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KATHRYN JONES

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


    Collapse Biography 
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    2019Norton Rose Fulbright Faculty Excellence Award, Baylor College of Medicine

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mancino C, Pollet J, Zinger A, Jones KM, Villar MJ, Leao AC, Adhikari R, Versteeg L, Tyagi Kundu R, Strych U, Giordano F, Hotez PJ, Bottazzi ME, Taraballi F, Poveda C. Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease. ACS Appl Mater Interfaces. 2024 Apr 03; 16(13):15832-15846. PMID: 38518375; PMCID: PMC10996878.
      Citations: 2     Fields:    Translation:Animals
    2. Qian Q, Wu H, Hayon J, Lupo S, Poveda C, Jones KM, Giordano TP, Fleischmann CJ, Bern C, Whitman JD, Clark EH. Adaptation of Chagas Disease Screening Recommendations for a Community of At-risk HIV in the United States. Clin Infect Dis. 2024 02 17; 78(2):453-456. PMID: 37805935.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2023 Nov; 17(11):e0011519. PMID: 37988389; PMCID: PMC10697595.
      Citations:    Fields:    Translation:Animals
    4. Liu Z, Ulrich vonBargen R, Kendricks AL, Wheeler K, Le?o AC, Sankaranarayanan K, Dean DA, Kane SS, Hossain E, Pollet J, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease. Nat Commun. 2023 10 25; 14(1):6769. PMID: 37880260; PMCID: PMC10600178.
      Citations: 3     Fields:    Translation:Animals
    5. Jones KM, Zhan B, Ernste KJ, Villar MJ, Bisht N, Nguyen D, Chang LY, Poveda C, Robinson GJ, Trivedi AJ, Hofferek CJ, Decker WK, Konduri V. Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection. Front Parasitol. 2023; 2. PMID: 38239430; PMCID: PMC10795693.
      Citations:    
    6. Cl?maco MC, de Figueiredo LA, Lucas RC, Pinheiro GRG, Dias Magalh?es LM, Oliveira ALG, Almeida RM, Barbosa FS, Castanheira Bartholomeu D, Bueno LL, Mendes TA, Zhan B, Jones KM, Hotez P, Bottazzi ME, Oliveira FMS, Fujiwara RT. Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis. Vaccine. 2023 08 23; 41(37):5400-5411. PMID: 37479612.
      Citations:    Fields:    Translation:HumansAnimals
    7. Poveda C, Mancino C, Taraballi F, Chen YL, Adhikari R, Villar MJ, Kundu R, Nguyen DM, Versteeg L, Strych U, Hotez PJ, Bottazzi ME, Pollet J, Jones KM, Le?o AC. Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells. Curr Res Immunol. 2023; 4:100066. PMID: 37534309; PMCID: PMC10393535.
      Citations: 1     
    8. MatRahim NA, Jones KM, Keegan BP, Strych U, Zhan B, Lee HY, AbuBakar S. TonB-Dependent Receptor Protein Displayed on Spores of Bacillus subtilis Stimulates Protective Immune Responses against Acinetobacter baumannii. Vaccines (Basel). 2023 Jun 16; 11(6). PMID: 37376495; PMCID: PMC10302887.
      Citations:    
    9. Casta?eda S, Mu?oz M, Hotez PJ, Bottazzi ME, Paniz-Mondolfi AE, Jones KM, Mejia R, Poveda C, Ram?rez JD. Microbiome Alterations Driven by Trypanosoma cruzi Infection in Two Disjunctive Murine Models. Microbiol Spectr. 2023 06 15; 11(3):e0019923. PMID: 37140369; PMCID: PMC10269900.
      Citations:    Fields:    Translation:Animals
    10. Teh-Poot CF, Dzul-Huchim VM, Mercado JM, Villanueva-Lizama LE, Bottazzi ME, Jones KM, Tsai FTF, Cruz-Chan JV. A short-term method to evaluate anti-leishmania drugs by inhibition of stage differentiation in Leishmania mexicana using flow cytometry. Exp Parasitol. 2023 Jun; 249:108519. PMID: 37004860; PMCID: PMC10231665.
      Citations:    Fields:    Translation:HumansAnimals
    11. Jones KM, Mangin EN, Reynolds CL, Villanueva LE, Cruz JV, Versteeg L, Keegan B, Kendricks A, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ. Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease. Front Cell Infect Microbiol. 2023; 13:1106315. PMID: 36844399; PMCID: PMC9947347.
      Citations: 1     Fields:    Translation:Animals
    12. Chen WH, Pollet J, Asojo O, Jones KM, Hotez PJ, Elena Bottazzi M, Gonz?lez-L?pez C, Alfaro-Chac?n A, Villanueva-Lizama LE, Rosado-Vallado M, Ramirez-Sierra MJ, Teh-Poot CF, Cruz-Chan JV. A novel multi-epitope recombinant protein elicits an antigen-specific CD8+?T cells response in Trypanosoma cruzi-infected mice. Vaccine. 2022 10 26; 40(45):6445-6449. PMID: 36184402.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Jones KM, Poveda C, Versteeg L, Bottazzi ME, Hotez PJ. Preclinical advances and the immunophysiology of a new therapeutic Chagas disease vaccine. Expert Rev Vaccines. 2022 09; 21(9):1185-1203. PMID: 35735065.
      Citations:    Fields:    
    14. Wei J, Hegde VL, Yanamandra AV, O'Hara MP, Keegan B, Jones KM, Strych U, Bottazzi ME, Zhan B, Sastry KJ, Hotez PJ. Mucosal Vaccination With Recombinant Tm-WAP49 Protein Induces Protective Humoral and Cellular Immunity Against Experimental Trichuriasis in AKR Mice. Front Immunol. 2022; 13:800295. PMID: 35197976; PMCID: PMC8859434.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    15. Versteeg L, Adhikari R, Poveda C, Villar-Mondragon MJ, Jones KM, Hotez PJ, Bottazzi ME, Tijhaar E, Pollet J. Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi. PLoS Negl Trop Dis. 2021 09; 15(9):e0009689. PMID: 34478444; PMCID: PMC8415617.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:708325. PMID: 34504808; PMCID: PMC8421853.
      Citations: 1     Fields:    Translation:Animals
    17. Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. ACS Infect Dis. 2021 06 11; 7(6):1638-1649. PMID: 33843195; PMCID: PMC8588157.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Messenger LA, Lewis MD, Yeo M, Bartholomeu DC, Gorchakov R, Jones K, Nolan MS, Bottazzi ME, Hotez PJ, Murray KO, Burleigh B, Miles MA, Talavera-L?pez C, Reis-Cunha JL, Matos GM, Calzada JE, Salda?a A, Ram?rez JD, Guhl F, Oca?a-Mayorga S, Costales JA, Teixeira SMR, Carrasco HJ, Grijalva MJ, Grisard EC, Andersson B. Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen,?Trypanosoma cruzi. Front Cell Infect Microbiol. 2021; 11:614665. PMID: 33747978; PMCID: PMC7966520.
      Citations: 11     Fields:    Translation:Animals
    19. Cruz-Chan JV, Villanueva-Lizama LE, Versteeg L, Damania A, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM, Villar MJ, Gonz?lez-L?pez C. Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection. Sci Rep. 2021 02 05; 11(1):3222. PMID: 33547365; PMCID: PMC7865072.
      Citations: 4     Fields:    Translation:Animals
    20. Poveda C, Bottazzi ME, Jones KM. Mining the Metabolome for New and Innovative Chagas Disease Treatments. Trends Pharmacol Sci. 2021 01; 42(1):1-3. PMID: 33248705.
      Citations: 1     Fields:    Translation:HumansAnimals
    21. Villanueva-Lizama LE, Cruz-Chan JV, Versteeg L, Hoffman K, Kendricks A, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM, Teh-Poot CF. TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens. Parasite Immunol. 2020 10; 42(10):e12769. PMID: 32592180.
      Citations: 7     Fields:    Translation:Animals
    22. Kendricks AL, Gray SB, Wilkerson GK, Sands CM, Abee CR, Bernacky BJ, Hotez PJ, Bottazzi ME, Craig SL, Jones KM. Reproductive Outcomes in Rhesus Macaques (Macaca mulatta) with Naturally-acquired Trypanosoma cruzi Infection. Comp Med. 2020 04 01; 70(2):152-159. PMID: 32183928; PMCID: PMC7137543.
      Citations:    Fields:    Translation:Animals
    23. Versteeg L, Wei J, Liu Z, Keegan B, Fujiwara RT, Jones KM, Asojo O, Strych U, Bottazzi ME, Hotez PJ, Zhan B. Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLoS Negl Trop Dis. 2020 02; 14(2):e0008057. PMID: 32053593; PMCID: PMC7017989.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    24. Hoffman KA, Reynolds C, Bottazzi ME, Hotez P, Jones K. Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. J Am Heart Assoc. 2019 11 19; 8(22):e013365. PMID: 31718442; PMCID: PMC6915297.
      Citations: 5     Fields:    Translation:AnimalsCells
    25. Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413. PMID: 31145733; PMCID: PMC6542517.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC, Gazzinelli-Guimar?es PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT. IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection. Front Immunol. 2018; 9:2535. PMID: 30473693; PMCID: PMC6238660.
      Citations: 17     Fields:    Translation:AnimalsPHPublic Health
    27. Gunter SM, Versteeg L, Jones KM, Keegan BP, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Covalent vaccination with Trypanosoma cruzi Tc24 induces catalytic antibody production. Parasite Immunol. 2018 Nov; 40(11):e12585. PMID: 30132929.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Jones K, Versteeg L, Damania A, Keegan B, Kendricks A, Pollet J, Cruz-Chan JV, Gusovsky F, Hotez PJ, Bottazzi ME. Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease. Infect Immun. 2018 04; 86(4). PMID: 29311242; PMCID: PMC5865041.
      Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    29. Jones K, Hotez P, Bottazzi ME, Villanueva-Lizama LE, Cruz-Chan JV, Aguilar-Cetina ADC, Herrera-Sanchez LF, Rodriguez-Perez JM, Rosado-Vallado ME, Ramirez-Sierra MJ, Ortega-Lopez J, Dumonteil E. Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico. PLoS Negl Trop Dis. 2018 01; 12(1):e0006240. PMID: 29377898; PMCID: PMC5805372.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    30. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032; PMCID: PMC5563592.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Wei J, Versteeg L, Liu Z, Keegan B, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769. PMID: 28708895; PMCID: PMC5529013.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583. PMID: 28581897.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    33. Garcia MN, O'Day S, Fisher-Hoch S, Gorchakov R, Patino R, Feria Arroyo TP, Laing ST, Lopez JE, Ingber A, Jones KM, Murray KO. One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. PLoS Negl Trop Dis. 2016 Nov; 10(11):e0005074. PMID: 27832063; PMCID: PMC5104435.
      Citations: 16     Fields:    Translation:HumansAnimalsPHPublic Health
    34. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease. Hum Vaccin Immunother. 2017 03 04; 13(3):621-633. PMID: 27737611; PMCID: PMC5360114.
      Citations: 15     Fields:    Translation:AnimalsCells
    35. Barry MA, Murray KO, Hotez PJ, JONES KM. Impact of vectorborne parasitic neglected tropical diseases on child health. Archives of Diseases in Childhood. 2016; 7(101):640-7.
    36. Barry MA, Wang Q, JONES KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Human Vaccines and Immunotherapeutics. 2016; 4(12):976-87.
    37. Gunter SM, Jones KM, Zhan B, Essigmann HT, Murray KO, Garcia MN, Gorchakov R, Bottazzi ME, Hotez PJ, Brown EL. Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Am J Trop Med Hyg. 2016 Jan; 94(1):114-121. PMID: 26598565; PMCID: PMC4710414.
      Citations: 4     Fields:    Translation:HumansAnimals
    38. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641; PMCID: PMC3934375.
      Citations: 25     Fields:    Translation:HumansAnimals
    39. Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ, Dumonteil E, Ortega J, de Leon Rosales SP. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. PMID: 23151163; PMCID: PMC3819810.
      Citations: 47     Fields:    Translation:HumansAnimalsPHPublic Health
    40. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    41. Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, JONES K, Keegan B, Hotez PJ, Loukas A. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection. FASEB J. 2009; (9):3007-19.
    42. Nagase H, Jones KM, Anderson CF, Noben-Trauth N. Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility. J Immunol. 2007 Aug 15; 179(4):2435-44. PMID: 17675505.
      Citations: 20     Fields:    Translation:AnimalsCells
    43. Mansfield LS, Gauthier DT, Abner SR, Jones KM, Wilder SR, Urban JF. Enhancement of disease and pathology by synergy of Trichuris suis and Campylobacter jejuni in the colon of immunologically naive swine. Am J Trop Med Hyg. 2003 Mar; 68(3):70-80. PMID: 12685626.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Padungtod P, Kaneene JB, Jarman D, JONES K, Johnson R, Drummond A, Duprey Z, Chaichanapunpol I. “Enteric parasitosis in northern Thailand dairy heifers and heifer calves.” Prev Vet Med. 2001; 48(1):25-33.
    45. “Spinal malacia, abscess and meningioma in a German Shepherd dog”. Zimbabwe Veterinary Journal.
    46. “Enteric Parasitiasis in Northern Thailand Horses.”. 12(1).
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