TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
Address6501 Fannin St
Houston, TX 77030
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    F32EY016928     (DE PAIVA, CINTIA SADE)Sep 1, 2005 - Aug 31, 2007
    The stress of dry eye on corneal barrier function
    Role: Principal Investigator

    R21EY018888     (DE PAIVA, CINTIA S.)Aug 1, 2009 - Dec 31, 2011
    Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Role: Principal Investigator

    R01EY026893     (DE PAIVA, CINTIA S.)Sep 1, 2017 - Aug 31, 2022
    Commensal microbiota modulates ocular surface mucosal inflammation
    Role: Principal Investigator

    R01EY030447     (DE PAIVA, CINTIA S.)Sep 1, 2020 - Jun 30, 2024
    Defining the interplay of interferon-gamma and cathepsin S in age-related dry eye
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thein AS, Hedengran A, Azuara-Blanco A, Arita R, Cvenkel B, Gazzard G, Heegaard S, de Paiva CS, Petrovski G, Prokosch-Willing V, Utheim TP, Virgili G, Kolko M. Adverse Effects and Safety in Glaucoma Patients: Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)-A Delphi Consensus Statement. Am J Ophthalmol. 2022 09; 241:190-197. PMID: 35594917.
      Citations:    Fields:    
    2. Schaefer L, Hernandez H, Coats RA, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Author Correction: Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 Apr 21; 12(1):6581. PMID: 35449441.
      Citations:    Fields:    
    3. Alam J, Yazdanpanah G, Ratnapriya R, Borcherding N, de Paiva CS, Li D, Pflugfelder SC. Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal Immunol. 2022 04; 15(4):620-628. PMID: 35361907.
      Citations:    Fields:    Translation:AnimalsCells
    4. Alam J, Yazdanpanah G, Ratnapriya R, Borcherding N, de Paiva CS, Li D, Guimaraes de Souza R, Yu Z, Pflugfelder SC. IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRa Mutant Mouse. Front Med (Lausanne). 2022; 9:849990. PMID: 35402439.
      Citations: 1     
    5. Schaefer L, Hernandez H, Coats RA, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Gut-derived butyrate suppresses ocular surface inflammation. Sci Rep. 2022 03 16; 12(1):4512. PMID: 35296712.
      Citations: 1     Fields:    Translation:Animals
    6. Trujillo-Vargas CM, Mauk KE, Hernandez H, de Souza RG, Yu Z, Galletti JG, Dietrich J, Paulsen F, de Paiva CS. Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands. Geroscience. 2022 Mar 12. PMID: 35279788.
      Citations:    Fields:    
    7. Schaefer L, Trujillo-Vargas CM, Midani FS, Pflugfelder SC, Britton RA, de Paiva CS. Gut Microbiota From Sjögren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice. Front Med (Lausanne). 2022; 9:852918. PMID: 35355610.
    8. Yu Z, Li J, Govindarajan G, Hamm-Alvarez SF, Alam J, Li DQ, de Paiva CS. Cathepsin S is a novel target for age-related dry eye. Exp Eye Res. 2022 01; 214:108895. PMID: 34910926.
      Citations:    Fields:    Translation:AnimalsCells
    9. de Paiva CS, Trujillo-Vargas CM, Schaefer L, Yu Z, Britton RA, Pflugfelder SC. Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca. Front Immunol. 2021; 12:702755. PMID: 34349764.
      Citations: 3     Fields:    Translation:HumansCells
    10. Alam J, de Paiva CS, Pflugfelder SC. Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Front Immunol. 2021; 12:701415. PMID: 34305940.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Galletti JG, de Paiva CS. Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity. Immunology. 2021 09; 164(1):43-56. PMID: 33837534.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Galletti JG, de Paiva CS. The ocular surface immune system through the eyes of aging. Ocul Surf. 2021 04; 20:139-162. PMID: 33621658.
      Citations: 8     Fields:    Translation:Humans
    13. Alam J, Yu Z, de Paiva CS, Pflugfelder SC. Retinoid Regulation of Ocular Surface Innate Inflammation. Int J Mol Sci. 2021 Jan 22; 22(3). PMID: 33499199.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Trujillo-Vargas CM, Kutlehria S, Hernandez H, de Souza RG, Lee A, Yu Z, Pflugfelder SC, Singh M, de Paiva CS. Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23). PMID: 33255287.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. de Souza RG, Yu Z, Hernandez H, Trujillo-Vargas CM, Lee A, Mauk KE, Cai J, Alves MR, de Paiva CS. Modulation of Oxidative Stress and Inflammation in the Aged Lacrimal Gland. Am J Pathol. 2021 02; 191(2):294-308. PMID: 33159886.
      Citations: 8     Fields:    Translation:Animals
    16. Alam J, de Souza RG, Yu Z, Stern ME, de Paiva CS, Pflugfelder SC. Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685. PMID: 32721249.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Stepp MA, Pal-Ghosh S, Tadvalkar G, de Paiva CS. Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. Int J Mol Sci. 2020 Jul 21; 21(14). PMID: 32708332.
      Citations: 1     Fields:    Translation:AnimalsCells
    18. Pflugfelder SC, de Paiva CS. Goblet cells promote tolerance induction in the conjunctiva. Mucosal Immunol. 2020 09; 13(5):717-718. PMID: 32616838.
      Citations: 3     Fields:    Translation:Cells
    19. Hu J, Gao N, Zhang Y, Chen X, Li J, Bian F, Chi W, Liu Z, de Paiva CS, Pflugfelder SC, Li DQ. IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020 11; 13(6):919-930. PMID: 32358573.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    20. Khimani KS, Go JA, De Souza RG, Mitchell T, Yu Z, de Paiva CS, Saumur M, Pflugfelder SC. Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933. PMID: 32076085.
      Citations: 2     Fields:    Translation:HumansCells
    21. de Paiva CS, Pflugfelder SC. Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions. Int J Mol Sci. 2020 Jan 19; 21(2). PMID: 31963817.
      Citations: 3     Fields:    Translation:HumansCells
    22. Alam J, de Paiva CS, Pflugfelder SC. Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334. PMID: 31953222.
      Citations: 19     Fields:    Translation:AnimalsCells
    23. de Paiva CS. Highlights from the 22nd International Ocular Surface Society meeting. Ocul Surf. 2020 01; 18(1):13-18. PMID: 31785389.
      Citations:    Fields:    Translation:Humans
    24. Zhang R, Park M, Richardson A, Tedla N, Pandzic E, de Paiva CS, Watson S, Wakefield D, Di Girolamo N. Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease. Ocul Surf. 2020 01; 18(1):158-169. PMID: 31740391.
      Citations: 12     Fields:    Translation:Animals
    25. Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Britton RA, de Paiva CS. The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome. Ocul Surf. 2020 04; 18(2):335-344. PMID: 31644955.
      Citations: 22     Fields:    Translation:Animals
    26. Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233. PMID: 31618426.
      Citations: 6     Fields:    Translation:Animals
    27. de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK. Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051. PMID: 31517988.
      Citations: 18     Fields:    Translation:Humans
    28. Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, Uchino Y, Yokoi N, Zoukhri D, Sullivan DA. Corrigendum to "TFOS DEWS II pathophysiology report" [Ocul. Surf. 15 (3) (2017) 438-510]. Ocul Surf. 2019 Oct; 17(4):842. PMID: 31401339.
      Citations: 3     Fields:    
    29. de Souza RG, de Paiva CS, Alves MR. Age-related Autoimmune Changes in Lacrimal Glands. Immune Netw. 2019 Feb; 19(1):e3. PMID: 30838158.
      Citations: 7     
    30. Bian F, Xiao Y, Barbosa FL, de Souza RG, Hernandez H, Yu Z, Pflugfelder SC, de Paiva CS. Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908. PMID: 30696983.
      Citations: 17     Fields:    Translation:AnimalsCells
    31. Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921. PMID: 30515838.
      Citations: 13     Fields:    Translation:AnimalsCells
    32. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams AR, Pflugfelder SC, de Paiva CS. Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12). PMID: 30513621.
      Citations: 12     Fields:    Translation:Animals
    33. Xiao Y, de Paiva CS, Yu Z, de Souza RG, Li DQ, Pflugfelder SC. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470. PMID: 30010888.
      Citations: 16     Fields:    Translation:AnimalsCells
    34. Pflugfelder SC, Bian F, Gumus K, Farley W, Stern ME, De Paiva CS. Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. Int J Mol Sci. 2018 Sep 14; 19(9). PMID: 30223431.
      Citations: 18     Fields:    Translation:HumansCells
    35. de Paiva CS. Highlights from the 21st International Ocular Surface Society meeting. Ocul Surf. 2018 10; 16(4):394-397. PMID: 30130576.
      Citations:    Fields:    Translation:Humans
    36. Guimaraes de Souza R, Yu Z, Stern ME, Pflugfelder SC, de Paiva CS. Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549. PMID: 29958030.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS. Protective role of commensal bacteria in Sjögren Syndrome. J Autoimmun. 2018 09; 93:45-56. PMID: 29934134.
      Citations: 25     Fields:    Translation:AnimalsCells
    38. Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2). PMID: 29438346.
      Citations: 31     Fields:    Translation:AnimalsCells
    39. Ko BY, Xiao Y, Barbosa FL, de Paiva CS, Pflugfelder SC. Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3). PMID: 29415888.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    40. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98. PMID: 29407221.
      Citations: 28     Fields:    Translation:AnimalsCells
    41. Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13. PMID: 29055361.
      Citations: 100     Fields:    Translation:HumansCells
    42. Craig JP, Nelson JD, Azar DT, Belmonte C, Bron AJ, Chauhan SK, de Paiva CS, Gomes JAP, Hammitt KM, Jones L, Nichols JJ, Nichols KK, Novack GD, Stapleton FJ, Willcox MDP, Wolffsohn JS, Sullivan DA. TFOS DEWS II Report Executive Summary. Ocul Surf. 2017 10; 15(4):802-812. PMID: 28797892.
      Citations: 128     Fields:    Translation:Humans
    43. Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, Uchino Y, Yokoi N, Zoukhri D, Sullivan DA. TFOS DEWS II pathophysiology report. Ocul Surf. 2017 07; 15(3):438-510. PMID: 28736340.
      Citations: 310     Fields:    Translation:Humans
    44. Barbosa FL, Xiao Y, Bian F, Coursey TG, Ko BY, Clevers H, de Paiva CS, Pflugfelder SC. Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5). PMID: 28475124.
      Citations: 35     Fields:    Translation:AnimalsCells
    45. Rassi DM, De Paiva CS, Dias LC, Módulo CM, Adriano L, Fantucci MZ, Rocha EM. Review: MicroRNAS in ocular surface and dry eye diseases. Ocul Surf. 2017 10; 15(4):660-669. PMID: 28483646.
      Citations: 7     Fields:    Translation:Humans
    46. Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3). PMID: 28273882.
      Citations: 25     Fields:    Translation:Animals
    47. Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76. PMID: 28238526.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. de Paiva CS. Effects of Aging in Dry Eye. Int Ophthalmol Clin. 2017; 57(2):47-64. PMID: 28282314.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    49. Volpe EA, Henriksson JT, Wang C, Barbosa FL, Zaheer M, Zhang X, Pflugfelder SC, de Paiva CS. Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614. PMID: 27623073.
      Citations: 16     Fields:    Translation:AnimalsCells
    50. Bian F, Shin CS, Wang C, Pflugfelder SC, Acharya G, De Paiva CS. Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30. PMID: 27327581.
      Citations: 10     Fields:    Translation:Animals
    51. Simmons KT, Xiao Y, Pflugfelder SC, de Paiva CS. Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51. PMID: 27136463.
      Citations: 16     Fields:    Translation:AnimalsCells
    52. de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, Streckfus CF, Hutchinson DS, Ajami NJ, Petrosino JF, Pflugfelder SC. Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. Sci Rep. 2016 Apr 18; 6:23561. PMID: 27087247.
      Citations: 119     Fields:    Translation:HumansAnimals
    53. Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS, Pflugfelder SC. Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58. PMID: 27085137.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    54. Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16. PMID: 26923552.
      Citations: 5     Fields:    Translation:AnimalsCells
    55. Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54. PMID: 26772899.
      Citations: 26     Fields:    Translation:Animals
    56. Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50. PMID: 26618646.
      Citations: 56     Fields:    Translation:HumansCells
    57. de Paiva CS, Rocha EM. Sjögren syndrome: what and where are we looking for? Curr Opin Ophthalmol. 2015 Nov; 26(6):517-25. PMID: 26367089.
      Citations: 6     Fields:    Translation:HumansAnimals
    58. Krauss AH, Corrales RM, Pelegrino FS, Tukler-Henriksson J, Pflugfelder SC, de Paiva CS. Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95. PMID: 26348638.
      Citations: 11     Fields:    Translation:AnimalsCells
    59. Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmed F, De Paiva CS, Pflugfelder SC, Acharya G. Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174. PMID: 26184051.
      Citations: 22     Fields:    Translation:Animals
    60. Tukler Henriksson J, Coursey TG, Corry DB, De Paiva CS, Pflugfelder SC. IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97. PMID: 26132778.
      Citations: 43     Fields:    Translation:AnimalsCells
    61. Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18. PMID: 26225631.
      Citations: 11     Fields:    Translation:Animals
    62. Moore QL, De Paiva CS, Pflugfelder SC. Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1. PMID: 25868759.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    63. You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC. Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33. PMID: 25758816.
      Citations: 17     Fields:    Translation:Animals
    64. You IC, Coursey TG, Bian F, Barbosa FL, de Paiva CS, Pflugfelder SC. Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304. PMID: 25772203.
      Citations: 22     Fields:    Translation:AnimalsCells
    65. Bian F, Barbosa FL, Corrales RM, Pelegrino FS, Volpe EA, Pflugfelder SC, de Paiva CS. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53. PMID: 25889094.
      Citations: 18     Fields:    Translation:Animals
    66. Coursey TG, Bohat R, Barbosa FL, Pflugfelder SC, de Paiva CS. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72. PMID: 25288568.
      Citations: 31     Fields:    Translation:AnimalsCells
    67. Coursey TG, de Paiva CS. Managing Sjögren's Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy. Clin Ophthalmol. 2014; 8:1447-58. PMID: 25120351.
      Citations: 28     
    68. Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ. A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26. PMID: 24486456.
      Citations: 5     Fields:    Translation:AnimalsCells
    69. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    70. Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC. Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24. PMID: 24315969.
      Citations: 36     Fields:    Translation:AnimalsCells
    71. Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS. Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508. PMID: 24223818.
      Citations: 30     Fields:    Translation:AnimalsCells
    72. Suhalim JL, Parfitt GJ, Xie Y, De Paiva CS, De Pavia CS, Pflugfelder SC, Shah TN, Potma EO, Brown DJ, Jester JV. Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68. PMID: 24439047.
      Citations: 24     Fields:    Translation:AnimalsCells
    73. Pflugfelder SC, Corrales RM, de Paiva CS. T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25. PMID: 24012834.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    74. Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301. PMID: 23983225.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    75. Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC. Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32. PMID: 23572103.
      Citations: 18     Fields:    Translation:HumansCells
    76. Henriksson JT, De Paiva CS, Farley W, Pflugfelder SC, Burns AR, Bergmanson JP. Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90. PMID: 23146932.
      Citations: 6     Fields:    Translation:AnimalsCells
    77. Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, De Paiva CS, Pflugfelder SC, Li DQ. A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571. PMID: 23166715.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    78. Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS. Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234. PMID: 23116218.
      Citations: 21     Fields:    Translation:AnimalsCells
    79. de Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303. PMID: 22257864.
      Citations: 40     Fields:    Translation:AnimalsCells
    80. Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822. PMID: 22590618.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    81. Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC. Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75. PMID: 22395876.
      Citations: 34     Fields:    Translation:AnimalsCells
    82. De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. Disruption of TGF-ß signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017. PMID: 22194977.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    83. Chang E, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC, De Paiva CS. Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. J Clin Exp Ophthalmol. 2011 Nov 01; 2(11). PMID: 23560247.
      Citations: 7     
    84. Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62. PMID: 21880984.
      Citations: 75     Fields:    Translation:AnimalsCells
    85. Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14. PMID: 21843497.
      Citations: 37     Fields:    Translation:AnimalsCells
    86. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85. PMID: 21474767.
      Citations: 57     Fields:    Translation:AnimalsCells
    87. Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2. PMID: 21820713.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    88. Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9. PMID: 21421863.
      Citations: 29     Fields:    Translation:AnimalsCells
    89. Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7. PMID: 21273534.
      Citations: 18     Fields:    Translation:AnimalsCells
    90. Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54. PMID: 20539212.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    91. Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53. PMID: 20566743.
      Citations: 29     Fields:    Translation:AnimalsCells
    92. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91. PMID: 20130281.
      Citations: 44     Fields:    Translation:AnimalsCells
    93. Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82. PMID: 20107175.
      Citations: 19     Fields:    Translation:AnimalsCells
    94. Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102. PMID: 19746420.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    95. De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58. PMID: 20007286.
      Citations: 59     Fields:    Translation:AnimalsCells
    96. De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31. PMID: 20008718.
      Citations: 21     Fields:    Translation:AnimalsCells
    97. De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31. PMID: 19878594.
      Citations: 18     
    98. Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9. PMID: 19255163.
      Citations: 128     Fields:    Translation:HumansCells
    99. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1. PMID: 18992869.
      Citations: 173     Fields:    Translation:Humans
    100. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159.
      Citations: 8     Fields:    Translation:HumansCells
    101. Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40. PMID: 18724157.
      Citations: 20     Fields:    Translation:AnimalsCells
    102. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11. PMID: 18813079.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    103. Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC, Lako M. A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. Stem Cells. 2008 Jun; 26(6):1609-19. PMID: 18356573.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    104. Pflugfelder SC, De Paiva CS, Villarreal AL, Stern ME. Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9. PMID: 18245969.
      Citations: 53     Fields:    Translation:HumansCells
    105. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21. PMID: 17988834.
      Citations: 21     Fields:    Translation:AnimalsCells
    106. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417.
      Citations: 29     Fields:    Translation:Humans
    107. Kim HH, De Paiva CS, Yen MT. Effects of upper eyelid blepharoplasty on ocular surface sensation and tear production. Can J Ophthalmol. 2007 Oct; 42(5):739-42. PMID: 17823642.
      Citations: 5     Fields:    Translation:Humans
    108. De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60. PMID: 17525184.
      Citations: 136     Fields:    Translation:AnimalsCells
    109. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9. PMID: 17525185.
      Citations: 90     Fields:    Translation:AnimalsCells
    110. Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301. PMID: 17003418.
      Citations: 8     Fields:    Translation:HumansCells
    111. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302. PMID: 16877394.
      Citations: 70     Fields:    Translation:AnimalsCells
    112. De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56. PMID: 16799024.
      Citations: 75     Fields:    Translation:Animals
    113. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46. PMID: 16639001.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    114. De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35. PMID: 16643899.
      Citations: 158     Fields:    Translation:AnimalsCells
    115. Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, Siemasko K. Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7. PMID: 16547229.
      Citations: 157     Fields:    Translation:AnimalsCells
    116. De Paiva CS, Chen Z, Koch DD, Hamill MB, Manuel FK, Hassan SS, Wilhelmus KR, Pflugfelder SC. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45. PMID: 16490488.
      Citations: 60     Fields:    Translation:Humans
    117. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7. PMID: 17216108.
      Citations: 16     Fields:    
    118. De Paiva CS, Pflugfelder SC, Li DQ. Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75. PMID: 16123387.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    119. Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90. PMID: 15781286.
      Citations: 35     Fields:    Translation:HumansCells
    120. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73. PMID: 15625123.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    121. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. PMID: 15632000.
      Citations: 114     Fields:    Translation:AnimalsCells
    122. Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57. PMID: 15364229.
      Citations: 65     Fields:    Translation:HumansCTClinical Trials
    123. Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9. PMID: 15183099.
      Citations: 89     Fields:    Translation:HumansCells
    124. de Paiva CS, Pflugfelder SC. Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7. PMID: 15106918.
      Citations: 6     Fields:    Translation:Humans
    125. De Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15. PMID: 14700652.
      Citations: 50     Fields:    Translation:HumansCells
    126. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66. PMID: 15153612.
      Citations: 170     Fields:    Translation:HumansCells
    127. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9. PMID: 12799233.
      Citations: 27     Fields:    Translation:Humans
    128. De Paiva CS, Harris LD, Pflugfelder SC. Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4. PMID: 12502943.
      Citations: 4     Fields:    Translation:Humans
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