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RICK GUAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guan X, Li Q, Yan J. Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Sci Rep. 2017 Feb 06; 7:42240. PMID: 28165042.
      View in: PubMed
    2. Liu X, Lu YF, Guan X, Zhao M, Wang J, Li F. Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016; 109(Jun ):70-82.
    3. Li Q, Guan X, Yen K, Zhang J, Yan J. The single transmembrane segment determines the modulatory function of the BK channel auxiliary ? subunit. J Gen Physiol. 2016 Apr; 147(4):337-51. PMID: 27022192; PMCID: PMC4810070 [Available on 10/01/16].
    4. Liu X, Lu YF, Guan X, Zhao M, Wang J, Li F. Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 Jun 1; 109:70-82. PMID: 27021842.
      View in: PubMed
    5. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 1; 97(1):111-21. PMID: 26212543.
      View in: PubMed
    6. Guan X. The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307(6):R585-96. PMID: 24990862; PMCID: PMC4166762.
    7. Li J, Li X, Lan T, Qi C, He X, Yang H, Li Y, Wang L, Guan X. [Type I collagen secreted by lung cancer cells promotes cancer cell growth in a three- dimensional culture system]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jul; 34(8):1129-34. PMID: 25176080.
      View in: PubMed
    8. Wong AM, Kong KL, Chen L, Liu M, Wong AM, Zhu C, Tsang JW, Guan XY. Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. Int J Cancer. 2013 Nov 15; 133(10):2284-95. PMID: 23649311.
      View in: PubMed
    9. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 2; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
    10. Zhu YH, Fu L, Chen L, Qin YR, Liu H, Xie F, Zeng T, Dong SS, Li J, Li Y, Dai Y, Xie D, Guan XY. Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2013 Apr 1; 73(7):2298-309. PMID: 23436800.
      View in: PubMed
    11. Deng W, Tsao SW, Guan XY, Cheung AL. Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. PLoS One. 2012; 7(10):e48576. PMID: 23119062; PMCID: PMC3485353.
    12. Chen J, Kwong DL, Zhu CL, Chen LL, Dong SS, Zhang LY, Tian J, Qi CB, Cao TT, Wong AM, Kong KL, Li Y, Liu M, Fu L, Guan XY. RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis. PLoS One. 2012; 7(9):e44636. PMID: 22957092; PMCID: PMC3434166.
    13. Guan X, Shi X, Li X, Chang B, Wang Y, Li D, Chan L. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1; 303(7):E853-64. PMID: 22829581; PMCID: PMC3469617.
    14. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang de P, Guan XY, Chen JP. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biol Ther. 2012 Feb 1; 13(3):138-47. PMID: 22231406.
      View in: PubMed
    15. Lin H, Hu L, Chen L, Yu H, Wang Q, Chen P, Hu XT, Cai XJ, Guan XY. Chemically-induced cancers do not originate from bone marrow-derived cells. PLoS One. 2012; 7(1):e30493. PMID: 22291966; PMCID: PMC3265477.
    16. Wang Y, Shi X, Qi J, Li X, Uray K, Guan X. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15; 302(2):G207-17. PMID: 22038824; PMCID: PMC3341113.
    17. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2011 Oct 1; 71(19):6106-15. PMID: 21844183.
      View in: PubMed
    18. Cai MY, Tong ZT, Zhu W, Wen ZZ, Rao HL, Kong LL, Guan XY, Kung HF, Zeng YX, Xie D. H3K27me3 protein is a promising predictive biomarker of patients' survival and chemoradioresistance in human nasopharyngeal carcinoma. Mol Med. 2011; 17(11-12):1137-45. PMID: 21738951; PMCID: PMC3321814.
    19. He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D. Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients. Int J Cancer. 2011 Jul 1; 129(1):143-50. PMID: 20830705.
      View in: PubMed
    20. Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL, Guan XY. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/?-catenin signalling pathway. Gut. 2011 Dec; 60(12):1635-43. PMID: 21672941.
      View in: PubMed
    21. Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut. 2011 Jul; 60(7):967-76. PMID: 21330577.
      View in: PubMed
    22. Shi X, Li X, Wang Y, Zhang K, Zhou F, Chan L, Li D, Guan X. Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway. Am J Physiol Endocrinol Metab. 2011 Mar; 300(3):E554-63. PMID: 21177288; PMCID: PMC3279303.
    23. Ma S, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng I, Man K, Wong N, To KF, Zheng BJ, Lai PB, Lo CM, Chan KW, Guan XY. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell. 2010 Dec 3; 7(6):694-707. PMID: 21112564.
      View in: PubMed
    24. Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J, Guan XY. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut. 2011 Apr; 60(4):534-43. PMID: 21068133.
      View in: PubMed
    25. Wang Y, Liu YH, Mai SJ, He LJ, Liao YJ, Deng HX, Guan XY, Zeng YX, Kung HF, Xie D. Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis. J Gastroenterol Hepatol. 2010 Jun; 25(6):1123-8. PMID: 20594228.
      View in: PubMed
    26. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism. 2010 Jul; 59(7):967-76. PMID: 20015518; PMCID: PMC2882509.
    27. Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010 Feb; 298(2):E156-66. PMID: 19920220; PMCID: PMC2822481.
    28. Chen L, Hu L, Chan TH, Tsao GS, Xie D, Huo KK, Fu L, Ma S, Zheng BJ, Guan XY. Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival. Hepatology. 2009 Jul; 50(1):122-9. PMID: 19441106.
      View in: PubMed
    29. Chow BH, Chua DT, Sham JS, Zhang MY, Chow LW, Bi J, Ma NF, Xie D, Loo WT, Fung JM, Fu L, Guan XY. Increased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumors. Proteomics Clin Appl. 2009 Jun; 3(6):654-62. PMID: 21136977.
      View in: PubMed
    30. Bi J, Lau SH, Hu L, Rao HL, Liu HB, Zhan WH, Chen G, Wen JM, Wang Q, Li B, Guan XY. Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer. Int J Cancer. 2009 Apr 1; 124(7):1587-93. PMID: 19117059.
      View in: PubMed
    31. Ma NF, Lau SH, Hu L, Xie D, Wu J, Yang J, Wang Y, Wu MC, Fung J, Bai X, Tzang CH, Fu L, Yang M, Su YA, Guan XY. COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res. 2008 Aug 15; 14(16):5061-8. PMID: 18698024.
      View in: PubMed
    32. Luo JH, Xie D, Liu MZ, Chen W, Liu YD, Wu GQ, Kung HF, Zeng YX, Guan XY. Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Int J Cancer. 2008 Jun 1; 122(11):2554-61. PMID: 18246597.
      View in: PubMed
    33. Janeczko MJ, Stoll B, Chang X, Guan X, Burrin DG. Extensive gut metabolism limits the intestinal absorption of excessive supplemental dietary glutamate loads in infant pigs. J Nutr. 2007 Nov; 137(11):2384-90. PMID: 17951474.
      View in: PubMed
    34. Lee TK, Poon RT, Wo JY, Ma S, Guan XY, Myers JN, Altevogt P, Yuen AP. Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res. 2007 Sep 15; 67(18):8800-9. PMID: 17875721.
      View in: PubMed
    35. Ma S, Guan XY, Lee TK, Chan KW. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol. 2007 Aug; 38(8):1201-6. PMID: 17442377.
      View in: PubMed
    36. Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology. 2007 Jun; 132(7):2542-56. PMID: 17570225.
      View in: PubMed
    37. Zhang Z, Xie D, Li X, Wong YC, Xin D, Guan XY, Chua CW, Leung SC, Na Y, Wang X. Significance of TWIST expression and its association with E-cadherin in bladder cancer. Hum Pathol. 2007 Apr; 38(4):598-606. PMID: 17258791.
      View in: PubMed
    38. Farmer C, Guan X, Trottier NL. Mammary arteriovenous differences of glucose, insulin, prolactin and IGF-I in lactating sows under different protein intake levels. Domest Anim Endocrinol. 2008 Jan; 34(1):54-62. PMID: 17118618.
      View in: PubMed
    39. Burrin DG, Stoll B, Guan X, Cui L, Chang X, Hadsell D. GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E281-91. PMID: 16954336.
      View in: PubMed
    40. Lee TK, Poon RT, Yuen AP, Man K, Yang ZF, Guan XY, Fan ST. Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. Clin Cancer Res. 2006 Sep 1; 12(17):5082-9. PMID: 16951224.
      View in: PubMed
    41. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.
      View in: PubMed
    42. Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Burrin DG, Tomé D. Postprandial intestinal and whole body nitrogen kinetics and distribution in piglets fed a single meal. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E436-46. PMID: 15507535.
      View in: PubMed
    43. Burrin DG, Stoll B, Guan X, Cui L, Chang X, Holst JJ. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets. Endocrinology. 2005 Jan; 146(1):22-32. PMID: 15486229.
      View in: PubMed
    44. Guan X, Bequette BJ, Ku PK, Tempelman RJ, Trottier NL. The amino acid need for milk synthesis is defined by the maximal uptake of plasma amino acids by porcine mammary glands. J Nutr. 2004 Sep; 134(9):2182-90. PMID: 15333702.
      View in: PubMed
    45. Niinikoski H, Stoll B, Guan X, Kansagra K, Lambert BD, Stephens J, Hartmann B, Holst JJ, Burrin DG. Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets. J Nutr. 2004 Jun; 134(6):1467-74. PMID: 15173413.
      View in: PubMed
    46. Wang T, Wang Y, Wu MC, Guan XY, Yin ZF. Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma. World J Gastroenterol. 2004 Feb 1; 10(3):356-60. PMID: 14760757; PMCID: PMC4724905.
    47. Wang Y, Lau SH, Sham JS, Wu MC, Wang T, Guan XY. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene. 2004 Jan 8; 23(1):142-8. PMID: 14712219.
      View in: PubMed
    48. Hu L, Lau SH, Tzang CH, Wen JM, Wang W, Xie D, Huang M, Wang Y, Wu MC, Huang JF, Zeng WF, Sham JS, Yang M, Guan XY. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene. 2004 Jan 8; 23(1):298-302. PMID: 14647434.
      View in: PubMed
    49. Burrin D, Guan X, Stoll B, Petersen YM, Sangild PT. Glucagon-like peptide 2: a key link between nutrition and intestinal adaptation in neonates? J Nutr. 2003 Nov; 133(11):3712-6. PMID: 14608101.
      View in: PubMed
    50. Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Tomé D, Burrin DG. Intestinal lysine metabolism is driven by the enteral availability of dietary lysine in piglets fed a bolus meal. Am J Physiol Endocrinol Metab. 2003 Dec; 285(6):E1246-57. PMID: 12851176.
      View in: PubMed
    51. Guan X, Stoll B, Lu X, Tappenden KA, Holst JJ, Hartmann B, Burrin DG. GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1. Gastroenterology. 2003 Jul; 125(1):136-47. PMID: 12851879.
      View in: PubMed
    52. Wang Y, Wu MC, Sham JS, Zhang W, Wu WQ, Guan XY. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer. 2002 Dec 1; 95(11):2346-52. PMID: 12436441.
      View in: PubMed
    53. Wang Y, Wu MC, Sham JS, Tai LS, Fang Y, Wu WQ, Xie D, Guan XY. Different expression of hepatitis B surface antigen between hepatocellular carcinoma and its surrounding liver tissue, studied using a tissue microarray. J Pathol. 2002 Aug; 197(5):610-6. PMID: 12210080.
      View in: PubMed
    54. Guan X, Bequette BJ, Calder G, Ku PK, Ames KN, Trottier NL. Amino acid availability affects amino acid flux and protein metabolism in the porcine mammary gland. J Nutr. 2002 Jun; 132(6):1224-34. PMID: 12042438.
      View in: PubMed
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