TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
Address6501 Fannin St
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    Collapse Research 
    Collapse research activities and funding
    R01EY023598     (LI, DE-QUAN)Aug 1, 2014 - Jul 31, 2020
    Role: Principal Investigator

    W81XWH-07-1-0617     (De-Quan Li)Aug 15, 2007 - Aug 14, 2012
    Department of Defense (DoD)
    Repair of Corneal Injury with Stem Cell-Based Bioengineered Tissue
    Role Description: The goal of this study is to bioengineer the stem cell based corneal constructs using human limbal epithelial progenitor cells for therapeutic repair of corneal injury
    Role: Principal Investigator

    R03EY014553     (LI, DE-QUAN)Jun 1, 2003 - May 31, 2007
    Cornea Epithelial Stem Cell Isolation for Bioengineering
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li DQ, Kim S, Li JM, Gao Q, Choi J, Bian F, Hu J, Zhang Y, Li J, Lu R, Li Y, Pflugfelder SC, Miao H, Chen R. Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea. Ocul Surf. 2021 04; 20:20-32. PMID: 33388438; PMCID: PMC8359589.
      Citations: 11     Fields:    Translation:HumansCells
    2. Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, Wang C, de Souza RG, Lu F, Pflugfelder SC, Li DQ. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019 09; 12(5):1141-1149. PMID: 31350466; PMCID: PMC7285437.
      Citations: 3     Fields:    Translation:AnimalsCells
    3. Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921. PMID: 30515838; PMCID: PMC7190079.
      Citations: 13     Fields:    Translation:AnimalsCells
    4. Xiao Y, de Paiva CS, Yu Z, de Souza RG, Li DQ, Pflugfelder SC. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470. PMID: 30010888; PMCID: PMC6153729.
      Citations: 16     Fields:    Translation:AnimalsCells
    5. Li J, Xiao Y, Coursey TG, Chen X, Deng R, Lu F, Pflugfelder SC, Li DQ. Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Sci Rep. 2017 07 12; 7(1):5169. PMID: 28701781; PMCID: PMC5507988.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Zhao YE, Gong XH, Zhu XN, Li HM, Tu MJ, Coursey TG, Pflugfelder SC, Gu F, Chen D. Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study. PLoS One. 2017; 12(3):e0172979. PMID: 28301497; PMCID: PMC5354427.
      Citations: 9     Fields:    Translation:Humans
    7. Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3). PMID: 28273882; PMCID: PMC5372578.
      Citations: 25     Fields:    Translation:Animals
    8. Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76. PMID: 28238526; PMCID: PMC5536896.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Chen D, Qu Y, Hua X, Zhang L, Liu Z, Pflugfelder SC, Li DQ. A hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo expansion of human corneal epithelial stem cells. Eye (Lond). 2017 Jun; 31(6):962-971. PMID: 28211875; PMCID: PMC5518843.
      Citations: 12     Fields:    Translation:HumansCells
    10. Li J, Zhang L, Chen X, Chen D, Hua X, Bian F, Deng R, Lu F, Li Z, Pflugfelder SC, Li DQ. Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Sci Rep. 2016 10 31; 6:36150. PMID: 27796360; PMCID: PMC5087075.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    11. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      Citations: 9     Fields:    Translation:Animals
    12. Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16. PMID: 26923552; PMCID: PMC4946998.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Li J, Hua X, Zhang L, Lu F, Coursey TG, Pflugfelder SC, Li DQ. Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Sci Rep. 2016 Jan 14; 6:19408. PMID: 26762881; PMCID: PMC4725955.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    14. Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54. PMID: 26772899; PMCID: PMC4842328.
      Citations: 26     Fields:    Translation:Animals
    15. Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50. PMID: 26618646; PMCID: PMC4669202.
      Citations: 56     Fields:    Translation:HumansCells
    16. Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015 Oct; 133(10):1117-23. PMID: 26204109; PMCID: PMC5496815.
      Citations: 20     Fields:    Translation:HumansCells
    17. Hua X, Deng R, Li J, Chi W, Su Z, Lin J, Pflugfelder SC, Li DQ. Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5503-11. PMID: 26284556; PMCID: PMC4544189.
      Citations: 24     Fields:    Translation:HumansCells
    18. Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18. PMID: 26225631; PMCID: PMC4525635.
      Citations: 11     Fields:    Translation:Animals
    19. Hua X, Yuan X, Li Z, Coursey TG, Pflugfelder SC, Li DQ. A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PLoS One. 2015; 10(6):e0128039. PMID: 26039076; PMCID: PMC4454663.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Deng R, Hua X, Li J, Chi W, Zhang Z, Lu F, Zhang L, Pflugfelder SC, Li DQ. Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PLoS One. 2015; 10(5):e0126561. PMID: 26024535; PMCID: PMC4449087.
      Citations: 57     Fields:    Translation:HumansCells
    21. Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z, Pflugfelder SC, Li DQ. Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One. 2015; 10(2):e0117139. PMID: 25658308; PMCID: PMC4319935.
      Citations: 9     Fields:    Translation:HumansCells
    22. Hua X, Su Z, Deng R, Lin J, Li DQ, Pflugfelder SC. Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res. 2015 Jul; 40(7):657-67. PMID: 25271595; PMCID: PMC4793974.
      Citations: 30     Fields:    Translation:HumansCells
    23. Deng R, Su Z, Hua X, Zhang Z, Li DQ, Pflugfelder SC. Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Mol Vis. 2014; 20:1243-52. PMID: 25352733; PMCID: PMC4165325.
      Citations: 20     Fields:    Translation:HumansCells
    24. Hua X, Yuan X, Tang X, Li Z, Pflugfelder SC, Li DQ. Human corneal epithelial cells produce antimicrobial peptides LL-37 and ?-defensins in response to heat-killed Candida albicans. Ophthalmic Res. 2014; 51(4):179-86. PMID: 24662332; PMCID: PMC5744485.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ. A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26. PMID: 24486456; PMCID: PMC4057919.
      Citations: 5     Fields:    Translation:AnimalsCells
    26. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165; PMCID: PMC3936306.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    27. Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC. Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24. PMID: 24315969; PMCID: PMC3901360.
      Citations: 36     Fields:    Translation:AnimalsCells
    28. Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS. CD8? cells regulate the T helper-17 response in an experimental murine model of Sj?gren syndrome. Mucosal Immunol. 2014 Mar; 7(2):417-27. PMID: 24022789; PMCID: PMC3869878.
      Citations: 27     Fields:    Translation:AnimalsCells
    29. Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301. PMID: 23983225; PMCID: PMC4051277.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    30. Lin J, Zhang L, Zhao G, Su Z, Deng R, Pflugfelder SC, Li DQ. A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. PLoS One. 2013; 8(4):e60963. PMID: 23585867; PMCID: PMC3622010.
      Citations: 13     Fields:    Translation:HumansCells
    31. Su Z, Lin J, Lu F, Zhang X, Zhang L, Gandhi NB, de Paiva CS, Pflugfelder SC, Li DQ. Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol. 2013 Sep; 6(5):921-30. PMID: 23299617; PMCID: PMC3904307.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    32. Lu R, Qu Y, Ge J, Zhang L, Su Z, Pflugfelder SC, Li DQ. Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells. 2012 Apr; 30(4):753-61. PMID: 22232078; PMCID: PMC5610543.
      Citations: 33     Fields:    Translation:HumansCells
    33. De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. Disruption of TGF-? signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017. PMID: 22194977; PMCID: PMC3237576.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    34. Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. Desiccating stress induces CD4+ T-cell-mediated Sj?gren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14. PMID: 21843497; PMCID: PMC3181354.
      Citations: 37     Fields:    Translation:AnimalsCells
    35. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85. PMID: 21474767; PMCID: PMC3176027.
      Citations: 57     Fields:    Translation:AnimalsCells
    36. Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2. PMID: 21820713; PMCID: PMC3229670.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    37. Zhang L, Lu R, Zhao G, Pflugfelder SC, Li DQ. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011 Sep; 43(9):1383-91. PMID: 21684348; PMCID: PMC3175488.
      Citations: 41     Fields:    Translation:HumansCells
    38. Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9. PMID: 21421863; PMCID: PMC3109039.
      Citations: 29     Fields:    Translation:AnimalsCells
    39. Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7. PMID: 21273534; PMCID: PMC3109024.
      Citations: 18     Fields:    Translation:AnimalsCells
    40. Lu R, Bian F, Zhang X, Qi H, Chuang EY, Pflugfelder SC, Li DQ. The ?-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2011 May; 43(5):751-9. PMID: 21292023; PMCID: PMC3131198.
      Citations: 20     Fields:    Translation:HumansCells
    41. De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011 Jul; 4(4):397-408. PMID: 21178983; PMCID: PMC3577073.
      Citations: 51     Fields:    Translation:AnimalsCells
    42. Bian F, Qi H, Ma P, Zhang L, Yoon KC, Pflugfelder SC, Li DQ. An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells. 2010 Dec; 28(12):2172-81. PMID: 20936708; PMCID: PMC3577923.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    43. Qi H, Zheng X, Yuan X, Pflugfelder SC, Li DQ. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010 Oct; 225(1):180-5. PMID: 20458737; PMCID: PMC8317437.
      Citations: 11     Fields:    Translation:HumansCells
    44. Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54. PMID: 20539212; PMCID: PMC3582018.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    45. Li DQ, Zhou N, Zhang L, Ma P, Pflugfelder SC. Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5623-9. PMID: 20538995; PMCID: PMC3061501.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    46. Bian F, Liu W, Yoon KC, Lu R, Zhou N, Ma P, Pflugfelder SC, Li DQ. Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2010 Jul; 42(7):1142-53. PMID: 20363357; PMCID: PMC2939451.
      Citations: 14     Fields:    Translation:HumansCells
    47. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91. PMID: 20130281; PMCID: PMC2891467.
      Citations: 44     Fields:    Translation:AnimalsCells
    48. Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82. PMID: 20107175; PMCID: PMC2891466.
      Citations: 19     Fields:    Translation:AnimalsCells
    49. Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102. PMID: 19746420; PMCID: PMC2789678.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    50. De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58. PMID: 20007286; PMCID: PMC2909796.
      Citations: 59     Fields:    Translation:AnimalsCells
    51. De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31. PMID: 20008718; PMCID: PMC3583514.
      Citations: 21     Fields:    Translation:AnimalsCells
    52. De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31. PMID: 19878594; PMCID: PMC2777897.
      Citations: 18     
    53. Ma P, Wang Z, Pflugfelder SC, Li DQ. Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Exp Eye Res. 2010 Jan; 90(1):130-6. PMID: 19799901; PMCID: PMC2836933.
      Citations: 17     Fields:    Translation:Humans
    54. Yeh S, de Paiva CS, Hwang CS, Trinca K, Lingappan A, Rafati JK, Farley WJ, Li DQ, Pflugfelder SC. Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol. 2009 Sep; 93(9):1260-4. PMID: 19429577; PMCID: PMC3586820.
      Citations: 9     Fields:    Translation:AnimalsCells
    55. Chen D, Ge J, Wang L, Gao Q, Ma P, Li N, Li DQ, Wang Z. A simple and evolutional approach proven to recanalise the nasolacrimal duct obstruction. Br J Ophthalmol. 2009 Nov; 93(11):1438-43. PMID: 19416937; PMCID: PMC2760725.
      Citations: 9     Fields:    Translation:HumansAnimals
    56. Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9. PMID: 19255163; PMCID: PMC3594995.
      Citations: 128     Fields:    Translation:HumansCells
    57. De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53. PMID: 19242409; PMCID: PMC3594767.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    58. Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2702-9. PMID: 19151401; PMCID: PMC5496816.
      Citations: 30     Fields:    Translation:HumansCells
    59. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159; PMCID: PMC4529993.
      Citations: 8     Fields:    Translation:HumansCells
    60. Chuang EY, Li DQ, Bian F, Zheng X, Pflugfelder SC. Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function. Eye Contact Lens. 2008 Sep; 34(5):281-6. PMID: 18779668; PMCID: PMC8313347.
      Citations: 9     Fields:    Translation:HumansCells
    61. Qi H, Li DQ, Bian F, Chuang EY, Jones DB, Pflugfelder SC. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. Br J Ophthalmol. 2008 Sep; 92(9):1269-74. PMID: 18723744; PMCID: PMC2906381.
      Citations: 12     Fields:    Translation:HumansCells
    62. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11. PMID: 18813079; PMCID: PMC4082978.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    63. Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC, Lako M. A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. Stem Cells. 2008 Jun; 26(6):1609-19. PMID: 18356573.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    64. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):539-49. PMID: 18234997; PMCID: PMC8320337.
      Citations: 34     Fields:    Translation:HumansCells
    65. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21. PMID: 17988834; PMCID: PMC2443953.
      Citations: 21     Fields:    Translation:AnimalsCells
    66. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417; PMCID: PMC2185513.
      Citations: 29     Fields:    Translation:Humans
    67. Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40. PMID: 17980361; PMCID: PMC2198932.
      Citations: 37     Fields:    Translation:HumansCells
    68. Corrales RM, Villarreal A, Farley W, Stern ME, Li DQ, Pflugfelder SC. Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84. PMID: 17525655.
      Citations: 43     Fields:    Translation:AnimalsCells
    69. De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60. PMID: 17525184.
      Citations: 136     Fields:    Translation:AnimalsCells
    70. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9. PMID: 17525185.
      Citations: 90     Fields:    Translation:AnimalsCells
    71. Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea. 2007 May; 26(4):452-60. PMID: 17457195.
      Citations: 54     Fields:    Translation:HumansCells
    72. Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301. PMID: 17003418.
      Citations: 8     Fields:    Translation:HumansCells
    73. Chen Z, Li DQ, Tong L, Stewart P, Chu C, Pflugfelder SC. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Mol Vis. 2006 Aug 23; 12:983-94. PMID: 16943770; PMCID: PMC2906388.
      Citations: 13     Fields:    Translation:HumansCells
    74. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302. PMID: 16877394.
      Citations: 70     Fields:    Translation:AnimalsCells
    75. De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56. PMID: 16799024.
      Citations: 75     Fields:    Translation:Animals
    76. Chen Z, Mok H, Pflugfelder SC, Li DQ, Barry MA. Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Exp Eye Res. 2006 Oct; 83(4):798-806. PMID: 16793039; PMCID: PMC2906397.
      Citations: 6     Fields:    Translation:HumansCells
    77. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46. PMID: 16639001; PMCID: PMC2906387.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    78. De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35. PMID: 16643899.
      Citations: 158     Fields:    Translation:AnimalsCells
    79. Chen Z, Evans WH, Pflugfelder SC, Li DQ. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006 May; 24(5):1265-73. PMID: 16424398; PMCID: PMC2906383.
      Citations: 43     Fields:    Translation:HumansCells
    80. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006 Apr; 82(4):588-96. PMID: 16202406; PMCID: PMC2198933.
      Citations: 130     Fields:    Translation:HumansCells
    81. McDermott AM, Perez V, Huang AJ, Pflugfelder SC, Stern ME, Baudouin C, Beuerman RW, Burns AR, Calder VL, Calonge M, Chodosh J, Coster DJ, Dana R, Hazlett LD, Jones DB, Kim SK, Knop E, Li DQ, Mitchell BM, Niederkorn JY, Pearlman E, Wilhelmus KR, Kurie E. Pathways of corneal and ocular surface inflammation: a perspective from the cullen symposium. Ocul Surf. 2005 Oct; 3(4 Suppl):S131-8. PMID: 17216102.
      Citations: 20     Fields:    
    82. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7. PMID: 17216108.
      Citations: 16     Fields:    
    83. Huang AJ, Li DQ, Li CH, Shang TY, Hernandez E. Modulation of corneal vascularization. Ocul Surf. 2005 Oct; 3(4 Suppl):S190-3. PMID: 17216117.
      Citations: 3     Fields:    
    84. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93. PMID: 16163009.
      Citations: 113     Fields:    Translation:AnimalsCells
    85. De Paiva CS, Pflugfelder SC, Li DQ. Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75. PMID: 16123387; PMCID: PMC2906390.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    86. Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90. PMID: 15781286; PMCID: PMC2906384.
      Citations: 35     Fields:    Translation:HumansCells
    87. Kim HS, Luo L, Pflugfelder SC, Li DQ. Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):840-8. PMID: 15728539.
      Citations: 50     Fields:    Translation:HumansCells
    88. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. PMID: 15632000; PMCID: PMC1602302.
      Citations: 114     Fields:    Translation:AnimalsCells
    89. Ji J, Chang P, Pennesi ME, Yang Z, Zhang J, Li D, Wu SM, Gross RL. Effects of elevated intraocular pressure on mouse retinal ganglion cells. Vision Res. 2005 Jan; 45(2):169-79. PMID: 15581918.
      Citations: 41     Fields:    Translation:AnimalsCells
    90. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73. PMID: 15625123; PMCID: PMC2906389.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    91. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301. PMID: 15557435.
      Citations: 218     Fields:    Translation:AnimalsCells
    92. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4302-11. PMID: 15557436.
      Citations: 115     Fields:    Translation:HumansCells
    93. Kim HS, Shang T, Chen Z, Pflugfelder SC, Li DQ. TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res. 2004 Aug; 79(2):263-74. PMID: 15325573.
      Citations: 30     Fields:    Translation:HumansCells
    94. Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9. PMID: 15183099; PMCID: PMC2906376.
      Citations: 94     Fields:    Translation:HumansCells
    95. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66. PMID: 15153612; PMCID: PMC2906385.
      Citations: 180     Fields:    Translation:HumansCells
    96. Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9. PMID: 14507865.
      Citations: 39     Fields:    Translation:AnimalsCells
    97. Li DQ, Shang TY, Kim HS, Solomon A, Lokeshwar BL, Pflugfelder SC. Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Jul; 44(7):2928-36. PMID: 12824233.
      Citations: 35     Fields:    Translation:HumansCells
    98. Solomon A, Grueterich M, Li DQ, Meller D, Lee SB, Tseng SC. Overexpression of Insulin-like growth factor-binding protein-2 in pterygium body fibroblasts. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):573-80. PMID: 12556385.
      Citations: 18     Fields:    Translation:HumansCells
    99. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9. PMID: 12506064.
      Citations: 102     Fields:    Translation:AnimalsCells
    100. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8. PMID: 11867577.
      Citations: 103     Fields:    Translation:AnimalsCells
    101. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern M, Pflugfelder SC. Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55. PMID: 12613973.
      Citations: 17     Fields:    Translation:AnimalsCells
    102. Pflugfelder SC, Solomon A, Dursun D, Li DQ. Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43. PMID: 12613986.
      Citations: 9     Fields:    Translation:HumansAnimals
    103. Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001 Oct; 73(4):449-59. PMID: 11825017.
      Citations: 79     Fields:    Translation:Humans
    104. Li DQ, Lee SB, Gunja-Smith Z, Liu Y, Solomon A, Meller D, Tseng SC. Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts. Arch Ophthalmol. 2001 Jan; 119(1):71-80. PMID: 11146729.
      Citations: 37     Fields:    Translation:HumansCells
    105. Meller D, Li DQ, Tseng SC. Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha. Invest Ophthalmol Vis Sci. 2000 Sep; 41(10):2922-9. PMID: 10967046.
      Citations: 33     Fields:    Translation:HumansCells
    106. Solomon A, Li DQ, Lee SB, Tseng SC. Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2154-63. PMID: 10892857.
      Citations: 22     Fields:    Translation:HumansCells
    107. Pflugfelder SC, Liu Z, Monroy D, Li DQ, Carvajal ME, Price-Schiavi SA, Idris N, Solomon A, Perez A, Carraway KL. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1316-26. PMID: 10798646.
      Citations: 51     Fields:    Translation:Humans
    108. Lee SB, Li DQ, Tan DT, Meller DC, Tseng SC. Suppression of TGF-beta signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane. Curr Eye Res. 2000 Apr; 20(4):325-34. PMID: 10806447.
      Citations: 81     Fields:    Translation:HumansCells
    109. Li DQ, Meller D, Liu Y, Tseng SC. Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):404-10. PMID: 10670469.
      Citations: 24     Fields:    Translation:HumansCells
    110. Li DQ, Lee SB, Tseng SC. Differential expression and regulation of TGF-beta1, TGF-beta2, TGF-beta3, TGF-betaRI, TGF-betaRII and TGF-betaRIII in cultured human corneal, limbal, and conjunctival fibroblasts. Curr Eye Res. 1999 Aug; 19(2):154-61. PMID: 10420185.
      Citations: 15     Fields:    Translation:HumansCells
    111. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol. 1999 Jun; 179(3):325-35. PMID: 10228951.
      Citations: 139     Fields:    Translation:HumansCells
    112. Li DQ, Tseng SC. Differential regulation of keratinocyte growth factor and hepatocyte growth factor/scatter factor by different cytokines in human corneal and limbal fibroblasts. J Cell Physiol. 1997 Sep; 172(3):361-72. PMID: 9284956.
      Citations: 19     Fields:    Translation:HumansCells
    113. Tseng SC, Kruse FE, Merritt J, Li DQ. Comparison between serum-free and fibroblast-cocultured single-cell clonal culture systems: evidence showing that epithelial anti-apoptotic activity is present in 3T3 fibroblast-conditioned media. Curr Eye Res. 1996 Sep; 15(9):973-84. PMID: 8921219.
      Citations: 31     Fields:    Translation:AnimalsCells
    114. Li DQ, Tseng SC. Differential regulation of cytokine and receptor transcript expression in human corneal and limbal fibroblasts by epidermal growth factor, transforming growth factor-alpha, platelet-derived growth factor B, and interleukin-1 beta. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2068-80. PMID: 8814146.
      Citations: 16     Fields:    Translation:HumansCells
    115. Tseng SC, Li DQ. Comparison of protein kinase C subtype expression between normal and aniridic human ocular surfaces: implications for limbal stem cell dysfunction in aniridia. Cornea. 1996 Mar; 15(2):168-78. PMID: 8925665.
      Citations: 5     Fields:    Translation:HumansCells
    116. Li DQ, Tseng SC. Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol. 1995 Apr; 163(1):61-79. PMID: 7896901.
      Citations: 84     Fields:    Translation:HumansCells
    117. Li DQ, Kuang AK, Ding T, Chen JL, Xu MY. Nuclear 3,5,3'-triiodothyronine receptors (T3R) of circulating human lymphocytes in hyper- and hypothyroidism and nonthyroidal diseases. Chin Med J (Engl). 1990 May; 103(5):355-8. PMID: 2118049.
      Citations:    Fields:    Translation:HumansCells
    118. Li DQ, Kuang AK, Ding T. [Nuclear 3,5,3'-triiodothyronine receptors in circulating human lymphocytes in normal, hyper-and hypothyroid subjects]. Zhonghua Nei Ke Za Zhi. 1989 May; 28(5):286-9, 315. PMID: 2805969.
      Citations:    Fields:    Translation:HumansCells
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