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Lefkothea Karaviti

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Endocrinology/Metabolism
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Lefkothea P. Karaviti, M.D., Ph.D., is Professor of Pediatrics, Endocrinology and Diabetes. She has more than 23 years of experience treating pediatric patients at Texas Children’s Hospital (TCH)/BCM. She received her M.D. from National University in Athens, Greece, and her Ph.D. from UCLA, where she trained in sexual differentiation of the brain and collaborated with the pediatric endocrinology division. She did her residency and post-graduate training at Cornell Medical College (Cornell University), where her focus was on pediatric endocrinology and diabetes, as well as congenital adrenal hyperplasia (CAH) under renowned expert Maria New. She currently trains fellows in the development of evidence-based and best-practice guidelines for multidisciplinary approaches to disorders of sexual development (DSD) from the neonatal period to adolescence. She is a member of the Pediatric Endocrinology Society, American Pediatric Society, American Diabetes Association, American Association of Clinical Endocrinologists, and the Endocrine Society. Her clinical practice involves patients with type I diabetes, growth disorders, CAH, and DSD. Dr. Karaviti was a pioneer in the establishment of a multidisciplinary approach to treating DSD, adding an ethicist to the team and incorporating education of parents so they could participate in an informed decision-making process, as well as in the development of guidelines for treating DSD.

    Lefke Karaviti MD.,PhD
    Professor of Pediatrics
    Baylor College of Medicine
    Texas Children's Hospital

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Merchant N, Viau-Colindres JM, Hicks KA, Balazs AE, Wesson DE, Lopez ME, Karaviti L. McCune-Albright Syndrome With Unremitting Hyperthyroidism at Early Age: Management Perspective for Early Thyroidectomy. Glob Pediatr Health. 2019; 6:2333794X19875153. PMID: 31523703.
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    2. Jain S, Karaviti LP. Case 2: A 4-year-old Boy with Recurrent Vomiting. Pediatr Rev. 2019 Aug; 40(8):425-427. PMID: 31371636.
      View in: PubMed
    3. McCann-Crosby B, Hyle L, Mann D, Gunn S, Flynn K, Bercaw-Pratt J, Adeyemi O, Dietrich J, Tu D, Austin PF, Sutton VR, Axelrad M, Karaviti L. Hormones and their Structural and Functional Effects on the Brain: How Can We Change our Practice Moving Forward? Pediatr Endocrinol Rev. 2019 Jun; 16(4):452-456. PMID: 31245940.
      View in: PubMed
    4. Rossetti LZ, Glinton K, Yuan B, Liu P, Pillai N, Mizerik E, Magoulas P, Rosenfeld JA, Karaviti L, Sutton VR, Lalani SR, Scott DA. Review of the phenotypic spectrum associated with haploinsufficiency of MYRF. Am J Med Genet A. 2019 Jul; 179(7):1376-1382. PMID: 31069960.
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    5. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 2019 Mar 07; 104(3):422-438. PMID: 30773277.
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    6. Luckie TM, Danzig M, Zhou S, Wu H, Cost NG, Karaviti L, Venkatramani R. A Multicenter Retrospective Review of Pediatric Leydig Cell Tumor of the Testis. J Pediatr Hematol Oncol. 2019 01; 41(1):74-76. PMID: 29554024.
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    7. Chen MJ, Karaviti LP, Roth DR, Schlomer BJ. Birth prevalence of hypospadias and hypospadias risk factors in newborn males in the United States from 1997 to 2012. J Pediatr Urol. 2018 10; 14(5):425.e1-425.e7. PMID: 30322769.
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    8. McCann-Crosby B, Placencia FX, Adeyemi-Fowode O, Dietrich J, Franciskovich R, Gunn S, Axelrad M, Tu D, Mann D, Karaviti L, Sutton VR. Challenges in Prenatal Treatment with Dexamethasone. Pediatr Endocrinol Rev. 2018 Sep; 16(1):186-193. PMID: 30371037.
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    9. Tosur M, Karaviti LP. Case 2: 3-month-old Boy with Micropenis. Pediatr Rev. 2018 Jul; 39(7):363-365. PMID: 29967081.
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    10. Calarge CA, Mills JA, Karaviti L, Teixeira AL, Zemel BS, Garcia JM. Selective Serotonin Reuptake Inhibitors Reduce Longitudinal Growth in Risperidone-Treated Boys. J Pediatr. 2018 10; 201:245-251. PMID: 29958671.
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    11. Hilliard ME, Eshtehardi SS, Minard CG, Saber R, Thompson D, Karaviti LP, Rojas Y, Anderson BJ. Strengths-Based Behavioral Intervention for Parents of Adolescents With Type 1 Diabetes Using an mHealth App (Type 1 Doing Well): Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2018 Mar 13; 7(3):e77. PMID: 29535081.
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    12. Tosur M, Collins MT, Ponder SW, Stratakis CA, Karaviti LP, Jeha GS. Persistent Diabetes Mellitus Postadrenalectomy in Neonatal McCune-Albright Syndrome. Glob Pediatr Health. 2017; 4:2333794X17742748. PMID: 29201948.
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    13. Viau-Colindres J, Axelrad M, Karaviti LP. Bringing Back the Term "Intersex". Pediatrics. 2017 11; 140(5). PMID: 29070532.
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    14. Chen MJ, McCann-Crosby B, Gunn S, Georgiadis P, Placencia F, Mann D, Axelrad M, Karaviti LP, McCullough LB. Fluidity models in ancient Greece and current practices of sex assignment. Semin Perinatol. 2017 06; 41(4):206-213. PMID: 28478088.
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    15. Colindres JV, Childress KJ, Axelrad M, McCullough LB, Shao Y, Macias C, Loveless J, Gunn SK, Bercaw-Pratt J, Sutton R, Karaviti LP, Dietrich JE. A Multidisciplinary Approach to Puberty and Fertility in Girls with Turner Syndrome. Pediatr Endocrinol Rev. 2016 Sep; 14(1):33-47. PMID: 28508615.
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    16. Colindres JV, Axelrad M, McCullough L, Smith EO, Huang GO, Tu DD, Bercaw-Pratt JL, Cheni MJ, Mendiratta M, Gunn S, Sutton R, Macias C, Karaviti LP. Evidence-Based Management of Patients with 45,X/46,XY Gonadal Dysgenesis and Male Sex Assignment: from Infancy to Adulthood. Pediatr Endocrinol Rev. 2016 Mar; 13(3):585-601. PMID: 27116846.
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    17. Bartz SK, Karaviti LP, Brandt ML, Lopez ME, Masand P, Devaraj S, Hicks J, Anderson L, Lodish M, Keil M, Stratakis CA. Residual manifestations of hypercortisolemia following surgical treatment in a patient with Cushing syndrome. Int J Pediatr Endocrinol. 2015; 2015(1):19. PMID: 26322079.
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    18. McCann-Crosby B, Gunn S, Smith EO, Karaviti L, Hicks MJ. Association of immunohistochemical markers with premalignancy in Gonadal Dysgenesis. Int J Pediatr Endocrinol. 2015; 2015(1):14. PMID: 26089923.
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    19. Chen MJ, Vu BM, Axelrad M, Dietrich JE, Gargollo P, Gunn S, Macias CG, McCullough LB, Roth DR, Sutton VR, Karaviti LP. Androgen Insensitivity Syndrome: Management Considerations from Infancy to Adulthood. Pediatr Endocrinol Rev. 2015 Jun; 12(4):373-87. PMID: 26182482.
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    20. Antonini TN, Van Horn Kerne V, Axelrad ME, Karaviti LP, Schwartz DD. Neurocognitive profile of a young adolescent with DK phocomelia/von Voss phocomelia/von Voss Cherstvoy syndrome. Am J Med Genet A. 2015 Jul; 167(7):1632-6. PMID: 25899150.
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    21. Karageorgiadis AS, Papadakis GZ, Biro J, Keil MF, Lyssikatos C, Quezado MM, Merino M, Schrump DS, Kebebew E, Patronas NJ, Hunter MK, Alwazeer MR, Karaviti LP, Balazs AE, Lodish MB, Stratakis CA. Ectopic adrenocorticotropic hormone and corticotropin-releasing hormone co-secreting tumors in children and adolescents causing cushing syndrome: a diagnostic dilemma and how to solve it. J Clin Endocrinol Metab. 2015 Jan; 100(1):141-8. PMID: 25291050.
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    22. McCann-Crosby B, Chen MJ, Lyons SK, Lin Y, Axelrad M, Dietrich JE, Sutton VR, Macias CG, Gunn S, Karaviti L. Nonclassical congenital adrenal hyperplasia: targets of treatment and transition. Pediatr Endocrinol Rev. 2014 Dec; 12(2):224-38. PMID: 25581988.
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    23. Larsen CC, Karaviti LP, Seghers V, Weiss RE, Refetoff S, Dumitrescu AM. A new family with an activating mutation (G431S) in the TSH receptor gene: a phenotype discussion and review of the literature. Int J Pediatr Endocrinol. 2014; 2014(1):23. PMID: 25873976.
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    24. Chen MJ, Macias CG, Gunn SK, Dietrich JE, Roth DR, Schlomer BJ, Karaviti LP. Intrauterine growth restriction and hypospadias: is there a connection? Int J Pediatr Endocrinol. 2014; 2014(1):20. PMID: 25337123.
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    25. Chen MJ, Karaviti LP, Macias CG, Roth DR, Gunn S, Sutton VR, Schlomer B. State of the art review in hypospadias: challenges in diagnosis and medical management. Pediatr Endocrinol Rev. 2014 Sep; 12(1):46-54. PMID: 25345085.
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    26. McCann-Crosby B, Mansouri R, Dietrich JE, McCullough LB, Sutton VR, Austin EG, Schlomer B, Roth DR, Karaviti L, Gunn S, Hicks MJ, Macias CG. State of the art review in gonadal dysgenesis: challenges in diagnosis and management. Int J Pediatr Endocrinol. 2014; 2014(1):4. PMID: 24731683.
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    27. Suresh D, Crawford J, Axelrad ME, Gunn SK, McCullough L, Smith OB, Sutton VR, Roth D, Karaviti LP, Dietrich JE. Assessing sex assignment concordance with genotype and phenotype. Int J Pediatr Endocrinol. 2013 Mar 14; 2013(1):7. PMID: 23496938.
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    28. Douglas G, Axelrad ME, Brandt ML, Crabtree E, Dietrich JE, French S, Gunn S, Karaviti L, Lopez ME, Macias CG, McCullough LB, Suresh D, Austin E, Reid Sutton V. Guidelines for evaluating and managing children born with disorders of sexual development. Pediatr Ann. 2012 Apr; 41(4):e1-7. PMID: 22494213.
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    29. Almeida MQ, Azevedo MF, Xekouki P, Bimpaki EI, Horvath A, Collins MT, Karaviti LP, Jeha GS, Bhattacharyya N, Cheadle C, Watkins T, Bourdeau I, Nesterova M, Stratakis CA. Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations. J Clin Endocrinol Metab. 2012 Apr; 97(4):E687-93. PMID: 22259056.
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    30. Bercaw-Pratt JL, Moorjani TP, Santos XM, Karaviti L, Dietrich JE. Diagnosis and management of precocious puberty in atypical presentations of McCune-Albright syndrome: a case series review. J Pediatr Adolesc Gynecol. 2012 Feb; 25(1):e9-e13. PMID: 22051789.
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    31. Mendiratta MS, Yang Y, Balazs AE, Willis AS, Eng CM, Karaviti LP, Potocki L. Early onset obesity and adrenal insufficiency associated with a homozygous POMC mutation. Int J Pediatr Endocrinol. 2011; 2011(1):5. PMID: 21860632.
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    32. Douglas G, Axelrad ME, Brandt ML, Crabtree E, Dietrich JE, French S, Gunn S, Karaviti L, Lopez ME, Macias CG, McCullough LB, Suresh D, Sutton VR. Consensus in Guidelines for Evaluation of DSD by the Texas Children's Hospital Multidisciplinary Gender Medicine Team. Int J Pediatr Endocrinol. 2010; 2010:919707. PMID: 20981291.
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    33. Amaral JM, Abrams S, Karaviti L, McKay SV. Effects of 1,25-dihydroxycholecalciferol on recovery and resolution of late transient neonatal hypocalcemia. Int J Pediatr Endocrinol. 2010; 2010:409670. PMID: 20339510.
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    34. French S, Rodriguez L, Schlesinger A, McCullough L, Dietrich J, Hicks J, Karaviti L. FSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development. Int J Pediatr Endocrinol. 2009; 2009:507964. PMID: 20145723.
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    35. Nagamani SC, Erez A, Shen J, Li C, Roeder E, Cox S, Karaviti L, Pearson M, Kang SH, Sahoo T, Lalani SR, Stankiewicz P, Sutton VR, Cheung SW. Clinical spectrum associated with recurrent genomic rearrangements in chromosome 17q12. Eur J Hum Genet. 2010 Mar; 18(3):278-84. PMID: 19844256.
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    36. Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P. Pituitary and systemic autoimmunity in a case of intrasellar germinoma. Pituitary. 2011 Dec; 14(4):388-94. PMID: 19466616.
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    37. Axelrad ME, Berg JS, Coker LA, Dietrich J, Adcock L, French SL, Gunn S, Ligon BL, McCullough LB, Sutton VR, Karaviti LP. The gender medicine team: "it takes a village". Adv Pediatr. 2009; 56:145-64. PMID: 19968947.
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    38. Balazs A, Jeha G, Gunn SK, Karaviti LP. X-linked hypophosphatemic rickets associated with respiratory failure. Clin Pediatr (Phila). 2008 Apr; 47(3):293-5. PMID: 18057152.
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    39. Berg JS, French SL, McCullough LB, Kleppe S, Sutton VR, Gunn SK, Karaviti LP. Ethical and legal implications of genetic testing in androgen insensitivity syndrome. J Pediatr. 2007 Apr; 150(4):434-8. PMID: 17382127.
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    40. Balazs AE, Athanassaki I, Gunn SK, Tatevian N, Huang SA, Haymond MW, Karaviti LP. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci. 2007; 37(3):280-4. PMID: 17709695.
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    41. Kaplan W, Haymond MW, McKay S, Karaviti LP. Osteopenic effects of MgSO4 in multiple pregnancies. J Pediatr Endocrinol Metab. 2006 Oct; 19(10):1225-30. PMID: 17172083.
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    42. Jeha GS, Lowenthal ED, Chan WY, Wu SM, Karaviti LP. Variable presentation of precocious puberty associated with the D564G mutation of the LHCGR gene in children with testotoxicosis. J Pediatr. 2006 Aug; 149(2):271-4. PMID: 16887451.
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    43. Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger D, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. J Am Soc Nephrol. 2006 May; 17(5):1429-36. PMID: 16611713.
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    44. Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS, Haymond MW. Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursions and the risk of hypoglycemia. Diabetes Technol Ther. 2005 Dec; 7(6):876-84. PMID: 16386093.
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    45. Jeha GS, Venkatesh MP, Edelen RC, Kienstra KA, Karaviti L, Fernandes CJ. Neonatal diabetes mellitus: patient reports and review of current knowledge and clinical practice. J Pediatr Endocrinol Metab. 2005 Nov; 18(11):1095-102. PMID: 16459456.
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    46. Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS, Haymond MW. Continuous glucose monitoring and the reality of metabolic control in preschool children with type 1 diabetes. Diabetes Care. 2004 Dec; 27(12):2881-6. PMID: 15562201.
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    47. Brunetti-Pierri N, Mendoza-Londono R, Shah MR, Karaviti L, Lee B. von Voss-Cherstvoy syndrome with transient thrombocytopenia and normal psychomotor development. Am J Med Genet A. 2004 Apr 30; 126A(3):299-302. PMID: 15054846.
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    48. Hooper HT, Figueiredo BC, Pavan-Senn CC, De Lacerda L, Sandrini R, Mengarelli JK, Japp K, Karaviti LP. Concordance of phenotypic expression and gender identity in a large kindred with a mutation in the androgen receptor. Clin Genet. 2004 Mar; 65(3):183-90. PMID: 14756668.
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    49. Durham LG, Karaviti LP. Hypothyroidism presenting as a pituitary adenoma: an old problem underrecognized. Clin Pediatr (Phila). 1996 Dec; 35(12):649-51. PMID: 8970757.
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    50. Flannery TK, Kirkland JL, Copeland KC, Bertuch AA, Karaviti LP, Brandt ML. Papillary thyroid cancer: a pediatric perspective. Pediatrics. 1996 Sep; 98(3 Pt 1):464-6. PMID: 8784379.
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    51. Bakos JT, Goen P, Ogden A, Brown FR, Karaviti LP. Adrenoleukodystrophy: a link between adrenal insufficiency and school performance. J Clin Endocrinol Metab. 1995 Oct; 80(10):2869-72. PMID: 7559867.
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    52. Karaviti LP, Mercado AB, Mercado MB, Speiser PW, Buegeleisen M, Crawford C, Antonian L, White PC, New MI. Prenatal diagnosis/treatment in families at risk for infants with steroid 21-hydroxylase deficiency (congenital adrenal hyperplasia). J Steroid Biochem Mol Biol. 1992 Mar; 41(3-8):445-51. PMID: 1562517.
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