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DONALD MCDONNELL

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01CA276089     (MCDONNELL, DONALD P)Feb 7, 2023 - Jan 31, 2028
    NIH
    Manipulating normal estrogen physiology as a therapeutic approach in cancer
    Role: Principal Investigator
    R01CA271168     (MCDONNELL, DONALD P)Sep 1, 2022 - Jul 31, 2027
    NIH
    Elucidation of the mechanisms by which cells recognize and respond to different levels of androgens
    Role: Principal Investigator
    R21CA263414     (MCDONNELL, DONALD P)Sep 1, 2022 - Aug 31, 2024
    NIH
    Development of Novel ERRalpha Antagonists as Breast Cancer Therapeutics
    Role: Principal Investigator
    R01HD058640     (MCDONNELL, DONALD P)Jul 27, 2009 - Jun 30, 2011
    NIH
    The pharmacological actions of antiprogestins in uterine fibroids
    Role: Principal Investigator
    R01DK074652     (MCDONNELL, DONALD P)Dec 20, 2007 - Jan 31, 2013
    NIH
    Validation of the Estrogen Related Receptor as a therapeutic target in cancer
    Role: Principal Investigator
    R01CA174643     (MCDONNELL, DONALD P)Apr 1, 2006 - Jan 31, 2018
    NIH
    The role of ERRalpha/PGC-1 in disease pathogenesis
    Role: Principal Investigator
    R13DK070484     (MCDONNELL, DONALD P)Sep 20, 2004 - Oct 31, 2005
    NIH
    Conference on Tissue-Selective Nuclear Receptors
    Role: Principal Investigator
    R13CA106219     (MCDONNELL, DONALD P)Apr 1, 2004 - Feb 20, 2005
    NIH
    Nuclear Receptors: Steroid Sisters
    Role: Principal Investigator
    R01CA139818     (MCDONNELL, DONALD P)Jul 15, 2003 - Nov 30, 2013
    NIH
    Molecular Determinants of Androgen Receptor Pharmacology
    Role: Principal Investigator
    R01DK065251     (MCDONNELL, DONALD P)Jul 15, 2003 - Mar 30, 2008
    NIH
    Molecular Determinants of Androgen Receptor Pharmacology
    Role: Principal Investigator
    R01CA090645     (MCDONNELL, DONALD P)Apr 1, 2001 - Mar 31, 2006
    NIH
    Development of peptide antagonists of estrogen signaling
    Role: Principal Investigator
    R01DK050494     (MCDONNELL, DONALD P)May 1, 1995 - Apr 30, 2005
    NIH
    GENETIC DISSECTION OF PROGESTERONE RECEPTOR FUNCTION
    Role: Principal Investigator
    R01DK048807     (MCDONNELL, DONALD P)Dec 1, 1994 - Jan 31, 2020
    NIH
    ER and LXR as mediators of the pathobiology of hypercholesterolemia
    Role: Principal Investigator
    R37DK048807     (MCDONNELL, DONALD P)Dec 1, 1994 - Jan 31, 2015
    NIH
    Mechanism of Action of Estrogens and Antiestrogens
    Role: Principal Investigator
    R29DK043267     (MCDONNELL, DONALD P)Dec 1, 1990 - Nov 30, 1995
    NIH
    BIOLOGICAL ACTIONS OF 1,25-DIHYDROXY-VITAMIN D3
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Safi R, Wardell SE, Watkinson P, Qin X, Lee M, Park S, Krebs T, Dolan EL, Blattler A, Tsuji T, Nayak S, Khater M, Fontanillo C, Newlin MA, Kirkland ML, Xie Y, Long H, Fink EC, Fanning SW, Runyon S, Brown M, Xu S, Owzar K, Norris JD, McDonnell DP. Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells. Nat Commun. 2024 Sep 03; 15(1):7675. PMID: 39227594; PMCID: PMC11371910.
      Citations:    
    2. Halabi S, Guo S, Park JJ, Nanus DM, George DJ, Antonarakis ES, Danila DC, Szmulewitz RZ, McDonnell DP, Norris JD, Lu C, Luo J, Armstrong AJ. The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide. Clin Cancer Res. 2024 Mar 15; 30(6):1152-1159. PMID: 38236581; PMCID: PMC10947837.
      Citations: 3     Fields:    Translation:HumansCells
    3. Mukherjee D, Previs RA, Haines C, Al Abo M, Juras PK, Strickland KC, Chakraborty B, Artham S, Whitaker RS, Hebert K, Fontenot J, Patierno SR, Freedman JA, Lau FH, Burow ME, Chang CY, McDonnell DP. Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis. Cancer Res. 2023 09 01; 83(17):2889-2907. PMID: 37335130; PMCID: PMC10472110.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Yu L, Xu L, Chu H, Peng J, Sacharidou A, Hsieh HH, Weinstock A, Khan S, Ma L, Dur?n JGB, McDonald J, Nelson ER, Park S, McDonnell DP, Moore KJ, Huang LJ, Fisher EA, Mineo C, Huang L, Shaul PW. Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nat Commun. 2023 07 25; 14(1):4101. PMID: 37491347; PMCID: PMC10368733.
      Citations:    Fields:    Translation:AnimalsCells
    5. Mayro B, Hoj JP, Cerda-Smith CG, Hutchinson HM, Caminear MW, Thrash HL, Winter PS, Wardell SE, McDonnell DP, Wu C, Wood KC, Pendergast AM. ABL kinases regulate the stabilization of HIF-1a and MYC through?CPSF1. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2210418120. PMID: 37040401; PMCID: PMC10120083.
      Citations:    Fields:    Translation:HumansCells
    6. Chakraborty B, Byemerwa J, Krebs T, Lim F, Chang CY, McDonnell DP. Estrogen Receptor Signaling in the Immune System. Endocr Rev. 2023 01 12; 44(1):117-141. PMID: 35709009.
      Citations:    Fields:    
    7. Wells C, Liang Y, Pulliam TL, Lin C, Awad D, Eduful B, O'Byrne S, Hossain MA, Catta-Preta CMC, Ramos PZ, Gileadi O, Gileadi C, Cou?ago RM, Stork B, Langendorf CG, Nay K, Oakhill JS, Mukherjee D, Racioppi L, Means AR, York B, McDonnell DP, Scott JW, Frigo DE, Drewry DH. SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells. 2023 01 11; 12(2). PMID: 36672221; PMCID: PMC9856672.
      Citations:    Fields:    
    8. Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D'Agostino L, Chang CY, McDonnell DP. Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Cancer Immunol Res. 2023 01 03; 11(1):109-122. PMID: 36301267; PMCID: PMC9812906.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Artham S, Chang CY, McDonnell DP. Eosinophilia in cancer and its regulation by sex hormones. Trends Endocrinol Metab. 2023 01; 34(1):5-20. PMID: 36443206; PMCID: PMC10122120.
      Citations: 1     Fields:    Translation:HumansCells
    10. Russell S, Lim F, Peters PN, Wardell SE, Whitaker R, Chang CY, Previs RA, McDonnell DP. Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer. Cancers (Basel). 2022 Aug 30; 14(17). PMID: 36077756; PMCID: PMC9454869.
      Citations:    
    11. Sha Y, Wu J, Paul B, Zhao Y, Mathews P, Li Z, Norris J, Wang E, McDonnell DP, Kang Y. PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo. Cancer Lett. 2022 10 01; 545:215832. PMID: 35872263; PMCID: PMC10355274.
      Citations:    Fields:    
    12. Haines CN, Wardell SE, McDonnell DP. Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer. Essays Biochem. 2021 12 17; 65(6):985-1001. PMID: 34328178.
      Citations: 2     Fields:    Translation:HumansCells
    13. Chakraborty B, Byemerwa J, Shepherd J, Haines CN, Baldi R, Gong W, Liu W, Mukherjee D, Artham S, Lim F, Bae Y, Brueckner O, Tavares K, Wardell SE, Hanks BA, Perou CM, Chang CY, McDonnell DP. Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma. J Clin Invest. 2021 12 01; 131(23). PMID: 34637400; PMCID: PMC8631601.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    14. Liu W, Chakraborty B, Safi R, Kazmin D, Chang CY, McDonnell DP. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nat Commun. 2021 08 24; 12(1):5103. PMID: 34429409; PMCID: PMC8385107.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    15. McDonnell DP, Wardell SE, Chang CY, Norris JD. Next-Generation Endocrine Therapies for Breast Cancer. J Clin Oncol. 2021 04 20; 39(12):1383-1388. PMID: 33705209; PMCID: PMC8274744.
      Citations: 3     Fields:    Translation:Humans
    16. Andreano KJ, Baker JG, Park S, Safi R, Artham S, Oesterreich S, Jeselsohn R, Brown M, Sammons S, Wardell SE, Chang CY, Norris JD, McDonnell DP. The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. Mol Cancer Ther. 2020 07; 19(7):1395-1405. PMID: 32381587; PMCID: PMC7335351.
      Citations: 8     Fields:    Translation:HumansCells
    17. Wardell SE, Yllanes AP, Chao CA, Bae Y, Andreano KJ, Desautels TK, Heetderks KA, Blitzer JT, Norris JD, McDonnell DP. Correction to: Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-a degrader activity in antitumor efficacy. Breast Cancer Res Treat. 2020 02; 179(3):769. PMID: 31734822; PMCID: PMC6997263.
      Citations:    Fields:    
    18. Ochsner SA, Abraham D, Martin K, Ding W, McOwiti A, Kankanamge W, Wang Z, Andreano K, Hamilton RA, Chen Y, Hamilton A, Gantner ML, Dehart M, Qu S, Hilsenbeck SG, Becnel LB, Bridges D, Ma'ayan A, Huss JM, Stossi F, Foulds CE, Kralli A, McDonnell DP, McKenna NJ. The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. Sci Data. 2019 10 31; 6(1):252. PMID: 31672983; PMCID: PMC6823428.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    19. Cocce KJ, Jasper JS, Desautels TK, Everett L, Wardell S, Westerling T, Baldi R, Wright TM, Tavares K, Yllanes A, Bae Y, Blitzer JT, Logsdon C, Rakiec DP, Ruddy DA, Jiang T, Broadwater G, Hyslop T, Hall A, Laine M, Phung L, Greene GL, Martin LA, Pancholi S, Dowsett M, Detre S, Marks JR, Crawford GE, Brown M, Norris JD, Chang CY, McDonnell DP. The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. Cell Rep. 2019 10 22; 29(4):889-903.e10. PMID: 31644911; PMCID: PMC6874102.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    20. Wardell SE, Yllanes AP, Chao CA, Bae Y, Andreano KJ, Desautels TK, Heetderks KA, Blitzer JT, Norris JD, McDonnell DP. Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-a degrader activity in antitumor efficacy. Breast Cancer Res Treat. 2020 Jan; 179(1):67-77. PMID: 31562570; PMCID: PMC6985185.
      Citations: 10     Fields:    Translation:Animals
    21. Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP. Inhibition of ERRa Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019 06 18; 27(12):3587-3601.e4. PMID: 31216477; PMCID: PMC6604861.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    22. Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, Businaro L, Geradts J, Hall A, Means AR, Chao N, Chang CY, McDonnell DP. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nat Commun. 2019 06 04; 10(1):2450. PMID: 31164648; PMCID: PMC6547743.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    23. Andreano KJ, Gay LM, Steiner M, Jorgensen MS, Davidson BA, Havrilesky LJ, Alvarez Secord A, Valea FA, Colon-Otero G, Zajchowski DA, Chang CY, McDonnell DP, Berchuck A, Elvin JA, Gaillard SL. Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies. Gynecol Oncol. 2019 07; 154(1):199-206. PMID: 30987772.
      Citations: 8     Fields:    Translation:HumansCells
    24. Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS. Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome. iScience. 2019 May 31; 15:552-591. PMID: 31152742; PMCID: PMC6542189.
      Citations: 1     
    25. Wardell SE, Norris JD, McDonnell DP. Targeting mutant estrogen receptors. Elife. 2019 01 16; 8. PMID: 30648967; PMCID: PMC6335051.
      Citations: 4     Fields:    Translation:Humans
    26. Johng D, Torga G, Ewing CM, Jin K, Norris JD, McDonnell DP, Isaacs WB. HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. Prostate. 2019 03; 79(4):414-424. PMID: 30560549.
      Citations: 18     Fields:    Translation:HumansCells
    27. Anderson GR, Wardell SE, Cakir M, Yip C, Ahn YR, Ali M, Yllanes AP, Chao CA, McDonnell DP, Wood KC. Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. Nat Commun. 2018 04 26; 9(1):1677. PMID: 29700304; PMCID: PMC5919970.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    28. McDonnell DP, Norris JD, Chang CY. Neomorphic ERa Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 2018 02 12; 33(2):153-155. PMID: 29438688.
      Citations: 2     Fields:    Translation:HumansCells
    29. McLeod AB, Stice JP, Wardell SE, Alley HM, Chang CY, McDonnell DP. Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. Prostate. 2018 03; 78(4):266-277. PMID: 29243324.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Baek AE, Yu YA, He S, Wardell SE, Chang CY, Kwon S, Pillai RV, McDowell HB, Thompson JW, Dubois LG, Sullivan PM, Kemper JK, Gunn MD, McDonnell DP, Nelson ER. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nat Commun. 2017 10 11; 8(1):864. PMID: 29021522; PMCID: PMC5636879.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    31. Coons LA, Hewitt SC, Burkholder AB, McDonnell DP, Korach KS. DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. Endocrinology. 2017 10 01; 158(10):3212-3234. PMID: 28977594; PMCID: PMC5659708.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    32. Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 03; 26(4):648-659.e8. PMID: 28918937; PMCID: PMC5629112.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    33. Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, Figg WD, McDonnell DP. Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. J Clin Invest. 2017 Jun 01; 127(6):2326-2338. PMID: 28463227; PMCID: PMC5451248.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    34. Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP. CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC. Mol Cancer Res. 2017 06; 15(6):660-669. PMID: 28209757; PMCID: PMC6295664.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    35. Christenson JL, Butterfield KT, Spoelstra NS, Norris JD, Josan JS, Pollock JA, McDonnell DP, Katzenellenbogen BS, Katzenellenbogen JA, Richer JK. MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. Horm Cancer. 2017 04; 8(2):69-77. PMID: 28194662; PMCID: PMC5407486.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    36. Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 04 01; 77(7):1662-1673. PMID: 28130224; PMCID: PMC5687884.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    37. Nelson ER, Li S, Kennedy M, Payne S, Kilibarda K, Groth J, Bowie M, Parilla-Castellar E, de Ridder G, Marcom PK, Lyes M, Peterson BL, Cook M, Pizzo SV, McDonnell DP, Bachelder RE. Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. Oncotarget. 2016 Dec 20; 7(51):84030-84042. PMID: 27768598; PMCID: PMC5356642.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    38. Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC. PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Sci Transl Med. 2016 12 14; 8(369):369ra175. PMID: 27974663; PMCID: PMC5626456.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    39. Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer. J Biol Chem. 2017 Jan 13; 292(2):748-759. PMID: 27903634; PMCID: PMC5241747.
      Citations: 15     Fields:    Translation:HumansCells
    40. Xu X, Zhang Y, Jasper J, Lykken E, Alexander PB, Markowitz GJ, McDonnell DP, Li QJ, Wang XF. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. 2016 Apr 12; 7(15):20381-94. PMID: 26967387; PMCID: PMC4991462.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    41. Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRa-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep. 2016 Apr 12; 15(2):323-35. PMID: 27050525; PMCID: PMC4833658.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    42. Blessing AM, Ganesan S, Rajapakshe K, Ying Sung Y, Reddy Bollu L, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP, Frigo DE. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Mol Endocrinol. 2015 Oct; 29(10):1426-39. PMID: 26305679; PMCID: PMC4588732.
      Citations: 11     Fields:    Translation:HumansCells
    43. Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocr Relat Cancer. 2015 Oct; 22(5):713-24. PMID: 26162914; PMCID: PMC4545300.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    44. Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. Angew Chem Int Ed Engl. 2015 Aug 10; 54(33):9659-62. PMID: 26083457; PMCID: PMC4547777.
      Citations: 54     Fields:    Translation:HumansCells
    45. Lontay B, Bodoor K, Sipos A, Weitzel DH, Loiselle D, Safi R, Zheng D, Devente J, Hickner RC, McDonnell DP, Ribar T, Haystead TA. Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. J Biol Chem. 2015 Jul 17; 290(29):17985-17998. PMID: 26048986; PMCID: PMC4505045.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    46. McDonnell DP, Wardell SE, Norris JD. Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer. J Med Chem. 2015 Jun 25; 58(12):4883-7. PMID: 26039356; PMCID: PMC4708081.
      Citations: 41     Fields:    Translation:HumansAnimals
    47. Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S. Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer. Clin Cancer Res. 2015 Nov 15; 21(22):5121-5130. PMID: 25991817; PMCID: PMC4644714.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    48. Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 12 23; 7(357):ra121. PMID: 25538079; PMCID: PMC4353587.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    49. Nelson ER, Chang CY, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014 Dec; 25(12):649-55. PMID: 25458418; PMCID: PMC4268141.
      Citations: 59     Fields:    Translation:Humans
    50. Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP. Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014 Oct 15; 74(20):5819-31. PMID: 25320179; PMCID: PMC4203427.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    51. Choudhary M, Kazmin D, Hu P, Thomas RS, McDonnell DP, Malek G. Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. J Pathol. 2015 Jan; 235(1):101-12. PMID: 25186463; PMCID: PMC4277859.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    52. Wright TM, Wardell SE, Jasper JS, Stice JP, Safi R, Nelson ER, McDonnell DP. Delineation of a FOXA1/ERa/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. Mol Cancer Res. 2014 Dec; 12(12):1829-39. PMID: 25100862; PMCID: PMC4272635.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    53. Wardell SE, Nelson ER, McDonnell DP. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). Steroids. 2014 Nov; 90:30-8. PMID: 25084324; PMCID: PMC4192009.
      Citations: 15     Fields:    Translation:HumansAnimals
    54. McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. Obesity, cholesterol metabolism, and breast cancer pathogenesis. Cancer Res. 2014 Sep 15; 74(18):4976-82. PMID: 25060521; PMCID: PMC4167494.
      Citations: 39     Fields:    Translation:Humans
    55. Yang J, Fuller PJ, Morgan J, Shibata H, McDonnell DP, Clyne CD, Young MJ. Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. Mol Endocrinol. 2014 Sep; 28(9):1571-84. PMID: 25000480; PMCID: PMC5414797.
      Citations: 7     Fields:    Translation:HumansCells
    56. Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013 Nov 29; 342(6162):1094-8. PMID: 24288332; PMCID: PMC3899689.
      Citations: 299     Fields:    Translation:HumansAnimalsCells
    57. Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer MA, Yang P, Qi X, Thomas RS, Jaffe GJ, Boulton ME, McDonnell DP, Malek G. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):E4069-78. PMID: 24106308; PMCID: PMC3808645.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    58. Wardell SE, Nelson ER, Chao CA, McDonnell DP. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clin Cancer Res. 2013 May 01; 19(9):2420-31. PMID: 23536434; PMCID: PMC3643989.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    59. Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY, Knudsen KE. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. J Clin Invest. 2013 Jan; 123(1):493-508. PMID: 23257359; PMCID: PMC3533295.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    60. Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol. 2013 Feb; 27(2):280-95. PMID: 23250485; PMCID: PMC3683804.
      Citations: 44     Fields:    Translation:HumansCells
    61. Nelson ER, Wardell SE, McDonnell DP. The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. Bone. 2013 Mar; 53(1):42-50. PMID: 23168292; PMCID: PMC3552054.
      Citations: 35     Fields:    Translation:Humans
    62. Chang CY, McDonnell DP. Molecular pathways: the metabolic regulator estrogen-related receptor a as a therapeutic target in cancer. Clin Cancer Res. 2012 Nov 15; 18(22):6089-95. PMID: 23019305; PMCID: PMC3500439.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    63. Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERa-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20; 7(7):1221-31. PMID: 22533360; PMCID: PMC3582702.
      Citations: 32     Fields:    Translation:HumansCells
    64. Wardell SE, Kazmin D, McDonnell DP. Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Mol Endocrinol. 2012 Jul; 26(7):1235-48. PMID: 22570330; PMCID: PMC3385791.
      Citations: 30     Fields:    Translation:HumansCells
    65. Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Estrogen-related receptor-a is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18348-53. PMID: 22042850; PMCID: PMC3215012.
      Citations: 113     Fields:    Translation:AnimalsCells
    66. Chang CY, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP. The metabolic regulator ERRa, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell. 2011 Oct 18; 20(4):500-10. PMID: 22014575; PMCID: PMC3199323.
      Citations: 80     Fields:    Translation:HumansCells
    67. Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec; 152(12):4691-705. PMID: 21933863; PMCID: PMC3230052.
      Citations: 38     Fields:    Translation:AnimalsCells
    68. Bodoor K, Lontay B, Safi R, Weitzel DH, Loiselle D, Wei Z, Lengyel S, McDonnell DP, Haystead TA. Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. J Biol Chem. 2011 Sep 09; 286(36):31839-51. PMID: 21771785; PMCID: PMC3173130.
      Citations: 7     Fields:    Translation:AnimalsCells
    69. Wardell SE, Marks JR, McDonnell DP. The turnover of estrogen receptor a by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011 Jul 15; 82(2):122-30. PMID: 21501600; PMCID: PMC3109090.
      Citations: 44     Fields:    Translation:HumansCells
    70. Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G. Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Mol Endocrinol. 2011 Feb; 25(2):360-72. PMID: 21239617; PMCID: PMC3386542.
      Citations: 37     Fields:    Translation:HumansCells
    71. McDonnell DP, Wardell SE. The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Curr Opin Pharmacol. 2010 Dec; 10(6):620-8. PMID: 20926342; PMCID: PMC2981619.
      Citations: 64     Fields:    Translation:HumansCells
    72. Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. Mol Endocrinol. 2011 Jan; 25(1):32-43. PMID: 21106883; PMCID: PMC5417296.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    73. Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Res. 2011 Jan 15; 71(2):528-37. PMID: 21098087; PMCID: PMC3074523.
      Citations: 68     Fields:    Translation:HumansCells
    74. Kobayashi S, Stice JP, Kazmin D, Wittmann BM, Kimbrel EA, Edwards DP, Chang CY, McDonnell DP. Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer. Mol Endocrinol. 2010 Dec; 24(12):2292-302. PMID: 20980435; PMCID: PMC2999472.
      Citations: 18     Fields:    Translation:HumansCells
    75. Dwyer MA, Joseph JD, Wade HE, Eaton ML, Kunder RS, Kazmin D, Chang CY, McDonnell DP. WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Res. 2010 Nov 15; 70(22):9298-308. PMID: 20870744; PMCID: PMC2982857.
      Citations: 76     Fields:    Translation:HumansCells
    76. Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J Biol Chem. 2010 Nov 12; 285(46):35567-77. PMID: 20826791; PMCID: PMC2975181.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    77. DuSell CD, Nelson ER, Wang X, Abdo J, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP, M?dder UI. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010 Aug; 151(8):3675-85. PMID: 20501668; PMCID: PMC2940523.
      Citations: 44     Fields:    Translation:AnimalsCells
    78. Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010 Mar 31; 28(3):523-34. PMID: 20054864; PMCID: PMC3909217.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    79. Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. Multimodal regulation of E2F1 gene expression by progestins. Mol Cell Biol. 2010 Apr; 30(8):1866-77. PMID: 20123965; PMCID: PMC2849472.
      Citations: 16     Fields:    Translation:HumansCells
    80. Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, Thomas RS. Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Mol Endocrinol. 2010 Feb; 24(2):359-69. PMID: 20032195; PMCID: PMC2817602.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    81. Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE. Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. Protein Expr Purif. 2010 May; 71(1):21-7. PMID: 19995608; PMCID: PMC2830347.
      Citations: 3     Fields:    Translation:HumansCells
    82. Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010 Feb; 24(2):299-309. PMID: 19965931; PMCID: PMC2817599.
      Citations: 33     Fields:    Translation:HumansAnimals
    83. Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol. 2010 Jan; 24(1):1-10. PMID: 19934345; PMCID: PMC2802897.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    84. Norris JD, Chang CY, Wittmann BM, Kunder RS, Cui H, Fan D, Joseph JD, McDonnell DP. The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol Cell. 2009 Nov 13; 36(3):405-16. PMID: 19917249; PMCID: PMC2788777.
      Citations: 106     Fields:    Translation:HumansCells
    85. DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, McDonnell DP. Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan; 24(1):33-46. PMID: 19901195; PMCID: PMC2802893.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    86. Joseph JD, Wittmann BM, Dwyer MA, Cui H, Dye DA, McDonnell DP, Norris JD. Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12178-83. PMID: 19574450; PMCID: PMC2715477.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    87. Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol. 2009 Sep; 23(9):1385-96. PMID: 19460858; PMCID: PMC2737557.
      Citations: 40     Fields:    Translation:HumansCells
    88. Norris JD, Joseph JD, Sherk AB, Juzumiene D, Turnbull PS, Rafferty SW, Cui H, Anderson E, Fan D, Dye DA, Deng X, Kazmin D, Chang CY, Willson TM, McDonnell DP. Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. Chem Biol. 2009 Apr 24; 16(4):452-60. PMID: 19389631; PMCID: PMC2673463.
      Citations: 34     Fields:    Translation:HumansCells
    89. Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol. 2009 Aug; 23(8):1171-82. PMID: 19389810; PMCID: PMC2718748.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    90. Stein RA, McDonnell DP, Gaillard S. Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol. 2009 Mar; 114(1-2):106-12. PMID: 19429439; PMCID: PMC2680788.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    91. Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol. 2009 Mar; 23(3):388-401. PMID: 19106193; PMCID: PMC2654518.
      Citations: 40     Fields:    Translation:HumansCells
    92. Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP. Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. Mol Endocrinol. 2009 Feb; 23(2):188-201. PMID: 19106195; PMCID: PMC2646618.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    93. Stein RA, Chang CY, Kazmin DA, Way J, Schroeder T, Wergin M, Dewhirst MW, McDonnell DP. Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer Res. 2008 Nov 01; 68(21):8805-12. PMID: 18974123; PMCID: PMC2633645.
      Citations: 78     Fields:    Translation:HumansCells
    94. Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 Sep 15; 68(18):7475-83. PMID: 18794135; PMCID: PMC2562281.
      Citations: 106     Fields:    Translation:HumansCells
    95. DuSell CD, McDonnell DP. 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. Trends Pharmacol Sci. 2008 Oct; 29(10):510-4. PMID: 18722677; PMCID: PMC2702440.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    96. Frigo DE, McDonnell DP. Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. Mol Cancer Ther. 2008 Mar; 7(3):659-69. PMID: 18347151.
      Citations: 20     Fields:    Translation:HumansCells
    97. Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. On the intractability of estrogen-related receptor alpha as a target for activation by small molecules. J Med Chem. 2007 Dec 27; 50(26):6722-4. PMID: 18052088; PMCID: PMC2556064.
      Citations: 9     Fields:    Translation:HumansCells
    98. Wittmann BM, Sherk A, McDonnell DP. Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. Cancer Res. 2007 Oct 01; 67(19):9549-60. PMID: 17909066.
      Citations: 48     Fields:    Translation:HumansCells
    99. DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan; 22(1):65-77. PMID: 17872378; PMCID: PMC2194632.
      Citations: 125     Fields:    Translation:HumansCells
    100. Mettu NB, Stanley TB, Dwyer MA, Jansen MS, Allen JE, Hall JM, McDonnell DP. The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Mol Endocrinol. 2007 Oct; 21(10):2361-77. PMID: 17595321.
      Citations: 15     Fields:    Translation:HumansCells
    101. Hall JM, McDonnell DP. The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. Mol Endocrinol. 2007 Aug; 21(8):1756-68. PMID: 17488971.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    102. Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP, Gaillard S. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol Cell. 2006 Dec 08; 24(5):797-803. PMID: 17157261.
      Citations: 35     Fields:    Translation:HumansCells
    103. Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec; 58(4):782-97. PMID: 17132855.
      Citations: 121     Fields:    Translation:HumansAnimals
    104. McDonnell DP. Mechanism-based discovery as an approach to identify the next generation of estrogen receptor modulators. FASEB J. 2006 Dec; 20(14):2432-4. PMID: 17142791.
      Citations: 3     Fields:    Translation:Cells
    105. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem. 2006 Dec 29; 281(52):39897-906. PMID: 17079227.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    106. Dwyer MA, McDonnell DP, Gaillard S. Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. Mol Endocrinol. 2007 Jan; 21(1):62-76. PMID: 17053040.
      Citations: 25     Fields:    Translation:HumansCells
    107. Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11707-12. PMID: 16857736; PMCID: PMC1544234.
      Citations: 190     Fields:    Translation:HumansAnimalsCells
    108. Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 2006 Jul 18; 45(28):8579-89. PMID: 16834332; PMCID: PMC2515391.
      Citations: 29     Fields:    Translation:HumansCells
    109. Kazmin D, Prytkova T, Cook CE, Wolfinger R, Chu TM, Beratan D, Norris JD, Chang CY, McDonnell DP. Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. Mol Endocrinol. 2006 Jun; 20(6):1201-17. PMID: 16574741.
      Citations: 31     Fields:    Translation:HumansCells
    110. Safi R, Kovacic A, Murata Y, Simpson ER, McDonnell DP, Clyne CD, Gaillard S. Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. Cancer Res. 2005 Dec 15; 65(24):11762-70. PMID: 16357189.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    111. Hall JM, McDonnell DP. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv. 2005 Dec; 5(6):343-57. PMID: 16394250.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    112. Chao EY, Collins JL, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ, Gaillard S. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):821-4. PMID: 16307879.
      Citations: 30     Fields:    Translation:HumansCells
    113. Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. J Mol Biol. 2005 Dec 16; 354(5):1091-102. PMID: 16289203.
      Citations: 22     Fields:    Translation:HumansCells
    114. Juzumiene D, Chang CY, Fan D, Hartney T, Norris JD, McDonnell DP. Single-step purification of full-length human androgen receptor. Nucl Recept Signal. 2005; 3:e001. PMID: 16604169; PMCID: PMC1402216.
      Citations: 8     Fields:    
    115. Chang CY, Abdo J, Hartney T, McDonnell DP. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Mol Endocrinol. 2005 Oct; 19(10):2478-90. PMID: 16051662.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    116. Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM, Greene GL. Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol Cell. 2005 May 13; 18(4):413-24. PMID: 15893725.
      Citations: 79     Fields:    Translation:HumansCells
    117. Zuercher WJ, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM, Gaillard S. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005 May 05; 48(9):3107-9. PMID: 15857113.
      Citations: 33     Fields:    Translation:HumansCells
    118. Chang CY, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci. 2005 May; 26(5):225-8. PMID: 15860367.
      Citations: 30     Fields:    Translation:Cells
    119. Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol. 2005 Apr; 12(4):357-63. PMID: 15723037.
      Citations: 79     Fields:    Translation:HumansCells
    120. Shaffer PL, McDonnell DP, Gewirth DT. Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. Biochemistry. 2005 Feb 22; 44(7):2678-85. PMID: 15709781.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    121. McDonnell DP. The molecular pharmacology of estrogen receptor modulators: implications for the treatment of breast cancer. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 2):871s-7s. PMID: 15701880.
      Citations: 16     Fields:    Translation:Humans
    122. McDonnell DP. The molecular determinants of estrogen receptor pharmacology. Maturitas. 2004 Aug 30; 48 Suppl 1:S7-12. PMID: 15337242.
      Citations: 12     Fields:    Translation:Humans
    123. Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11599-604. PMID: 15289619; PMCID: PMC511007.
      Citations: 54     Fields:    Translation:HumansCells
    124. Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7199-204. PMID: 15103026; PMCID: PMC406489.
      Citations: 31     Fields:    Translation:AnimalsCells
    125. Kurebayashi S, Nakajima T, Kim SC, Chang CY, McDonnell DP, Renaud JP, Jetten AM. Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):919-27. PMID: 14985100.
      Citations: 21     Fields:    Translation:AnimalsCells
    126. Sathya G, Chang CY, Kazmin D, Cook CE, McDonnell DP. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res. 2003 Nov 15; 63(22):8029-36. PMID: 14633736.
      Citations: 14     Fields:    Translation:HumansAnimals
    127. McDonnell DP. Mining the complexities of the estrogen signaling pathways for novel therapeutics. Endocrinology. 2003 Oct; 144(10):4237-40. PMID: 14500558.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    128. Rincavage HL, McDonnell DP, Kuhn CM. Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. Endocrinology. 2003 Jul; 144(7):2829-35. PMID: 12810537.
      Citations: 3     Fields:    Translation:AnimalsCells
    129. Chang CY, Norris JD, Jansen M, Huang HJ, McDonnell DP. Application of random peptide phage display to the study of nuclear hormone receptors. Methods Enzymol. 2003; 364:118-42. PMID: 14631842.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    130. Huang HJ, Norris JD, McDonnell DP. Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. Mol Endocrinol. 2002 Aug; 16(8):1778-92. PMID: 12145334.
      Citations: 31     Fields:    Translation:HumansCells
    131. Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP. Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Endocrinology. 2002 Aug; 143(8):3071-82. PMID: 12130573.
      Citations: 7     Fields:    Translation:HumansCells
    132. McDonnell DP, Wijayaratne A, Chang CY, Norris JD. Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol. 2002 Jul 03; 90(1A):35F-43F. PMID: 12106639.
      Citations: 9     Fields:    Translation:Humans
    133. Li X, Kimbrel EA, Kenan DJ, McDonnell DP. Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation. Mol Endocrinol. 2002 Jul; 16(7):1482-91. PMID: 12089344.
      Citations: 15     Fields:    Translation:HumansCells
    134. Li X, McDonnell DP. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. Mol Cell Biol. 2002 Jun; 22(11):3663-73. PMID: 11997503; PMCID: PMC133817.
      Citations: 16     Fields:    Translation:AnimalsCells
    135. McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science. 2002 May 31; 296(5573):1642-4. PMID: 12040178.
      Citations: 178     Fields:    Translation:HumansCells
    136. Chang CY, McDonnell DP. Evaluation of ligand-dependent changes in AR structure using peptide probes. Mol Endocrinol. 2002 Apr; 16(4):647-60. PMID: 11923463.
      Citations: 22     Fields:    Translation:AnimalsCells
    137. Norris JD, Fan D, Sherk A, McDonnell DP. A negative coregulator for the human ER. Mol Endocrinol. 2002 Mar; 16(3):459-68. PMID: 11875103.
      Citations: 29     Fields:    Translation:HumansCells
    138. Hall JM, McDonnell DP, Korach KS. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol Endocrinol. 2002 Mar; 16(3):469-86. PMID: 11875105.
      Citations: 76     Fields:    Translation:HumansCells
    139. McDonnell DP, Connor CE, Wijayaratne A, Chang CY, Norris JD. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. Recent Prog Horm Res. 2002; 57:295-316. PMID: 12017549.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
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