. Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol. 2017 Oct 23; 17(1):8. PMID: 29058611.
      View in: PubMed
    2. Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 Nov; 6(11):1350-1359. PMID: 29107283.
      View in: PubMed
    3. Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016; 7:11612. PMID: 27194471; PMCID: PMC4874037.
      View in: PubMed, PubMed Central
    4. Yang Y, Chan L. Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev. 2016 Jun; 37(3):190-222. PMID: 27035557; PMCID: PMC4890265 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    5. Urabe H, Terashima T, Kojima H, Chan L. Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy. Am J Physiol Endocrinol Metab. 2016 Feb 15; 310(4):E269-75. PMID: 26695138.
      View in: PubMed
    6. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ER?-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425.
      View in: PubMed
    7. Nuotio-Antar AM, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, Zou F, Chan L. FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. Endocrinology. 2015 Nov; 156(11):4020-32. PMID: 26248218.
      View in: PubMed
    8. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107.
      View in: PubMed
    9. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HC, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015; 6:7339. PMID: 26081744.
      View in: PubMed
    10. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-3548. PMID: 25953849.
      View in: PubMed
    11. Poungvarin N, Chang B, Imamura M, Chen J, Moolsuwan K, Sae-Lee C, Li W, Chan L. Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin. Endocrinology. 2015 Jun; 156(6):1982-94. PMID: 25751637; PMCID: PMC4430618.
      View in: PubMed, PubMed Central
    12. Urabe H, Terashima T, Lin F, Kojima H, Chan L. Bone marrow-derived TNF-? causes diabetic neuropathy in mice. Diabetologia. 2015 Feb; 58(2):402-10. PMID: 25399355; PMCID: PMC4289451.
      View in: PubMed, PubMed Central
    13. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2015 Feb; 64(2):529-40. PMID: 25332429; PMCID: PMC4303975.
      View in: PubMed, PubMed Central
    14. Chen W, Zhou H, Saha P, Li L, Chan L. Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology. 2014 Nov; 155(11):4215-25. PMID: 25093462; PMCID: PMC4197977.
      View in: PubMed, PubMed Central
    15. Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H. Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration. J Neurosci Res. 2014 Jul; 92(7):856-69. PMID: 24936617; PMCID: PMC4061499.
      View in: PubMed, PubMed Central
    16. Zhao L, Nakae Y, Qin H, Ito T, Kimura T, Kojima H, Chan L, Komatsu N. Polyglycerol-functionalized nanodiamond as a platform for gene delivery: Derivatization, characterization, and hybridization with DNA. Beilstein J Org Chem. 2014; 10:707-13. PMID: 24778723; PMCID: PMC3999746.
      View in: PubMed, PubMed Central
    17. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-? expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One. 2014; 9(3):e92073. PMID: 24642694; PMCID: PMC3958473.
      View in: PubMed, PubMed Central
    18. Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS Lett. 2014 Mar 18; 588(6):1080-6. PMID: 24583009; PMCID: PMC4004028.
      View in: PubMed, PubMed Central
    19. Kojima H, Kim J, Chan L. Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab. 2014 Apr; 25(4):178-87. PMID: 24507996; PMCID: PMC3975817.
      View in: PubMed, PubMed Central
    20. Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. The REG? proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab. 2013 Sep 3; 18(3):380-91. PMID: 24011073; PMCID: PMC3813599.
      View in: PubMed, PubMed Central
    21. Kohjima M, Tsai TH, Tackett BC, Thevananther S, Li L, Chang BH, Chan L. Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice. J Hepatol. 2013 Dec; 59(6):1246-54. PMID: 23928401; PMCID: PMC4001732.
      View in: PubMed, PubMed Central
    22. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 2; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
      View in: PubMed, PubMed Central
    23. Chen W, Chang B, Wu X, Li L, Sleeman M, Chan L. Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice. Am J Physiol Endocrinol Metab. 2013 Apr 1; 304(7):E770-9. PMID: 23423172; PMCID: PMC3625749.
      View in: PubMed, PubMed Central
    24. Chen W, Xie A, Chan L. Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Transl Res. 2013 Apr; 161(4):217-29. PMID: 23348026; PMCID: PMC3602320.
      View in: PubMed, PubMed Central
    25. Jin X, Chen J, Hu Z, Chan L, Wang Y. Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int. 2013 Apr; 83(4):604-14. PMID: 23302722; PMCID: PMC3612389.
      View in: PubMed, PubMed Central
    26. Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat Commun. 2013; 4:1526. PMID: 23443554; PMCID: PMC3640364.
      View in: PubMed, PubMed Central
    27. Yang Y, Chang BH, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013 Jan; 5(1):92-104. PMID: 23197416; PMCID: PMC3569656.
      View in: PubMed, PubMed Central
    28. Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y. Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve. PLoS One. 2012; 7(9):e44592. PMID: 23028564; PMCID: PMC3446933.
      View in: PubMed, PubMed Central
    29. Chan L, Terashima T, Urabe H, Lin F, Kojima H. Pathogenesis of diabetic neuropathy: bad to the bone. Ann N Y Acad Sci. 2011 Dec; 1240:70-6. PMID: 22172042; PMCID: PMC3636709.
      View in: PubMed, PubMed Central
    30. Terashima T, Kojima H, Chan L. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB J. 2012 Jan; 26(1):295-308. PMID: 21978940; PMCID: PMC3250244.
      View in: PubMed, PubMed Central
    31. Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H. Inactivation of TNF-? ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E844-52. PMID: 21810933; PMCID: PMC3213998.
      View in: PubMed, PubMed Central
    32. Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K. Interleukin-7 induces recruitment of monocytes/macrophages to endothelium. Eur Heart J. 2012 Dec; 33(24):3114-23. PMID: 21804111; PMCID: PMC3598429.
      View in: PubMed, PubMed Central
    33. Li Y, Kojima H, Fujino K, Matsumura K, Katagi M, Urabe H, Chan L, Eguchi Y, Zhao L, Kimura H. Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine. J Gastroenterol Hepatol. 2011 Jun; 26(6):1072-8. PMID: 21265880; PMCID: PMC3321643.
      View in: PubMed, PubMed Central
    34. Shi X, Li X, Wang Y, Zhang K, Zhou F, Chan L, Li D, Guan X. Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway. Am J Physiol Endocrinol Metab. 2011 Mar; 300(3):E554-63. PMID: 21177288; PMCID: PMC3279303.
      View in: PubMed, PubMed Central
    35. Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem. 2010 Dec 24; 285(52):40581-92. PMID: 20956520; PMCID: PMC3003357.
      View in: PubMed, PubMed Central
    36. Sharma R, Buras E, Terashima T, Serrano F, Massaad CA, Hu L, Bitner B, Inoue T, Chan L, Pautler RG. Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice. PLoS One. 2010; 5(10):e13463. PMID: 20976160; PMCID: PMC2956689.
      View in: PubMed, PubMed Central
    37. Chen W, Chang B, Li L, Chan L. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology. 2010 Sep; 52(3):1134-42. PMID: 20648554; PMCID: PMC2932863.
      View in: PubMed, PubMed Central
    38. Wagner RT, Lewis J, Cooney A, Chan L. Stem cell approaches for the treatment of type 1 diabetes mellitus. Transl Res. 2010 Sep; 156(3):169-79. PMID: 20801414; PMCID: PMC2935591.
      View in: PubMed, PubMed Central
    39. Kasahara T, Imai S, Kojima H, Katagi M, Kimura H, Chan L, Matsusue Y. Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone. 2010 Sep; 47(3):617-25. PMID: 20601287; PMCID: PMC2926189.
      View in: PubMed, PubMed Central
    40. Chang BH, Li L, Saha P, Chan L. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res. 2010 Aug; 51(8):2132-42. PMID: 20424269; PMCID: PMC2903828.
      View in: PubMed, PubMed Central
    41. Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 7; 395(3):395-400. PMID: 20382127; PMCID: PMC2874883.
      View in: PubMed, PubMed Central
    42. Yechoor V, Chan L. Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation. Mol Endocrinol. 2010 Aug; 24(8):1501-11. PMID: 20219891; PMCID: PMC2940465.
      View in: PubMed, PubMed Central
    43. Kohjima M, Sun Y, Chan L. Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model. Endocrinology. 2010 Apr; 151(4):1532-40. PMID: 20176720; PMCID: PMC2850232.
      View in: PubMed, PubMed Central
    44. Merched A, Tollefson K, Chan L. Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice. Cardiovasc Res. 2010 Mar 1; 85(4):853-63. PMID: 19843511; PMCID: PMC2819833.
      View in: PubMed, PubMed Central
    45. Yechoor V, Liu V, Paul A, Lee J, Buras E, Ozer K, Samson S, Chan L. Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. Endocrinology. 2009 Nov; 150(11):4863-73. PMID: 19819964; PMCID: PMC2775983.
      View in: PubMed, PubMed Central
    46. Chen W, Yechoor VK, Chang BH, Li MV, March KL, Chan L. The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology. 2009 Oct; 150(10):4552-61. PMID: 19574402; PMCID: PMC2754678.
      View in: PubMed, PubMed Central
    47. Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J Clin Invest. 2009 Jul; 119(7):2100-112. PMID: 19603551; PMCID: PMC2701884.
      View in: PubMed, PubMed Central
    48. Ko KW, Corry DB, Brayton CF, Paul A, Chan L. Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun. 2009 Jun 19; 384(1):93-9. PMID: 19393222; PMCID: PMC2739567.
      View in: PubMed, PubMed Central
    49. Yang Y, Chang BH, Samson SL, Li MV, Chan L. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 2009 May; 37(8):2529-38. PMID: 19264802; PMCID: PMC2677877.
      View in: PubMed, PubMed Central
    50. Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar; 16(3):358-73. PMID: 19289082; PMCID: PMC2676438.
      View in: PubMed, PubMed Central
    51. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009 Jan 7; 9(1):77-87. PMID: 19117548; PMCID: PMC2630393.
      View in: PubMed, PubMed Central
    52. Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19229-34. PMID: 19047629; PMCID: PMC2614744.
      View in: PubMed, PubMed Central
    53. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140; PMCID: PMC2668604.
      View in: PubMed, PubMed Central
    54. Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov; 16(11):1805-12. PMID: 18781141; PMCID: PMC2582376.
      View in: PubMed, PubMed Central
    55. Paul A, Chang BH, Li L, Yechoor VK, Chan L. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res. 2008 Jun 20; 102(12):1492-501. PMID: 18483409; PMCID: PMC2773502.
      View in: PubMed, PubMed Central
    56. Li MV, Chen W, Poungvarin N, Imamura M, Chan L. Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3. Mol Endocrinol. 2008 Jul; 22(7):1658-72. PMID: 18436566; PMCID: PMC2453601.
      View in: PubMed, PubMed Central
    57. Paul A, Yechoor V, Raja R, Li L, Chan L. Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice. Atherosclerosis. 2008 Oct; 200(2):257-63. PMID: 18289551; PMCID: PMC2613781.
      View in: PubMed, PubMed Central
    58. Oi J, Terashima T, Kojima H, Fujimiya M, Maeda K, Arai R, Chan L, Yasuda H, Kashiwagi A, Kimura H. Isolation of specific peptides that home to dorsal root ganglion neurons in mice. Neurosci Lett. 2008 Apr 4; 434(3):266-72. PMID: 18329804; PMCID: PMC2348187.
      View in: PubMed, PubMed Central
    59. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37. PMID: 17576812; PMCID: PMC1952143.
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    60. Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L. Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):4030-5. PMID: 17360472; PMCID: PMC1820703.
      View in: PubMed, PubMed Central
    61. Chang BH, Chan L. Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1465-8. PMID: 17194897.
      View in: PubMed
    62. Kojima H, Fujimiya M, Terashima T, Kimura H, Chan L. Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006 Dec; 53(6):715-22. PMID: 16960402.
      View in: PubMed
    63. Lin TY, Chan LC, Fan YH, Lin CH, Chow KC, Lin SL, Lan JL, Lin FJ, Chiou SH. Use of a recombinant protein containing major epitopes of hnRNP G to detect anti-hnRNP G antibodies in dogs with systemic lupus erythematosus. Res Vet Sci. 2006 Dec; 81(3):335-9. PMID: 16677675.
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    64. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006 May; 3(5):379-86. PMID: 16679295.
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    65. Li MV, Chang B, Imamura M, Poungvarin N, Chan L. Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes. 2006 May; 55(5):1179-89. PMID: 16644671.
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    66. Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr; 116(4):1102-9. PMID: 16557297; PMCID: PMC1409738.
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    67. Samson SL, Chan L. Gene therapy for diabetes: reinventing the islet. Trends Endocrinol Metab. 2006 Apr; 17(3):92-100. PMID: 16504534.
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    68. Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol. 2006 Feb; 26(3):1063-76. PMID: 16428458; PMCID: PMC1347045.
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    69. Chan L, Terashima T, Fujimiya M, Kojima H. Chronic diabetic complications: the body's adaptive response to hyperglycemia gone awry? Trans Am Clin Climatol Assoc. 2006; 117:341-51; discussion 351-2. PMID: 18528485; PMCID: PMC1500919.
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    70. Lau PP, Li L, Merched AJ, Zhang AL, Ko KW, Chan L. Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Jan; 26(1):143-9. PMID: 16254210.
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    71. Paul A, Yeh ET, Chan L. A proatherogenic role for C-reactive protein in vivo. Curr Opin Lipidol. 2005 Oct; 16(5):512-7. PMID: 16148535.
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    72. Ko KW, Paul A, Ma K, Li L, Chan L. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res. 2005 Dec; 46(12):2586-94. PMID: 16199802.
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    73. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
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    74. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12525-30. PMID: 16116088; PMCID: PMC1194942.
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    75. Merched AJ, Chan L. Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Circulation. 2004 Dec 21; 110(25):3830-41. PMID: 15596565.
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    76. Ma K, Forte T, Otvos JD, Chan L. Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):149-54. PMID: 15539616.
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    77. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8. PMID: 15197189.
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    78. Oka K, Chan L. Liver-directed gene therapy for dyslipidemia and diabetes. Curr Atheroscler Rep. 2004 May; 6(3):203-9. PMID: 15068745; PMCID: PMC1224746.
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    79. Pastore L, Belalcazar LM, Oka K, Cela R, Lee B, Chan L, Beaudet AL. Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice. Gene. 2004 Mar 3; 327(2):153-60. PMID: 14980712.
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    80. Kojima H, Fujimiya M, Matsumura K, Nakahara T, Hara M, Chan L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2458-63. PMID: 14983031; PMCID: PMC356972.
      View in: PubMed, PubMed Central
    81. Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Feb 10; 109(5):647-55. PMID: 14744975.
      View in: PubMed
    82. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. PMID: 14578284.
      View in: PubMed
    83. Lau PP, Chan L. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. J Biol Chem. 2003 Dec 26; 278(52):52988-96. PMID: 14559896.
      View in: PubMed
    84. Chan L, Fujimiya M, Kojima H. In vivo gene therapy for diabetes mellitus. Trends Mol Med. 2003 Oct; 9(10):430-5. PMID: 14557055.
      View in: PubMed
    85. Liao W, Chang BH, Mancini M, Chan L. Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells. J Cell Biochem. 2003 Aug 1; 89(5):1019-29. PMID: 12874835.
      View in: PubMed
    86. Merched AJ, Williams E, Chan L. Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling. Arterioscler Thromb Vasc Biol. 2003 Sep 1; 23(9):1608-14. PMID: 12842843.
      View in: PubMed
    87. Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003 May; 9(5):596-603. PMID: 12704384.
      View in: PubMed
    88. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2748-53. PMID: 12601178; PMCID: PMC151412.
      View in: PubMed, PubMed Central
    89. Chen KH, Chang BH, Younan P, Shlykov SG, Sanborn BM, Chan L. Increased intracellular calcium transients by calmodulin antagonists differentially modulate tumor necrosis factor-alpha-induced E-selectin and ICAM-1 expression. Atherosclerosis. 2002 Nov; 165(1):5-13. PMID: 12208465.
      View in: PubMed
    90. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, Paul A, Chan L. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20; 277(38):34658-61. PMID: 12151381.
      View in: PubMed
    91. Oka K, Chan L. Recent advances in liver-directed gene therapy for dyslipidemia. Curr Atheroscler Rep. 2002 May; 4(3):199-207. PMID: 11931717.
      View in: PubMed
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