Institute for Clinical and Translational Research

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OLUWATOYIN AJIBOLA ASOJO

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Tropical Medicine
AddressOne Baylor Plaza, BCM 320
Houston TX 77030
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    2013 - 2014CAPES-Fiocruz/CDTS Visiting Professor, CAPES-Fiocruz/CDTS Brazil
    2015 - 2017MemberUS National Committee for Crystallography , The National Academies of Sciences, Engineering and Mathematics
    2006UNO Women of Color Award in Science and Technology, University of Nebraska Omaha
    2001 - 2002IATAP Fellow, NCI Frederick
    2004Gladys Pearson Fellowship in Pediatric Cancer, UNMC Nebraska
    2005 - 2011NCI K01 Career Development Award, UNMC Nebraska
    2012AACR-MICR Faculty travel award, BCM
    2015Gordon Research Conference Carl Storm Underrepresented Minority Fellowship
    1989 - 1993Trent University CIDA full scholarship, Trent University Peterborough ON Canada
    1993 - 1999Graduate fellowship, University of Houston Texas
    1987 - 1989Lester B Pearson UWC Scholarship , Lester B. Pearson UWC College BC Canada
    2016 - 2021Fulbright Specialist Roster
    2016 - 2017Science Advocate Grant program, The Society for Science & the Public
    2016Carnegie African Diaspora Fellowship
    2017Norton Rose Fulbright Faculty Excellence Award in Teaching and Evaluation, Baylor College of Medicine

    Collapse Overview 
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    Crystallography, Education, Nigeria, STEM, Ibarapa, NTDs, CAP proteins / PR-1


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Asojo OA, Dranow DM, Serbzhinskiy D, Subramanian S, Staker B, Edwards TE, Myler PJ. Crystal structure of chorismate mutase from Burkholderia thailandensis. Acta Crystallogr F Struct Biol Commun. 2018 May 01; 74(Pt 5):294-299. PMID: 29717997.
      View in: PubMed
    2. Asojo OA, Subramanian S, Abendroth J, Exley I, Lorimer DD, Edwards TE, Myler PJ. Crystal structure of chorismate mutase from Burkholderia phymatum. Acta Crystallogr F Struct Biol Commun. 2018 Apr 01; 74(Pt 4):187-192. PMID: 29633965.
      View in: PubMed
    3. Darwiche R, Lugo F, Drurey C, Varossieau K, Smant G, Wilbers RHP, Maizels RM, Schneiter R, Asojo OA. Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis. Int J Parasitol. 2018 Mar 06. PMID: 29501266.
      View in: PubMed
    4. Asojo OA, Darwiche R, Gebremedhin S, Smant G, Lozano-Torres JL, Drurey C, Pollet J, Maizels RM, Schneiter R, Wilbers RHP. Heligmosomoides polygyrus Venom Allergen-like Protein-4 (HpVAL-4) is a sterol binding protein. Int J Parasitol. 2018 Mar 02. PMID: 29505764.
      View in: PubMed
    5. Luo Z, Kelleher AJ, Darwiche R, Hudspeth EM, Shittu OK, Krishnavajhala A, Schneiter R, Lopez JE, Asojo OA. Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated  gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. Sci Rep. 2017 Nov 10; 7(1):15310. PMID: 29127407.
      View in: PubMed
    6. Liu Z, Kelleher A, Tabb S, Wei J, Pollet J, Hotez PJ, Bottazzi ME, Zhan B, Asojo OA. Identification, Characterization, and Structure of Tm16 from Trichuris muris. J Parasitol Res. 2017; 2017:4342789. PMID: 28884022.
      View in: PubMed
    7. Baroni RM, Luo Z, Darwiche R, Hudspeth EM, Schneiter R, Pereira GAG, Mondego JMC, Asojo OA. Crystal Structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao. Sci Rep. 2017 Aug 10; 7(1):7818. PMID: 28798297.
      View in: PubMed
    8. Darwiche R, Mène-Saffrané L, Gfeller D, Asojo OA, Schneiter R. The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein. J Biol Chem. 2017 Apr 01. PMID: 28365570.
      View in: PubMed
    9. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 Mar; 11(3):e0005374. PMID: 28278244.
      View in: PubMed
    10. Asojo OA, Damania A, Turner TL, Slaughter G, Hirschi KD. Summer Research Training Provides Effective Tools for Underrepresented Minorities to Obtain Doctoral Level Degrees. J Racial Ethn Health Disparities. 2017 Jan 11. PMID: 28078659.
      View in: PubMed
    11. Darwiche R, Kelleher A, Hudspeth EM, Schneiter R, Asojo OA. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein. Sci Rep. 2016; 6:28838. PMID: 27344972; PMCID: PMC4921858.
      View in: PubMed, PubMed Central
    12. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 Feb 2; 1-14. PMID: 26839079.
      View in: PubMed
    13. Kelleher A, Liu Z, Seid CA, Zhan B, Asojo OA. Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143. Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):925-8. PMID: 26144240.
      View in: PubMed
    14. Kelleher A, Darwiche R, Rezende WC, Farias LP, Leite LC, Schneiter R, Asojo OA. Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs. Corrigendum. Acta Crystallogr D Biol Crystallogr. 2015 Apr; 71(Pt 4):1022. PMID: 25849410; PMCID: PMC4388274.
      View in: PubMed, PubMed Central
    15. Reiling S, Kelleher A, Matsumoto MM, Robinson G, Asojo OA. Structure of type II dehydroquinase from Pseudomonas aeruginosa. Acta Crystallogr F Struct Biol Commun. 2014 Nov; 70(Pt 11):1485-91. PMID: 25372814.
      View in: PubMed
    16. Asojo OA, Asuzu MC, Adebiyi AO. Ibarapa programme: half a century of rural health service, training, and international cooperation in Nigeria. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3201. PMID: 25275326; PMCID: PMC4183452.
      View in: PubMed, PubMed Central
    17. Asojo OA, Ceccarelli C. Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione. Acta Crystallogr F Struct Biol Commun. 2014 Sep; 70(Pt 9):1162-6. PMID: 25195885.
      View in: PubMed
    18. Kelleher A, Darwiche R, Rezende WC, Farias LP, Leite LC, Schneiter R, Asojo OA. Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs. Acta Crystallogr D Biol Crystallogr. 2014 Aug; 70(Pt 8):2186-96. PMID: 25084337; PMCID: PMC4118828.
      View in: PubMed, PubMed Central
    19. Asojo OA, Nelson SK, Mootien S, Lee Y, Rezende WC, Hyman DA, Matsumoto MM, Reiling S, Kelleher A, Ledizet M, Koski RA, Anthony KG. Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630. Acta Crystallogr D Biol Crystallogr. 2014 Jul; 70(Pt 7):1922-33. PMID: 25004969; PMCID: PMC4089486.
      View in: PubMed, PubMed Central
    20. Nelson SK, Kelleher A, Robinson G, Reiling S, Asojo OA. Structure of 2-keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase from Pseudomonas aeruginosa. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct; 69(Pt 10):1084-8. PMID: 24100553; PMCID: PMC3792661.
      View in: PubMed, PubMed Central
    21. Kelleher A, Zhan B, Asojo OA. Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug; 69(Pt 8):839-43. PMID: 23908024; PMCID: PMC3729155.
      View in: PubMed, PubMed Central
    22. Lee Y, Mootien S, Shoen C, Destefano M, Cirillo P, Asojo OA, Yeung KR, Ledizet M, Cynamon MH, Aristoff PA, Koski RA, Kaplan PA, Anthony KG. Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones. Biochem Pharmacol. 2013 Jul 15; 86(2):222-30. PMID: 23680030; PMCID: PMC3700342.
      View in: PubMed, PubMed Central
    23. Hotez PJ, Asojo OA, Adesina AM. Nigeria: "Ground Zero" for the high prevalence neglected tropical diseases. PLoS Negl Trop Dis. 2012; 6(7):e1600. PMID: 22860138; PMCID: PMC3409117.
      View in: PubMed, PubMed Central
    24. Bai F, Asojo OA, Cirillo P, Ciustea M, Ledizet M, Aristoff PA, Leng L, Koski RA, Powell TJ, Bucala R, Anthony KG. A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem. 2012 Aug 31; 287(36):30653-63. PMID: 22782901; PMCID: PMC3436310.
      View in: PubMed, PubMed Central
    25. Massilamany C, Asojo OA, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011 Dec; 23(12):729-39. PMID: 22058327.
      View in: PubMed
    26. Asojo OA, Koski RA, Bonafé N. Structural studies of human glioma pathogenesis-related protein 1. Acta Crystallogr D Biol Crystallogr. 2011 Oct; 67(Pt 10):847-55. PMID: 21931216; PMCID: PMC3176621.
      View in: PubMed, PubMed Central
    27. Asojo OA. Structure of a two-CAP-domain protein from the human hookworm parasite Necator americanus. Acta Crystallogr D Biol Crystallogr. 2011 May; 67(Pt 5):455-62. PMID: 21543848; PMCID: PMC3087624.
      View in: PubMed, PubMed Central
    28. Asojo OA, Asojo OA, Ngamelue MN, Homma K, Lockridge O. Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1; 67(Pt 4):434-7. PMID: 21505234; PMCID: PMC3080143.
      View in: PubMed, PubMed Central
    29. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011; 7(2):e1001287. PMID: 21347352; PMCID: PMC3037362.
      View in: PubMed, PubMed Central
    30. Reiling SA, Homma K, Asojo OA. Purification and crystallization of RNase HIII from Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1; 67(Pt 1):79-82. PMID: 21206030; PMCID: PMC3079978.
      View in: PubMed, PubMed Central
    31. Bonafé N, Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA. Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1; 66(Pt 11):1487-9. PMID: 21045302; PMCID: PMC3001655.
      View in: PubMed, PubMed Central
    32. Asojo OA, Goud GN, Zhan B, Ordonez K, Sedlacek M, Homma K, Deumic V, Gupta R, Brelsford J, Price MK, Ngamelue MN, Hotez PJ. Crystallization and preliminary X-ray analysis of Na-SAA-2 from the human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1; 66(Pt 2):172-6. PMID: 20124715; PMCID: PMC2815685.
      View in: PubMed, PubMed Central
    33. Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 2008 Sep; 21(9):1787-94. PMID: 18707141; PMCID: PMC2646670.
      View in: PubMed, PubMed Central
    34. Ngamelue MN, Homma K, Lockridge O, Asojo OA. Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1; 63(Pt 9):723-7. PMID: 17768338; PMCID: PMC2376307.
      View in: PubMed, PubMed Central
    35. Asojo OA, Homma K, Sedlacek M, Ngamelue M, Goud GN, Zhan B, Deumic V, Asojo O, Hotez PJ. X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanus. BMC Struct Biol. 2007; 7:42. PMID: 17594497; PMCID: PMC1924862.
      View in: PubMed, PubMed Central
    36. Asojo OA, Schott EJ, Vasta GR, Silva AM. Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1; 62(Pt 11):1072-5. PMID: 17077482; PMCID: PMC2225229.
      View in: PubMed, PubMed Central
    37. Nachon F, Asojo OA, Borgstahl G, Masson P, Lockridge O. Structural data on the aging of diethylphosphoryl-butyrylcholinesterase. Chem Biol Interact. 2005 Dec 15; 157-158:408-9. PMID: 16429549.
      View in: PubMed
    38. Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15; 23(39):4754-64. PMID: 16054275.
      View in: PubMed
    39. Asojo OA, Loukas A, Inan M, Barent R, Huang J, Plantz B, Swanson A, Gouthro M, Meagher MM, Hotez PJ. Crystallization and preliminary X-ray analysis of Na-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1; 61(Pt 4):391-4. PMID: 16511050; PMCID: PMC1952415.
      View in: PubMed, PubMed Central
    40. Nachon F, Asojo OA, Borgstahl GE, Masson P, Lockridge O. Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging. Biochemistry. 2005 Feb 1; 44(4):1154-62. PMID: 15667209.
      View in: PubMed
    41. Asojo OA, Goud G, Dhar K, Loukas A, Zhan B, Deumic V, Liu S, Borgstahl GE, Hotez PJ. X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection. J Mol Biol. 2005 Feb 25; 346(3):801-14. PMID: 15713464.
      View in: PubMed
    42. Asojo OA, Boulègue C, Hoover DM, Lu W, Lubkowski J. Structures of thymus and activation-regulated chemokine (TARC). Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1165-73. PMID: 12832759.
      View in: PubMed
    43. Asojo OA, Gulnik SV, Afonina E, Yu B, Ellman JA, Haque TS, Silva AM. Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum. J Mol Biol. 2003 Mar 14; 327(1):173-81. PMID: 12614616.
      View in: PubMed
    44. Asojo OA, Cater S, Hoover DM, Boulègue C, Lu W, Lubkowski J. Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC). Acta Crystallogr D Biol Crystallogr. 2003 Jan; 59(Pt 1):163-5. PMID: 12499558.
      View in: PubMed
    45. Asojo OA, Afonina E, Gulnik SV, Yu B, Erickson JW, Randad R, Medjahed D, Silva AM. Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370. Acta Crystallogr D Biol Crystallogr. 2002 Dec; 58(Pt 12):2001-8. PMID: 12454457.
      View in: PubMed
    46. Asojo O, Friedman J, Adir N, Belakhov V, Shoham Y, Baasov T. Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor. Biochemistry. 2001 May 29; 40(21):6326-34. PMID: 11371194.
      View in: PubMed
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