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Institute for Clinical and Translational Research

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Shelley Sazer

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    Other Positions
    TitleProfessor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01GM049119     (SAZER, SHELLEY)May 1, 1993 - Jun 30, 2003
    NIH/NIGMS
    CONTROL OF THE EXIT FROM MITOSIS IN FISSION YEAST
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sazer S, Schiessel H. The biology and polymer physics underlying large-scale chromosome organization. Traffic. 2018 02; 19(2):87-104. PMID: 29105235.
      View in: PubMed
    2. Lynch M, Field MC, Goodson HV, Malik HS, Pereira-Leal JB, Roos DS, Turkewitz AP, Sazer S. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):16990-4. PMID: 25404324.
      View in: PubMed
    3. Sazer S, Lynch M, Needleman D. Deciphering the evolutionary history of open and closed mitosis. Curr Biol. 2014 Nov 17; 24(22):R1099-103. PMID: 25458223.
      View in: PubMed
    4. Steglich B, Sazer S, Ekwall K. Transcriptional regulation at the yeast nuclear envelope. Nucleus. 2013 Sep-Oct; 4(5):379-89. PMID: 24021962.
      View in: PubMed
    5. Gonzalez Y, Saito A, Sazer S. Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina. Nucleus. 2012 Jan-Feb; 3(1):60-76. PMID: 22540024.
      View in: PubMed
    6. Sazer S. Nuclear membrane: nuclear envelope PORosity in fission yeast meiosis. Curr Biol. 2010 Nov 09; 20(21):R923-5. PMID: 21056831.
      View in: PubMed
    7. Gonzalez Y, Meerbrey K, Chong J, Torii Y, Padte NN, Sazer S. Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum. J Cell Sci. 2009 Jul 15; 122(Pt 14):2464-72. PMID: 19571115.
      View in: PubMed
    8. Nogare DE, Arguello A, Sazer S, Lane ME. Zebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression. Dev Dyn. 2007 Dec; 236(12):3427-35. PMID: 17969147.
      View in: PubMed
    9. Lim H W G, Huber G, Torii Y, Hirata A, Miller J, Sazer S. Vesicle-like biomechanics governs important aspects of nuclear geometry in fission yeast. PLoS One. 2007 Sep 26; 2(9):e948. PMID: 17895989.
      View in: PubMed
    10. Clarke PR, Sazer S. Mitosis: ran scales the alps of spindle formation. Curr Biol. 2007 Aug 21; 17(16):R643-5. PMID: 17714654.
      View in: PubMed
    11. Sazer S. New 'omics tools for fission yeast. Nat Biotechnol. 2006 Jul; 24(7):789-90. PMID: 16841061.
      View in: PubMed
    12. Sazer S. The view from Awaji island: past, present, and future of RCC1 and the Ran GTPase system. Dev Cell. 2005 Dec; 9(6):729-33. PMID: 16363093.
      View in: PubMed
    13. Kadura S, Sazer S. SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation. Cell Motil Cytoskeleton. 2005 Jul; 61(3):145-60. PMID: 15887295.
      View in: PubMed
    14. Umeda M, Izaddoost S, Cushman I, Moore MS, Sazer S. The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression. Genetics. 2005 Sep; 171(1):7-21. PMID: 15937127.
      View in: PubMed
    15. Sazer S. Nuclear envelope: nuclear pore complexity. Curr Biol. 2005 Jan 11; 15(1):R23-6. PMID: 15649347.
      View in: PubMed
    16. Kadura S, He X, Vanoosthuyse V, Hardwick KG, Sazer S. The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function. Mol Biol Cell. 2005 Jan; 16(1):385-95. PMID: 15525673.
      View in: PubMed
    17. Baï SW, Rouquette J, Umeda M, Faigle W, Loew D, Sazer S, Doye V. The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division. Mol Cell Biol. 2004 Jul; 24(14):6379-92. PMID: 15226438.
      View in: PubMed
    18. Yoshida M, Sazer S. Nucleocytoplasmic transport and nuclear envelope integrity in the fission yeast Schizosaccharomyces pombe. Methods. 2004 Jul; 33(3):226-38. PMID: 15157890.
      View in: PubMed
    19. Chang F, Re F, Sebastian S, Sazer S, Luban J. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Mol Biol Cell. 2004 Apr; 15(4):1793-801. PMID: 14767062.
      View in: PubMed
    20. Salus SS, Demeter J, Sazer S. The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport. Mol Cell Biol. 2002 Dec; 22(24):8491-505. PMID: 12446769.
      View in: PubMed
    21. Matynia A, Salus SS, Sazer S. Three proteins required for early steps in the protein secretory pathway also affect nuclear envelope structure and cell cycle progression in fission yeast. J Cell Sci. 2002 Jan 15; 115(Pt 2):421-31. PMID: 11839792.
      View in: PubMed
    22. Gopalakrishnan V, Simancek P, Houchens C, Snaith HA, Frattini MG, Sazer S, Kelly TJ. Redundant control of rereplication in fission yeast. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13114-9. PMID: 11606752.
      View in: PubMed
    23. Fleig U, Salus SS, Karig I, Sazer S. The fission yeast ran GTPase is required for microtubule integrity. J Cell Biol. 2000 Nov 27; 151(5):1101-11. PMID: 11086011.
      View in: PubMed
    24. Sazer S, Dasso M. The ran decathlon: multiple roles of Ran. J Cell Sci. 2000 Apr; 113 ( Pt 7):1111-8. PMID: 10704362.
      View in: PubMed
    25. Patterson TE, Albrecht EB, Nurse P, Sazer S, Stark GR. Effects of genome position and the DNA damage checkpoint on the structure and frequency of sod2 gene amplification in fission yeast. Mol Biol Cell. 1999 Jul; 10(7):2199-208. PMID: 10397759.
      View in: PubMed
    26. Noguchi E, Saitoh Yh, Sazer S, Nishimoto T. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1. J Biochem. 1999 Mar; 125(3):574-85. PMID: 10050047.
      View in: PubMed
    27. Wang Y, Dimitrov K, Garrity LK, Sazer S, Beverley SM. Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant. Mol Biochem Parasitol. 1998 Oct 30; 96(1-2):139-50. PMID: 9851613.
      View in: PubMed
    28. Demeter J, Sazer S. imp2, a new component of the actin ring in the fission yeast Schizosaccharomyces pombe. J Cell Biol. 1998 Oct 19; 143(2):415-27. PMID: 9786952.
      View in: PubMed
    29. Dimitrov K, Sazer S. The role of fnx1, a fission yeast multidrug resistance protein, in the transition of cells to a quiescent G0 state. Mol Cell Biol. 1998 Sep; 18(9):5239-46. PMID: 9710608.
      View in: PubMed
    30. Balasubramanian MK, McCollum D, Chang L, Wong KC, Naqvi NI, He X, Sazer S, Gould KL. Isolation and characterization of new fission yeast cytokinesis mutants. Genetics. 1998 Jul; 149(3):1265-75. PMID: 9649519.
      View in: PubMed
    31. He X, Jones MH, Winey M, Sazer S. Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J Cell Sci. 1998 Jun; 111 ( Pt 12):1635-47. PMID: 9601094.
      View in: PubMed
    32. Matynia A, Mueller U, Ong N, Demeter J, Granger AL, Hinata K, Sazer S. Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition. Genetics. 1998 Apr; 148(4):1799-811. PMID: 9560394.
      View in: PubMed
    33. He X, Hayashi N, Walcott NG, Azuma Y, Patterson TE, Bischoff FR, Nishimoto T, Sazer S. The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein. Genetics. 1998 Feb; 148(2):645-56. PMID: 9504913.
      View in: PubMed
    34. He X, Patterson TE, Sazer S. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7965-70. PMID: 9223296.
      View in: PubMed
    35. Matynia A, Dimitrov K, Mueller U, He X, Sazer S. Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences. Mol Cell Biol. 1996 Nov; 16(11):6352-62. PMID: 8887664.
      View in: PubMed
    36. Shi ZZ, Habib GM, Rhead WJ, Gahl WA, He X, Sazer S, Lieberman MW. Mutations in the glutathione synthetase gene cause 5-oxoprolinuria. Nat Genet. 1996 Nov; 14(3):361-5. PMID: 8896573.
      View in: PubMed
    37. Noguchi E, Hayashi N, Azuma Y, Seki T, Nakamura M, Nakashima N, Yanagida M, He X, Mueller U, Sazer S, Nishimoto T. Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1. EMBO J. 1996 Oct 15; 15(20):5595-605. PMID: 8896453.
      View in: PubMed
    38. Shi ZZ, Carter BZ, Habib GM, He X, Sazer S, Lebovitz RM, Lieberman MW. A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch Biochem Biophys. 1996 Jul 15; 331(2):215-24. PMID: 8660701.
      View in: PubMed
    39. Turi TG, Mueller UW, Sazer S, Rose JK. Characterization of a nuclear protein conferring brefeldin A resistance in Schizosaccharomyces pombe. J Biol Chem. 1996 Apr 12; 271(15):9166-71. PMID: 8621569.
      View in: PubMed
    40. Sazer S. The search for the primary function of the Ran GTPase continues. Trends Cell Biol. 1996 Mar; 6(3):81-5. PMID: 15157482.
      View in: PubMed
    41. Patterson TE, Stark GR, Sazer S. A strategy for quickly identifying all unique two-hybrid or library plasmids within a pool of yeast transformants. Nucleic Acids Res. 1995 Oct 25; 23(20):4222-3. PMID: 7479088.
      View in: PubMed
    42. Demeter J, Morphew M, Sazer S. A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1436-40. PMID: 7877997.
      View in: PubMed
    43. Ouspenski II, Mueller UW, Matynia A, Sazer S, Elledge SJ, Brinkley BR. Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem. 1995 Feb 03; 270(5):1975-8. PMID: 7836422.
      View in: PubMed
    44. Sazer S, Nurse P. A fission yeast RCC1-related protein is required for the mitosis to interphase transition. EMBO J. 1994 Feb 01; 13(3):606-15. PMID: 8313905.
      View in: PubMed
    45. Gould KL, Moreno S, Owen DJ, Sazer S, Nurse P. Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J. 1991 Nov; 10(11):3297-309. PMID: 1655416.
      View in: PubMed
    46. Sazer S, Sherwood SW. Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast. J Cell Sci. 1990 Nov; 97 ( Pt 3):509-16. PMID: 2074269.
      View in: PubMed
    47. Sazer S, Schimke RT. A re-examination of the 5' termini of mouse dihydrofolate reductase RNA. J Biol Chem. 1986 Apr 05; 261(10):4685-90. PMID: 3007471.
      View in: PubMed
    48. Dynan WS, Sazer S, Tjian R, Schimke RT. Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature. 1986 Jan 16-22; 319(6050):246-8. PMID: 3945313.
      View in: PubMed
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