Last Name


TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN, WT B.06104
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    Other Positions
    TitleGraduate Student
    InstitutionBaylor College of Medicine
    DepartmentClinical Scientist Training Program - PhD

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    Collapse Biography 
    Collapse awards and honors
    2011AAP Young Investigator Award, The American Academy of Pediatrics, Section on Perinatal Pediatrics
    2012SSPR Young Investigator Award, Southern Society of Pediatric Research
    2012The Arnold J.Rudolph Award, Baylor College of Medicine
    2015SSPR Young Faculty Award, Southern Society of Pediatric Research
    2016SSPR Young Faculty Award, Southern Society of Pediatric research
    2017SSPR Young Faculty Award, Southern Society of Pediatric research

    Collapse Overview 
    Collapse overview
    My research focuses on reducing long term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focises on the elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Coarfa C, Zhang Y, Maity S, Perera D, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 17; ajplung.00230.2017. PMID: 28818871.
      View in: PubMed
    2. Zhang Y, Jiang W, Wang L, Lingappan K. Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1?. Toxicol Appl Pharmacol. 2017 Jul 20; 332:8-14. PMID: 28734801.
      View in: PubMed
    3. Parmekar S, Arnold JL, Anselmo C, Pammi M, Hagan J, Fernandes CJ, Lingappan K. Mind the gap: can videolaryngoscopy bridge the competency gap in neonatal endotracheal intubation among pediatric trainees? a randomized controlled study. J Perinatol. 2017 May 18. PMID: 28518132.
      View in: PubMed
    4. Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 Apr 04; 7(1):642. PMID: 28377578.
      View in: PubMed
    5. Zhang Y, Lingappan K. Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2017 Mar 16. PMID: 28315681.
      View in: PubMed
    6. Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI. Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal ?-napthoflavone (BNF) administration: Implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Sci. 2017 Feb 13. PMID: 28201809.
      View in: PubMed
    7. Hoover J, Lingappan K. One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest. Clin Pediatr (Phila). 2016 Jun 28. PMID: 27356634.
      View in: PubMed
    8. Lingappan K, Jiang W, Wang L, Moorthy B. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 24; ajplung.00047.2016. PMID: 27343189.
      View in: PubMed
    9. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 May 25. PMID: 27235555.
      View in: PubMed
    10. Lingappan K, Kaiser JR, Srinivasan C, Gunn AJ. Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy. Pediatr Res. 2016 Apr 6. PMID: 27049290.
      View in: PubMed
    11. Lingappan K, Moorthy B. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1383-6. PMID: 26361877.
      View in: PubMed
    12. Tiwari KK, Moorthy B, Lingappan K. Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicol In Vitro. 2015 Oct; 29(7):1369-76. PMID: 26004619.
      View in: PubMed
    13. Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 4; 331:14-23. PMID: 25703676; PMCID: PMC4406849.
    14. Lingappan K, Arnold JL, Shaw TL, Fernandes CJ, Pammi M. Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. 2015; (2):CD009975. PMID: 25691129.
      View in: PubMed
    15. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282; PMCID: PMC4418801.
    16. Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581. PMID: 25003466; PMCID: PMC4086819.
    17. Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 8; 450(4):1345-50. PMID: 24997337; PMCID: PMC4216694.
    18. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714; PMCID: PMC4200035.
    19. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529; PMCID: PMC4169345.
    20. Lingappan K, Arunachalam A, Pammi M. Lactoferrin and the newborn: current perspectives. Expert Rev Anti Infect Ther. 2013 Jul; 11(7):695-707. PMID: 23879609.
      View in: PubMed
    21. Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90. PMID: 23792423; PMCID: PMC4201582.
    22. Singh M, Lingappan K. Whooping cough: the current scene. Chest. 2006 Nov; 130(5):1547-53. PMID: 17099036.
      View in: PubMed
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