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ROBB MOSES

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    T32GM008796     (MOSES, ROBB E)Jul 1, 2001 - Aug 31, 2007
    NIH
    MOLECULAR GENETIC BASIS OF HUMAN DISEASE
    Role: Principal Investigator
    R01GM059759     (MOSES, ROBB E)Aug 1, 1999 - Jul 31, 2005
    NIH
    YEAST G1 CYCLIN DEGRADATION BY THE SCF UBIQUITIN LIGASE
    Role: Principal Investigator
    R01GM058186     (MOSES, ROBB E)Aug 1, 1998 - Jul 31, 2003
    NIH
    REPAIR OF DNA CROSSLINKS IN YEAST
    Role: Principal Investigator
    P01HL048546     (GROMPE, MARKUS)Jul 1, 1994 - May 31, 2021
    NIH
    Pathophysiology and Treatment of Fanconi Anemia
    Role: Co-Principal Investigator
    T32AG000183     (DONEHOWER, LAWRENCE A.)Sep 14, 1989 - Apr 30, 2016
    NIH
    Biology of Aging Training Grant
    Role: Co-Principal Investigator
    R13GM038507     (MOSES, ROBB E)Jul 1, 1987 - Jun 30, 1988
    NIH
    ASM CONFERENCE ON DNA REPLICATION AND MUTAGENESIS
    Role: Principal Investigator
    R01CA037860     (MOSES, ROBB E)Sep 30, 1985 - Sep 29, 1990
    NIH
    TRANSFER OF DNA REPAIR GENES
    Role: Principal Investigator
    R01GM019122     (MOSES, ROBB E)Aug 1, 1978 - Feb 28, 1990
    NIH
    MECHANISMS OF CHROMOSOME REPLICATION
    Role: Principal Investigator
    R01GM024711     (MOSES, ROBB E)Jan 1, 1978 - Nov 30, 1993
    NIH
    CELLULAR DNA REPAIR MECHANISMS AND MUTAGENESIS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tu J, Zhang H, Yang T, Liu Y, Kibreab S, Zhang Y, Gao L, Moses RE, O'Malley BW, Xiao J, Li X. Aging-associated REG? proteasome decline predisposes to tauopathy. J Biol Chem. 2022 11; 298(11):102571. PMID: 36209822; PMCID: PMC9647549.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Wei C, Liu Y, Liu X, Cheng J, Fu J, Xiao X, Moses RE, Li X, Fu J. The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1. Cell Death Discov. 2022 Sep 17; 8(1):389. PMID: 36115849; PMCID: PMC9482615.
      Citations:    
    3. Xie Y, Gao R, Gao Y, Dong Z, Moses RE, Li X, Ge J. The proteasome activator REG? promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway. Transl Res. 2022 08; 246:33-48. PMID: 35367424.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Zhu X, Yang M, Lin Z, Mael SK, Li Y, Zhang L, Kong Y, Zhang Y, Ren Y, Li J, Wang Z, Zhang Y, Yang B, Huang T, Guan F, Li Z, Moses RE, Li L, Wang B, Li X, Zhang B. REG? drives Lgr5+ stem cells to potentiate radiation induced intestinal regeneration. Sci China Life Sci. 2022 08; 65(8):1608-1623. PMID: 34826093.
      Citations: 2     Fields:    
    5. Tan X, Tong L, Li L, Xu J, Xie S, Ji L, Fu J, Liu Q, Shen S, Liu Y, Xiao Y, Gao F, Moses RE, Bardeesy N, Wang Y, Zhang J, Tang L, Li L, Wong KK, Song D, Yang X, Liu J, Li X. Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. Nat Commun. 2021 08 11; 12(1):4853. PMID: 34381046; PMCID: PMC8357888.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. Yao L, Xuan Y, Zhang H, Yang B, Ma X, Wang T, Meng T, Sun W, Wei H, Ma X, Moses R, Xiao J, Zhang P, Ge C, Li J, Li L, Li X, Li J, Zhang B. Reciprocal REG?-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma. Oncogene. 2021 01; 40(3):677-692. PMID: 33230243.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Zhu X, Tian X, Yang M, Yu Y, Zhou Y, Gao Y, Zhang L, Li Z, Xiao Y, Moses RE, Li X, Zhang B. Procyanidin B2 Promotes Intestinal Injury Repair and Attenuates Colitis-Associated Tumorigenesis via Suppression of Oxidative Stress in Mice. Antioxid Redox Signal. 2021 07 10; 35(2):75-92. PMID: 32940048.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, O' Malley BW, Fares F, Zhang B, Li X, Li L, Xiao J. Author Correction: The REG? inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 Sep 23; 11(1):4888. PMID: 32968062; PMCID: PMC7511305.
      Citations: 1     Fields:    
    9. Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, Malley BWO, Fares F, Zhang B, Li X, Li L, Xiao J. The REG? inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 08 06; 11(1):3904. PMID: 32764536; PMCID: PMC7413384.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Xie Y, Gao Y, Gao R, Yang W, Dong Z, Moses RE, Sun A, Li X, Ge J. The proteasome activator REG? accelerates cardiac hypertrophy by declining PP2Aca-SOD2 pathway. Cell Death Differ. 2020 10; 27(10):2952-2972. PMID: 32424140; PMCID: PMC7494903.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Tong L, Shen S, Huang Q, Fu J, Wang T, Pan L, Zhang P, Chen G, Huang T, Li K, Liu Q, Xie S, Yang X, Moses RE, Li X, Li L. Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis. Cell Death Differ. 2020 06; 27(6):1795-1806. PMID: 31767934; PMCID: PMC7244558.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    12. Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X. REG? ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-? pathway. Cell Death Differ. 2020 02; 27(2):497-508. PMID: 31243343; PMCID: PMC7205985.
      Citations: 6     Fields:    Translation:HumansCells
    13. Yao L, Zhou L, Xuan Y, Zhang P, Wang X, Wang T, Meng T, Xue Y, Ma X, Shah AS, Shang S, Ma X, Xie W, Wang H, Fu Q, Xia Y, Moses RE, Wang H, Li L, Xiao J, Zhang B, Li X. The proteasome activator REG? counteracts immunoproteasome expression and autoimmunity. J Autoimmun. 2019 09; 103:102282. PMID: 31171475.
      Citations: 6     Fields:    Translation:AnimalsCells
    14. Wang Q, Gao X, Yu T, Yuan L, Dai J, Wang W, Chen G, Jiao C, Zhou W, Huang Q, Cui L, Zhang P, Moses RE, Yang J, Chen F, Fu J, Xiao J, Li L, Dang Y, Li X. REG? Controls Hippo Signaling and Reciprocal NF-?B-YAP Regulation to Promote Colon Cancer. Clin Cancer Res. 2018 04 15; 24(8):2015-2025. PMID: 29437787.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    15. Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X. The REG?-proteasome forms a regulatory circuit with I?B? and NF?B in experimental colitis. Nat Commun. 2016 Feb 22; 7:10761. PMID: 26899380; PMCID: PMC4764899.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    16. Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X. Upregulation of GSK3? Contributes to Brain Disorders in Elderly REG?-knockout Mice. Neuropsychopharmacology. 2016 Apr; 41(5):1340-9. PMID: 26370326; PMCID: PMC4793118.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Li L, Dang Y, Zhang J, Yan W, Zhai W, Chen H, Li K, Tong L, Gao X, Amjad A, Ji L, Jing T, Jiang Z, Shi K, Yao L, Song D, Liu T, Yang X, Yang C, Cai X, Xu W, Huang Q, He J, Liu J, Chen T, Moses RE, Fu J, Xiao J, Li X. REG? is critical for skin carcinogenesis by modulating the Wnt/?-catenin pathway. Nat Commun. 2015 Apr 24; 6:6875. PMID: 25908095.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    18. Li X, Moses RE, Jin J, Cao W, Caulin C. Stresses, aging, and age-related disorders. Oxid Med Cell Longev. 2014; 2014:320564. PMID: 25610525; PMCID: PMC4293784.
      Citations:    Fields:    Translation:HumansAnimals
    19. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340; PMCID: PMC3938540.
      Citations: 8     Fields:    Translation:HumansCells
    20. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X. REG? deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11005-10. PMID: 23766372; PMCID: PMC3703992.
      Citations: 35     Fields:    Translation:Animals
    21. Moses RE, O'Malley BW. DNA transcription and repair: a confluence. J Biol Chem. 2012 Jul 06; 287(28):23266-70. PMID: 22605334; PMCID: PMC3390605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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