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MOTONARI UESUGI

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    R01GM071800     (UESUGI, MOTONARI)Aug 1, 2004 - Jul 31, 2009
    NIH/NIGMS
    Synthetic modulators of transcription
    Role: Principal Investigator

    R01CA109277     (UESUGI, MOTONARI)Jun 20, 2005 - May 31, 2008
    NIH/NCI
    Small-molecule analysis of signaling pathways
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y. Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels. Br J Pharmacol. 2019 Sep; 176(17):3161-3179. PMID: 31116876.
      View in: PubMed
    2. Nagata A, Akagi Y, Masoud SS, Yamanaka M, Kittaka A, Uesugi M, Odagi M, Nagasawa K. Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25. J Org Chem. 2019 Jun 21; 84(12):7630-7641. PMID: 30985122.
      View in: PubMed
    3. Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M. Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment. ACS Chem Biol. 2019 Apr 19; 14(4):775-783. PMID: 30807095.
      View in: PubMed
    4. Nishikawa Y, Kodama Y, Shiokawa M, Matsumori T, Marui S, Kuriyama K, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Uesugi M, Kageyama R, Chiba T, Seno H. Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis. Oncogene. 2019 May; 38(22):4283-4296. PMID: 30705405.
      View in: PubMed
    5. Kawagoe F, Sugiyama T, Yasuda K, Uesugi M, Sakaki T, Kittaka A. Concise synthesis of 23-hydroxylated vitamin D3 metabolites. J Steroid Biochem Mol Biol. 2019 02; 186:161-168. PMID: 30367940.
      View in: PubMed
    6. Ohkanda J, Kusumoto A, Punzalan L, Masuda R, Wang C, Parvatkar P, Akase D, Aida M, Uesugi M, Higuchi Y, Kato N. Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity. Chemistry. 2018 Oct 26; 24(60):16066-16071. PMID: 30238524.
      View in: PubMed
    7. Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Shibata-Seki T, Yoshimoto K, Sakai R, Hakariya H, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y, Kamei KI. Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array. J Vis Exp. 2018 09 07; (139). PMID: 30247461.
      View in: PubMed
    8. Terada K, Sano Y, Takahata N, Ishida A, Tsuchiyama A, Nakamura T, Noguchi T, Karouji Y, Uesugi M, Yada T, Nakabayashi M, Fukuda K, Nagahara H. Thermal and impact histories of 25143 Itokawa recorded in Hayabusa particles. Sci Rep. 2018 Aug 07; 8(1):11806. PMID: 30087407.
      View in: PubMed
    9. Li Q, Yoshimura H, Komiya M, Tajiri K, Uesugi M, Hata Y, Ozawa T. A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules. Analyst. 2018 Jul 09; 143(14):3472-3480. PMID: 29944152.
      View in: PubMed
    10. Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M. Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Chem Commun (Camb). 2018 Jun 26; 54(52):7151-7154. PMID: 29882951.
      View in: PubMed
    11. Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 05 25; 293(21):8285-8294. PMID: 29523683.
      View in: PubMed
    12. Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M. Chemical decontamination of iPS cell-derived neural cell mixtures. Chem Commun (Camb). 2018 Feb 01; 54(11):1355-1358. PMID: 29350722.
      View in: PubMed
    13. Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M. Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe. Methods Mol Biol. 2018; 1649:305-318. PMID: 29130206.
      View in: PubMed
    14. Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, Watanabe A, Uesugi M, Osafune K. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Sci Rep. 2017 12 01; 7(1):16734. PMID: 29196668.
      View in: PubMed
    15. Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y. Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model. Sci Rep. 2017 08 17; 7(1):8630. PMID: 28819182.
      View in: PubMed
    16. Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y. Ivermectin activates GIRK channels in a PIP2 -dependent, Gß? -independent manner and an amino acid residue at the slide helix governs the activation. J Physiol. 2017 09 01; 595(17):5895-5912. PMID: 28715108.
      View in: PubMed
    17. Kawagoe F, Sugiyama T, Uesugi M, Kittaka A. Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain. J Steroid Biochem Mol Biol. 2018 03; 177:250-254. PMID: 28716761.
      View in: PubMed
    18. Kamei KI, Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Nakajima M, Shibata-Seki T, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y. Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments. Small. 2017 05; 13(18). PMID: 28272774.
      View in: PubMed
    19. Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017 Feb 16; 24(2):207-217. PMID: 28132894.
      View in: PubMed
    20. Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M. A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. Angew Chem Int Ed Engl. 2017 02 06; 56(7):1765-1770. PMID: 28067441.
      View in: PubMed
    21. Katsuda Y, Sato S, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc. 2016 07 27; 138(29):9037-40. PMID: 27410677.
      View in: PubMed
    22. Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S. Dopamine D2 Receptor-Mediated Regulation of Pancreatic ß Cell Mass. Stem Cell Reports. 2016 07 12; 7(1):95-109. PMID: 27373926.
      View in: PubMed
    23. Biswas T, Akagi Y, Usuda K, Yasui K, Shimizu I, Okamoto M, Uesugi M, Hosokawa S, Nagasawa K. Synthesis of 24,24-Difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 Derivatives and Evaluation of Their Vitamin D Receptor-Binding Affinity. Biol Pharm Bull. 2016; 39(8):1387-91. PMID: 27476947.
      View in: PubMed
    24. Usuda K, Biswas T, Yamaguchi T, Akagi Y, Yasui K, Uesugi M, Shimizu I, Hosokawa S, Nagasawa K. Synthesis of Diastereomers of 1,3-cis-25-Dihydroxy-19-norvitamin D3. Chem Pharm Bull (Tokyo). 2016; 64(8):1190-5. PMID: 27477659.
      View in: PubMed
    25. Matsumoto Y, Ito A, Uesugi M, Kittaka A. Efficient N-Acyldopamine Synthesis. Chem Pharm Bull (Tokyo). 2016; 64(7):935-40. PMID: 27373649.
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    26. Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23; 137(50):15859-64. PMID: 26630251.
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    27. Parvatkar P, Kato N, Uesugi M, Sato S, Ohkanda J. Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions. J Am Chem Soc. 2015 Dec 23; 137(50):15624-7. PMID: 26632868.
      View in: PubMed
    28. Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M. Live-cell imaging of endogenous mRNAs with a small molecule. Angew Chem Int Ed Engl. 2015 Feb 02; 54(6):1855-8. PMID: 25537455.
      View in: PubMed
    29. Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11208-13. PMID: 25196666.
      View in: PubMed
    30. Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M. Selective elimination of human pluripotent stem cells by a marine natural product derivative. J Am Chem Soc. 2014 Jul 16; 136(28):9798-801. PMID: 24992689.
      View in: PubMed
    31. Terada K, Ninomiya K, Osawa T, Tachibana S, Miyake Y, Kubo MK, Kawamura N, Higemoto W, Tsuchiyama A, Ebihara M, Uesugi M. A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam. Sci Rep. 2014 May 27; 4:5072. PMID: 24861282.
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    32. Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato SI, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M. A chemical probe that labels human pluripotent stem cells. Cell Rep. 2014 Mar 27; 6(6):1165-1174. PMID: 24613351.
      View in: PubMed
    33. Yoshida T, Ozawa Y, Kimura T, Sato Y, Kuznetsov G, Xu S, Uesugi M, Agoulnik S, Taylor N, Funahashi Y, Matsui J. Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Br J Cancer. 2014 Mar 18; 110(6):1497-505. PMID: 24569463.
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    34. Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One. 2014; 9(1):e84881. PMID: 24454758.
      View in: PubMed
    35. Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S. VMAT2 identified as a regulator of late-stage ß-cell differentiation. Nat Chem Biol. 2014 Feb; 10(2):141-8. PMID: 24316738.
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    36. Kita M, Hirayama Y, Yoneda K, Yamagishi K, Chinen T, Usui T, Sumiya E, Uesugi M, Kigoshi H. Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. J Am Chem Soc. 2013 Dec 04; 135(48):18089-95. PMID: 24228690.
      View in: PubMed
    37. Takemoto N, Suehara T, Frisco HL, Sato S, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc. 2013 Jul 31; 135(30):11032-9. PMID: 23822587.
      View in: PubMed
    38. Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 2013 Jul 15; 73(14):4559-70. PMID: 23720055.
      View in: PubMed
    39. Kumagai H, Suemori H, Uesugi M, Nakatsuji N, Kawase E. Identification of small molecules that promote human embryonic stem cell self-renewal. Biochem Biophys Res Commun. 2013 May 17; 434(4):710-6. PMID: 23541943.
      View in: PubMed
    40. Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15; 448(3):409-16. PMID: 23067267.
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    41. Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29; 2(5):1448-60. PMID: 23103164.
      View in: PubMed
    42. Uesugi M. [Control and analysis of cells by synthetic small molecules]. Yakugaku Zasshi. 2012; 132(5):575-86. PMID: 22687693.
      View in: PubMed
    43. Khambu B, Uesugi M, Kawazoe Y. Translational repression stabilizes messenger RNA of autophagy-related genes. Genes Cells. 2011 Aug; 16(8):857-67. PMID: 21790910.
      View in: PubMed
    44. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152.
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    45. Kawazoe Y, Shimogawa H, Sato A, Uesugi M. A mitochondrial surface-specific fluorescent probe activated by bioconversion. Angew Chem Int Ed Engl. 2011 Jun 06; 50(24):5478-81. PMID: 21542076.
      View in: PubMed
    46. Murata A, Sato S, Kawazoe Y, Uesugi M. Small-molecule fluorescent probes for specific RNA targets. Chem Commun (Camb). 2011 Apr 28; 47(16):4712-4. PMID: 21412566.
      View in: PubMed
    47. Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R. Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis. J Biomol Screen. 2011 Apr; 16(4):405-14. PMID: 21364087.
      View in: PubMed
    48. Sumiya E, Shimogawa H, Sasaki H, Tsutsumi M, Yoshita K, Ojika M, Suenaga K, Uesugi M. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol. 2011 May 20; 6(5):425-31. PMID: 21322638.
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    49. Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H, Uesugi M. Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol. 2011 Jan 28; 18(1):131-9. PMID: 21276946.
      View in: PubMed
    50. Shirakawa T, Kawazoe Y, Tsujikawa T, Jung D, Sato S, Uesugi M. Deactivation of STAT6 through serine 707 phosphorylation by JNK. J Biol Chem. 2011 Feb 04; 286(5):4003-10. PMID: 21123173.
      View in: PubMed
    51. Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget. 2010 Aug; 1(4):252-64. PMID: 21304177.
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    52. Sato S, Murata A, Shirakawa T, Uesugi M. Biochemical target isolation for novices: affinity-based strategies. Chem Biol. 2010 Jun 25; 17(6):616-23. PMID: 20609411.
      View in: PubMed
    53. Hoshino M, Tsujimoto T, Yamazoe S, Uesugi M, Terada S. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29; 427(2):297-304. PMID: 20146670.
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    54. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
      View in: PubMed
    55. Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M. A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol. 2009 07 31; 16(7):773-82. PMID: 19635414.
      View in: PubMed
    56. Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M. Wrenchnolol derivative optimized for gene activation in cells. J Am Chem Soc. 2009 Apr 08; 131(13):4774-82. PMID: 19290630.
      View in: PubMed
    57. Shinohara T, Uesugi M. [In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1816-7. PMID: 18051440.
      View in: PubMed
    58. Sato S, Murata A, Uesugi M. [Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1782-3. PMID: 18051424.
      View in: PubMed
    59. Kamisuki S, Uesugi M. [Discovering high-affinity ligands for proteins: SAR by NMR]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1818-9. PMID: 18051441.
      View in: PubMed
    60. Kugimiya A, Takagi J, Uesugi M. [Role of LXRs in control of lipogenesis]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1814-5. PMID: 18051439.
      View in: PubMed
    61. Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M. Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc. 2007 Jan 31; 129(4):873-80. PMID: 17243824.
      View in: PubMed
    62. Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL. Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3. Placenta. 2007 Feb-Mar; 28(2-3):152-60. PMID: 16730372.
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    63. Jung D, Choi Y, Uesugi M. Small organic molecules that modulate gene transcription. Drug Discov Today. 2006 May; 11(9-10):452-7. PMID: 16635809.
      View in: PubMed
    64. Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M. Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar; 13(3):241-9. PMID: 16638529.
      View in: PubMed
    65. Sato A, Kawazoe Y, Kamisuki S, Uesugi M. Synthesis of synthetic small molecule transcription factors (STF). Nucleic Acids Symp Ser (Oxf). 2006; (50):29-30. PMID: 17150801.
      View in: PubMed
    66. Uesugi M. [Small molecules that control gene expression]. Seikagaku. 2005 Sep; 77(9):1177-80. PMID: 16241004.
      View in: PubMed
    67. Kawazoe Y, Uesugi M. [Trends in chemical libraries for chemical genetics]. Tanpakushitsu Kakusan Koso. 2005 Aug; 50(9):1043-8. PMID: 16083041.
      View in: PubMed
    68. Kwon Y, Arndt HD, Mao Q, Choi Y, Kawazoe Y, Dervan PB, Uesugi M. Small molecule transcription factor mimic. J Am Chem Soc. 2004 Dec 15; 126(49):15940-1. PMID: 15584709.
      View in: PubMed
    69. Uesugi M. Synthetic molecules that modulate transcription and differentiation: hints for future drug discovery. Comb Chem High Throughput Screen. 2004 Nov; 7(7):653-9. PMID: 15578927.
      View in: PubMed
    70. Kawazoe Y, Tanaka S, Uesugi M. Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem Biol. 2004 Jul; 11(7):907-13. PMID: 15271349.
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    71. Shimogawa H, Kwon Y, Mao Q, Kawazoe Y, Choi Y, Asada S, Kigoshi H, Uesugi M. A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc. 2004 Mar 24; 126(11):3461-71. PMID: 15025473.
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    72. Asada S, Choi Y, Uesugi M. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc. 2003 Apr 30; 125(17):4992-3. PMID: 12708845.
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    73. Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28; 278(9):7320-4. PMID: 12496288.
      View in: PubMed
    74. Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W. Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene. 2002 Oct 10; 21(46):7100-13. PMID: 12370832.
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    75. Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12747-52. PMID: 12242338.
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    76. Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem. 2001 Mar 23; 276(12):8734-9. PMID: 11118440.
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    77. Park S, Uesugi M, Verdine GL. A second calcineurin binding site on the NFAT regulatory domain. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7130-5. PMID: 10860980.
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    78. Choi Y, Asada S, Uesugi M. Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem. 2000 May 26; 275(21):15912-6. PMID: 10821850.
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    79. Uesugi M, Verdine GL. The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14801-6. PMID: 10611293.
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    80. Nyanguile O, Uesugi M, Austin DJ, Verdine GL. A nonnatural transcriptional coactivator. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13402-6. PMID: 9391036.
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    81. Uesugi M, Nyanguile O, Lu H, Levine AJ, Verdine GL. Induced alpha helix in the VP16 activation domain upon binding to a human TAF. Science. 1997 Aug 29; 277(5330):1310-3. PMID: 9271577.
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    82. Kusakabe T, Uesugi M, Sugiura Y. Sequence preference for strand cleavage of gapped duplexes by dynemicin A: possible mechanism of sequence-dependent double-stranded breaks. Biochemistry. 1995 Aug 08; 34(31):9944-50. PMID: 7632693.
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    83. Uesugi M, Kusakabe T, Sugiura Y. Hydrophobic DNA binding of esperamicin requires conformational distortion of the host DNA. Biochim Biophys Acta. 1995 Mar 14; 1261(1):99-106. PMID: 7893766.
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    84. Totsuka R, Aizawa Y, Uesugi M, Okuno Y, Matsumoto T, Sugiura Y. RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: high selectivity to an anticodon arm. Biochem Biophys Res Commun. 1995 Mar 08; 208(1):168-73. PMID: 7887925.
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