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FRANK ORSON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Immunology, Allergy, Rheum
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


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    R01AG007068     (ORSON, FRANK M)Sep 1, 1987 - Aug 31, 1990
    NIH/NIA
    INTERLEUKIN 2 RECEPTORS IN AGING
    Role: Principal Investigator

    R03AI053207     (ORSON, FRANK M)Sep 15, 2002 - Sep 14, 2004
    NIH/NIAID
    Oral Delivery of DNA Vaccines
    Role: Principal Investigator

    R01DA026859     (ORSON, FRANK M)Jul 15, 2009 - May 31, 2013
    NIH/NIDA
    Vaccines for Sustainable Therapy of Opiate Addiction
    Role: Principal Investigator

    U01DA023898     (ORSON, FRANK M)Aug 1, 2009 - Jul 31, 2012
    NIH/NIDA
    Developing Immunotherapeutics for Methamphetamine Abuse
    Role: Principal Investigator

    R01DA030338     (WANG, RONGFU)Sep 30, 2010 - Aug 31, 2015
    NIH/NIDA
    Development of Novel Vaccines for Cocaine Abuse
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Arora R, Haile CN, Kosten TA, Wu Y, Ramakrishnan M, Hawkins LD, Orson FM, Kosten TR. Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant. Am J Addict. 2019 Feb; 28(2):119-126. PMID: 30701618.
      View in: PubMed
    2. Haile CN, Kosten TA, Shen XY, O'Malley PW, Winoske KJ, Kinsey BM, Wu Y, Huang Z, Lykissa ED, Naidu N, Cox JA, Arora R, Kosten TR, Orson FM. Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine. Am J Addict. 2015 Dec; 24(8):748-55. PMID: 26584468.
      View in: PubMed
    3. Kosten TA, Shen XY, Kinsey BM, Kosten TR, Orson FM. Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization. Am J Addict. 2014 Nov-Dec; 23(6):604-7. PMID: 25251469.
      View in: PubMed
    4. Ramakrishnan M, Kinsey BM, Singh RA, Kosten TR, Orson FM. Hapten optimization for cocaine vaccine with improved cocaine recognition. Chem Biol Drug Des. 2014 Sep; 84(3):354-63. PMID: 24803171.
      View in: PubMed
    5. Orson FM, Wang R, Brimijoin S, Kinsey BM, Singh RA, Ramakrishnan M, Wang HY, Kosten TR. The future potential for cocaine vaccines. Expert Opin Biol Ther. 2014 Sep; 14(9):1271-83. PMID: 24835496.
      View in: PubMed
    6. Kosten TR, Domingo CB, Shorter D, Orson F, Green C, Somoza E, Sekerka R, Levin FR, Mariani JJ, Stitzer M, Tompkins DA, Rotrosen J, Thakkar V, Smoak B, Kampman K. Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial. Drug Alcohol Depend. 2014 Jul 01; 140:42-7. PMID: 24793366.
      View in: PubMed
    7. Kosten T, Domingo C, Orson F, Kinsey B. Vaccines against stimulants: cocaine and MA. Br J Clin Pharmacol. 2014 Feb; 77(2):368-74. PMID: 23509915.
      View in: PubMed
    8. Kosten TA, Shen XY, O'Malley PW, Kinsey BM, Lykissa ED, Orson FM, Kosten TR. A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:223-9. PMID: 23739535.
      View in: PubMed
    9. Brimijoin S, Shen X, Orson F, Kosten T. Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse. Expert Rev Vaccines. 2013 Mar; 12(3):323-32. PMID: 23496671.
      View in: PubMed
    10. Orson FM, Rossen RD, Shen X, Lopez AY, Wu Y, Kosten TR. Spontaneous development of IgM anti-cocaine antibodies in habitual cocaine users: effect on IgG antibody responses to a cocaine cholera toxin B conjugate vaccine. Am J Addict. 2013 Mar-Apr; 22(2):169-74. PMID: 23414504.
      View in: PubMed
    11. Shen XY, Kosten TA, Lopez AY, Kinsey BM, Kosten TR, Orson FM. A vaccine against methamphetamine attenuates its behavioral effects in mice. Drug Alcohol Depend. 2013 Apr 01; 129(1-2):41-8. PMID: 23022610.
      View in: PubMed
    12. Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ, Gao Y. Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chem Biol Interact. 2013 Mar 25; 203(1):212-6. PMID: 22960160.
      View in: PubMed
    13. Singh RA, Kosten TA, Kinsey BM, Shen X, Lopez AY, Kosten TR, Orson FM. Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: low doses induce hypolocomotion. Pharmacol Biochem Behav. 2012 Dec; 103(2):230-6. PMID: 23010423.
      View in: PubMed
    14. Gao Y, Geng L, Orson F, Kinsey B, Kosten TR, Shen X, Brimijoin S. Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. Chem Biol Interact. 2013 Mar 25; 203(1):208-11. PMID: 22935511.
      View in: PubMed
    15. Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S. Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS One. 2012; 7(8):e43536. PMID: 22912888.
      View in: PubMed
    16. Ramakrishnan M, Alves De Melo F, Kinsey BM, Ladbury JE, Kosten TR, Orson FM. Probing cocaine-antibody interactions in buffer and human serum. PLoS One. 2012; 7(7):e40518. PMID: 22859949.
      View in: PubMed
    17. Shen XY, Orson FM, Kosten TR. Vaccines against drug abuse. Clin Pharmacol Ther. 2012 Jan; 91(1):60-70. PMID: 22130115.
      View in: PubMed
    18. Shen X, Orson FM, Kosten TR. Anti-addiction vaccines. F1000 Med Rep. 2011; 3:20. PMID: 22003367.
      View in: PubMed
    19. Khan F, Orson F, Ogawa Y, Parker C, Davis CM. Adult seafood allergy in the Texas Medical Center: A 13-year experience. Allergy Rhinol (Providence). 2011 Apr; 2(2):e71-7. PMID: 22852122.
      View in: PubMed
    20. Kinsey BM, Kosten TR, Orson FM. Anti-cocaine vaccine development. Expert Rev Vaccines. 2010 Sep; 9(9):1109-14. PMID: 20822352.
      View in: PubMed
    21. Maskatia ZK, Orson FM. Delayed diagnosis of hereditary angioedema. Am J Med Sci. 2010 Jul; 340(1):82-3. PMID: 20531165.
      View in: PubMed
    22. Kinsey BM, Kosten TR, Orson FM. Active immunotherapy for the Treatment of Cocaine Dependence. Drugs Future. 2010 Apr 01; 35(4):301-306. PMID: 21796226.
      View in: PubMed
    23. Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S. The concept of pharmacologic cocaine interception as a treatment for drug abuse. Chem Biol Interact. 2010 Sep 06; 187(1-3):421-4. PMID: 20219449.
      View in: PubMed
    24. Rossen RD, Rubio JA, Porter WJ, Trial J, Orson FM, Rodriguez-Barradas MC, Birdsall HH. Monocyte CD49e and 110-120 kDa fibronectin fragments: HIV prognostic indicators independent of viral load and CD4 T-cell counts. AIDS. 2009 Nov 13; 23(17):2247-53. PMID: 19710592.
      View in: PubMed
    25. Martell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T, Kosten TR. Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Arch Gen Psychiatry. 2009 Oct; 66(10):1116-23. PMID: 19805702.
      View in: PubMed
    26. Orson FM, Kinsey BM, Singh RA, Wu Y, Kosten TR. Vaccines for cocaine abuse. Hum Vaccin. 2009 Apr; 5(4):194-9. PMID: 19276665.
      View in: PubMed
    27. Kinsey BM, Jackson DC, Orson FM. Anti-drug vaccines to treat substance abuse. Immunol Cell Biol. 2009 May-Jun; 87(4):309-14. PMID: 19333250.
      View in: PubMed
    28. Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. Substance abuse vaccines. Ann N Y Acad Sci. 2008 Oct; 1141:257-69. PMID: 18991962.
      View in: PubMed
    29. Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. The future of vaccines in the management of addictive disorders. Curr Psychiatry Rep. 2007 Oct; 9(5):381-7. PMID: 17915077.
      View in: PubMed
    30. Orson FM, Kinsey BM, Densmore CL, Nguyen T, Wu Y, Mbawuike IN, Wyde PR. Protection against influenza infection by cytokine-enhanced aerosol genetic immunization. J Gene Med. 2006 Apr; 8(4):488-97. PMID: 16389596.
      View in: PubMed
    31. Watanabe M, Ebina M, Orson FM, Nakamura A, Kubota K, Koinuma D, Akiyama K, Maemondo M, Okouchi S, Tahara M, Matsumoto K, Nakamura T, Nukiwa T. Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. Mol Ther. 2005 Jul; 12(1):58-67. PMID: 15963921.
      View in: PubMed
    32. Kinsey BM, Densmore CL, Orson FM. Non-viral gene delivery to the lungs. Curr Gene Ther. 2005 Apr; 5(2):181-94. PMID: 15853726.
      View in: PubMed
    33. Kinsey BM, Marcelli M, Song L, Bhogal BS, Ittmann M, Orson FM. Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptotic protein Bax. J Gene Med. 2004 Apr; 6(4):445-54. PMID: 15079819.
      View in: PubMed
    34. Orson FM. Intravenous immunoglobulin therapy suppresses manifestations of the angioedema with hypereosinophilia syndrome. Am J Med Sci. 2003 Aug; 326(2):94-7. PMID: 12920441.
      View in: PubMed
    35. Chatel JM, Song L, Bhogal B, Orson FM. Various factors (allergen nature, mouse strain, CpG/recombinant protein expressed) influence the immune response elicited by genetic immunization. Allergy. 2003 Jul; 58(7):641-7. PMID: 12823125.
      View in: PubMed
    36. Chatel JM, Bernard H, Orson FM. Isolation and characterization of two complete Ara h 2 isoforms cDNA. Int Arch Allergy Immunol. 2003 May; 131(1):14-8. PMID: 12759484.
      View in: PubMed
    37. Orson FM, Kinsey BM, Bhogal BS, Song L, Densmore CL, Barry MA. Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates. Methods Mol Med. 2003; 75:575-90. PMID: 12407765.
      View in: PubMed
    38. Gautam A, Waldrep JC, Orson FM, Kinsey BM, Xu B, Densmore CL. Topical gene therapy for pulmonary diseases with PEI-DNA aerosol complexes. Methods Mol Med. 2003; 75:561-72. PMID: 12407764.
      View in: PubMed
    39. Orson FM, Song L, Gautam A, Densmore CL, Bhogal BS, Kinsey BM. Gene delivery to the lung using protein/polyethylenimine/plasmid complexes. Gene Ther. 2002 Apr; 9(7):463-71. PMID: 11938461.
      View in: PubMed
    40. Orson FM, Kinsey BM, Hua PJ, Bhogal BS, Densmore CL, Barry MA. Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses. J Immunol. 2000 Jun 15; 164(12):6313-21. PMID: 10843685.
      View in: PubMed
    41. Densmore CL, Orson FM, Xu B, Kinsey BM, Waldrep JC, Hua P, Bhogal B, Knight V. Aerosol delivery of robust polyethyleneimine-DNA complexes for gene therapy and genetic immunization. Mol Ther. 2000 Feb; 1(2):180-8. PMID: 10933929.
      View in: PubMed
    42. Barry ME, Pinto-González D, Orson FM, McKenzie GJ, Petry GR, Barry MA. Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum Gene Ther. 1999 Oct 10; 10(15):2461-80. PMID: 10543612.
      View in: PubMed
    43. Orson FM, Klysik J, Bergstrom DE, Ward B, Glass GA, Hua P, Kinsey BM. Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interruptions in a polypurine target. Nucleic Acids Res. 1999 Feb 01; 27(3):810-6. PMID: 9889277.
      View in: PubMed
    44. Klysik J, Kinsey BM, Hua P, Glass GA, Orson FM. A 15-base acridine-conjugated oligodeoxynucleotide forms triplex DNA with its IL-2R alpha promoter target with greatly improved avidity. Bioconjug Chem. 1997 May-Jun; 8(3):318-26. PMID: 9177837.
      View in: PubMed
    45. Orson FM, Klysik J, Glass GA, Kinsey BM. Comparison of triple helix formation by polypurine versus polypyrimidine oligodeoxynucleotides when conjugated to a DNA intercalator. J Exp Ther Oncol. 1996 May; 1(3):177-85. PMID: 9414402.
      View in: PubMed
    46. Orson FM, McShan WM, Kinsey BM. Sequence-specific binding and cleavage of duplex DNA by a radioiodinated, intercalator-linked, triplex-forming oligonucleotide. Nucl Med Biol. 1996 May; 23(4):519-24. PMID: 8832710.
      View in: PubMed
    47. Orson FM. Photodocumentation of UV shadowing with DNA gels. Biotechniques. 1994 Apr; 16(4):592-4, 596. PMID: 8024774.
      View in: PubMed
    48. Orson FM, Kinsey BM, McShan WM. Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides. Nucleic Acids Res. 1994 Feb 11; 22(3):479-84. PMID: 8127688.
      View in: PubMed
    49. McShan WM, Rossen RD, Laughter AH, Trial J, Kessler DJ, Zendegui JG, Hogan ME, Orson FM. Inhibition of transcription of HIV-1 in infected human cells by oligodeoxynucleotides designed to form DNA triple helices. J Biol Chem. 1992 Mar 15; 267(8):5712-21. PMID: 1544943.
      View in: PubMed
    50. Patke CL, Orson FM, Shearer WT. Cyclic AMP-mediated modulation of immunoglobulin production in B cells by prostaglandin E1. Cell Immunol. 1991 Oct 01; 137(1):36-45. PMID: 1715816.
      View in: PubMed
    51. Orson FM, Thomas DW, McShan WM, Kessler DJ, Hogan ME. Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region collinear triplex formation in lymphocytes. Nucleic Acids Res. 1991 Jun 25; 19(12):3435-41. PMID: 2062658.
      View in: PubMed
    52. Barron KS, DeCunto CL, Montalvo JF, Orson FM, Lewis DE. Abnormalities of immunoregulation in juvenile rheumatoid arthritis. J Rheumatol. 1989 Jul; 16(7):940-8. PMID: 2671366.
      View in: PubMed
    53. Rossen RD, Smith CW, Laughter AH, Noonan CA, Anderson DC, McShan WM, Hurvitz MY, Orson FM. HIV-1-stimulated expression of CD11/CD18 integrins and ICAM-1: a possible mechanism for extravascular dissemination of HIV-1-infected cells. Trans Assoc Am Physicians. 1989; 102:117-30. PMID: 2576928.
      View in: PubMed
    54. Shearer WT, Gilliam EB, Rosenblatt HM, Orson FM. Anti-mu antibody stimulates the phosphatidylinositol cycle and immunoglobulin secretion in a human lymphoblastoid B-cell line, LA350. Cell Immunol. 1988 Feb; 111(2):296-315. PMID: 2827896.
      View in: PubMed
    55. Rossen RD, Laughter AH, Orson FM, Flagge FP, Cashaw JL, Sumaya CV. Human peripheral blood monocytes release a 30,000 dalton factor (30 KD MF) that stimulates immunoglobulin production by activated B cells. J Immunol. 1985 Nov; 135(5):3289-97. PMID: 3930602.
      View in: PubMed
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