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JOSE MANUEL GARCIA

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleAdjunct Associate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology


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    I01CX000174     (GARCIA, JOSE M.)Apr 1, 2009 - Dec 31, 2014
    VA
    The Role of Ghrelin in Cancer Cachexia
    Role: Principal Investigator

    R21HD060870     (GARCIA, JOSE M.)Sep 3, 2009 - Aug 31, 2011
    NIH/NICHD
    The role of ghrelin in cisplatin-induced infertility
    Role: Principal Investigator

    I01BX000507     (GARCIA, JOSE M.)Oct 1, 2009 - Sep 30, 2013
    VA
    Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Role: Principal Investigator

    R03AG040583     (GARCIA, JOSE M.)Aug 15, 2011 - Jul 31, 2014
    NIH/NIA
    The role of ghrelin and the ghrelin receptor GHSR1a in sarcopenia of aging
    Role: Principal Investigator

    I01BX002807     (GARCIA, JOSE M.)Oct 1, 2015 - Sep 30, 2019
    VA
    Mechanisms of action of ghrelin in muscle and adipose tissue in cancer cachexia
    Role: Principal Investigator

    R01CA239208     (GARCIA, JOSE M.)May 8, 2019 - Apr 30, 2024
    NIH/NCI
    Improving Patient-Important Outcomes with Testosterone Replacement in Hypogonadal Men with a Prior History of Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. White DL, Oluyomi A, Royse K, Dong Y, Nguyen H, Chang E, Richardson P, Jiao L, Garcia JM, Kramer JR, Thrift AP, Chiao E. Incidence of AIDS-Related Kaposi Sarcoma in All 50 United States From 2000 to 2014. J Acquir Immune Defic Syndr. 2019 Aug 01; 81(4):387-394. PMID: 31242141.
      View in: PubMed
    2. Narsale A, Moya R, Ma J, Anderson LJ, Wu D, Garcia JM, Davies JD. Cancer-driven changes link T cell frequency to muscle strength in people with cancer: a pilot study. J Cachexia Sarcopenia Muscle. 2019 Apr 12. PMID: 30977974.
      View in: PubMed
    3. Lu L, Rong H, Wu C, Cui B, Huang Y, Tan Y, Zhang L, Peng Y, Garcia JM, Chen JA. Levels of phthalate acid esters and sex hormones and their possible sources in traffic-patrol policemen in Chongqing. Environ Sci Pollut Res Int. 2019 Mar; 26(9):9005-9013. PMID: 30715702.
      View in: PubMed
    4. Nguyen P, Valanejad L, Cast A, Wright M, Garcia JM, El-Serag HB, Karns R, Timchenko NA. Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPa-p300 Axis. Cell Rep. 2018 Aug 07; 24(6):1597-1609. PMID: 30089269.
      View in: PubMed
    5. Wang Z, White DL, Hoogeveen R, Chen L, Whitsel EA, Richardson PA, Virani SS, Garcia JM, El-Serag HB, Jiao L. Anti-Hypertensive Medication Use, Soluble Receptor for Glycation End Products and Risk of Pancreatic Cancer in the Women's Health Initiative Study. J Clin Med. 2018 Aug 02; 7(8). PMID: 30072610.
      View in: PubMed
    6. Garcia JM, Biller BMK, Korbonits M, Popovic V, Luger A, Strasburger CJ, Chanson P, Medic-Stojanoska M, Schopohl J, Zakrzewska A, Pekic S, Bolanowski M, Swerdloff R, Wang C, Blevins T, Marcelli M, Ammer N, Sachse R, Yuen KCJ. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 08 01; 103(8):3083-3093. PMID: 29860473.
      View in: PubMed
    7. Calarge CA, Mills JA, Karaviti L, Teixeira AL, Zemel BS, Garcia JM. Selective Serotonin Reuptake Inhibitors Reduce Longitudinal Growth in Risperidone-Treated Boys. J Pediatr. 2018 10; 201:245-251. PMID: 29958671.
      View in: PubMed
    8. Garcia JM, Shamliyan TA. Management of Opioid-Induced Constipation in Patients with Malignancy. Am J Med. 2018 Sep; 131(9):1041-1051.e3. PMID: 29621475.
      View in: PubMed
    9. Maldonado M, Molfese DL, Viswanath H, Curtis K, Jones A, Hayes TG, Marcelli M, Mediwala S, Baldwin P, Garcia JM, Salas R. The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study. J Cachexia Sarcopenia Muscle. 2018 06; 9(3):497-504. PMID: 29575771.
      View in: PubMed
    10. Garcia JM, Shamliyan TA. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun; 131(6):623-629.e1. PMID: 29784194.
      View in: PubMed
    11. Garcia JM, Shamliyan TA. Cannabinoids in Patients with Nausea and Vomiting Associated with Malignancy and Its Treatments. Am J Med. 2018 Jul; 131(7):755-759.e2. PMID: 29909841.
      View in: PubMed
    12. Garcia JM. What is next after anamorelin? Curr Opin Support Palliat Care. 2017 Dec; 11(4):266-271. PMID: 28957883.
      View in: PubMed
    13. Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG. Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia. Curr Opin Support Palliat Care. 2017 Dec; 11(4):278-286. PMID: 28957880.
      View in: PubMed
    14. Huang Y, Garcia JM, Shu W, Rong H, Zhang L, Wang Y, Tan Y, Lin H, Zeng H, Chen JA. Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy. Reprod Toxicol. 2018 01; 75:121-126. PMID: 29061543.
      View in: PubMed
    15. Guillory B, Jawanmardi N, Iakova P, Anderson B, Zang P, Timchenko NA, Garcia JM. Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBPa-p300/DGAT1 pathway. Aging Cell. 2018 02; 17(1). PMID: 29024407.
      View in: PubMed
    16. Graf SA, Garcia JM. Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome: design, development, and potential place in therapy. Drug Des Devel Ther. 2017; 11:2325-2331. PMID: 28848326.
      View in: PubMed
    17. Garcia JM, Shamliyan TA. Omega-3 Fatty Acids in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2017 10; 130(10):1151-1155. PMID: 29016347.
      View in: PubMed
    18. Anderson LJ, Tamayose JM, Garcia JM. Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. Mol Cell Endocrinol. 2018 03 15; 464:65-74. PMID: 28606865.
      View in: PubMed
    19. Guillory B, Chen JA, Patel S, Luo J, Splenser A, Mody A, Ding M, Baghaie S, Anderson B, Iankova B, Halder T, Hernandez Y, Garcia JM. Deletion of ghrelin prevents aging-associated obesity and muscle dysfunction without affecting longevity. Aging Cell. 2017 08; 16(4):859-869. PMID: 28585250.
      View in: PubMed
    20. Garcia JM, Shamliyan TA. Nonsteroidal Anti-Inflammatory Drugs in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2017 09; 130(9):1033-1036. PMID: 29016346.
      View in: PubMed
    21. Zhang G, Liu Z, Ding H, Miao H, Garcia JM, Li YP. Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. Sci Rep. 2017 05 23; 7(1):2273. PMID: 28536426.
      View in: PubMed
    22. Rong H, Cheng X, Garcia JM, Zhang L, Lu L, Fang J, Le M, Hu P, Dong X, Yang J, Wang Y, Luo T, Liu J, Chen JA. Survey of health literacy level and related influencing factors in military college students in Chongqing, China: A cross-sectional analysis. PLoS One. 2017; 12(5):e0177776. PMID: 28545133.
      View in: PubMed
    23. Anderson LJ, Albrecht ED, Garcia JM. Erratum to: Update on Management of Cancer-Related Cachexia. Curr Oncol Rep. 2017 03; 19(3):22. PMID: 28293870.
      View in: PubMed
    24. Anderson LJ, Albrecht ED, Garcia JM. Update on Management of Cancer-Related Cachexia. Curr Oncol Rep. 2017 Jan; 19(1):3. PMID: 28138933.
      View in: PubMed
    25. Anderson LJ, Liu H, Garcia JM. Sex Differences in Muscle Wasting. Adv Exp Med Biol. 2017; 1043:153-197. PMID: 29224095.
      View in: PubMed
    26. Erickson M, Braun K, List R, Utech A, Moore C, White DL, Garcia JM. Evaluation of US Veterans Nutrition Education for Diabetes Prevention. J Nutr Educ Behav. 2016 09; 48(8):538-543.e1. PMID: 27614279.
      View in: PubMed
    27. Mason MC, Garcia JM, Sansgiry S, Walder A, Berger DH, Anaya DA. Preoperative cancer cachexia and short-term outcomes following surgery. J Surg Res. 2016 10; 205(2):398-406. PMID: 27664889.
      View in: PubMed
    28. Braun K, Erickson M, Utech A, List R, Garcia JM. Evaluation of Veterans MOVE! Program for Weight Loss. J Nutr Educ Behav. 2016 05; 48(5):299-303.e1. PMID: 27169639.
      View in: PubMed
    29. He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12; 23(4):610-21. PMID: 27076076.
      View in: PubMed
    30. Mody A, White D, Kanwal F, Garcia JM. Relevance of low testosterone to non-alcoholic fatty liver disease. Cardiovasc Endocrinol. 2015 Sep 01; 4(3):83-89. PMID: 26405614.
      View in: PubMed
    31. Garcia JM, Chen JA, Guillory B, Donehower LA, Smith RG, Lamb DJ. Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice. Biol Reprod. 2015 Jul; 93(1):24. PMID: 26019260.
      View in: PubMed
    32. Zhang H, Garcia JM. Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC. Expert Opin Pharmacother. 2015 Jun; 16(8):1245-53. PMID: 25945893.
      View in: PubMed
    33. Lerner L, Hayes TG, Tao N, Krieger B, Feng B, Wu Z, Nicoletti R, Chiu MI, Gyuris J, Garcia JM. Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients. J Cachexia Sarcopenia Muscle. 2015 Dec; 6(4):317-24. PMID: 26672741.
      View in: PubMed
    34. Chen JA, Splenser A, Guillory B, Luo J, Mendiratta M, Belinova B, Halder T, Zhang G, Li YP, Garcia JM. Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved. J Cachexia Sarcopenia Muscle. 2015 Jun; 6(2):132-43. PMID: 26136189.
      View in: PubMed
    35. Whirledge SD, Garcia JM, Smith RG, Lamb DJ. Ghrelin partially protects against cisplatin-induced male murine gonadal toxicity in a GHSR-1a-dependent manner. Biol Reprod. 2015 Mar; 92(3):76. PMID: 25631345.
      View in: PubMed
    36. Garcia JM, Boccia RV, Graham CD, Yan Y, Duus EM, Allen S, Friend J. Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncol. 2015 Jan; 16(1):108-16. PMID: 25524795.
      View in: PubMed
    37. Casal RF, Phan MN, Keshava K, Garcia JM, Grosu H, Lazarus DR, Iribarren J, Rosen DG. The use of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of thyroid lesions. BMC Endocr Disord. 2014 Nov 22; 14:88. PMID: 25416021.
      View in: PubMed
    38. White DL, Liu Y, Garcia J, El-Serag HB, Jiao L, Tsavachidis S, Franco LM, Lee JS, Tavakoli-Tabasi S, Moore D, Goldman R, Kuzniarek J, Ramsey DJ, Kanwal F, Marcelli M. Sex hormone pathway gene polymorphisms are associated with risk of advanced hepatitis C-related liver disease in males. Int J Mol Epidemiol Genet. 2014; 5(3):164-76. PMID: 25379136.
      View in: PubMed
    39. Agrawal V, Garcia JM. The macimorelin-stimulated growth hormone test for adult growth hormone deficiency diagnosis. Expert Rev Mol Diagn. 2014 Jul; 14(6):647-54. PMID: 24834478.
      View in: PubMed
    40. Ali S, Garcia JM. Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review. Gerontology. 2014; 60(4):294-305. PMID: 24731978.
      View in: PubMed
    41. Mathur S, Boparai J, Mediwala SN, Garcia JM, Cunningham GR, Marcelli M, Vasudevan MM. Reversible Adrenal Insufficiency in Three Patients With Post-Roux-en-Y Gastric Bypass Noninsulinoma Pancreatogenous Hypoglycemia Syndrome. J Investig Med High Impact Case Rep. 2014 Jan-Mar; 2(1):2324709614526992. PMID: 26425596.
      View in: PubMed
    42. Huang Y, Li J, Garcia JM, Lin H, Wang Y, Yan P, Wang L, Tan Y, Luo J, Qiu Z, Chen JA, Shu W. Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women. PLoS One. 2014; 9(2):e87430. PMID: 24503621.
      View in: PubMed
    43. Thrift AP, Garcia JM, El-Serag HB. A multibiomarker risk score helps predict risk for Barrett's esophagus. Clin Gastroenterol Hepatol. 2014 Aug; 12(8):1267-71. PMID: 24362047.
      View in: PubMed
    44. Ali S, Chen JA, Garcia JM. Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment. Curr Opin Support Palliat Care. 2013 Dec; 7(4):368-75. PMID: 24145681.
      View in: PubMed
    45. Engineer DR, Burney BO, Hayes TG, Garcia JM. Exposure to ACEI/ARB and ß-Blockers Is Associated with Improved Survival and Decreased Tumor Progression and Hospitalizations in Patients with Advanced Colon Cancer. Transl Oncol. 2013; 6(5):539-45. PMID: 24151534.
      View in: PubMed
    46. Garcia JM, Splenser AE, Kramer J, Alsarraj A, Fitzgerald S, Ramsey D, El-Serag HB. Circulating inflammatory cytokines and adipokines are associated with increased risk of Barrett's esophagus: a case-control study. Clin Gastroenterol Hepatol. 2014 Feb; 12(2):229-238.e3. PMID: 23954649.
      View in: PubMed
    47. Garcia JM, Scherer T, Chen JA, Guillory B, Nassif A, Papusha V, Smiechowska J, Asnicar M, Buettner C, Smith RG. Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Endocrinology. 2013 Sep; 154(9):3118-29. PMID: 23832960.
      View in: PubMed
    48. Garcia JM, Swerdloff R, Wang C, Kyle M, Kipnes M, Biller BM, Cook D, Yuen KC, Bonert V, Dobs A, Molitch ME, Merriam GR. Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab. 2013 Jun; 98(6):2422-9. PMID: 23559086.
      View in: PubMed
    49. El-Serag HB, Hashmi A, Garcia J, Richardson P, Alsarraj A, Fitzgerald S, Vela M, Shaib Y, Abraham NS, Velez M, Cole R, Rodriguez MB, Anand B, Graham DY, Kramer JR. Visceral abdominal obesity measured by CT scan is associated with an increased risk of Barrett's oesophagus: a case-control study. Gut. 2014 Feb; 63(2):220-9. PMID: 23408348.
      View in: PubMed
    50. Guillory B, Splenser A, Garcia J. The role of ghrelin in anorexia-cachexia syndromes. Vitam Horm. 2013; 92:61-106. PMID: 23601421.
      View in: PubMed
    51. Garcia JM, Friend J, Allen S. Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study. Support Care Cancer. 2013 Jan; 21(1):129-37. PMID: 22699302.
      View in: PubMed
    52. Utech AE, Tadros EM, Hayes TG, Garcia JM. Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers. J Cachexia Sarcopenia Muscle. 2012 Dec; 3(4):245-51. PMID: 22648739.
      View in: PubMed
    53. Burney BO, Garcia JM. Hypogonadism in male cancer patients. J Cachexia Sarcopenia Muscle. 2012 Sep; 3(3):149-55. PMID: 22528986.
      View in: PubMed
    54. Burney BO, Hayes TG, Smiechowska J, Cardwell G, Papusha V, Bhargava P, Konda B, Auchus RJ, Garcia JM. Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. J Clin Endocrinol Metab. 2012 May; 97(5):E700-9. PMID: 22419719.
      View in: PubMed
    55. Engineer DR, Garcia JM. Leptin in anorexia and cachexia syndrome. Int J Pept. 2012; 2012:287457. PMID: 22518191.
      View in: PubMed
    56. Garcia JM, Sharafkhaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh A. Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res. 2011 Jun 15; 12(1):80. PMID: 21676224.
      View in: PubMed
    57. Smiechowska J, Utech A, Taffet G, Hayes T, Marcelli M, Garcia JM. Adipokines in patients with cancer anorexia and cachexia. J Investig Med. 2010 Mar; 58(3):554-9. PMID: 20215915.
      View in: PubMed
    58. Sun Y, Butte NF, Garcia JM, Smith RG. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology. 2008 Feb; 149(2):843-50. PMID: 18006636.
      View in: PubMed
    59. Garcia JM, Cata JP, Dougherty PM, Smith RG. Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology. 2008 Feb; 149(2):455-60. PMID: 17962345.
      View in: PubMed
    60. Garcia JM, Polvino WJ. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist. 2007 May; 12(5):594-600. PMID: 17522248.
      View in: PubMed
    61. Sun Y, Garcia JM, Smith RG. Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology. 2007 Mar; 148(3):1323-9. PMID: 17158206.
      View in: PubMed
    62. Garcia JM, Iyer D, Poston WS, Marcelli M, Reeves R, Foreyt J, Balasubramanyam A. Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. Obesity (Silver Spring). 2006 Oct; 14(10):1716-23. PMID: 17062800.
      View in: PubMed
    63. Garcia JM, Garcia V, Silva J, Peña C, Dominguez G, Sanchez A, Sanfrutos L, Provencio M, Millan I, Chaparro D, España P, Bonilla F. Extracellular tumor DNA in plasma and overall survival in breast cancer patients. Genes Chromosomes Cancer. 2006 Jul; 45(7):692-701. PMID: 16607614.
      View in: PubMed
    64. Garcia JM, Li H, Mann D, Epner D, Hayes TG, Marcelli M, Cunningham GR. Hypogonadism in male patients with cancer. Cancer. 2006 Jun 15; 106(12):2583-91. PMID: 16688773.
      View in: PubMed
    65. Silva JM, Silva J, Sanchez A, Garcia JM, Dominguez G, Provencio M, Sanfrutos L, Jareño E, Colas A, España P, Bonilla F. Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival. Clin Cancer Res. 2002 Dec; 8(12):3761-6. PMID: 12473587.
      View in: PubMed
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