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Lutfi A. Abu-Elheiga

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ibitokou SA, Dillon BE, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, Szabo C, Abu-Elheiga L, Porter C, Tuvdendorj D, Stephens R. Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 2018 01 15; 200(2):643-656. PMID: 29237780.
      View in: PubMed
    2. Ambati CS, Yuan F, Abu-Elheiga LA, Zhang Y, Shetty V. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics. J Am Soc Mass Spectrom. 2017 05; 28(5):929-938. PMID: 28315235.
      View in: PubMed
    3. Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15; 448(3):409-16. PMID: 23067267.
      View in: PubMed
    4. Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J Biol Chem. 2012 Apr 06; 287(15):12578-88. PMID: 22362781.
      View in: PubMed
    5. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152.
      View in: PubMed
    6. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18831-6. PMID: 19850873.
      View in: PubMed
    7. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
      View in: PubMed
    8. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res. 2009 Apr; 50 Suppl:S138-43. PMID: 19047759.
      View in: PubMed
    9. Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L. Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H256-65. PMID: 18487439.
      View in: PubMed
    10. Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16480-5. PMID: 17923673.
      View in: PubMed
    11. Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8552-7. PMID: 16717184.
      View in: PubMed
    12. Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12011-6. PMID: 16103361.
      View in: PubMed
    13. Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS, Wakil SJ. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1384-9. PMID: 15677334.
      View in: PubMed
    14. Abu-Elheiga L, Oh W, Kordari P, Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10207-12. PMID: 12920182.
      View in: PubMed
    15. Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6358-63. PMID: 12738878.
      View in: PubMed
    16. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30; 291(5513):2613-6. PMID: 11283375.
      View in: PubMed
    17. Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1444-9. PMID: 10677481.
      View in: PubMed
    18. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ. Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem. 1997 Apr 18; 272(16):10669-77. PMID: 9099716.
      View in: PubMed
    19. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ. Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8695-9. PMID: 7567999.
      View in: PubMed
    20. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):4011-5. PMID: 7732023.
      View in: PubMed
    21. Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ. Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene. Genomics. 1994 Sep 15; 23(2):420-4. PMID: 7835891.
      View in: PubMed
    22. Abu-Elheiga L, Yaneva M. Antigenic determinants of the 70-kDa subunit of the Ku autoantigen. Clin Immunol Immunopathol. 1992 Aug; 64(2):145-52. PMID: 1379527.
      View in: PubMed
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