DAVID TWEARDY

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address
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    K11HL001763     (TWEARDY, DAVID JOHN)Apr 1, 1986 - Mar 31, 1991
    NIH
    SUPPRESSION OF HEMOPOIESIS BY A NOVEL LYMPHOKINE
    Role: Principal Investigator

    T32AI007333     (MELLORS, JOHN W)Sep 1, 1988 - Aug 31, 2011
    NIH
    Training in AIDS Molecular Epi/Microbiology &STDs
    Role: Co-Principal Investigator

    R01CA072261     (TWEARDY, DAVID JOHN)May 1, 1996 - Jun 30, 2008
    NIH
    Mechanisms of G-CSF Receptor Mediated Differentiation
    Role: Principal Investigator

    R01CA086430     (TWEARDY, DAVID JOHN)Sep 1, 1999 - Jun 30, 2005
    NIH
    STAT3 INTERACTIONS IN CELL GROWTH AND DIFFERENTIATION
    Role: Principal Investigator

    T32AI055413     (GIORDANO, THOMAS P)Aug 1, 2003 - Jun 30, 2025
    NIH
    Research Training in Infection and Immunity
    Role: Co-Principal Investigator

    R01HL076169     (TWEARDY, DAVID JOHN)Feb 1, 2004 - Jan 31, 2009
    NIH
    REVERSAL OF HYPOVOLEMIC CIRCULATORY COLLAPSE BY IL-6
    Role: Principal Investigator

    R21CA149783     (TWEARDY, DAVID JOHN)Jul 1, 2010 - Jun 30, 2012
    NIH
    Stat3 Probes that Target Breast Cancer Stem Cells
    Role: Principal Investigator

    R41CA153658     (TWEARDY, DAVID JOHN)Sep 26, 2012 - Aug 31, 2014
    NIH
    Chemical probes that target Stat3 to treat cancer
    Role: Principal Investigator

    R21CA191556     (TWEARDY, DAVID JOHN)Dec 1, 2014 - Nov 30, 2017
    NIH
    Targeting Stat1 and Stat3 to Reverse Radioresistance in Head and Neck Cancer
    Role: Principal Investigator

    R42DK104494     (TWEARDY, DAVID JOHN)Apr 8, 2016 - Mar 31, 2021
    NIH
    Oral Small Molecule STAT3 Inhibitor to Treat Cachexia in Chronic Kidney Disease
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:708325. PMID: 34504808.
      Citations:    Fields:    Translation:Animals
    2. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol. 2021 Oct; 192:114688. PMID: 34274354.
      Citations:    Fields:    
    3. Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res. 2021 07; 169:105637. PMID: 33932608.
      Citations:    Fields:    
    4. Zhang L, Wang Y, Dong Y, Chen Z, Eckols TK, Kasembeli MM, Tweardy DJ, Mitch WE. Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease. Am J Physiol Renal Physiol. 2020 07 01; 319(1):F84-F92. PMID: 32475130.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Minus MB, Wang H, Munoz JO, Stevens AM, Mangubat-Medina AE, Krueger MJ, Liu W, Kasembeli MM, Cooper JC, Kolosov MI, Tweardy DJ, Redell MS, Ball ZT. Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Org Biomol Chem. 2020 05 06; 18(17):3288-3296. PMID: 32286579.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev. 2020 04; 72(2):486-526. PMID: 32198236.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    7. Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE. Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E625-E635. PMID: 32101031.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW. Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 01 31; 11(1):661. PMID: 32005826.
      Citations: 24     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    9. Vicente D, Patino M, Marcus R, Lillemoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP. Correction: Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget. 2019 Oct 29; 10(59):6397. PMID: 31695849.
      Citations:    Fields:    
    10. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. Clin Cancer Res. 2019 07 01; 25(13):3996-4013. PMID: 30867218.
      Citations: 29     Fields:    Translation:HumansCells
    11. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2019 02 22; 10(16):1603. PMID: 30899429.
      Citations:    Fields:    
    12. Vicente D, Patino M, Marcus R, Lillmoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy D, Gottumukkala V, Vauthey JN, Aloia T, Cata JP. Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget. 2019 Jan 15; 10(5):584-594. PMID: 30728909.
      Citations: 2     Fields:    
    13. Pedroza M, To S, Assassi S, Wu M, Tweardy D, Agarwal SK. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). 2018 10 01; 57(10):1838-1850. PMID: 29029263.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    14. Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci. 2018 Aug 05; 19(8). PMID: 30081609.
      Citations: 31     Fields:    Translation:HumansAnimals
    15. Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun. 2017 11 13; 8(1):1447. PMID: 29129918.
      Citations: 26     Fields:    Translation:AnimalsCells
    16. Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy D, Phan AT, Hawk E, Javle M, Lee JS, Torres HA, Rashid A, Lenzi R, Hassabo HM, Abaza Y, Shalaby AS, Lacin S, Morris J, Patt YZ, Amos CI, Khaderi SA, Goss JA, Jalal PK, Kaseb AO. Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2017 Nov; 15(11):1791-1799. PMID: 28579181.
      Citations: 21     Fields:    Translation:Humans
    17. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. Clin Cancer Res. 2017 Sep 15; 23(18):5537-5546. PMID: 28533225.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    18. Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J. 2016 06 07; 110(11):2377-2385. PMID: 27276256.
      Citations: 2     Fields:    Translation:HumansCells
    19. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    20. Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep. 2016 Apr 26; 15(4):843-856. PMID: 27149849.
      Citations: 15     Fields:    
    21. Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA. Association Between Hepatitis C Virus and Head and Neck Cancers. J Natl Cancer Inst. 2016 08; 108(8). PMID: 27075854.
      Citations: 17     Fields:    Translation:HumansCells
    22. Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2016 07; 138(1):187-199. PMID: 26948077.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int. 2016; 2016:1959270. PMID: 26981525.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    24. Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci. 2015 Nov 06; 16(11):26706-20. PMID: 26561808.
      Citations: 23     Fields:    Translation:HumansCells
    25. Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R. The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3ß in Esophageal Squamous Cell Carcinoma. Clin Cancer Res. 2016 Feb 01; 22(3):691-703. PMID: 26405196.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    26. Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer. 2015 Nov; 90(2):182-90. PMID: 26410177.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13085-9. PMID: 26480340.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    28. Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK. STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J. 2016 Jan; 30(1):129-40. PMID: 26324850.
      Citations: 45     Fields:    Translation:AnimalsCells
    29. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". Biomed Res Int. 2015; 2015:869648. PMID: 26078968.
      Citations:    Fields:    
    30. Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87. PMID: 25787076.
      Citations: 61     Fields:    Translation:AnimalsCells
    31. DiNardo AR, Schmidt D, Mitchell A, Kaufman Y, Tweardy DJ. First Description of Oral Cryptococcus neoformans Causing Osteomyelitis of the Mandible, Manubrium and Third Rib with Associated Soft Tissue Abscesses in an Immunocompetent Host. Clin Microbiol Case Rep. 2015; 1(3). PMID: 27227123.
      Citations: 1     
    32. Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ. Contribution of chaperones to STAT pathway signaling. JAKSTAT. 2014; 3(3):e970459. PMID: 26413421.
      Citations: 14     
    33. Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells. 2014 Oct; 32(10):2571-82. PMID: 24891218.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    34. Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3ß Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel). 2014 Sep 29; 6(4):2012-34. PMID: 25268166.
      Citations: 6     
    35. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2014; 2014:247182. PMID: 25530957.
      Citations: 1     Fields:    Translation:HumansAnimals
    36. Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG. Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor. FEBS Lett. 2014 Jun 13; 588(13):2133-40. PMID: 24846140.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    37. Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 2014 Apr; 12(4):e1001844. PMID: 24756126.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    38. Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013 Dec 31; 2:e00996. PMID: 24381245.
      Citations: 24     Fields:    Translation:Animals
    39. Thacker S, Moran A, Lionakis M, Mastrangelo MA, Halder T, del Pilar Huby M, Wu Y, Tweardy DJ. Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect. 2014 Mar; 68(3):231-41. PMID: 24291043.
      Citations: 5     Fields:    Translation:AnimalsCells
    40. Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBPd to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 03; 18(3):368-79. PMID: 24011072.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    41. Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM. Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma. 2014 May; 55(5):1194-7. PMID: 23829279.
      Citations: 9     Fields:    Translation:HumansAnimals
    42. Fan Y, Kong R, Tweardy DJ, Wong ST. WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. J Struct Biol. 2013 Feb 18. PMID: 23428430.
      Citations:    Fields:    
    43. Thacker SA, Robinson P, Abel A, Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep. 2013; 3:1187. PMID: 23378918.
      Citations: 8     Fields:    Translation:AnimalsCells
    44. Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood. 2013 Feb 14; 121(7):1083-93. PMID: 23243289.
      Citations: 20     Fields:    Translation:HumansCells
    45. Anne Morrison C, Moran A, Patel S, Vidaurre Mdel P, Carrick MM, Tweardy DJ. Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect. 2013 Jan; 66(1):87-94. PMID: 23063873.
      Citations: 6     Fields:    Translation:HumansCells
    46. Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One. 2012; 7(8):e30207. PMID: 22879872.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    47. Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog. 2012 Feb; 8(2):e1002489. PMID: 22346746.
      Citations: 15     Fields:    Translation:HumansAnimals
    48. Roig IL, Musher DM, Tweardy DJ. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis. 2012 Jan 01; 54(1):91-4. PMID: 22042876.
      Citations: 6     Fields:    Translation:HumansCells
    49. Weatherhead JE, Tweardy DJ. Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg? J Infect. 2012 Feb; 64(2):225-7. PMID: 21945880.
      Citations: 5     Fields:    Translation:HumansCells
    50. Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B, Tweardy DJ. IL-6-mediated activation of Stat3a prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One. 2011; 6(6):e21449. PMID: 21738667.
      Citations: 6     Fields:    Translation:Animals
    51. Kelly JD, Teeter LD, Graviss EA, Tweardy DJ. Intracranial tuberculomas in adults: a report of twelve consecutive patients in Houston, Texas. Scand J Infect Dis. 2011 Oct; 43(10):785-91. PMID: 21696248.
      Citations: 1     Fields:    Translation:HumansCells
    52. Tweardy D, Chang JC. Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol. 2011 Jun 20; 29(18):2443-4. PMID: 21576641.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    53. Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26; 117(21):5701-9. PMID: 21447830.
      Citations: 92     Fields:    Translation:HumansCells
    54. Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol. 2010; 2010:597086. PMID: 20150970.
      Citations: 10     Fields:    Translation:AnimalsCells
    55. Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010 Jan 21; 115(3):643-52. PMID: 19965660.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    56. Tweardy DJ, Belmont JW. "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. Transl Res. 2009 Dec; 154(6):288-94. PMID: 19931194.
      Citations: 4     Fields:    Translation:Humans
    57. Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy D, Musher DM. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore). 2009 May; 88(3):154-159. PMID: 19440118.
      Citations: 34     Fields:    Translation:HumansCells
    58. Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One. 2009; 4(3):e4783. PMID: 19274102.
      Citations: 58     Fields:    Translation:HumansCells
    59. Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci. 2009 Feb; 2(1):41-9. PMID: 20443866.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    60. Kasembeli MM, Xu X, Tweardy DJ. SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed). 2009 Jan 01; 14:1010-22. PMID: 19273114.
      Citations: 5     Fields:    Translation:Cells
    61. Robinson P, Martin P, Garza A, D'Souza M, Mastrangelo MA, Tweardy D. Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol. 2008 Oct; 94(5):1150-4. PMID: 18576802.
      Citations: 4     Fields:    Translation:AnimalsCells
    62. Weerasinghe P, Li Y, Guan Y, Zhang R, Tweardy DJ, Jing N. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate. 2008 Sep 15; 68(13):1430-42. PMID: 18615483.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    63. Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med. 2008; 1(3):213-47. PMID: 18997875.
      Citations: 12     
    64. Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One. 2008 Feb 13; 3(2):e1605. PMID: 18270592.
      Citations: 14     Fields:    Translation:AnimalsCells
    65. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem. 2007 Nov 30; 282(48):34958-67. PMID: 17855361.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    66. Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell. 2007 Oct; 18(10):3941-51. PMID: 17671166.
      Citations: 4     Fields:    Translation:HumansCells
    67. Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol. 2007 Oct; 82(4):975-85. PMID: 17634277.
      Citations: 9     Fields:    Translation:AnimalsCells
    68. Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun. 2007 Mar; 75(3):1137-43. PMID: 17158891.
      Citations: 10     Fields:    Translation:Animals
    69. Tweardy DJ, Khoshnevis MR, Yu B, Mastrangelo MA, Hardison EG, López JA. Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock. 2006 Oct; 26(4):386-90. PMID: 16980886.
      Citations: 9     Fields:    Translation:AnimalsCells
    70. Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect. 2007 Feb; 54(2):e99-101. PMID: 16824611.
      Citations: 1     Fields:    Translation:HumansCells
    71. Arikan AA, Yu B, Mastrangelo MA, Tweardy DJ. Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med. 2006 Mar; 34(3):771-7. PMID: 16521270.
      Citations: 6     Fields:    Translation:Animals
    72. Shao H, Xu X, Jing N, Tweardy DJ. Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. J Immunol. 2006 Mar 01; 176(5):2933-41. PMID: 16493051.
      Citations: 5     Fields:    Translation:HumansCells
    73. Jing N, Zhu Q, Yuan P, Li Y, Mao L, Tweardy DJ. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther. 2006 Feb; 5(2):279-86. PMID: 16505101.
      Citations: 37     Translation:HumansAnimals
    74. Tweardy DJ, Jing N. Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc. 2006; 117:33-51; discussion 51-2. PMID: 18528463.
      Citations:    Fields:    Translation:HumansAnimalsCells
    75. Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006; 3(3):261-7. PMID: 24980527.
      Citations: 7     Fields:    
    76. Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis. 2005 Nov 15; 192(10):1741-8. PMID: 16235172.
      Citations: 51     Fields:    Translation:HumansCells
    77. Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs. 2005 Jul; 16(6):601-7. PMID: 15930886.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    78. Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1272-7. PMID: 15706046.
      Citations: 7     Translation:Animals
    79. Jing N, Sha W, Li Y, Xiong W, Tweardy DJ. Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des. 2005; 11(22):2841-54. PMID: 16101441.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    80. Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des. 2005; 11(22):2873-87. PMID: 16101443.
      Citations: 24     Fields:    Translation:HumansAnimals
    81. Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 2004 Sep 15; 64(18):6603-9. PMID: 15374974.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    82. Ono M, Yu B, Hardison EG, Mastrangelo MA, Tweardy DJ. Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. Shock. 2004 Jun; 21(6):519-25. PMID: 15167680.
      Citations: 19     Fields:    Translation:Animals
    83. Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol. 2004 May; 24(10):4465-75. PMID: 15121864.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    84. Shao H, Xu X, Mastrangelo MA, Jing N, Cook RG, Legge GB, Tweardy DJ. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem. 2004 Apr 30; 279(18):18967-73. PMID: 14966128.
      Citations: 22     Fields:    Translation:HumansCells
    85. Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G225-33. PMID: 14715517.
      Citations: 35     Fields:    Translation:Animals
    86. Dong S, Chen SJ, Tweardy DJ. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leuk Lymphoma. 2003 Dec; 44(12):2023-9. PMID: 14959844.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    87. Jing N, Li Y, Xu X, Sha W, Li P, Feng L, Tweardy DJ. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol. 2003 Nov; 22(11):685-96. PMID: 14659041.
      Citations: 32     Fields:    Translation:HumansCells
    88. Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res. 2003 Jul 15; 63(14):3923-30. PMID: 12873986.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    89. Brundage SI, Schreiber MA, Holcomb JB, Zautke N, Mastrangelo MA, Xq X, Macaitis J, Tweardy DJ. Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine. J Surg Res. 2003 Jul; 113(1):74-80. PMID: 12943813.
      Citations: 3     Fields:    Translation:Animals
    90. Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Aoki N, Meng ZH, Tweardy DJ, Hoots K. The effect of recombinant factor VIIa on noncoagulopathic pigs with grade V liver injuries. J Am Coll Surg. 2003 May; 196(5):691-7. PMID: 12742197.
      Citations: 6     Fields:    Translation:Animals
    91. Dong S, Qiu J, Stenoien DL, Brinkley WR, Mancini MA, Tweardy DJ. Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene. 2003 Feb 13; 22(6):858-68. PMID: 12584566.
      Citations: 4     Fields:    Translation:AnimalsCells
    92. Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood. 2002 Apr 15; 99(8):2637-46. PMID: 11929748.
      Citations: 25     Fields:    Translation:HumansCells
    93. Hierholzer C, Billiar TR, Tweardy DJ. Requirements for NF-kappaB activation in hemorrhagic shock. Arch Orthop Trauma Surg. 2002 Feb; 122(1):44-7. PMID: 11995880.
      Citations:    Fields:    Translation:Animals
    94. Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, Harbrecht BG. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock. 2002 Feb; 17(2):98-103. PMID: 11837796.
      Citations: 7     Fields:    Translation:AnimalsCells
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