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DEBORAH HYINK

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R21DK065836     (HYINK, DEBORAH P)Dec 1, 2003 - Nov 30, 2006
    NIH/NIDDK
    Modeling renal development
    Role: Principal Investigator
    K01DK002783     (HYINK, DEBORAH P)Sep 30, 2000 - Jul 31, 2004
    NIH/NIDDK
    MULTIPOTENT PROGENITOR CELLS IN THE KIDNEY
    Role: Principal Investigator
    F32DK009615     (HYINK, DEBORAH P)Aug 9, 1997
    NIH/NIDDK
    MOLECULAR CONTROL OF RENAL EPITHELIAL DIFFERENTIATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang X, Liu R, Zhang W, Hyink DP, Das GC, Das B, Li Z, Wang A, Yuan W, Klotman PE, Lee K, He JC. Role of SIRT1 in HIV-associated kidney disease. Am J Physiol Renal Physiol. 2020 08 01; 319(2):F335-F344. PMID: 32657157; PMCID: PMC7473906.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    2. Matsukura T, Inaba C, Weygant EA, Kitamura D, Janknecht R, Matsumoto H, Hyink DP, Kashiwada S, Obara T. Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model. Physiol Rep. 2019 07; 7(14):e14172. PMID: 31325249; PMCID: PMC6642321.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    3. Li H, Zhang W, Zhong F, Das GC, Xie Y, Li Z, Cai W, Jiang G, Choi J, Sidani M, Hyink DP, Lee K, Klotman PE, He JC. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury. Kidney Int. 2018 12; 94(6):1160-1176. PMID: 30366682.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    4. Hays T, Ma'ayan A, Clark NR, Tan CM, Teixeira A, Teixeira A, Choi JW, Burdis N, Jung SY, Bajaj AO, O'Malley BW, He JC, Hyink DP, Klotman PE. Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte. PLoS One. 2014; 9(6):e100660. PMID: 24949636; PMCID: PMC4065073.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Sharma M, Magenheimer LK, Home T, Tamano KN, Singhal PC, Hyink DP, Klotman PE, Vanden Heuvel GB, Fields TA. Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy. Am J Physiol Renal Physiol. 2013 Apr 15; 304(8):F1127-36. PMID: 23389453; PMCID: PMC3625839.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    6. Hays T, D'Agati VD, Garellek JA, Warren T, Trubin ME, Hyink DP, He JC, Klotman PE. Glomerular MYH9 expression is reduced by HIV-1. AIDS. 2012 Apr 24; 26(7):797-803. PMID: 22313957; PMCID: PMC3913730.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Hyink D. Three-dimensional imaging of fetal mouse kidneys. Methods Mol Biol. 2012; 886:87-93. PMID: 22639253.
      Citations:    Fields:    Translation:Animals
    8. Li X, Iomini C, Hyink D, Wilson PD. PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev Biol. 2011 Aug 15; 356(2):475-85. PMID: 21684272.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Boucher CA, Ward HH, Case RL, Thurston KS, Li X, Needham A, Romero E, Hyink D, Qamar S, Roitbak T, Powell S, Ward C, Wilson PD, Wandinger-Ness A, Sandford RN. Receptor protein tyrosine phosphatases are novel components of a polycystin complex. Biochim Biophys Acta. 2011 Oct; 1812(10):1225-38. PMID: 21126580; PMCID: PMC3156852.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    10. Kuure S, Cebrian C, Machingo Q, Lu BC, Chi X, Hyink D, D'Agati V, Gurniak C, Witke W, Costantini F. Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. PLoS Genet. 2010 Oct 28; 6(10):e1001176. PMID: 21060807; PMCID: PMC2965756.
      Citations: 30     Fields:    Translation:AnimalsCells
    11. Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F, Michos O. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet. 2010 Jan 15; 6(1):e1000809. PMID: 20084103; PMCID: PMC2797609.
      Citations: 78     Fields:    Translation:AnimalsCells
    12. Villarroya J, Diaz-Delfin J, Hyink D, Domingo P, Giralt M, Klotman PE, Villarroya F. HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Antivir Ther. 2010; 15(7):1021-8. PMID: 21041917.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, Xiong H, Ouyang X, Shen Y, Levy DE, Hyink D, Klotman M, D'Agati V, Iyengar R, Klotman PE, He JC. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol. 2009 Oct; 20(10):2138-46. PMID: 19608706; PMCID: PMC2754106.
      Citations: 39     Fields:    Translation:AnimalsCells
    14. Li X, Hyink DP, Radbill B, Sudol M, Zhang H, Zheleznova NN, Wilson PD. Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development. Kidney Int. 2009 Jul; 76(1):54-62. PMID: 19367327.
      Citations: 5     Fields:    Translation:Animals
    15. Chi X, Hadjantonakis AK, Wu Z, Hyink D, Costantini F. A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching. Genesis. 2009 Feb; 47(2):61-6. PMID: 19111008; PMCID: PMC2880702.
      Citations: 34     Fields:    Translation:AnimalsCells
    16. Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. Biochim Biophys Acta. 2008 Jan; 1782(1):1-9. PMID: 17980165.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Polgar K, Striker G, Elliott J, Hyink D, Weber O, Fehling HJ, Keller G, Burrow C, Wilson P, Vigneau C. Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. J Am Soc Nephrol. 2007 Jun; 18(6):1709-20. PMID: 17475814.
      Citations: 59     Fields:    Translation:AnimalsCells
    18. Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD. Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Dev Biol. 2006 Nov 15; 299(2):466-77. PMID: 17022962.
      Citations: 78     Fields:    Translation:Animals
    19. Wilson SJ, Amsler K, Hyink DP, Li X, Lu W, Zhou J, Burrow CR, Wilson PD. Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia. Biochim Biophys Acta. 2006 Jul; 1762(7):647-55. PMID: 16797938.
      Citations: 31     Fields:    Translation:HumansCells
    20. Clendenon JL, Byars JM, Hyink DP. Image processing software for 3D light microscopy. Nephron Exp Nephrol. 2006; 103(2):e50-4. PMID: 16543764.
      Citations: 8     Fields:    Translation:Animals
    21. Li X, Hyink DP, Polgar K, Gusella GL, Wilson PD, Burrow CR. Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney. J Am Soc Nephrol. 2005 Dec; 16(12):3543-52. PMID: 16236808.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Polgar K, Burrow CR, Hyink DP, Fernandez H, Thornton K, Li X, Gusella GL, Wilson PD. Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys. Dev Biol. 2005 Oct 01; 286(1):16-30. PMID: 16122726.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Qiu L, Hyink DP, Gans WH, Amsler K, Wilson PD, Burrow CR. Midkine promotes selective expansion of the nephrogenic mesenchyme during kidney organogenesis. Organogenesis. 2004 Jul; 1(1):14-21. PMID: 19521555; PMCID: PMC2633669.
      Citations: 2     Fields:    
    24. Gross I, Morrison DJ, Hyink DP, Georgas K, English MA, Mericskay M, Hosono S, Sassoon D, Wilson PD, Little M, Licht JD. The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development. J Biol Chem. 2003 Oct 17; 278(42):41420-30. PMID: 12882970.
      Citations: 31     Fields:    Translation:AnimalsCells
    25. Kaletta T, Van der Craen M, Van Geel A, Dewulf N, Bogaert T, Branden M, King KV, Buechner M, Barstead R, Hyink D, Li HP, Geng L, Burrow C, Wilson P. Towards understanding the polycystins. Nephron Exp Nephrol. 2003 Jan; 93(1):e9-17. PMID: 12411744.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    26. Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR. PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9260-5. PMID: 12082174; PMCID: PMC123128.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    27. Hyink DP, Rappoport JZ, Wilson PD, Abramson RG. Expression of the urate transporter/channel is developmentally regulated in human kidneys. Am J Physiol Renal Physiol. 2001 Nov; 281(5):F875-86. PMID: 11592946.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    28. Hosono S, Luo X, Hyink DP, Schnapp LM, Wilson PD, Burrow CR, Reddy JC, Atweh GF, Licht JD. WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene. 1999 Jan 14; 18(2):417-27. PMID: 9927198.
      Citations: 13     Fields:    Translation:AnimalsCells
    29. Abrahamson DR, Robert B, Hyink DP, St John PL, Daniel TO. Origins and formation of microvasculature in the developing kidney. Kidney Int Suppl. 1998 Sep; 67:S7-11. PMID: 9736245.
      Citations: 26     Fields:    Translation:HumansAnimals
    30. Robert B, St John PL, Hyink DP, Abrahamson DR. Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts. Am J Physiol. 1996 Sep; 271(3 Pt 2):F744-53. PMID: 8853438.
      Citations: 32     Fields:    Translation:Animals
    31. Hyink DP, Tucker DC, St John PL, Leardkamolkarn V, Accavitti MA, Abrass CK, Abrahamson DR. Endogenous origin of glomerular endothelial and mesangial cells in grafts of embryonic kidneys. Am J Physiol. 1996 May; 270(5 Pt 2):F886-99. PMID: 8928852.
      Citations: 35     Fields:    Translation:AnimalsCells
    32. Hyink DP, Abrahamson DR. Origin of the glomerular vasculature in the developing kidney. Semin Nephrol. 1995 Jul; 15(4):300-14. PMID: 7569410.
      Citations: 9     Fields:    Translation:Animals
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