LUTFI ABU-ELHEIGA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ibitokou SA, Dillon BE, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, Szabo C, Abu-Elheiga L, Porter C, Tuvdendorj D, Stephens R. Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 2018 01 15; 200(2):643-656. PMID: 29237780.
      Citations: 10     Fields:    Translation:AnimalsCells
    2. Ambati CS, Yuan F, Abu-Elheiga LA, Zhang Y, Shetty V. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics. J Am Soc Mass Spectrom. 2017 05; 28(5):929-938. PMID: 28315235.
      Citations: 2     Fields:    Translation:HumansAnimals
    3. Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15; 448(3):409-16. PMID: 23067267.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J Biol Chem. 2012 Apr 06; 287(15):12578-88. PMID: 22362781.
      Citations: 34     Fields:    Translation:AnimalsCells
    5. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18831-6. PMID: 19850873.
      Citations: 106     Fields:    Translation:AnimalsCells
    7. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    8. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res. 2009 Apr; 50 Suppl:S138-43. PMID: 19047759.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    9. Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L. Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H256-65. PMID: 18487439.
      Citations: 14     Translation:AnimalsCells
    10. Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16480-5. PMID: 17923673.
      Citations: 127     Fields:    Translation:AnimalsCells
    11. Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8552-7. PMID: 16717184.
      Citations: 100     Fields:    Translation:AnimalsCells
    12. Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12011-6. PMID: 16103361.
      Citations: 76     Fields:    Translation:AnimalsCells
    13. Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS, Wakil SJ. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1384-9. PMID: 15677334.
      Citations: 36     Fields:    Translation:AnimalsCells
    14. Abu-Elheiga L, Oh W, Kordari P, Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10207-12. PMID: 12920182.
      Citations: 113     Fields:    Translation:AnimalsCells
    15. Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6358-63. PMID: 12738878.
      Citations: 78     Fields:    Translation:AnimalsCells
    16. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30; 291(5513):2613-6. PMID: 11283375.
      Citations: 254     Fields:    Translation:AnimalsCells
    17. Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1444-9. PMID: 10677481.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    18. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem. 1997 Apr 18; 272(16):10669-77. PMID: 9099716.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    19. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ. Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8695-9. PMID: 7567999.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    20. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):4011-5. PMID: 7732023.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    21. Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ. Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. Genomics. 1994 Sep 15; 23(2):420-4. PMID: 7835891.
      Citations: 11     Fields:    Translation:HumansCells
    22. Abu-Elheiga L, Yaneva M. Antigenic determinants of the 70-kDa subunit of the Ku autoantigen. Clin Immunol Immunopathol. 1992 Aug; 64(2):145-52. PMID: 1379527.
      Citations: 4     Fields:    Translation:HumansCells
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