LEFKOTHEA KARAVITI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6701 FANNIN
Houston, TX 77030
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    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Lefkothea P. Karaviti, M.D., Ph.D., is Professor of Pediatrics, Endocrinology and Diabetes. She has more than 23 years of experience treating pediatric patients at Texas Children’s Hospital (TCH)/BCM. She received her M.D. from National University in Athens, Greece, and her Ph.D. from UCLA, where she trained in sexual differentiation of the brain and collaborated with the pediatric endocrinology division. She did her residency and post-graduate training at Cornell Medical College (Cornell University), where her focus was on pediatric endocrinology and diabetes, as well as congenital adrenal hyperplasia (CAH) under renowned expert Maria New. She currently trains fellows in the development of evidence-based and best-practice guidelines for multidisciplinary approaches to disorders of sexual development (DSD) from the neonatal period to adolescence. She is a member of the Pediatric Endocrinology Society, American Pediatric Society, American Diabetes Association, American Association of Clinical Endocrinologists, and the Endocrine Society. Her clinical practice involves patients with type I diabetes, growth disorders, CAH, and DSD. Dr. Karaviti was a pioneer in the establishment of a multidisciplinary approach to treating DSD, adding an ethicist to the team and incorporating education of parents so they could participate in an informed decision-making process, as well as in the development of guidelines for treating DSD.

    Lefke Karaviti MD.,PhD
    Professor of Pediatrics
    Baylor College of Medicine
    Texas Children's Hospital

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Angelides PK, Jindal I, Karaviti L, Geffner ME. It's X-Related: Biological Bases of Increased COVID-19 Morbidity and Mortality in Men. J Endocr Soc. 2020 Nov 01; 4(11):bvaa133. PMID: 33117953.
      Citations:    
    2. Slater B, Glinton K, Dai H, Lay E, Karaviti L, Mizerik E, Murali CN, Lalani SR, Bacino CA, Rossetti LZ. Sudden infant death with dysgenesis of the testes syndrome in a non-Amish infant: A case report. Am J Med Genet A. 2020 11; 182(11):2751-2754. PMID: 32885560.
      Citations:    
    3. Hilliard ME, Cao VT, Eshtehardi SS, Minard CG, Saber R, Thompson D, Karaviti LP, Anderson BJ. Type 1 Doing Well: Pilot Feasibility and Acceptability Study of a Strengths-Based mHealth App for Parents of Adolescents with Type 1 Diabetes. Diabetes Technol Ther. 2020 Nov; 22(11):835-845. PMID: 32379496.
      Citations:    Fields:    
    4. D'Oro A, Rosoklija I, Jacobson DL, Finlayson C, Chen D, Tu DD, Austin PF, Karaviti LP, Gunn SK, Nahata L, Kapa HM, Kokorowski PJ, Kim MS, Messina AC, Kolon TF, Yerkes EB, Cheng EY, Johnson EK. Patient and Caregiver Attitudes toward Disorders of Sex Development Nomenclature. J Urol. 2020 10; 204(4):835-842. PMID: 32302259.
      Citations:    Fields:    Translation:Humans
    5. Jain S, Karaviti LP. Visual Diagnosis: Multiple Falls and a Pigmented Skin Lesion in a 5-year-old Boy. Pediatr Rev. 2020 Jan; 41(1):e1-e3. PMID: 31894077.
      Citations:    Fields:    
    6. Merchant N, Viau-Colindres JM, Hicks KA, Balazs AE, Wesson DE, Lopez ME, Karaviti L. McCune-Albright Syndrome With Unremitting Hyperthyroidism at Early Age: Management Perspective for Early Thyroidectomy. Glob Pediatr Health. 2019; 6:2333794X19875153. PMID: 31523703.
      Citations:    
    7. Jain S, Karaviti LP. Case 2: A 4-year-old Boy with Recurrent Vomiting. Pediatr Rev. 2019 Aug; 40(8):425-427. PMID: 31371636.
      Citations:    Fields:    Translation:Humans
    8. McCann-Crosby B, Hyle L, Mann D, Gunn S, Flynn K, Bercaw-Pratt J, Adeyemi O, Dietrich J, Tu D, Austin PF, Sutton VR, Axelrad M, Karaviti L. Hormones and their Structural and Functional Effects on the Brain: How Can We Change our Practice Moving Forward? Pediatr Endocrinol Rev. 2019 Jun; 16(4):452-456. PMID: 31245940.
      Citations:    Fields:    Translation:Humans
    9. Rossetti LZ, Glinton K, Yuan B, Liu P, Pillai N, Mizerik E, Magoulas P, Rosenfeld JA, Karaviti L, Sutton VR, Lalani SR, Scott DA. Review of the phenotypic spectrum associated with haploinsufficiency of MYRF. . 2019 07; 179(7):1376-1382. PMID: 31069960.
      Citations:    
    10. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 2019 03 07; 104(3):422-438. PMID: 30773277.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Luckie TM, Danzig M, Zhou S, Wu H, Cost NG, Karaviti L, Venkatramani R. A Multicenter Retrospective Review of Pediatric Leydig Cell Tumor of the Testis. J Pediatr Hematol Oncol. 2019 01; 41(1):74-76. PMID: 29554024.
      Citations:    Fields:    Translation:Humans
    12. Chen MJ, Karaviti LP, Roth DR, Schlomer BJ. Birth prevalence of hypospadias and hypospadias risk factors in newborn males in the United States from 1997 to 2012. J Pediatr Urol. 2018 10; 14(5):425.e1-425.e7. PMID: 30322769.
      Citations:    Fields:    Translation:Humans
    13. McCann-Crosby B, Placencia FX, Adeyemi-Fowode O, Dietrich J, Franciskovich R, Gunn S, Axelrad M, Tu D, Mann D, Karaviti L, Sutton VR. Challenges in Prenatal Treatment with Dexamethasone. Pediatr Endocrinol Rev. 2018 Sep; 16(1):186-193. PMID: 30371037.
      Citations: 2     Fields:    Translation:Humans
    14. Tosur M, Karaviti LP. Case 2: 3-month-old Boy with Micropenis. Pediatr Rev. 2018 Jul; 39(7):363-365. PMID: 29967081.
      Citations:    Fields:    Translation:Humans
    15. Calarge CA, Mills JA, Karaviti L, Teixeira AL, Zemel BS, Garcia JM. Selective Serotonin Reuptake Inhibitors Reduce Longitudinal Growth in Risperidone-Treated Boys. J Pediatr. 2018 10; 201:245-251. PMID: 29958671.
      Citations:    Fields:    Translation:Humans
    16. Hilliard ME, Eshtehardi SS, Minard CG, Saber R, Thompson D, Karaviti LP, Rojas Y, Anderson BJ. Strengths-Based Behavioral Intervention for Parents of Adolescents With Type 1 Diabetes Using an mHealth App (Type 1 Doing Well): Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2018 Mar 13; 7(3):e77. PMID: 29535081.
      Citations:    
    17. Tosur M, Collins MT, Ponder SW, Stratakis CA, Karaviti LP, Jeha GS. Persistent Diabetes Mellitus Postadrenalectomy in Neonatal McCune-Albright Syndrome. Glob Pediatr Health. 2017; 4:2333794X17742748. PMID: 29201948.
      Citations:    
    18. Viau-Colindres J, Axelrad M, Karaviti LP. Bringing Back the Term "Intersex". Pediatrics. 2017 11; 140(5). PMID: 29070532.
      Citations: 1     Fields:    Translation:Humans
    19. Chen MJ, McCann-Crosby B, Gunn S, Georgiadis P, Placencia F, Mann D, Axelrad M, Karaviti LP, McCullough LB. Fluidity models in ancient Greece and current practices of sex assignment. Semin Perinatol. 2017 06; 41(4):206-213. PMID: 28478088.
      Citations: 1     Fields:    Translation:Humans
    20. Colindres JV, Childress KJ, Axelrad M, McCullough LB, Shao Y, Macias C, Loveless J, Gunn SK, Bercaw-Pratt J, Sutton R, Karaviti LP, Dietrich JE. A Multidisciplinary Approach to Puberty and Fertility in Girls with Turner Syndrome. Pediatr Endocrinol Rev. 2016 Sep; 14(1):33-47. PMID: 28508615.
      Citations: 1     Fields:    Translation:Humans
    21. Colindres JV, Axelrad M, McCullough L, Smith EO, Huang GO, Tu DD, Bercaw-Pratt JL, Cheni MJ, Mendiratta M, Gunn S, Sutton R, Macias C, Karaviti LP. Evidence-Based Management of Patients with 45,X/46,XY Gonadal Dysgenesis and Male Sex Assignment: from Infancy to Adulthood. Pediatr Endocrinol Rev. 2016 Mar; 13(3):585-601. PMID: 27116846.
      Citations:    Fields:    Translation:Humans
    22. Bartz SK, Karaviti LP, Brandt ML, Lopez ME, Masand P, Devaraj S, Hicks J, Anderson L, Lodish M, Keil M, Stratakis CA. Residual manifestations of hypercortisolemia following surgical treatment in a patient with Cushing syndrome. Int J Pediatr Endocrinol. 2015; 2015(1):19. PMID: 26322079.
      Citations:    
    23. McCann-Crosby B, Gunn S, Smith EO, Karaviti L, Hicks MJ. Association of immunohistochemical markers with premalignancy in Gonadal Dysgenesis. Int J Pediatr Endocrinol. 2015; 2015(1):14. PMID: 26089923.
      Citations:    
    24. Chen MJ, Vu BM, Axelrad M, Dietrich JE, Gargollo P, Gunn S, Macias CG, McCullough LB, Roth DR, Sutton VR, Karaviti LP. Androgen Insensitivity Syndrome: Management Considerations from Infancy to Adulthood. Pediatr Endocrinol Rev. 2015 Jun; 12(4):373-87. PMID: 26182482.
      Citations: 3     Fields:    Translation:Humans
    25. Antonini TN, Van Horn Kerne V, Axelrad ME, Karaviti LP, Schwartz DD. Neurocognitive profile of a young adolescent with DK phocomelia/von Voss phocomelia/von Voss Cherstvoy syndrome. . 2015 Jul; 167(7):1632-6. PMID: 25899150.
      Citations:    
    26. Karageorgiadis AS, Papadakis GZ, Biro J, Keil MF, Lyssikatos C, Quezado MM, Merino M, Schrump DS, Kebebew E, Patronas NJ, Hunter MK, Alwazeer MR, Karaviti LP, Balazs AE, Lodish MB, Stratakis CA. Ectopic adrenocorticotropic hormone and corticotropin-releasing hormone co-secreting tumors in children and adolescents causing cushing syndrome: a diagnostic dilemma and how to solve it. J Clin Endocrinol Metab. 2015 Jan; 100(1):141-8. PMID: 25291050.
      Citations: 20     Fields:    Translation:Humans
    27. McCann-Crosby B, Chen MJ, Lyons SK, Lin Y, Axelrad M, Dietrich JE, Sutton VR, Macias CG, Gunn S, Karaviti L. Nonclassical congenital adrenal hyperplasia: targets of treatment and transition. Pediatr Endocrinol Rev. 2014 Dec; 12(2):224-38. PMID: 25581988.
      Citations: 3     Fields:    Translation:Humans
    28. Larsen CC, Karaviti LP, Seghers V, Weiss RE, Refetoff S, Dumitrescu AM. A new family with an activating mutation (G431S) in the TSH receptor gene: a phenotype discussion and review of the literature. Int J Pediatr Endocrinol. 2014; 2014(1):23. PMID: 25873976.
      Citations:    
    29. Chen MJ, Macias CG, Gunn SK, Dietrich JE, Roth DR, Schlomer BJ, Karaviti LP. Intrauterine growth restriction and hypospadias: is there a connection? Int J Pediatr Endocrinol. 2014; 2014(1):20. PMID: 25337123.
      Citations:    
    30. Chen MJ, Karaviti LP, Macias CG, Roth DR, Gunn S, Sutton VR, Schlomer B. State of the art review in hypospadias: challenges in diagnosis and medical management. Pediatr Endocrinol Rev. 2014 Sep; 12(1):46-54. PMID: 25345085.
      Citations: 1     Fields:    Translation:Humans
    31. McCann-Crosby B, Mansouri R, Dietrich JE, McCullough LB, Sutton VR, Austin EG, Schlomer B, Roth DR, Karaviti L, Gunn S, Hicks MJ, Macias CG. State of the art review in gonadal dysgenesis: challenges in diagnosis and management. Int J Pediatr Endocrinol. 2014; 2014(1):4. PMID: 24731683.
      Citations:    
    32. Suresh D, Crawford J, Axelrad ME, Gunn SK, McCullough L, Smith OB, Sutton VR, Roth D, Karaviti LP, Dietrich JE. Assessing sex assignment concordance with genotype and phenotype. Int J Pediatr Endocrinol. 2013 Mar 14; 2013(1):7. PMID: 23496938.
      Citations:    
    33. Douglas G, Axelrad ME, Brandt ML, Crabtree E, Dietrich JE, French S, Gunn S, Karaviti L, Lopez ME, Macias CG, McCullough LB, Suresh D, Austin E, Reid Sutton V. Guidelines for evaluating and managing children born with disorders of sexual development. Pediatr Ann. 2012 Apr; 41(4):e1-7. PMID: 22494213.
      Citations: 4     Fields:    Translation:Humans
    34. Almeida MQ, Azevedo MF, Xekouki P, Bimpaki EI, Horvath A, Collins MT, Karaviti LP, Jeha GS, Bhattacharyya N, Cheadle C, Watkins T, Bourdeau I, Nesterova M, Stratakis CA. Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations. J Clin Endocrinol Metab. 2012 Apr; 97(4):E687-93. PMID: 22259056.
      Citations: 19     Fields:    Translation:HumansCells
    35. Bercaw-Pratt JL, Moorjani TP, Santos XM, Karaviti L, Dietrich JE. Diagnosis and management of precocious puberty in atypical presentations of McCune-Albright syndrome: a case series review. J Pediatr Adolesc Gynecol. 2012 Feb; 25(1):e9-e13. PMID: 22051789.
      Citations: 5     Fields:    Translation:Humans
    36. Mendiratta MS, Yang Y, Balazs AE, Willis AS, Eng CM, Karaviti LP, Potocki L. Early onset obesity and adrenal insufficiency associated with a homozygous POMC mutation. Int J Pediatr Endocrinol. 2011; 2011(1):5. PMID: 21860632.
      Citations:    
    37. Douglas G, Axelrad ME, Brandt ML, Crabtree E, Dietrich JE, French S, Gunn S, Karaviti L, Lopez ME, Macias CG, McCullough LB, Suresh D, Sutton VR. Consensus in Guidelines for Evaluation of DSD by the Texas Children's Hospital Multidisciplinary Gender Medicine Team. Int J Pediatr Endocrinol. 2010; 2010:919707. PMID: 20981291.
      Citations:    
    38. Amaral JM, Abrams S, Karaviti L, McKay SV. Effects of 1,25-dihydroxycholecalciferol on recovery and resolution of late transient neonatal hypocalcemia. Int J Pediatr Endocrinol. 2010; 2010:409670. PMID: 20339510.
      Citations:    
    39. French S, Rodriguez L, Schlesinger A, McCullough L, Dietrich J, Hicks J, Karaviti L. FSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development. Int J Pediatr Endocrinol. 2009; 2009:507964. PMID: 20145723.
      Citations:    
    40. Nagamani SC, Erez A, Shen J, Li C, Roeder E, Cox S, Karaviti L, Pearson M, Kang SH, Sahoo T, Lalani SR, Stankiewicz P, Sutton VR, Cheung SW. Clinical spectrum associated with recurrent genomic rearrangements in chromosome 17q12. Eur J Hum Genet. 2010 Mar; 18(3):278-84. PMID: 19844256.
      Citations: 28     Fields:    Translation:HumansCells
    41. Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P. Pituitary and systemic autoimmunity in a case of intrasellar germinoma. Pituitary. 2011 Dec; 14(4):388-94. PMID: 19466616.
      Citations: 8     Fields:    Translation:Humans
    42. Axelrad ME, Berg JS, Coker LA, Dietrich J, Adcock L, French SL, Gunn S, Ligon BL, McCullough LB, Sutton VR, Karaviti LP. The gender medicine team: "it takes a village". Adv Pediatr. 2009; 56:145-64. PMID: 19968947.
      Citations: 2     Fields:    Translation:Humans
    43. Balazs A, Jeha G, Gunn SK, Karaviti LP. X-linked hypophosphatemic rickets associated with respiratory failure. Clin Pediatr (Phila). 2008 Apr; 47(3):293-5. PMID: 18057152.
      Citations:    Fields:    Translation:Humans
    44. Berg JS, French SL, McCullough LB, Kleppe S, Sutton VR, Gunn SK, Karaviti LP. Ethical and legal implications of genetic testing in androgen insensitivity syndrome. J Pediatr. 2007 Apr; 150(4):434-8. PMID: 17382127.
      Citations: 2     Fields:    Translation:Humans
    45. Balazs AE, Athanassaki I, Gunn SK, Tatevian N, Huang SA, Haymond MW, Karaviti LP. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci. 2007; 37(3):280-4. PMID: 17709695.
      Citations: 8     Fields:    Translation:Humans
    46. Kaplan W, Haymond MW, McKay S, Karaviti LP. Osteopenic effects of MgSO4 in multiple pregnancies. J Pediatr Endocrinol Metab. 2006 Oct; 19(10):1225-30. PMID: 17172083.
      Citations: 7     Fields:    Translation:Humans
    47. Jeha GS, Lowenthal ED, Chan WY, Wu SM, Karaviti LP. Variable presentation of precocious puberty associated with the D564G mutation of the LHCGR gene in children with testotoxicosis. J Pediatr. 2006 Aug; 149(2):271-4. PMID: 16887451.
      Citations: 5     Fields:    Translation:Humans
    48. Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger D, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. J Am Soc Nephrol. 2006 May; 17(5):1429-36. PMID: 16611713.
      Citations: 27     Fields:    Translation:Humans
    49. Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS, Haymond MW. Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursions and the risk of hypoglycemia. Diabetes Technol Ther. 2005 Dec; 7(6):876-84. PMID: 16386093.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    50. Jeha GS, Venkatesh MP, Edelen RC, Kienstra KA, Karaviti L, Fernandes CJ. Neonatal diabetes mellitus: patient reports and review of current knowledge and clinical practice. J Pediatr Endocrinol Metab. 2005 Nov; 18(11):1095-102. PMID: 16459456.
      Citations: 8     Fields:    Translation:Humans
    51. Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS, Haymond MW. Continuous glucose monitoring and the reality of metabolic control in preschool children with type 1 diabetes. Diabetes Care. 2004 Dec; 27(12):2881-6. PMID: 15562201.
      Citations: 5     Fields:    Translation:Humans
    52. Brunetti-Pierri N, Mendoza-Londono R, Shah MR, Karaviti L, Lee B. von Voss-Cherstvoy syndrome with transient thrombocytopenia and normal psychomotor development. . 2004 Apr 30; 126A(3):299-302. PMID: 15054846.
      Citations:    
    53. Hooper HT, Figueiredo BC, Pavan-Senn CC, De Lacerda L, Sandrini R, Mengarelli JK, Japp K, Karaviti LP. Concordance of phenotypic expression and gender identity in a large kindred with a mutation in the androgen receptor. Clin Genet. 2004 Mar; 65(3):183-90. PMID: 14756668.
      Citations: 3     Fields:    Translation:Humans
    54. Kayes-Wandover KM, Tannin GM, Shulman D, Peled D, Jones KL, Karaviti L, White PC. Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene. J Clin Endocrinol Metab. 2001 Nov; 86(11):5379-82. PMID: 11701710.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    55. Durham LG, Karaviti LP. Hypothyroidism presenting as a pituitary adenoma: an old problem underrecognized. Clin Pediatr (Phila). 1996 Dec; 35(12):649-51. PMID: 8970757.
      Citations:    Fields:    Translation:Humans
    56. Flannery TK, Kirkland JL, Copeland KC, Bertuch AA, Karaviti LP, Brandt ML. Papillary thyroid cancer: a pediatric perspective. Pediatrics. 1996 Sep; 98(3 Pt 1):464-6. PMID: 8784379.
      Citations: 2     Fields:    Translation:Humans
    57. Bakos JT, Goen P, Ogden A, Brown FR, Karaviti LP. Adrenoleukodystrophy: a link between adrenal insufficiency and school performance. J Clin Endocrinol Metab. 1995 Oct; 80(10):2869-72. PMID: 7559867.
      Citations: 1     Fields:    Translation:Humans
    58. Karaviti LP, Mercado AB, Mercado MB, Speiser PW, Buegeleisen M, Crawford C, Antonian L, White PC, New MI. Prenatal diagnosis/treatment in families at risk for infants with steroid 21-hydroxylase deficiency (congenital adrenal hyperplasia). J Steroid Biochem Mol Biol. 1992 Mar; 41(3-8):445-51. PMID: 1562517.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
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