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PATRICK BARTH

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
DivisionPharmacology
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    R01GM097207     (WENSEL, THEODORE G)Aug 1, 2012 - May 31, 2021
    NIH/NIGMS
    EXPLORING STRUCTURE AND SEQUENCE SPACES OF G PROTEIN-COUPLED RECEPTOR SIGNALING
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature. 2020 Jun 11. PMID: 32528175.
      View in: PubMed
    2. Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, Bradley P, Bystroff C, Conway P, Cooper S, Correia BE, Coventry B, Das R, De Jong RM, DiMaio F, Dsilva L, Dunbrack R, Ford AS, Frenz B, Fu DY, Geniesse C, Goldschmidt L, Gowthaman R, Gray JJ, Gront D, Guffy S, Horowitz S, Huang PS, Huber T, Jacobs TM, Jeliazkov JR, Johnson DK, Kappel K, Karanicolas J, Khakzad H, Khar KR, Khare SD, Khatib F, Khramushin A, King IC, Kleffner R, Koepnick B, Kortemme T, Kuenze G, Kuhlman B, Kuroda D, Labonte JW, Lai JK, Lapidoth G, Leaver-Fay A, Lindert S, Linsky T, London N, Lubin JH, Lyskov S, Maguire J, Malmström L, Marcos E, Marcu O, Marze NA, Meiler J, Moretti R, Mulligan VK, Nerli S, Norn C, Ó'Conchúir S, Ollikainen N, Ovchinnikov S, Pacella MS, Pan X, Park H, Pavlovicz RE, Pethe M, Pierce BG, Pilla KB, Raveh B, Renfrew PD, Burman SSR, Rubenstein A, Sauer MF, Scheck A, Schief W, Schueler-Furman O, Sedan Y, Sevy AM, Sgourakis NG, Shi L, Siegel JB, Silva DA, Smith S, Song Y, Stein A, Szegedy M, Teets FD, Thyme SB, Wang RY, Watkins A, Zimmerman L, Bonneau R. Macromolecular modeling and design in Rosetta: recent methods and frameworks. Nat Methods. 2020 Jul; 17(7):665-680. PMID: 32483333.
      View in: PubMed
    3. Chen KM, Keri D, Barth P. Computational design of G Protein-Coupled Receptor allosteric signal transductions. Nat Chem Biol. 2020 01; 16(1):77-86. PMID: 31792443.
      View in: PubMed
    4. Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL, Zoghbi HY. An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. Mol Psychiatry. 2019 Jan 04. PMID: 30610205.
      View in: PubMed
    5. Lai JK, Ambia J, Wang Y, Barth P. Enhancing Structure Prediction and Design of Soluble and Membrane Proteins with Explicit Solvent-Protein Interactions. Structure. 2017 11 07; 25(11):1758-1770.e8. PMID: 28966016.
      View in: PubMed
    6. Arber C, Young M, Barth P. Reprogramming cellular functions with engineered membrane proteins. Curr Opin Biotechnol. 2017 10; 47:92-101. PMID: 28709113.
      View in: PubMed
    7. Feng X, Ambia J, Chen KM, Young M, Barth P. Computational design of ligand-binding membrane receptors with high selectivity. Nat Chem Biol. 2017 Jul; 13(7):715-723. PMID: 28459439.
      View in: PubMed
    8. Barth P, Senes A. Toward high-resolution computational design of the structure and function of helical membrane proteins. Nat Struct Mol Biol. 2016 06 07; 23(6):475-80. PMID: 27273630.
      View in: PubMed
    9. Basanta B, Chan KK, Barth P, King T, Sosnick TR, Hinshaw JR, Liu G, Everett JK, Xiao R, Montelione GT, Baker D. Introduction of a polar core into the de novo designed protein Top7. Protein Sci. 2016 07; 25(7):1299-307. PMID: 26873166.
      View in: PubMed
    10. Feng X, Barth P. A topological and conformational stability alphabet for multipass membrane proteins. Nat Chem Biol. 2016 Mar; 12(3):167-73. PMID: 26780406.
      View in: PubMed
    11. Arber C, Feng X, Abhyankar H, Romero E, Wu MF, Heslop HE, Barth P, Dotti G, Savoldo B. Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest. 2015 Jan; 125(1):157-68. PMID: 25415440.
      View in: PubMed
    12. Chen KY, Sun J, Salvo JS, Baker D, Barth P. High-resolution modeling of transmembrane helical protein structures from distant homologues. PLoS Comput Biol. 2014 May; 10(5):e1003636. PMID: 24854015.
      View in: PubMed
    13. Swick MC, Evangelista MA, Bodine TJ, Easton-Marks JR, Barth P, Shah MJ, Bormann Chung CA, Stanley S, McLaughlin SF, Lee CC, Sheth V, Doan Q, Hamill RJ, Steffen D, Becnel LB, Sucgang R, Zechiedrich L. Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates. PLoS One. 2013; 8(6):e65961. PMID: 23824211.
      View in: PubMed
    14. Chen KY, Zhou F, Fryszczyn BG, Barth P. Naturally evolved G protein-coupled receptors adopt metastable conformations. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13284-9. PMID: 22847407.
      View in: PubMed
    15. Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA. The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Mol Cell. 2009 Apr 24; 34(2):234-49. PMID: 19394300.
      View in: PubMed
    16. Barth P, Schoeffler A, Alber T. Targeting metastable coiled-coil domains by computational design. J Am Chem Soc. 2008 Sep 10; 130(36):12038-44. PMID: 18698842.
      View in: PubMed
    17. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. PMID: 17920020.
      View in: PubMed
    18. Barth P. Modulating membrane protein stability and association by design. Curr Opin Struct Biol. 2007 Aug; 17(4):460-6. PMID: 17870471.
      View in: PubMed
    19. Barth P, Savarin P, Gilquin B, Lagoutte B, Ochsenbein F. Solution NMR structure and backbone dynamics of the PsaE subunit of photosystem I from Synechocystis sp. PCC 6803. Biochemistry. 2002 Nov 26; 41(47):13902-14. PMID: 12437347.
      View in: PubMed
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