Dr. George P. Noon has focused his surgical career in organ transplantation and cardiac assist devices. In 1968, Dr. Noon, Dr. Michael E. DeBakey, and their surgical team performed their first heart and later lung transplant. The program was discontinued because worldwide results were discouraging. When the immunosuppressant cyclosporine became available in 1986, Drs. Noon and DeBakey restarted the transplant program.

It was crucial for the surgical team to provide mechanical ventricular assistance for patients with heart failure. Dr. Noon became the primary surgeon for the insertion of ventricular assist devices. In 1988, Drs. Noon and DeBakey met with engineers from NASA to develop a miniature axial flow blood pump. Ten years later, Dr. Noon participated in the care of President Boris Yeltsin, who needed a coronary bypass operation. In the same year, the first MicroMed DeBakey-Noon human implants were performed in Berlin, Germany. In 1999, Dr. Noon was inducted into the Space Technology Hall of Fame.

Dr. Noon is a member of multiple societies, has been invited as a guest lecturer and surgeon throughout the world, and has authored more than 350 publications. He is internationally known and respected for his pioneering research and clinical expertise in transplantation and assist devices.