Last Name


InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Surgical Research
AddressOne Baylor Plaza
Houston TX 77030
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    My research focuses on elucidating the roles and the underlying mechanisms of DNA damage and repair pathways in tumor development, progression, and metastasis, as well as developing novel therapeutic methods to target cancer cells.

    DNA damage response and genomic instability in cancer

    DNA repair deficiency and genomic instability are important hallmarks of cancer. By elucidating the roles of BRIT1/MCPH1, an important protein involved in DNA damage and repair pathways, I will provide insights into the relationship of DNA repair deficiency with genomic instability, cancer initiation, progression, and/or metastasis.

    Translational research and treatment of cancer

    In this area, I will investigate how to target cancer cells with genomic instability, which may eventually lead to the discovery of drugs for cancer treatment.

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    Breast cancer, DNA damage response, Double-strand breaks, Genomic instability, Homologous recombination, Liver cancer, Synthetic lethality model, Targeting therapy of cancer, Tumorigenesis

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang B, Wang E, Dai H, Hu R, Liang Y, Li K, Wang G, Peng G, Lin SY. BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer. Carcinogenesis. 2013 Oct; 34(10):2271-80. PMID: 23729656; PMCID: PMC3786380.
    2. Liang Y, Gao H, Lin SY, Goss JA, Brunicardi FC, Li K. siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS One. 2010; 5(9):e12860. PMID: 20877462; PMCID: PMC2942895.
    3. Lin SY, Liang Y, Li K. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei Med J. 2010 May; 51(3):295-301. PMID: 20376879; PMCID: PMC2852782.
    4. Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan; 6(1):e1000826. PMID: 20107607; PMCID: PMC2809772.
    5. Liang Y, Lin SY, Brunicardi FC, Goss J, Li K. DNA damage response pathways in tumor suppression and cancer treatment. World J Surg. 2009 Apr; 33(4):661-6. PMID: 19034564.
      View in: PubMed
    6. Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem. 2008 Oct 24; 283(43):29586-92. PMID: 18718915; PMCID: PMC2570891.
    7. Zhao H, Liang Y, Xu Z, Wang L, Zhou F, Li Z, Jin J, Yang Y, Fang Z, Hu Y, Zhang L, Su J, Zha X. N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435. J Cell Biochem. 2008 May 1; 104(1):162-75. PMID: 17979184.
      View in: PubMed
    8. Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007 Oct 15; 102(3):704-18. PMID: 17407140.
      View in: PubMed
    9. Sun L, Zhao H, Xu Z, Liu Q, Liang Y, Wang L, Cai X, Zhang L, Hu L, Wang G, Zha X. Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. Cell Signal. 2007 Nov; 19(11):2255-63. PMID: 17716861.
      View in: PubMed
    10. Fang Z, Fu Y, Liang Y, Li Z, Zhang W, Jin J, Yang Y, Zha X. Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. J Cell Biochem. 2007 Jun 1; 101(3):654-64. PMID: 17211849.
      View in: PubMed
    11. Wang L, Liang Y, Li Z, Cai X, Zhang W, Wu G, Jin J, Fang Z, Yang Y, Zha X. Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721. J Cell Biochem. 2007 Jan 1; 100(1):230-41. PMID: 16924681.
      View in: PubMed
    12. Mo Z, Wang H, Liang Y, Liu F, Xue Y. Highly reproducible hybridization assay of zeptomole DNA based on adsorption of nanoparticle-bioconjugate. Analyst. 2005 Dec; 130(12):1589-94. PMID: 16284656.
      View in: PubMed
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