TitleAdjunct Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schneider U, Mukharyamov M, Beyersdorf F, Dewald O, Liebold A, Gaudino M, Fremes S, Doenst T. The value of perioperative biomarker release for the assessment of myocardial injury or infarction in cardiac surgery. Eur J Cardiothorac Surg. 2022 03 24; 61(4):735-741. PMID: 34791135.
      Citations:    Fields:    Translation:Humans
    2. Levelink M, Reinhold AK, Dewald O, Brütt AL. Psychological burden and coping in destination therapy patients with a left ventricular assist device: A qualitative content analysis. Artif Organs. 2022 Jun; 46(6):1165-1180. PMID: 34932234.
      Citations:    Fields:    
    3. Guenther U, Wolke M, Hansen HC, Feldmann N, Diers A, Dewald O, Ely EW, Weyland A. [Disorientation and delirium assessment : A secondary analysis of a prospective, observational study]. Med Klin Intensivmed Notfmed. 2021 Aug 25. PMID: 34432084.
      Citations:    Fields:    
    4. Guenther U, Wolke M, Schelling R, Kohse KP, Book M, Dewald O, Weyland A. Low cholinesterase activity is a risk factor for delirium after cardiac surgery: A prospective cohort study. Eur J Anaesthesiol. 2021 May 01; 38(5):554-556. PMID: 33821836.
      Citations:    Fields:    Translation:Humans
    5. Bakhtiary F, Ahmad AE, Autschbach R, Benedikt P, Bonaros N, Borger M, Dewald O, Feyrer R, Geißler HJ, Grünenfelder J, Lam KY, Leyh R, Liebold A, Czesla M, Mehdiani A, Pollari F, Salamate S, Strauch J, Vötsch A, Weber A, Wendt D, Botta B, Bramlage P, Zierer A. Impact of pre-existing comorbidities on outcomes of patients undergoing surgical aortic valve replacement - rationale and design of the international IMPACT registry. J Cardiothorac Surg. 2021 Mar 25; 16(1):51. PMID: 33766089.
      Citations:    Fields:    Translation:Humans
    6. Balks J, Mueller A, Herberg U, Geipel A, Gembruch U, Schroeder L, Dewald O, Breuer J, Weidenbach M, Berg C, Kipfmueller F. [Therapy and Outcome of Neonates with Congenital Diaphragmatic Hernia and Congenital Heart Defects]. Z Geburtshilfe Neonatol. 2021 Oct; 225(5):432-440. PMID: 33694149.
      Citations:    Fields:    Translation:HumansAnimals
    7. Guenther U, Hoffmann F, Dewald O, Malek R, Brimmers K, Theuerkauf N, Putensen C, Popp J. Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study. Geriatrics (Basel). 2020 Oct 03; 5(4). PMID: 33022910.
      Citations: 1     
    8. Duerr GD, Wu S, Schneider ML, Marggraf V, Weisheit CK, Velten M, Verfuerth L, Frede S, Boehm O, Treede H, Dewald O, Baumgarten G, Kim SC. CpG postconditioning after reperfused myocardial infarction is associated with modulated inflammation, less apoptosis, and better left ventricular function. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H995-H1007. PMID: 32857588.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Habicht I, Mohsen G, Eichhorn L, Frede S, Weisheit C, Hilbert T, Treede H, Güresir E, Dewald O, Duerr GD, Velten M. DHA Supplementation Attenuates MI-Induced LV Matrix Remodeling and Dysfunction in Mice. Oxid Med Cell Longev. 2020; 2020:7606938. PMID: 32832005.
      Citations: 2     Fields:    Translation:Animals
    10. Hamiko M, Slottosch I, Scherner M, Gestrich C, Wahlers T, Putensen C, Mellert F, Treede H, Dewald O, Duerr GD. Timely extracorporeal membrane oxygenation assist reduces mortality after bypass surgery in patients with acute myocardial infarction. J Card Surg. 2019 Nov; 34(11):1243-1255. PMID: 31523850.
      Citations:    Fields:    Translation:Humans
    11. Duerr GD, Heinemann JC, Kley J, Eichhorn L, Frede S, Weisheit C, Wehner S, Bindila L, Lutz B, Zimmer A, Dewald O. Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. J Mol Cell Cardiol. 2019 08; 133:86-98. PMID: 31181227.
      Citations: 3     Fields:    Translation:AnimalsCells
    12. Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O. CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion. Life Sci. 2018 Dec 15; 215:96-105. PMID: 30403990.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Kipfmueller F, Heindel K, Schroeder L, Berg C, Dewald O, Reutter H, Bartmann P, Mueller A. Early postnatal echocardiographic assessment of pulmonary blood flow in newborns with congenital diaphragmatic hernia. J Perinat Med. 2018 Sep 25; 46(7):735-743. PMID: 28742524.
      Citations: 3     Fields:    Translation:Humans
    14. Gatzweiler E, Hoppe B, Dewald O, Berg C, Müller A, Reutter H, Kipfmueller F. Extracorporeal membrane oxygenation support in a newborn with lower urinary tract obstruction and pulmonary hypoplasia: a case report. J Med Case Rep. 2018 Jul 17; 12(1):210. PMID: 30012211.
      Citations:    Fields:    Translation:Humans
    15. Baehner T, Dewald O, Heinze I, Mueller M, Schindler E, Schirmer U, Baumgarten G, Hoeft A, Ellerkmann RK. The provision of pediatric cardiac anesthesia services in Germany: current status of structural and personnel organization. Paediatr Anaesth. 2017 Aug; 27(8):801-809. PMID: 28419616.
      Citations: 1     Fields:    Translation:Humans
    16. Herberg U, Linden K, Dewald O, Gatzweiler E, Seehase M, Duerr GD, Dörner J, Kleppe S, Ladage D, Breuer J. 3D Real-Time Echocardiography Combined with Mini Pressure Wire Generate Reliable Pressure-Volume Loops in Small Hearts. PLoS One. 2016; 11(10):e0165397. PMID: 27776179.
      Citations: 2     Fields:    Translation:Animals
    17. Duerr GD, Dewald D, Schmitz EJ, Verfuerth L, Keppel K, Peigney C, Ghanem A, Welz A, Dewald O. Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice. Mediators Inflamm. 2016; 2016:7174127. PMID: 27403038.
      Citations: 7     Fields:    Translation:Animals
    18. Linden K, Ladage D, Dewald O, Gatzweiler E, Pieper A, Seehase M, Duerr GD, Breuer J, Herberg U. Comparison of stroke volumes assessed by three-dimensional echocardiography and transpulmonary thermodilution in a pediatric animal model. J Clin Monit Comput. 2017 Apr; 31(2):353-360. PMID: 26886899.
      Citations: 3     Fields:    Translation:Animals
    19. Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O. Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int. 2015; 2015:456582. PMID: 26539497.
      Citations: 5     Fields:    Translation:Humans
    20. Stein K, Stoffels M, Lysson M, Schneiker B, Dewald O, Krönke G, Kalff JC, Wehner S. A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. J Leukoc Biol. 2016 Feb; 99(2):231-9. PMID: 26292977.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Dewald O, Zimmer A. Endocannabinoids in adaptation to injury: Ready to move from bench to bedside? Life Sci. 2015 Oct 01; 138:1-2. PMID: 26092483.
      Citations:    Fields:    Translation:HumansAnimals
    22. Heinemann JC, Duerr GD, Keppel K, Breitbach M, Fleischmann BK, Zimmer A, Wehner S, Welz A, Dewald O. CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes. Life Sci. 2015 Oct 01; 138:18-28. PMID: 25497711.
      Citations: 5     Fields:    Translation:AnimalsCells
    23. Duerr GD, Heinemann JC, Gestrich C, Heuft T, Klaas T, Keppel K, Roell W, Klein A, Zimmer A, Velten M, Kilic A, Bindila L, Lutz B, Dewald O. Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life Sci. 2015 Oct 01; 138:8-17. PMID: 25447445.
      Citations: 7     Fields:    Translation:AnimalsCells
    24. Rühl H, Müller J, Wäschenbach J, Oldenburg J, Dewald O, Pötzsch B. Short-term venous stasis induces fibrinolytic activation but not thrombin formation. J Atheroscler Thromb. 2014; 21(12):1260-70. PMID: 25069814.
      Citations: 3     Fields:    Translation:HumansCells
    25. Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O. The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol. 2014 Jul; 109(4):425. PMID: 24980781.
      Citations: 20     Fields:    Translation:AnimalsCells
    26. Duerr GD, Mesenholl B, Heinemann JC, Zoerlein M, Huebener P, Schneider P, Feisst A, Ghanem A, Tiemann K, Dewald D, Welz A, Dewald O. Cardioprotective effects of osteopontin-1 during development of murine ischemic cardiomyopathy. Biomed Res Int. 2014; 2014:124063. PMID: 24971311.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    27. Duerr GD, Heinemann JC, Arnoldi V, Feisst A, Kley J, Ghanem A, Welz A, Dewald O. Cardiomyocyte specific peroxisome proliferator-activated receptor-a overexpression leads to irreversible damage in ischemic murine heart. Life Sci. 2014 May 02; 102(2):88-97. PMID: 24657893.
      Citations: 12     Fields:    Translation:AnimalsCells
    28. Duerr GD, Heinemann JC, Dunkel S, Zimmer A, Lutz B, Lerner R, Roell W, Mellert F, Probst C, Esmailzadeh B, Welz A, Dewald O. Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis. Life Sci. 2013 May 30; 92(20-21):976-83. PMID: 23567807.
      Citations: 11     Fields:    Translation:Humans
    29. Dörner J, Struck R, Zimmer S, Peigney C, Duerr GD, Dewald O, Kim SC, Malan D, Bettinger T, Nickenig G, Ghanem A. Ultrasound-mediated stimulation of microbubbles after acute myocardial infarction and reperfusion ameliorates left-ventricular remodelling in mice via improvement of borderzone vascularization. PLoS One. 2013; 8(2):e56841. PMID: 23437254.
      Citations: 7     Fields:    Translation:Animals
    30. Velten M, Duerr GD, Pessies T, Schild J, Lohner R, Mersmann J, Dewald O, Zacharowski K, Klaschik S, Hilbert T, Hoeft A, Baumgarten G, Meyer R, Boehm O, Knuefermann P. Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice. Cardiovasc Res. 2012 Dec 01; 96(3):422-32. PMID: 22977006.
      Citations: 27     Fields:    Translation:Animals
    31. Ghanem A, Röll W, Bostani T, Dewald O, Fleischmann BK, Stypmann J, Nickenig G, Tiemann K. Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiography. Cell Transplant. 2011; 20(10):1621-8. PMID: 21439129.
      Citations: 2     Fields:    Translation:Animals
    32. Duerr GD, Elhafi N, Bostani T, Ellinger J, Swieny L, Kolobara E, Welz A, Dewald O. Comparison of myocardial remodeling between cryoinfarction and reperfused infarction in mice. J Biomed Biotechnol. 2011; 2011:961298. PMID: 21151617.
      Citations: 10     Fields:    Translation:Animals
    33. Haudek SB, Gupta D, Dewald O, Schwartz RJ, Wei L, Trial J, Entman ML. Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res. 2009 Aug 01; 83(3):511-8. PMID: 19406912.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    34. Lohse F, Lang N, Schiller W, Roell W, Dewald O, Preusse CJ, Welz A, Schmitz C. Quality of life after replacement of the ascending aorta in patients with true aneurysms. Tex Heart Inst J. 2009; 36(2):104-10. PMID: 19436802.
      Citations: 7     Fields:    Translation:Humans
    35. Schiller W, Rudorf H, Welzel CB, Kiderlen MJ, Probst C, Dewald O, Welz A. Sutureless anastomoses of rabbit carotid arteries with BioGlue. J Thorac Cardiovasc Surg. 2007 Dec; 134(6):1513-8. PMID: 18023675.
      Citations: 5     Fields:    Translation:Animals
    36. Ghanem A, Troatz C, Elhafi N, Dewald O, Heeschen C, Nickenig G, Stypmann J, Tiemann K. Quantitation of myocardial borderzone using reconstructive 3-D echocardiography after chronic infarction in rats: incremental value of low-dose dobutamine. Ultrasound Med Biol. 2008 Apr; 34(4):559-66. PMID: 17996357.
      Citations: 5     Fields:    Translation:Animals
    37. Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM, Fries JW, Tiemann K, Bohlen H, Hescheler J, Welz A, Bloch W, Jacobsen SE, Fleischmann BK. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood. 2007 Aug 15; 110(4):1362-9. PMID: 17483296.
      Citations: 216     Fields:    Translation:AnimalsCells
    38. Frangogiannis NG, Dewald O, Xia Y, Ren G, Haudek S, Leucker T, Kraemer D, Taffet G, Rollins BJ, Entman ML. Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation. 2007 Feb 06; 115(5):584-92. PMID: 17283277.
      Citations: 121     Fields:    Translation:AnimalsCells
    39. Ghanem A, Röll W, Hashemi T, Dewald O, Djoufack PC, Fink KB, Schrickel J, Lewalter T, Lüderitz B, Tiemann K. Echocardiographic assessment of left ventricular mass in neonatal and adult mice: accuracy of different echocardiographic methods. Echocardiography. 2006 Nov; 23(10):900-7. PMID: 17069614.
      Citations: 15     Fields:    Translation:Animals
    40. Sharma S, Dewald O, Adrogue J, Salazar RL, Razeghi P, Crapo JD, Bowler RP, Entman ML, Taegtmeyer H. Induction of antioxidant gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species. Free Radic Biol Med. 2006 Jun 15; 40(12):2223-31. PMID: 16785036.
      Citations: 12     Fields:    Translation:AnimalsCells
    41. Lehmann LE, Schroeder S, Hartmann W, Dewald O, Book M, Weber SU, Schewe JC, Stüber F. A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass. Eur J Cardiothorac Surg. 2006 Jul; 30(1):59-63. PMID: 16527487.
      Citations: 10     Fields:    Translation:Humans
    42. Dewald O, Sharma S, Adrogue J, Salazar R, Duerr GD, Crapo JD, Entman ML, Taegtmeyer H. Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation. 2005 Jul 19; 112(3):407-15. PMID: 16009788.
      Citations: 40     Fields:    Translation:AnimalsCells
    43. Frangogiannis NG, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, Winkelmann K, Michael LH, Lawler J, Entman ML. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005 Jun 07; 111(22):2935-42. PMID: 15927970.
      Citations: 142     Fields:    Translation:AnimalsCells
    44. Hackenbroch M, Nehrke K, Gieseke J, Meyer C, Tiemann K, Litt H, Dewald O, Naehle CP, Schild H, Sommer T. 3D motion adapted gating (3D MAG): a new navigator technique for accelerated acquisition of free breathing navigator gated 3D coronary MR-angiography. Eur Radiol. 2005 Aug; 15(8):1598-606. PMID: 15815910.
      Citations: 6     Fields:    Translation:Humans
    45. Dewald O, Schmitz C, Diem H, Goehring P, Vetter HO, Roell W, Goedje O, Tschoepe D, Reichart B. Platelet activation markers in patients with heart assist device. Artif Organs. 2005 Apr; 29(4):292-9. PMID: 15787623.
      Citations: 4     Fields:    Translation:Humans
    46. Dewald O, Zymek P, Winkelmann K, Koerting A, Ren G, Abou-Khamis T, Michael LH, Rollins BJ, Entman ML, Frangogiannis NG. CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res. 2005 Apr 29; 96(8):881-9. PMID: 15774854.
      Citations: 277     Fields:    Translation:AnimalsCells
    47. Dewald O, Frangogiannis NG, Zoerlein MP, Duerr GD, Taffet G, Michael LH, Welz A, Entman ML. A murine model of ischemic cardiomyopathy induced by repetitive ischemia and reperfusion. Thorac Cardiovasc Surg. 2004 Oct; 52(5):305-11. PMID: 15470614.
      Citations: 10     Fields:    Translation:Animals
    48. Dewald O, Ren G, Duerr GD, Zoerlein M, Klemm C, Gersch C, Tincey S, Michael LH, Entman ML, Frangogiannis NG. Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol. 2004 Feb; 164(2):665-77. PMID: 14742270.
      Citations: 159     Fields:    Translation:AnimalsCells
    49. Ren G, Dewald O, Frangogiannis NG. Inflammatory mechanisms in myocardial infarction. Curr Drug Targets Inflamm Allergy. 2003 Sep; 2(3):242-56. PMID: 14561159.
      Citations: 58     Fields:    Translation:HumansAnimals
    50. Dewald O, Frangogiannis NG, Zoerlein M, Duerr GD, Klemm C, Knuefermann P, Taffet G, Michael LH, Crapo JD, Welz A, Entman ML. Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2700-5. PMID: 12586861.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    51. Gersch C, Dewald O, Zoerlein M, Michael LH, Entman ML, Frangogiannis NG. Mast cells and macrophages in normal C57/BL/6 mice. Histochem Cell Biol. 2002 Jul; 118(1):41-9. PMID: 12122446.
      Citations: 44     Fields:    Translation:AnimalsCells
    52. Frangogiannis NG, Shimoni S, Chang SM, Ren G, Dewald O, Gersch C, Shan K, Aggeli C, Reardon M, Letsou GV, Espada R, Ramchandani M, Entman ML, Zoghbi WA. Active interstitial remodeling: an important process in the hibernating human myocardium. J Am Coll Cardiol. 2002 May 01; 39(9):1468-74. PMID: 11985909.
      Citations: 29     Fields:    Translation:HumansCells
    53. Nossuli TO, Frangogiannis NG, Knuefermann P, Lakshminarayanan V, Dewald O, Evans AJ, Peschon J, Mann DL, Michael LH, Entman ML. Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2549-58. PMID: 11709422.
      Citations: 24     Fields:    Translation:Animals
    54. Schmitz C, Roell W, Dewald O, Goetz AE, Kilger E, Roth M, Reichenspurner H, Reichart B. Replacement of the valves of a Novacor LVAS without cardiopulmonary bypass. Thorac Cardiovasc Surg. 2000 Dec; 48(6):380-1. PMID: 11145412.
      Citations:    Fields:    Translation:Humans
    55. Schmitz C, Welz A, Dewald O, Kozlik-Feldmann R, Netz H, Reichart B. Switch from a BIVAD to a LVAD in a boy with Kawasaki disease. Ann Thorac Surg. 2000 Apr; 69(4):1270-1. PMID: 10800841.
      Citations: 2     Fields:    Translation:Humans
    56. Godje O, Peyerl M, Seebauer T, Dewald O, Reichart B. Reproducibility of double indicator dilution measurements of intrathoracic blood volume compartments, extravascular lung water, and liver function. Chest. 1998 Apr; 113(4):1070-7. PMID: 9554649.
      Citations: 22     Fields:    Translation:Humans
    57. Dewald O, Fischlein T, Vetter HO, Schmitz C, Gödje O, Göhring P, Reichart B. Platelet morphology in patients with mechanical circulatory support. Eur J Cardiothorac Surg. 1997 Oct; 12(4):634-41. PMID: 9370410.
      Citations: 4     Fields:    Translation:HumansCells
    58. Gödje O, Fuchs A, Dewald O, Fischlein T, Reichart B. [On-site laboratory monitoring on the intensive care unit. Blood gas, electrolyte, glucose, hemoglobin and lactate determination with the CIBA Corning 865 Analysis System]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1997 Sep; 32(9):549-56. PMID: 9417255.
      Citations:    Fields:    Translation:Humans
    59. Nollert G, Fischlein T, Bouterwek S, Böhmer C, Dewald O, Kreuzer E, Welz A, Netz H, Klinner W, Reichart B. Long-term results of total repair of tetralogy of Fallot in adulthood: 35 years follow-up in 104 patients corrected at the age of 18 or older. Thorac Cardiovasc Surg. 1997 Aug; 45(4):178-81. PMID: 9323819.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    60. Roell W, Goedje O, Vetter HO, Schmitz C, Dewald O, Reichart B. Improvement of heart-, lung-, and liver-performance during mechanical circulatory support by the Novacor-system. Eur J Cardiothorac Surg. 1997 Jun; 11(6):1045-51. PMID: 9237585.
      Citations:    Fields:    Translation:Humans
    61. Vetter HO, Kaulbach HG, Schmitz C, Forst A, Uberfuhr P, Kreuzer E, Pfeiffer M, Brenner P, Dewald O, Reichart B. Experience with the Novacor left ventricular assist system as a bridge to cardiac transplantation, including the new wearable system. J Thorac Cardiovasc Surg. 1995 Jan; 109(1):74-80. PMID: 7815810.
      Citations: 6     Fields:    Translation:Humans
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