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BUFORD L NICHOLS JR

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
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    N01HD022814     (NICHOLS, BUFORD L)Jun 1, 1982 - May 31, 1986
    NIH/NICHD
    CLINICAL STUDIES ON HUMAN MILK
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nichols BL. 90th Anniversary Commentary: Malnutrition Affects Cellular Growth and Competency; Propositions by Myron Winick. J Nutr. 2018 10 01; 148(10):1650-1651. PMID: 30281111.
      View in: PubMed
    2. Nichols B, Klish WJ. Complementary Starch Feeding of the Young Child: Starch Digestion Consortium Workshop 18. J Pediatr Gastroenterol Nutr. 2018 06; 66 Suppl 3:S1-S3. PMID: 29762366.
      View in: PubMed
    3. Chumpitazi BP, Robayo-Torres CC, Tsai CM, Opekun AR, Baker SS, Nichols BL, Gilger MA. Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. J Pediatr Gastroenterol Nutr. 2018 Jun; 66 Suppl 3:S52-S55. PMID: 29762379.
      View in: PubMed
    4. Nichols BL, Baker SS, Quezada-Calvillo R. Metabolic Impacts of Maltase Deficiencies. J Pediatr Gastroenterol Nutr. 2018 06; 66 Suppl 3:S24-S29. PMID: 29762372.
      View in: PubMed
    5. Robayo-Torres CC, Diaz-Sotomayor M, Hamaker BR, Baker SS, Chumpitazi BP, Opekun AR, Nichols BL. 13C-Labeled-Starch Breath Test in Congenital Sucrase-isomaltase Deficiency. J Pediatr Gastroenterol Nutr. 2018 Jun; 66 Suppl 3:S61-S64. PMID: 29762381.
      View in: PubMed
    6. Chegeni M, Amiri M, Nichols BL, Naim HY, Hamaker BR. Dietary starch breakdown product sensing mobilizes and apically activates a-glucosidases in small intestinal enterocytes. FASEB J. 2018 07; 32(7):3903-3911. PMID: 29465310.
      View in: PubMed
    7. Cisse F, Erickson DP, Hayes AMR, Opekun AR, Nichols BL, Hamaker BR. Traditional Malian Solid Foods Made from Sorghum and Millet Have Markedly Slower Gastric Emptying than Rice, Potato, or Pasta. Nutrients. 2018 Jan 26; 10(2). PMID: 29373493.
      View in: PubMed
    8. Nichols BL, Avery SE, Quezada-Calvillo R, Kilani SB, Lin AH, Burrin DG, Hodges BE, Chacko SK, Opekun AR, Hindawy ME, Hamaker BR, Oda SI. Improved Starch Digestion of Sucrase-deficient Shrews Treated With Oral Glucoamylase Enzyme Supplements. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):e35-e42. PMID: 28267073.
      View in: PubMed
    9. Simsek M, Quezada-Calvillo R, Nichols BL, Hamaker BR. Phenolic compounds increase the transcription of mouse intestinal maltase-glucoamylase and sucrase-isomaltase. Food Funct. 2017 May 24; 8(5):1915-1924. PMID: 28443839.
      View in: PubMed
    10. Naim HY, Zimmer KP, Nichols B. Molecular biology of the gut. Mol Cell Pediatr. 2016 Dec; 3(1):32. PMID: 27518572.
      View in: PubMed
    11. Lee BH, Rose DR, Lin AH, Quezada-Calvillo R, Nichols BL, Hamaker BR. Contribution of the Individual Small Intestinal a-Glucosidases to Digestion of Unusual a-Linked Glycemic Disaccharides. J Agric Food Chem. 2016 Aug 24; 64(33):6487-94. PMID: 27480812.
      View in: PubMed
    12. Sukumaran SK, Yee KK, Iwata S, Kotha R, Quezada-Calvillo R, Nichols BL, Mohan S, Pinto BM, Shigemura N, Ninomiya Y, Margolskee RF. Taste cell-expressed a-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6035-40. PMID: 27162343.
      View in: PubMed
    13. Simsek M, Quezada-Calvillo R, Ferruzzi MG, Nichols BL, Hamaker BR. Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release. J Agric Food Chem. 2015 Apr 22; 63(15):3873-9. PMID: 25816913.
      View in: PubMed
    14. Lin AH, Ao Z, Quezada-Calvillo R, Nichols BL, Lin CT, Hamaker BR. Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase. Carbohydr Polym. 2014 Oct 13; 111:33-40. PMID: 25037326.
      View in: PubMed
    15. Lee BH, Lin AH, Nichols BL, Jones K, Rose DR, Quezada-Calvillo R, Hamaker BR. Mucosal C-terminal maltase-glucoamylase hydrolyzes large size starch digestion products that may contribute to rapid postprandial glucose generation. Mol Nutr Food Res. 2014 May; 58(5):1111-21. PMID: 24442968.
      View in: PubMed
    16. Cheng MW, Chegeni M, Kim KH, Zhang G, Benmoussa M, Quezada-Calvillo R, Nichols BL, Hamaker BR. Different sucrose-isomaltase response of Caco-2 cells to glucose and maltose suggests dietary maltose sensing. J Clin Biochem Nutr. 2014 Jan; 54(1):55-60. PMID: 24426192.
      View in: PubMed
    17. Diaz-Sotomayor M, Quezada-Calvillo R, Avery SE, Chacko SK, Yan LK, Lin AH, Ao ZH, Hamaker BR, Nichols BL. Maltase-glucoamylase modulates gluconeogenesis and sucrase-isomaltase dominates starch digestion glucogenesis. J Pediatr Gastroenterol Nutr. 2013 Dec; 57(6):704-12. PMID: 23838818.
      View in: PubMed
    18. Lee BH, Yan L, Phillips RJ, Reuhs BL, Jones K, Rose DR, Nichols BL, Quezada-Calvillo R, Yoo SH, Hamaker BR. Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal a-glucosidase level and are slowly digestible in vivo. PLoS One. 2013; 8(4):e59745. PMID: 23565164.
      View in: PubMed
    19. Ubelmann F, Chamaillard M, El-Marjou F, Simon A, Netter J, Vignjevic D, Nichols BL, Quezada-Calvillo R, Grandjean T, Louvard D, Revenu C, Robine S. Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):E1380-9. PMID: 23520048.
      View in: PubMed
    20. Lin AH, Hamaker BR, Nichols BL. Direct starch digestion by sucrase-isomaltase and maltase-glucoamylase. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S43-5. PMID: 23103656.
      View in: PubMed
    21. Robayo-Torres CC, Baker SS, Chumpitazi BP, Lecea CE, Nichols BL, Opekun AR. Poor starch digestion in children with CSID and recurrent abdominal pain. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S32-4. PMID: 23103649.
      View in: PubMed
    22. Nichols BL, Adams B, Roach CM, Ma CX, Baker SS. Frequency of sucrase deficiency in mucosal biopsies. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S28-30. PMID: 23103647.
      View in: PubMed
    23. Ao Z, Quezada-Calvillo R, Nichols BL, Rose DR, Sterchi EE, Hamaker BR. The nature of raw starch digestion. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S42-3. PMID: 23103655.
      View in: PubMed
    24. Chumpitazi BP, Robayo-Torres CC, Opekun AR, Nichols BL, Naim HY. Congenital sucrase-isomaltase deficiency: summary of an evaluation in one family. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S36. PMID: 23103651.
      View in: PubMed
    25. Gilger M, Hamaker B, Nichols BL, Auricchio S, Treem WR, Naim HY, Heine M, Zimmer KP, Jones K, Eskandari R, Pinto BM, Rose DR, Lee BH, Quezada-Calvillo R, Adams B, Roach CM, Ma CX, Baker SS, Slawson MH, Robayo-Torres CC, Chumpitazi BP, Lecea CE, Opekun AR, Uhrich S, Wu Z, Huang JY, Scott CR, Chumpitazi BP, McMeans AR, Scholz D, Shulman RJ, Ao Z, Sterchi EE, Lin AH. Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S1. PMID: 23103641.
      View in: PubMed
    26. Lee BH, Quezada-Calvillo R, Nichols BL, Rose DR, Hamaker BR. Inhibition of maltase-glucoamylase activity to hydrolyze a-1,4 linkages by the presence of undigested sucrose. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S45-7. PMID: 23103657.
      View in: PubMed
    27. Nichols BL, Auricchio S. 50 years of progress since congenital sucrase-isomaltase deficiency recognition. J Pediatr Gastroenterol Nutr. 2012 Nov; 55 Suppl 2:S2-7. PMID: 23103644.
      View in: PubMed
    28. Lin AH, Lee BH, Nichols BL, Quezada-Calvillo R, Rose DR, Naim HY, Hamaker BR. Starch source influences dietary glucose generation at the mucosal a-glucosidase level. J Biol Chem. 2012 Oct 26; 287(44):36917-21. PMID: 22988246.
      View in: PubMed
    29. Lee BH, Eskandari R, Jones K, Reddy KR, Quezada-Calvillo R, Nichols BL, Rose DR, Hamaker BR, Pinto BM. Modulation of starch digestion for slow glucose release through "toggling" of activities of mucosal a-glucosidases. J Biol Chem. 2012 Sep 14; 287(38):31929-38. PMID: 22851177.
      View in: PubMed
    30. Lin AH, Nichols BL, Quezada-Calvillo R, Avery SE, Sim L, Rose DR, Naim HY, Hamaker BR. Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal a-glucosidase subunit. PLoS One. 2012; 7(5):e35473. PMID: 22563462.
      View in: PubMed
    31. Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM, Rose DR. Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. Bioorg Med Chem. 2011 Jul 01; 19(13):3929-34. PMID: 21669536.
      View in: PubMed
    32. Nichols BL. Samuel J. Fomon, MD: Champion of growth. J Nutr. 2011 Apr 01; 141(4):545-7. PMID: 21367938.
      View in: PubMed
    33. Robayo-Torres CC, Opekun AR, Quezada-Calvillo R, Villa X, Smith EO, Navarrete M, Baker SS, Nichols BL. 13C-breath tests for sucrose digestion in congenital sucrase isomaltase-deficient and sacrosidase-supplemented patients. J Pediatr Gastroenterol Nutr. 2009 Apr; 48(4):412-8. PMID: 19330928.
      View in: PubMed
    34. Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Butte NF, Marini J, Jahoor F, Sterchi EE. Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice. J Nutr. 2009 Apr; 139(4):684-90. PMID: 19193815.
      View in: PubMed
    35. Nichols BL. Establishment of the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine and Texas Children's Hospital in 1978. J Nutr. 2009 Jan; 139(1):188-91. PMID: 19056811.
      View in: PubMed
    36. Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL. Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. J Nutr. 2008 Apr; 138(4):685-92. PMID: 18356321.
      View in: PubMed
    37. Sim L, Quezada-Calvillo R, Sterchi EE, Nichols BL, Rose DR. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. J Mol Biol. 2008 Jan 18; 375(3):782-92. PMID: 18036614.
      View in: PubMed
    38. Nichols BL. Indicators of normal carbohydrate digestion in children. J Pediatr Gastroenterol Nutr. 2007 Aug; 45(2):176-7. PMID: 17667711.
      View in: PubMed
    39. Quezada-Calvillo R, Robayo-Torres CC, Opekun AR, Sen P, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Wattler S, Nehls MC, Sterchi EE, Nichols BL. Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis. J Nutr. 2007 Jul; 137(7):1725-33. PMID: 17585022.
      View in: PubMed
    40. Quezada-Calvillo R, Robayo-Torres CC, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Baker SS, Nichols BL. Luminal substrate "brake" on mucosal maltase-glucoamylase activity regulates total rate of starch digestion to glucose. J Pediatr Gastroenterol Nutr. 2007 Jul; 45(1):32-43. PMID: 17592362.
      View in: PubMed
    41. Ao Z, Quezada-Calvillo R, Sim L, Nichols BL, Rose DR, Sterchi EE, Hamaker BR. Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant). FEBS Lett. 2007 May 29; 581(13):2381-8. PMID: 17485087.
      View in: PubMed
    42. Robayo-Torres CC, Nichols BL. Molecular differentiation of congenital lactase deficiency from adult-type hypolactasia. Nutr Rev. 2007 Feb; 65(2):95-8. PMID: 17345962.
      View in: PubMed
    43. Rossi EJ, Sim L, Kuntz DA, Hahn D, Johnston BD, Ghavami A, Szczepina MG, Kumar NS, Sterchi EE, Nichols BL, Pinto BM, Rose DR. Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives. FEBS J. 2006 Jun; 273(12):2673-83. PMID: 16817895.
      View in: PubMed
    44. Robayo-Torres CC, Quezada-Calvillo R, Nichols BL. Disaccharide digestion: clinical and molecular aspects. Clin Gastroenterol Hepatol. 2006 Mar; 4(3):276-87. PMID: 16527688.
      View in: PubMed
    45. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.
      View in: PubMed
    46. Nichols BL. Icie Macy and Elsie Widdowson: pioneers of child nutrition and growth. J Nutr. 2003 Nov; 133(11):3690-2. PMID: 14608096.
      View in: PubMed
    47. Nichols BL. The Shwachman Award of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition 2002: acceptance. Dietary management of the malnourished child with chronic diarrhea: both nurture and nature. J Pediatr Gastroenterol Nutr. 2003 Feb; 36(2):168-9. PMID: 12548049.
      View in: PubMed
    48. Nichols BL, Avery S, Sen P, Swallow DM, Hahn D, Sterchi E. The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1432-7. PMID: 12547908.
      View in: PubMed
    49. Karnsakul W, Luginbuehl U, Hahn D, Sterchi E, Avery S, Sen P, Swallow D, Nichols B. Disaccharidase activities in dyspeptic children: biochemical and molecular investigations of maltase-glucoamylase activity. J Pediatr Gastroenterol Nutr. 2002 Oct; 35(4):551-6. PMID: 12394383.
      View in: PubMed
    50. Nichols BL, Avery SE, Karnsakul W, Jahoor F, Sen P, Swallow DM, Luginbuehl U, Hahn D, Sterchi EE. Congenital maltase-glucoamylase deficiency associated with lactase and sucrase deficiencies. J Pediatr Gastroenterol Nutr. 2002 Oct; 35(4):573-9. PMID: 12394387.
      View in: PubMed
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