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MICHAEL SCHNEIDER

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Cardiology
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    Other Positions
    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01HL039141     (SCHNEIDER, MICHAEL D.)Apr 1, 1988 - Mar 31, 1993
    NIH/NHLBI
    CONTROL OF CARDIAC GROWTH BY CELLULAR ONCOGENES
    Role: Principal Investigator

    R01HL047567     (SCHNEIDER, MICHAEL D.)Feb 1, 1992 - Jan 31, 2007
    NIH/NHLBI
    Molecular Mechanisms of Cardiac Growth
    Role: Principal Investigator

    T32HL007706     (ENTMAN, MARK L)Sep 1, 1992 - Jun 30, 2010
    NIH/NHLBI
    Training Grant in Molecular Cardiology
    Role: Co-Principal Investigator

    R01HL052555     (SCHNEIDER, MICHAEL D.)Aug 1, 1995 - Nov 30, 2009
    NIH/NHLBI
    TGF Beta-activated Kinase and Cardiac Muscle
    Role: Principal Investigator

    R01HL060270     (SCHNEIDER, MICHAEL D.)May 1, 1998 - Apr 30, 2004
    NIH/NHLBI
    APOPTOSIS OF CARDIAC MUSCLE AS A TARGET FOR GENE THERAPY
    Role: Principal Investigator

    R01HL061668     (SCHNEIDER, MICHAEL D.)Sep 30, 1998 - Nov 30, 2009
    NIH/NHLBI
    Cyclin-dependent Kinases and Cardiac Growth
    Role: Principal Investigator

    R13HL078309     (KITSIS, RICHARD N)Jul 1, 2004 - Jun 30, 2011
    NIH/NHLBI
    Symposium: AHA Council on Basic Cardiovascular Sciences
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Constantinou C, Miranda AMA, Chaves P, Bellahcene M, Massaia A, Cheng K, Samari S, Rothery SM, Chandler AM, Schwarz RP, Harding SE, Punjabi P, Schneider MD, Noseda M. Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Sci Rep. 2020 Aug 03; 10(1):13016. PMID: 32747668.
      View in: PubMed
    2. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2020 Mar 05; 26(3):458. PMID: 32142664.
      View in: PubMed
    3. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 04 04; 24(4):579-591.e12. PMID: 30853557.
      View in: PubMed
    4. Biswas S, Li P, Wu H, Shafiquzzaman M, Murakami S, Schneider MD, Mishina Y, Li B, Li J. BMPRIA is required for osteogenic differentiation and RANKL expression in adult bone marrow mesenchymal stromal cells. Sci Rep. 2018 05 31; 8(1):8475. PMID: 29855498.
      View in: PubMed
    5. Fujita J, Freire P, Coarfa C, Benham AL, Gunaratne P, Schneider MD, Dejosez M, Zwaka TP. Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs. Cell Rep. 2017 Nov 07; 21(6):1562-1573. PMID: 29117561.
      View in: PubMed
    6. Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM. Multimodal Hydrogel-Based Platform To Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment. ACS Cent Sci. 2017 Apr 26; 3(4):338-348. PMID: 28470052.
      View in: PubMed
    7. Schneider MD. Heartbreak hotel: a convergence in cardiac regeneration. Development. 2016 05 01; 143(9):1435-41. PMID: 27143752.
      View in: PubMed
    8. Laury-Kleintop LD, Mulgrew JR, Heletz I, Nedelcoviciu RA, Chang MY, Harris DM, Koch WJ, Schneider MD, Muller AJ, Prendergast GC. Cardiac-specific disruption of Bin1 in mice enables a model of stress- and age-associated dilated cardiomyopathy. J Cell Biochem. 2015 Nov; 116(11):2541-51. PMID: 25939245.
      View in: PubMed
    9. Gallego-Colon E, Sampson RD, Sattler S, Schneider MD, Rosenthal N, Tonkin J. Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction. Mediators Inflamm. 2015; 2015:484357. PMID: 26491228.
      View in: PubMed
    10. Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. 2015 Sep 24; 525(7570):479-85. PMID: 26375005.
      View in: PubMed
    11. Morez C, Noseda M, Paiva MA, Belian E, Schneider MD, Stevens MM. Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues. Biomaterials. 2015 Nov; 70:94-104. PMID: 26302234.
      View in: PubMed
    12. Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R. ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ Cardiovasc Genet. 2015 Oct; 8(5):643-52. PMID: 26175529.
      View in: PubMed
    13. Noseda M, Abreu-Paiva M, Schneider MD. The Quest for the Adult Cardiac Stem Cell. Circ J. 2015; 79(7):1422-30. PMID: 26073608.
      View in: PubMed
    14. Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS One. 2015; 10(6):e0125384. PMID: 26047103.
      View in: PubMed
    15. Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD. PDGFRa demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. Nat Commun. 2015 May 18; 6:6930. PMID: 25980517.
      View in: PubMed
    16. Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Microtubules regulate focal adhesion dynamics through MAP4K4. Dev Cell. 2014 Dec 08; 31(5):572-85. PMID: 25490267.
      View in: PubMed
    17. Qi B, Cong Q, Li P, Ma G, Guo X, Yeh J, Xie M, Schneider MD, Liu H, Li B. Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice. Sci Rep. 2014 Nov 24; 4:7158. PMID: 25418008.
      View in: PubMed
    18. Földes G, Matsa E, Kriston-Vizi J, Leja T, Amisten S, Kolker L, Kodagoda T, Dolatshad NF, Mioulane M, Vauchez K, Arányi T, Ketteler R, Schneider MD, Denning C, Harding SE. Aberrant a-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells. Stem Cell Reports. 2014 Nov 11; 3(5):905-14. PMID: 25418732.
      View in: PubMed
    19. Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J. CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol Med. 2014 Oct; 6(10):1231-45. PMID: 25193973.
      View in: PubMed
    20. Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13499-504. PMID: 25197047.
      View in: PubMed
    21. Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Gröne HJ, Katus HA, Olson EN, Backs J. Cardiac CaM Kinase II genes d and ? contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation. 2014 Oct 07; 130(15):1262-73. PMID: 25124496.
      View in: PubMed
    22. Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan TH. HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun. 2014 Aug 06; 5:4602. PMID: 25098764.
      View in: PubMed
    23. Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J, Marston Linehan W. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation. Hum Mol Genet. 2014 Nov 01; 23(21):5706-19. PMID: 24908670.
      View in: PubMed
    24. Liu Y, Kaneda R, Leja TW, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz RJ, Barahona M, Schneider MD. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells. 2014 Jun; 32(6):1515-26. PMID: 24585688.
      View in: PubMed
    25. Fiedler LR, Maifoshie E, Schneider MD. Mouse models of heart failure: cell signaling and cell survival. Curr Top Dev Biol. 2014; 109:171-247. PMID: 24947238.
      View in: PubMed
    26. Földes G, Mioulane M, Kodagoda T, Lendvai Z, Iqbal A, Ali NN, Schneider MD, Harding SE. Immunosuppressive agents modulate function, growth, and survival of cardiomyocytes and endothelial cells derived from human embryonic stem cells. Stem Cells Dev. 2014 Mar 01; 23(5):467-76. PMID: 24192059.
      View in: PubMed
    27. Oakley RH, Ren R, Cruz-Topete D, Bird GS, Myers PH, Boyle MC, Schneider MD, Willis MS, Cidlowski JA. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17035-40. PMID: 24082121.
      View in: PubMed
    28. Arechederra M, Carmona R, González-Nuñez M, Gutiérrez-Uzquiza A, Bragado P, Cruz-González I, Cano E, Guerrero C, Sánchez A, López-Novoa JM, Schneider MD, Maina F, Muñoz-Chápuli R, Porras A. Met signaling in cardiomyocytes is required for normal cardiac function in adult mice. Biochim Biophys Acta. 2013 Dec; 1832(12):2204-15. PMID: 23994610.
      View in: PubMed
    29. McSweeney SJ, Schneider MD. Virgin birth: engineered heart muscle from parthenogenetic stem cells. J Clin Invest. 2013 Mar; 123(3):1010-3. PMID: 23434596.
      View in: PubMed
    30. Palacios JA, Schneider MD. Heart to heart: grafting cardiosphere-derived cells augments cardiac self-repair by both myocytes and stem cells. EMBO Mol Med. 2013 Feb; 5(2):177-9. PMID: 23382000.
      View in: PubMed
    31. Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, Hu P, Estrov Z, Bueso-Ramos CE, Darnay BG. Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice. PLoS One. 2012; 7(12):e51228. PMID: 23251462.
      View in: PubMed
    32. Lamothe B, Lai Y, Xie M, Schneider MD, Darnay BG. TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis. Mol Cell Biol. 2013 Feb; 33(3):582-95. PMID: 23166301.
      View in: PubMed
    33. Mioulane M, Foldes G, Ali NN, Schneider MD, Harding SE. Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes. J Cardiovasc Transl Res. 2012 Oct; 5(5):593-604. PMID: 22896035.
      View in: PubMed
    34. Genet G, Guilbeau-Frugier C, Honton B, Dague E, Schneider MD, Coatrieux C, Calise D, Cardin C, Nieto C, Payré B, Dubroca C, Marck P, Heymes C, Dubrac A, Arvanitis D, Despas F, Altié MF, Seguelas MH, Delisle MB, Davy A, Sénard JM, Pathak A, Galés C. Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion. Circ Res. 2012 Mar 02; 110(5):688-700. PMID: 22302788.
      View in: PubMed
    35. Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun. 2011 Dec 20; 2:593. PMID: 22186889.
      View in: PubMed
    36. Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012 Feb 24; 287(9):6604-14. PMID: 22157755.
      View in: PubMed
    37. Schneider MD. EPO and super-EPO: erythropoietins direct neoangiogenesis by cardiac progenitor cells. Cell Stem Cell. 2011 Aug 05; 9(2):95-6. PMID: 21816360.
      View in: PubMed
    38. Song W, Dyer E, Stuckey DJ, Copeland O, Leung MC, Bayliss C, Messer A, Wilkinson R, Tremoleda JL, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D, Marston SB. Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem. 2011 Aug 05; 286(31):27582-93. PMID: 21622575.
      View in: PubMed
    39. Schneider MD. Development. A cardiac nonproliferation treaty. Science. 2011 Apr 22; 332(6028):426-7. PMID: 21512022.
      View in: PubMed
    40. Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ. TGF-ß1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney. Am J Physiol Renal Physiol. 2011 Jun; 300(6):F1410-21. PMID: 21367917.
      View in: PubMed
    41. Mercola M, Ruiz-Lozano P, Schneider MD. Cardiac muscle regeneration: lessons from development. Genes Dev. 2011 Feb 15; 25(4):299-309. PMID: 21325131.
      View in: PubMed
    42. Noseda M, Peterkin T, Simões FC, Patient R, Schneider MD. Cardiopoietic factors: extracellular signals for cardiac lineage commitment. Circ Res. 2011 Jan 07; 108(1):129-52. PMID: 21212394.
      View in: PubMed
    43. Földes G, Mioulane M, Wright JS, Liu AQ, Novak P, Merkely B, Gorelik J, Schneider MD, Ali NN, Harding SE. Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy? J Mol Cell Cardiol. 2011 Feb; 50(2):367-76. PMID: 21047517.
      View in: PubMed
    44. Schneider MD. Making muscle: overview to "Cardiovascular lineage commitment during development and regeneration" series. Circ Res. 2010 Sep 03; 107(5):575-8. PMID: 20814027.
      View in: PubMed
    45. Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15565-70. PMID: 20713697.
      View in: PubMed
    46. Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul; 120(7):2457-73. PMID: 20551513.
      View in: PubMed
    47. Lin SC, Dollé P, Ryckebüsch L, Noseda M, Zaffran S, Schneider MD, Niederreither K. Endogenous retinoic acid regulates cardiac progenitor differentiation. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9234-9. PMID: 20439714.
      View in: PubMed
    48. Noseda M, Schneider MD. Previews. Unleashing cardiopoiesis: a novel role for G-CSF. Cell Stem Cell. 2010 Mar 05; 6(3):188-9. PMID: 20207218.
      View in: PubMed
    49. Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010 Feb 19; 285(8):5347-60. PMID: 20038579.
      View in: PubMed
    50. Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, Morisaki T. The cellular prion protein identifies bipotential cardiomyogenic progenitors. Circ Res. 2010 Jan 08; 106(1):111-9. PMID: 19910576.
      View in: PubMed
    51. Shirai M, Imanaka-Yoshida K, Schneider MD, Schwartz RJ, Morisaki T. T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18604-9. PMID: 19846762.
      View in: PubMed
    52. Ma X, Takeda K, Singh A, Yu ZX, Zerfas P, Blount A, Liu C, Towbin JA, Schneider MD, Adelstein RS, Wei Q. Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice. Circ Res. 2009 Nov 20; 105(11):1102-9. PMID: 19815823.
      View in: PubMed
    53. Morikawa Y, Zehir A, Maska E, Deng C, Schneider MD, Mishina Y, Cserjesi P. BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development. 2009 Nov; 136(21):3575-84. PMID: 19793887.
      View in: PubMed
    54. Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22; 28(14):2028-41. PMID: 19536134.
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    55. Noseda M, Schneider MD. Fibroblasts inform the heart: control of cardiomyocyte cycling and size by age-dependent paracrine signals. Dev Cell. 2009 Feb; 16(2):161-2. PMID: 19217417.
      View in: PubMed
    56. Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J. Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem. 2008 Sep 05; 283(36):24497-505. PMID: 18617512.
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    57. Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M. Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res. 2008 Apr 11; 102(7):813-22. PMID: 18292603.
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    58. Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2111-6. PMID: 18256189.
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    59. Stroud DM, Gaussin V, Burch JB, Yu C, Mishina Y, Schneider MD, Fishman GI, Morley GE. Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation. 2007 Nov 27; 116(22):2535-43. PMID: 17998461.
      View in: PubMed
    60. Haudek SB, Taffet GE, Schneider MD, Mann DL. TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. J Clin Invest. 2007 Sep; 117(9):2692-701. PMID: 17694177.
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    61. Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen YE, Schneider MD, Mangelsdorf DJ, Evans RM, Yang Q. Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res. 2007 Nov 01; 76(2):269-79. PMID: 17678635.
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    62. Qu J, Zhou J, Yi XP, Dong B, Zheng H, Miller LM, Wang X, Schneider MD, Li F. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction. J Mol Cell Cardiol. 2007 Sep; 43(3):319-26. PMID: 17673255.
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    63. Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC. Positron emission tomography imaging of conditional gene activation in the heart. J Mol Cell Cardiol. 2007 Jul; 43(1):18-26. PMID: 17467733.
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    64. Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, Chen M, Schwartz RJ, Schneider MD. Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3859-64. PMID: 17360443.
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    65. Matus M, Lewin G, Stümpel F, Buchwalow IB, Schneider MD, Schütz G, Schmitz W, Müller FU. Cardiomyocyte-specific inactivation of transcription factor CREB in mice. FASEB J. 2007 Jun; 21(8):1884-92. PMID: 17307839.
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    66. Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell. 2007 Feb 09; 128(3):589-600. PMID: 17289576.
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    67. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD. Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab. 2007 Feb; 5(2):129-42. PMID: 17276355.
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    68. Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS, Schneider MD. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17378-83. PMID: 17085580.
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    69. Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14495-500. PMID: 16983089.
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    70. Eckardt D, Kirchhoff S, Kim JS, Degen J, Theis M, Ott T, Wiesmann F, Doevendans PA, Lamers WH, de Bakker JM, van Rijen HV, Schneider MD, Willecke K. Cardiomyocyte-restricted deletion of connexin43 during mouse development. J Mol Cell Cardiol. 2006 Dec; 41(6):963-71. PMID: 16963078.
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    71. Mysliwiec MR, Chen J, Powers PA, Bartley CR, Schneider MD, Lee Y. Generation of a conditional null allele of jumonji. Genesis. 2006 Sep; 44(9):407-11. PMID: 16900512.
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    72. Liu HH, Xie M, Schneider MD, Chen ZJ. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11677-82. PMID: 16857737.
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    73. van Oort RJ, van Rooij E, Bourajjaj M, Schimmel J, Jansen MA, van der Nagel R, Doevendans PA, Schneider MD, van Echteld CJ, De Windt LJ. MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure. Circulation. 2006 Jul 25; 114(4):298-308. PMID: 16847152.
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    74. Garcia-Gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJ. Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest. 2006 Jul; 116(7):2012-21. PMID: 16823493.
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    75. Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol. 2006 Aug; 7(8):851-8. PMID: 16799562.
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    76. Schwartz RJ, Schneider MD. CAMTA in cardiac hypertrophy. Cell. 2006 May 05; 125(3):427-9. PMID: 16678087.
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    77. Zhang YM, Bo J, Taffet GE, Chang J, Shi J, Reddy AK, Michael LH, Schneider MD, Entman ML, Schwartz RJ, Wei L. Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J. 2006 May; 20(7):916-25. PMID: 16675849.
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    78. Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res. 2006 Apr 14; 98(7):923-30. PMID: 16543498.
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    79. Schneider MD. Dual roles of telomerase in cardiac protection and repair. Novartis Found Symp. 2006; 274:260-7; discussion 267-76. PMID: 17019817.
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    80. Wang J, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, Epstein JA, Kaartinen V. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol. 2005 Oct 01; 286(1):299-310. PMID: 16140292.
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    81. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005 Sep 23; 122(6):927-39. PMID: 16179260.
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    82. Gaussin V, Morley GE, Cox L, Zwijsen A, Vance KM, Emile L, Tian Y, Liu J, Hong C, Myers D, Conway SJ, Depre C, Mishina Y, Behringer RR, Hanks MC, Schneider MD, Huylebroeck D, Fishman GI, Burch JB, Vatner SF. Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res. 2005 Aug 05; 97(3):219-26. PMID: 16037571.
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    83. Schneider MD. Cyclophilin D: knocking on death's door. Sci STKE. 2005 Jun 07; 2005(287):pe26. PMID: 15942033.
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    84. Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005 Sep 16; 280(37):32531-8. PMID: 15929941.
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    85. Sano M, Schneider MD. Energizer: PGC-1 alpha keeps the heart going. Cell Metab. 2005 Apr; 1(4):216-8. PMID: 16054065.
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    86. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest. 2005 Mar; 115(3):572-83. PMID: 15765139.
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    87. Benjamin IJ, Schneider MD. Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest. 2005 Mar; 115(3):495-9. PMID: 15765130.
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    88. McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan; 132(1):189-201. PMID: 15576406.
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    89. Schneider MD. Regenerative medicine: Prometheus unbound. Nature. 2004 Nov 25; 432(7016):451-3. PMID: 15565135.
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    90. Spyridopoulos I, Haendeler J, Urbich C, Brummendorf TH, Oh H, Schneider MD, Zeiher AM, Dimmeler S. Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. Circulation. 2004 Nov 09; 110(19):3136-42. PMID: 15520325.
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    91. Sano M, Schneider MD. Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades. Circ Res. 2004 Oct 29; 95(9):867-76. PMID: 15514168.
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    92. Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004 Nov; 10(11):1245-50. PMID: 15475963.
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    93. Imahashi K, Schneider MD, Steenbergen C, Murphy E. Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury. Circ Res. 2004 Oct 01; 95(7):734-41. PMID: 15345651.
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    94. de Lange FJ, Moorman AF, Anderson RH, Männer J, Soufan AT, de Gier-de Vries C, Schneider MD, Webb S, van den Hoff MJ, Christoffels VM. Lineage and morphogenetic analysis of the cardiac valves. Circ Res. 2004 Sep 17; 95(6):645-54. PMID: 15297379.
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    95. Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD. Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J. 2004 Sep 01; 23(17):3559-69. PMID: 15297879.
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    96. Schneider MD. First annual symposium of the American Heart Association Council on Basic Cardiovascular Sciences: stress signals, molecular targets, and the genome. Circ Res. 2004 Jun 25; 94(12):1523. PMID: 15217914.
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    97. Hilfiker-Kleiner D, Hilfiker A, Fuchs M, Kaminski K, Schaefer A, Schieffer B, Hillmer A, Schmiedl A, Ding Z, Podewski E, Podewski E, Poli V, Schneider MD, Schulz R, Park JK, Wollert KC, Drexler H. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res. 2004 Jul 23; 95(2):187-95. PMID: 15192020.
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    98. Oh H, Chi X, Bradfute SB, Mishina Y, Pocius J, Michael LH, Behringer RR, Schwartz RJ, Entman ML, Schneider MD. Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci. 2004 May; 1015:182-9. PMID: 15201159.
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    99. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-31. PMID: 15073151.
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    100. Wei L, Taffet GE, Khoury DS, Bo J, Li Y, Yatani A, Delaughter MC, Klevitsky R, Hewett TE, Robbins J, Michael LH, Schneider MD, Entman ML, Schwartz RJ. Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. FASEB J. 2004 May; 18(7):857-9. PMID: 15033930.
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    101. Brühl T, Heeschen C, Aicher A, Jadidi AS, Haendeler J, Hoffmann J, Schneider MD, Zeiher AM, Dimmeler S, Rössig L. p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization. Circ Res. 2004 Mar 19; 94(5):686-92. PMID: 14752032.
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    102. Kulkarni PA, Sano M, Schneider MD. Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9. Recent Prog Horm Res. 2004; 59:125-39. PMID: 14749500.
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    103. Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MD. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12313-8. PMID: 14530411.
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    104. Hamamori Y, Schneider MD. HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy. J Clin Invest. 2003 Sep; 112(6):824-6. PMID: 12975465.
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    105. Olson EN, Schneider MD. Sizing up the heart: development redux in disease. Genes Dev. 2003 Aug 15; 17(16):1937-56. PMID: 12893779.
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    106. Nakamura T, Schneider MD. The way to a human's heart is through the stomach: visceral endoderm-like cells drive human embryonic stem cells to a cardiac fate. Circulation. 2003 Jun 03; 107(21):2638-9. PMID: 12782614.
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    107. Holtwick R, van Eickels M, Skryabin BV, Baba HA, Bubikat A, Begrow F, Schneider MD, Garbers DL, Kuhn M. Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest. 2003 May; 111(9):1399-407. PMID: 12727932.
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    108. Nakamura T, Sano M, Songyang Z, Schneider MD. A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5834-9. PMID: 12719544.
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    109. Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffet GE, Michael LH, Youker KA, Entman ML, Schneider MD. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5378-83. PMID: 12702777.
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    110. Ito K, Nakayama M, Hasan F, Yan X, Schneider MD, Lorell BH. Contractile reserve and calcium regulation are depressed in myocytes from chronically unloaded hearts. Circulation. 2003 Mar 04; 107(8):1176-82. PMID: 12615798.
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    111. Sano M, Schneider MD. Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size. Cell Cycle. 2003 Mar-Apr; 2(2):99-104. PMID: 12695656.
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    112. Schneider MD, Gaussin V, Lyons KM. Tempting fate: BMP signals for cardiac morphogenesis. Cytokine Growth Factor Rev. 2003 Feb; 14(1):1-4. PMID: 12485614.
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    113. Bonow R, Clark EB, Curfman GD, Guttmacher A, Hill MN, Miller DC, Morrison AR, Myerburg RJ, Schneider MD, Weisfeldt ML, Willerson JT, Young JB. Task Force on Strategic Research Direction: Clinical Science Subgroup key science topics report. Circulation. 2002 Nov 12; 106(20):e162-6. PMID: 12427671.
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    114. Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, Michael LH, DeMayo FJ, Schneider MD. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med. 2002 Nov; 8(11):1310-7. PMID: 12368904.
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    115. Oh H, Schneider MD. The emerging role of telomerase in cardiac muscle cell growth and survival. J Mol Cell Cardiol. 2002 Jul; 34(7):717-24. PMID: 12099712.
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    116. Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002 Apr; 129(7):1705-14. PMID: 11923206.
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    117. Minamino T, Yujiri T, Terada N, Taffet GE, Michael LH, Johnson GL, Schneider MD. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3866-71. PMID: 11891332.
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    118. Schneider MD. Serial killer: angiotensin drives cardiac hypertrophy via TGF-beta1. J Clin Invest. 2002 Mar; 109(6):715-6. PMID: 11901178.
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    119. Gaussin V, Van de Putte T, Mishina Y, Hanks MC, Zwijsen A, Huylebroeck D, Behringer RR, Schneider MD. Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2878-83. PMID: 11854453.
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    120. Sano M, Schneider MD. Still stressed out but doing fine: normalization of wall stress is superfluous to maintaining cardiac function in chronic pressure overload. Circulation. 2002 Jan 01; 105(1):8-10. PMID: 11772868.
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