InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

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    R03AI149201     (HIRSCHI, KENDAL D)Jan 23, 2020 - Dec 31, 2021
    Plant Exosomes and MicroRNAs Regulate the Microbiome and Intestinal Homeostasis
    Role: Principal Investigator

    R01DK062366     (HIRSCHI, KENDAL D)Feb 21, 2004 - Dec 31, 2010
    Nutritional Impact of Modifying Calcium Partitioning
    Role: Principal Investigator

    R01GM057427     (HIRSCHI, KENDAL D)May 1, 1998 - Apr 30, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mathew IE, Rhein HS, Yang J, Gradogna A, Carpaneto A, Guo Q, Tappero R, Scholz-Starke J, Barkla BJ, Hirschi KD, Punshon T. Sequential?removal of cation/H+ exchangers reveals their additive role in elemental distribution, calcium depletion?and anoxia tolerance. Plant Cell Environ. 2024 Feb; 47(2):557-573. PMID: 37916653.
      Citations:    Fields:    Translation:Animals
    2. Mathew IE, Rhein HS, Green AJ, Hirschi KD. Generating Reproducing Anoxia Conditions for Plant Phenotyping. Bio Protoc. 2023 Feb 05; 13(3):e4603. PMID: 36816988; PMCID: PMC9909309.
    3. Dee Hirschi K, Shadgou Rhein H, Nalliah V, Hirschi KD, Nalliah V, Rhein HS. Instead of Calories, Should We Be Counting our Consumption of Exosomes and MicroRNAs? Microrna. 2023; 12(3):165-170. PMID: 37005545.
      Citations:    Fields:    
    4. Rao X, Cheng N, Mathew IE, Hirschi KD, Nakata PA. Crucial role of Arabidopsis glutaredoxin S17 in heat stress response revealed by transcriptome analysis. Funct Plant Biol. 2023 01; 50(1):58-70. PMID: 36099929.
    5. Yang J, Mathew IE, Rhein H, Barker R, Guo Q, Brunello L, Loreti E, Barkla BJ, Gilroy S, Perata P, Hirschi KD. The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses. Plant Physiol. 2022 11 28; 190(4):2617-2636. PMID: 35972350; PMCID: PMC9706465.
    6. Sprague SA, Tamang TM, Steiner T, Wu Q, Hu Y, Kakeshpour T, Park J, Yang J, Peng Z, Bergkamp B, Somayanda I, Peterson M, Oliveira Garcia E, Hao Y, St Amand P, Bai G, Nakata PA, Rieu I, Jackson DP, Cheng N, Valent B, Hirschi KD, Jagadish SK, Liu S, White FF, Park S. Redox-engineering enhances maize thermotolerance and grain yield in the field. Plant Biotechnol J. 2022 09; 20(9):1819-1832. PMID: 35656643; PMCID: PMC9398381.
      Citations:    Fields:    
    7. Hirschi KD. Milking miRNAs for All Their Worth. J Nutr. 2022 01 11; 152(1):1-2. PMID: 34642747; PMCID: PMC8754565.
      Citations:    Fields:    Translation:Animals
    8. Cheng N, Mo Q, Donelson J, Wang L, Breton G, Rodney GG, Wang J, Hirschi KD, Wehrens XHT, Nakata PA. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883. PMID: 34345213; PMCID: PMC8326124.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Engevik MA, Danhof HA, Ruan W, Engevik AC, Chang-Graham AL, Engevik KA, Shi Z, Zhao Y, Brand CK, Krystofiak ES, Venable S, Liu X, Hirschi KD, Hyser JM, Spinler JK, Britton RA, Versalovic J. Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation. mBio. 2021 03 02; 12(2). PMID: 33653893; PMCID: PMC8092269.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Hirschi KD. Genetically Modified Plants: Nutritious, Sustainable, yet Underrated. J Nutr. 2020 10 12; 150(10):2628-2634. PMID: 32725215; PMCID: PMC7549299.
      Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    11. McNeill EM, Hirschi KD. Roles of Regulatory RNAs in Nutritional Control. Annu Rev Nutr. 2020 09 23; 40:77-104. PMID: 32966184.
      Citations: 3     Fields:    Translation:HumansAnimals
    12. Spinler JK, Oezguen N, Runge JK, Luna RA, Karri V, Yang J, Hirschi KD. Dietary impact of a plant-derived microRNA on the gut microbiome. ExRNA. 2020; 2. PMID: 33542959; PMCID: PMC7856875.
      Citations: 3     
    13. Karri V, Hirschi KD. Gut Bacteria have a novel sweet tooth: ribose sensing and scavenging from fiber. Gut Microbes. 2020 11 01; 11(6):1483-1485. PMID: 32552224; PMCID: PMC7527073.
      Citations:    Fields:    Translation:HumansCells
    14. Cheng N, Yu H, Rao X, Park S, Connolly EL, Hirschi KD, Nakata PA. Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress. Plant Signal Behav. 2020 06 02; 15(6):1758455. PMID: 32351167; PMCID: PMC8570760.
      Citations: 2     Fields:    Translation:Animals
    15. Yang J, Hirschi KD, Kakeshpour T, Tamang TM, Park WD, Manohar M, Park S. Expression of mouse small interfering RNAs in lettuce using artificial microRNA technology. Biotechniques. 2020 Apr; 68(4):214-218. PMID: 31939314.
      Citations: 2     Fields:    Translation:Animals
    16. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071. PMID: 31033205; PMCID: PMC6487472.
      Citations: 6     Fields:    Translation:AnimalsCells
    17. Spinler JK, Karri V, Hirschi KD. Planting the Microbiome. Trends Microbiol. 2019 02; 27(2):90-93. PMID: 30600139.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Scholz-Starke J, Primo C, Yang J, Kandel R, Gaxiola RA, Hirschi KD. The flip side of the Arabidopsis type I proton-pumping pyrophosphatase (AVP1): Using a transmembrane H+ gradient to synthesize pyrophosphate. J Biol Chem. 2019 01 25; 294(4):1290-1299. PMID: 30510138; PMCID: PMC6349097.
      Citations: 9     Fields:    Translation:AnimalsCells
    19. Yang J, Elbaz-Younes I, Primo C, Murungi D, Hirschi KD. Intestinal permeability, digestive stability and oral bioavailability of dietary small RNAs. Sci Rep. 2018 07 06; 8(1):10253. PMID: 29980707; PMCID: PMC6035168.
      Citations: 14     Fields:    Translation:Animals
    20. Hirschi KD. Uptake of Dietary Milk microRNAs by Adult Humans: Rules for the Game of Hide and Seek. J Nutr. 2018 01 01; 148(1):5-6. PMID: 29378059.
      Citations: 1     Fields:    Translation:HumansAnimals
    21. Hu Y, Wu Q, Peng Z, Sprague SA, Wang W, Park J, Akhunov E, Jagadish KSV, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Silencing of OsGRXS17 in rice improves drought stress tolerance by modulating ROS accumulation and stomatal closure. Sci Rep. 2017 11 21; 7(1):15950. PMID: 29162892; PMCID: PMC5698295.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Hirschi KD, Gaxiola RA, Pizzio GA. Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1). Front Plant Sci. 2017; 8:1572. PMID: 28955362; PMCID: PMC5601048.
      Citations: 1     
    23. Wu Q, Hu Y, Sprague SA, Kakeshpour T, Park J, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Expression of a monothiol glutaredoxin, AtGRXS17, in tomato (Solanum lycopersicum) enhances drought tolerance. Biochem Biophys Res Commun. 2017 09 30; 491(4):1034-1039. PMID: 28780355.
      Citations: 15     Fields:    Translation:AnimalsCells
    24. Hocking B, Conn SJ, Manohar M, Xu B, Athman A, Stancombe MA, Webb AR, Hirschi KD, Gilliham M. Heterodimerization of Arabidopsis calcium/proton exchangers contributes to regulation of guard cell dynamics and plant defense responses. J Exp Bot. 2017 07 10; 68(15):4171-4183. PMID: 28645169; PMCID: PMC5853972.
      Citations: 13     Fields:    Translation:AnimalsCells
    25. . Bioavailability of transgenic microRNAs in genetically modified plants. Genes and Nutrition. 2017; (12):6. View Publication.
    26. Yang J, Primo C, Elbaz-Younes I, Hirschi KD. Bioavailability of transgenic microRNAs in genetically modified plants. Genes Nutr. 2017; 12:17. PMID: 29507644; PMCID: PMC5831112.
      Citations: 8     
    27. Hirschi KD. Navigating dietary small RNAs. Genes Nutr. 2017; 12:16. PMID: 28694876; PMCID: PMC5501344.
      Citations: 3     
    28. . Navigating dietary small RNAs. Genes and Nutrition. 2017; 16(12):1. View Publication.
    29. Yu H, Yang J, Shi Y, Donelson J, Thompson SM, Sprague S, Roshan T, Wang DL, Liu J, Park S, Nakata PA, Connolly EL, Hirschi KD, Grusak MA, Cheng N. Arabidopsis Glutaredoxin S17 Contributes to Vegetative Growth, Mineral Accumulation, and Redox Balance during Iron Deficiency. Front Plant Sci. 2017; 8:1045. PMID: 28674546; PMCID: PMC5474874.
      Citations: 9     
    30. Yang J, Kongchan N, Primo Planta C, Neilson JR, Hirschi KD. The atypical genesis and bioavailability of the plant-based small RNA MIR2911: Bulking up while breaking down. Mol Nutr Food Res. 2017 09; 61(9). PMID: 28319645; PMCID: PMC5583006.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Asojo OA, Damania A, Turner TL, Slaughter G, Hirschi KD. RETRACTED ARTICLE: Summer Research Training Provides Effective Tools for Underrepresented Minorities to Obtain Doctoral Level Degrees. J Racial Ethn Health Disparities. 2017 12; 4(6):1224. PMID: 28078659; PMCID: PMC5705752.
      Citations:    Fields:    
    32. Yang J, Hotz T, Broadnax L, Yarmarkovich M, Elbaz-Younes I, Hirschi KD. Anomalous uptake and circulatory characteristics of the plant-based small RNA MIR2911. Sci Rep. 2016 06 02; 6:26834. PMID: 27251858; PMCID: PMC4890004.
      Citations: 28     Fields:    Translation:AnimalsCells
    33. Pittman JK, Hirschi KD. Phylogenetic analysis and protein structure modelling identifies distinct Ca(2+)/Cation antiporters and conservation of gene family structure within Arabidopsis and rice species. Rice (N Y). 2016 Dec; 9(1):3. PMID: 26833031; PMCID: PMC4735048.
      Citations: 16     
    34. Gaxiola RA, Regmi K, Hirschi KD. Moving On Up: H(+)-PPase Mediated Crop Improvement. Trends Biotechnol. 2016 05; 34(5):347-349. PMID: 26818803.
      Citations: 5     Fields:    Translation:AnimalsCells
    35. Hu Y, Wu Q, Sprague SA, Park J, Oh M, Rajashekar CB, Koiwa H, Nakata PA, Cheng N, Hirschi KD, White FF, Park S. Tomato expressing Arabidopsis glutaredoxin gene AtGRXS17 confers tolerance to chilling stress via modulating cold responsive components. Hortic Res. 2015; 2:15051. PMID: 26623076; PMCID: PMC4641303.
      Citations: 10     
    36. Zempleni J, Baier SR, Hirschi K. Diet-responsive MicroRNAs Are Likely Exogenous. J Biol Chem. 2015 Oct 09; 290(41):25197. PMID: 26453700; PMCID: PMC4599022.
      Citations: 16     Fields:    Translation:Animals
    37. Yang J, Farmer LM, Agyekum AA, Elbaz-Younes I, Hirschi KD. Detection of an Abundant Plant-Based Small RNA in Healthy Consumers. PLoS One. 2015; 10(9):e0137516. PMID: 26335106; PMCID: PMC4559308.
      Citations: 40     Fields:    Translation:Animals
    38. Hirschi KD, Pruss GJ, Vance V. Dietary delivery: a new avenue for microRNA therapeutics? Trends Biotechnol. 2015 Aug; 33(8):431-2. PMID: 26113189.
      Citations: 22     Fields:    Translation:HumansAnimals
    39. Yarmarkovich M, Hirschi KD. Digesting dietary miRNA therapeutics. Oncotarget. 2015 Jun 10; 6(16):13848-9. PMID: 26116837; PMCID: PMC4546433.
      Citations: 5     Fields:    Translation:HumansAnimals
    40. Yang J, Hirschi KD, Farmer LM. Dietary RNAs: New Stories Regarding Oral Delivery. Nutrients. 2015 Apr 30; 7(5):3184-99. PMID: 25942490; PMCID: PMC4446746.
      Citations: 14     Fields:    Translation:Humans
    41. Zhao J, Li P, Motes CM, Park S, Hirschi KD. CHX14 is a plasma membrane K-efflux transporter that regulates K(+) redistribution in Arabidopsis thaliana. Plant Cell Environ. 2015 Nov; 38(11):2223-38. PMID: 25754420.
      Citations: 12     Fields:    Translation:AnimalsCells
    42. Yang J, Farmer LM, Agyekum AA, Hirschi KD. Detection of dietary plant-based small RNAs in animals. Cell Res. 2015 Apr; 25(4):517-20. PMID: 25721324; PMCID: PMC4387557.
      Citations: 54     Fields:    Translation:Animals
    43. Witwer KW, Hirschi KD. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays. 2014 Apr; 36(4):394-406. PMID: 24436255; PMCID: PMC4109825.
      Citations: 50     Fields:    Translation:HumansAnimals
    44. Punshon T, Tappero R, Ricachenevsky FK, Hirschi K, Nakata PA. Contrasting calcium localization and speciation in leaves of the Medicago truncatula mutant cod5 analyzed via synchrotron X-ray techniques. Plant J. 2013 Nov; 76(4):627-33. PMID: 24033783; PMCID: PMC3957323.
      Citations: 2     Fields:    Translation:AnimalsCells
    45. Liu X, Liu S, Feng Y, Liu JZ, Chen Y, Pham K, Deng H, Hirschi KD, Wang X, Cheng N. Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):9565-70. PMID: 23690600; PMCID: PMC3677505.
      Citations: 15     Fields:    Translation:AnimalsCells
    46. Wu Q, Shigaki T, Han JS, Kim CK, Hirschi KD, Park S. Ectopic expression of a maize calreticulin mitigates calcium deficiency-like disorders in sCAX1-expressing tobacco and tomato. Plant Mol Biol. 2012 Dec; 80(6):609-19. PMID: 23007728.
      Citations: 2     Fields:    Translation:Animals
    47. Cho D, Villiers F, Kroniewicz L, Lee S, Seo YJ, Hirschi KD, Leonhardt N, Kwak JM. Vacuolar CAX1 and CAX3 influence auxin transport in guard cells via regulation of apoplastic pH. Plant Physiol. 2012 Nov; 160(3):1293-302. PMID: 22932758; PMCID: PMC3490596.
      Citations: 29     Fields:    Translation:AnimalsCells
    48. Yang J, Punshon T, Guerinot ML, Hirschi KD. Plant calcium content: ready to remodel. Nutrients. 2012 08; 4(8):1120-36. PMID: 23016135; PMCID: PMC3448090.
      Citations: 6     Fields:    Translation:HumansAnimals
    49. Wu Q, Lin J, Liu JZ, Wang X, Lim W, Oh M, Park J, Rajashekar CB, Whitham SA, Cheng NH, Hirschi KD, Park S. Ectopic expression of Arabidopsis glutaredoxin AtGRXS17 enhances thermotolerance in tomato. Plant Biotechnol J. 2012 Oct; 10(8):945-55. PMID: 22762155.
      Citations: 26     Fields:    Translation:AnimalsCells
    50. Hirschi KD. New foods for thought. Trends Plant Sci. 2012 Mar; 17(3):123-5. PMID: 22265093.
      Citations: 11     Fields:    Translation:HumansAnimals
    51. Emery L, Whelan S, Hirschi KD, Pittman JK. Protein Phylogenetic Analysis of Ca(2+)/cation Antiporters and Insights into their Evolution in Plants. Front Plant Sci. 2012; 3:1. PMID: 22645563; PMCID: PMC3355786.
      Citations: 47     
    52. Undurraga SF, Santos MP, Paez-Valencia J, Yang H, Hepler PK, Facanha AR, Hirschi KD, Gaxiola RA. Arabidopsis sodium dependent and independent phenotypes triggered by H?-PPase up-regulation are SOS1 dependent. Plant Sci. 2012 Feb; 183:96-105. PMID: 22195582.
      Citations: 14     Fields:    Translation:AnimalsCells
    53. Punshon T, Hirschi K, Yang J, Lanzirotti A, Lai B, Guerinot ML. The role of CAX1 and CAX3 in elemental distribution and abundance in Arabidopsis seed. Plant Physiol. 2012 Jan; 158(1):352-62. PMID: 22086421; PMCID: PMC3252103.
      Citations: 27     Fields:    Translation:Animals
    54. Manohar M, Shigaki T, Mei H, Park S, Marshall J, Aguilar J, Hirschi KD. Characterization of Arabidopsis Ca2+/H+ exchanger CAX3. Biochemistry. 2011 Jul 19; 50(28):6189-95. PMID: 21657244.
      Citations: 13     Fields:    Translation:Animals
    55. Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD. A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J. 2011 Jul; 278(14):2525-2539. PMID: 21575136; PMCID: PMC4038268.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    56. Cheng NH, Liu JZ, Liu X, Wu Q, Thompson SM, Lin J, Chang J, Whitham SA, Park S, Cohen JD, Hirschi KD. Arabidopsis monothiol glutaredoxin, AtGRXS17, is critical for temperature-dependent postembryonic growth and development via modulating auxin response. J Biol Chem. 2011 Jun 10; 286(23):20398-406. PMID: 21515673; PMCID: PMC3121514.
      Citations: 44     Fields:    Translation:AnimalsCells
    57. Conn SJ, Gilliham M, Athman A, Schreiber AW, Baumann U, Moller I, Cheng NH, Stancombe MA, Hirschi KD, Webb AA, Burton R, Kaiser BN, Tyerman SD, Leigh RA. Cell-specific vacuolar calcium storage mediated by CAX1 regulates apoplastic calcium concentration, gas exchange, and plant productivity in Arabidopsis. Plant Cell. 2011 Jan; 23(1):240-57. PMID: 21258004; PMCID: PMC3051233.
      Citations: 83     Fields:    Translation:AnimalsCells
    58. Manohar M, Mei H, Franklin AJ, Sweet EM, Shigaki T, Riley BB, Macdiarmid CW, Hirschi K. Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development. Biochemistry. 2010 Aug 10; 49(31):6557-66. PMID: 20578725.
      Citations: 9     Fields:    Translation:AnimalsCells
    59. Wu Q, Shigaki T, Williams KA, Han JS, Kim CK, Hirschi KD, Park S. Expression of an Arabidopsis Ca2+/H+ antiporter CAX1 variant in petunia enhances cadmium tolerance and accumulation. J Plant Physiol. 2011 Jan 15; 168(2):167-73. PMID: 20633955.
      Citations: 17     Fields:    Translation:AnimalsPHPublic Health
    60. Li L, Cheng N, Hirschi KD, Wang X. Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp. Acta Crystallogr D Biol Crystallogr. 2010 Jun; 66(Pt 6):725-32. PMID: 20516625; PMCID: PMC2879357.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    61. Zhao J, Connorton JM, Guo Y, Li X, Shigaki T, Hirschi KD, Pittman JK. Functional studies of split Arabidopsis Ca2+/H+ exchangers. J Biol Chem. 2009 Dec 04; 284(49):34075-83. PMID: 19819871; PMCID: PMC2797178.
      Citations: 21     Fields:    Translation:AnimalsCells
    62. Mei H, Cheng NH, Zhao J, Park S, Escareno RA, Pittman JK, Hirschi KD. Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4. New Phytol. 2009; 183(1):95-105. PMID: 19368667.
      Citations: 32     Fields:    Translation:AnimalsCells
    63. Korenkov V, King B, Hirschi K, Wagner GJ. Root-selective expression of AtCAX4 and AtCAX2 results in reduced lamina cadmium in field-grown Nicotiana tabacum L. Plant Biotechnol J. 2009 Apr; 7(3):219-26. PMID: 19175521.
      Citations: 17     Fields:    Translation:AnimalsCells
    64. Hirschi KD. Nutrient biofortification of food crops. Annu Rev Nutr. 2009; 29:401-21. PMID: 19400753.
      Citations: 30     Fields:    Translation:HumansAnimalsPHPublic Health
    65. Zhao J, Shigaki T, Mei H, Guo YQ, Cheng NH, Hirschi KD. Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3. J Biol Chem. 2009 Feb 13; 284(7):4605-15. PMID: 19098009.
      Citations: 29     Fields:    Translation:Animals
    66. Park S, Elless MP, Park J, Jenkins A, Lim W, Chambers E, Hirschi KD. Sensory analysis of calcium-biofortified lettuce. Plant Biotechnol J. 2009 Jan; 7(1):106-17. PMID: 19021875.
      Citations: 21     Fields:    Translation:Animals
    67. Morris J, Tian H, Park S, Sreevidya CS, Ward JM, Hirschi KD. AtCCX3 is an Arabidopsis endomembrane H+ -dependent K+ transporter. Plant Physiol. 2008 Nov; 148(3):1474-86. PMID: 18775974; PMCID: PMC2577254.
      Citations: 24     Fields:    Translation:Animals
    68. Zhao J, Cheng NH, Motes CM, Blancaflor EB, Moore M, Gonzales N, Padmanaban S, Sze H, Ward JM, Hirschi KD. AtCHX13 is a plasma membrane K+ transporter. Plant Physiol. 2008 Oct; 148(2):796-807. PMID: 18676662; PMCID: PMC2556814.
      Citations: 29     Fields:    Translation:AnimalsCells
    69. Hirschi K. Nutritional improvements in plants: time to bite on biofortified foods. Trends Plant Sci. 2008 Sep; 13(9):459-63. PMID: 18635389.
      Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    70. Hirschi KD, Pittman JK, Barkla BJ. Exchangers man the pumps: Functional interplay between proton pumps and proton-coupled Ca exchangers. Plant Signal Behav. 2008 May; 3(5):354-6. PMID: 19841670; PMCID: PMC2634282.
      Citations: 4     Fields:    
    71. Morris J, Hawthorne KM, Hotze T, Abrams SA, Hirschi KD. Nutritional impact of elevated calcium transport activity in carrots. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1431-5. PMID: 18202180; PMCID: PMC2234161.
      Citations: 32     Fields:    Translation:HumansAnimals
    72. Zhao J, Barkla BJ, Marshall J, Pittman JK, Hirschi KD. The Arabidopsis cax3 mutants display altered salt tolerance, pH sensitivity and reduced plasma membrane H+-ATPase activity. Planta. 2008 Feb; 227(3):659-69. PMID: 17968588.
      Citations: 42     Fields:    Translation:AnimalsCells
    73. Mei H, Zhao J, Pittman JK, Lachmansingh J, Park S, Hirschi KD. In planta regulation of the Arabidopsis Ca(2+)/H(+) antiporter CAX1. J Exp Bot. 2007; 58(12):3419-27. PMID: 17898422.
      Citations: 23     Fields:    Translation:AnimalsCells
    74. Korenkov V, Hirschi K, Crutchfield JD, Wagner GJ. Enhancing tonoplast Cd/H antiport activity increases Cd, Zn, and Mn tolerance, and impacts root/shoot Cd partitioning in Nicotiana tabacum L. Planta. 2007 Nov; 226(6):1379-87. PMID: 17636324.
      Citations: 34     Fields:    Translation:AnimalsCells
    75. Morris J, Nakata PA, McConn M, Brock A, Hirschi KD. Increased calcium bioavailability in mice fed genetically engineered plants lacking calcium oxalate. Plant Mol Biol. 2007 Jul; 64(5):613-8. PMID: 17514431.
      Citations: 9     Fields:    Translation:Animals
    76. Kim CK, Han JS, Lee HS, Oh JY, Shigaki T, Park SH, Hirschi K. Expression of an Arabidopsis CAX2 variant in potato tubers increases calcium levels with no accumulation of manganese. Plant Cell Rep. 2006 Nov; 25(11):1226-32. PMID: 17024452.
      Citations: 9     Fields:    Translation:AnimalsCells
    77. Cheng NH, Liu JZ, Brock A, Nelson RS, Hirschi KD. AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage. J Biol Chem. 2006 Sep 08; 281(36):26280-8. PMID: 16829529.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    78. Bock KW, Honys D, Ward JM, Padmanaban S, Nawrocki EP, Hirschi KD, Twell D, Sze H. Integrating membrane transport with male gametophyte development and function through transcriptomics. Plant Physiol. 2006 Apr; 140(4):1151-68. PMID: 16607029; PMCID: PMC1435806.
      Citations: 70     Fields:    Translation:AnimalsCells
    79. Park S, Li J, Pittman JK, Berkowitz GA, Yang H, Undurraga S, Morris J, Hirschi KD, Gaxiola RA. Up-regulation of a H+-pyrophosphatase (H+-PPase) as a strategy to engineer drought-resistant crop plants. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18830-5. PMID: 16361442; PMCID: PMC1323196.
      Citations: 74     Fields:    Translation:AnimalsCells
    80. Park S, Cheng NH, Pittman JK, Yoo KS, Park J, Smith RH, Hirschi KD. Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters. Plant Physiol. 2005 Nov; 139(3):1194-206. PMID: 16244156; PMCID: PMC1283758.
      Citations: 32     Fields:    Translation:Animals
    81. Shigaki T, Kole M, Ward JM, Sze H, Hirschi KD. Cre-loxP recombination vectors for the expression of Riken Arabidopsis full-length cDNAs in plants. Biotechniques. 2005 Sep; 39(3):301-2, 304. PMID: 16206900.
      Citations: 3     Fields:    Translation:AnimalsCells
    82. Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, LeClere S, Lahner B, Salt DE, Hirschi KD. Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis. Plant Physiol. 2005 Aug; 138(4):2048-60. PMID: 16055687; PMCID: PMC1183394.
      Citations: 80     Fields:    Translation:AnimalsCells
    83. Park S, Kang TS, Kim CK, Han JS, Kim S, Smith RH, Pike LM, Hirschi KD. Genetic manipulation for enhancing calcium content in potato tuber. J Agric Food Chem. 2005 Jul 13; 53(14):5598-603. PMID: 15998121.
      Citations: 18     Fields:    Translation:Animals
    84. Shigaki T, Vyzasatya RR, Sivitz AB, Ward JM, Sze H, Hirschi KD. The Cre-loxP recombination-based reporter system for plant transcriptional expression studies. Plant Mol Biol. 2005 May; 58(1):65-73. PMID: 16028117.
      Citations: 2     Fields:    Translation:AnimalsCells
    85. Pittman JK, Shigaki T, Hirschi KD. Evidence of differential pH regulation of the Arabidopsis vacuolar Ca2+/H+ antiporters CAX1 and CAX2. FEBS Lett. 2005 May 09; 579(12):2648-56. PMID: 15862304.
      Citations: 19     Fields:    Translation:AnimalsCells
    86. Pittman JK, Shigaki T, Marshall JL, Morris JL, Cheng NH, Hirschi KD. Functional and regulatory analysis of the Arabidopsis thaliana CAX2 cation transporter. Plant Mol Biol. 2004 Dec; 56(6):959-71. PMID: 15821993.
      Citations: 33     Fields:    Translation:AnimalsCells
    87. Pittman JK, Cheng NH, Shigaki T, Kunta M, Hirschi KD. Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p. Mol Microbiol. 2004 Nov; 54(4):1104-16. PMID: 15522090.
      Citations: 21     Fields:    Translation:AnimalsCells
    88. Sze H, Padmanaban S, Honys D, Cheng NH, Bock KW, Li X, Twell D, Ward JM, Hirschi KD, Cellier F, Con?j?ro G. Expression patterns of a novel AtCHX gene family highlight potential roles in osmotic adjustment and K+ homeostasis in pollen development. Plant Physiol. 2004 Sep; 136(1):2532-47. PMID: 15347787; PMCID: PMC523320.
      Citations: 57     Fields:    Translation:AnimalsCells
    89. Hirschi KD. The calcium conundrum. Both versatile nutrient and specific signal. Plant Physiol. 2004 Sep; 136(1):2438-42. PMID: 15375199; PMCID: PMC523310.
      Citations: 66     Fields:    Translation:AnimalsCells
    90. Cheng NH, Liu JZ, Nelson RS, Hirschi KD. Characterization of CXIP4, a novel Arabidopsis protein that activates the H+/Ca2+ antiporter, CAX1. FEBS Lett. 2004 Feb 13; 559(1-3):99-106. PMID: 14960315.
      Citations: 14     Fields:    Translation:AnimalsCells
    91. Hirschi KD. Strike while the ionome is hot: making the most of plant genomic advances. Trends Biotechnol. 2003 Dec; 21(12):520-1. PMID: 14624858.
      Citations: 5     Fields:    
    92. Cheng NH, Pittman JK, Zhu JK, Hirschi KD. The protein kinase SOS2 activates the Arabidopsis H(+)/Ca(2+) antiporter CAX1 to integrate calcium transport and salt tolerance. J Biol Chem. 2004 Jan 23; 279(4):2922-6. PMID: 14583601.
      Citations: 90     Fields:    Translation:AnimalsCells
    93. Park SH, Morris JL, Park JE, Hirschi KD, Smith RH. Efficient and genotype-independent Agrobacterium--mediated tomato transformation. J Plant Physiol. 2003 Oct; 160(10):1253-7. PMID: 14610894.
      Citations: 30     Fields:    Translation:AnimalsCells
    94. Hirschi KK, Burt JM, Hirschi KD, Dai C. Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation. Circ Res. 2003 Sep 05; 93(5):429-37. PMID: 12919949.
      Citations: 69     Fields:    Translation:AnimalsCells
    95. Pittman JK, Hirschi KD, Bartel B, Magidin M. ILR2, a novel gene regulating IAA conjugate sensitivity and metal transport in Arabidopsis thaliana. Plant J. 2003 Aug; 35(4):523-34. PMID: 12904214.
      Citations: 17     Fields:    Translation:AnimalsCells
    96. Pittman JK, Hirschi KD. Don't shoot the (second) messenger: endomembrane transporters and binding proteins modulate cytosolic Ca2+ levels. Curr Opin Plant Biol. 2003 Jun; 6(3):257-62. PMID: 12753975.
      Citations: 20     Fields:    Translation:AnimalsCells
    97. Hirschi KD. Insertional mutants: a foundation for assessing gene function. Trends Plant Sci. 2003 May; 8(5):205-7. PMID: 12758036.
      Citations: 6     Fields:    Translation:Animals
    98. Ward JM, Hirschi KD, Sze H. Plants pass the salt. Trends Plant Sci. 2003 May; 8(5):200-1. PMID: 12758034.
      Citations: 21     Fields:    Translation:AnimalsCells
    99. Cheng NH, Pittman JK, Barkla BJ, Shigaki T, Hirschi KD. The Arabidopsis cax1 mutant exhibits impaired ion homeostasis, development, and hormonal responses and reveals interplay among vacuolar transporters. Plant Cell. 2003 Feb; 15(2):347-64. PMID: 12566577; PMCID: PMC141206.
      Citations: 84     Fields:    Translation:AnimalsCells
    100. Shigaki T, Pittman JK, Hirschi KD. Manganese specificity determinants in the Arabidopsis metal/H+ antiporter CAX2. J Biol Chem. 2003 Feb 21; 278(8):6610-7. PMID: 12496310.
      Citations: 40     Fields:    Translation:AnimalsCells
    101. Cheng NH, Hirschi KD. Cloning and characterization of CXIP1, a novel PICOT domain-containing Arabidopsis protein that associates with CAX1. J Biol Chem. 2003 Feb 21; 278(8):6503-9. PMID: 12480930.
      Citations: 23     Fields:    Translation:AnimalsCells
    102. Shigaki T, Sreevidya C, Hirschi KD. Analysis of the Ca2+ domain in the Arabidopsis H+/Ca2+ antiporters CAX1 and CAX3. Plant Mol Biol. 2002 Oct; 50(3):475-83. PMID: 12369623.
      Citations: 7     Fields:    Translation:AnimalsCells
    103. Gaxiola RA, Fink GR, Hirschi KD. Genetic manipulation of vacuolar proton pumps and transporters. Plant Physiol. 2002 Jul; 129(3):967-73. PMID: 12114553; PMCID: PMC1540242.
      Citations: 37     Fields:    Translation:AnimalsCells
    104. Pittman JK, Shigaki T, Cheng NH, Hirschi KD. Mechanism of N-terminal autoinhibition in the Arabidopsis Ca(2+)/H(+) antiporter CAX1. J Biol Chem. 2002 Jul 19; 277(29):26452-9. PMID: 12006570.
      Citations: 24     Fields:    Translation:AnimalsCells
    105. Cheng NH, Pittman JK, Shigaki T, Hirschi KD. Characterization of CAX4, an Arabidopsis H(+)/cation antiporter. Plant Physiol. 2002 Apr; 128(4):1245-54. PMID: 11950973; PMCID: PMC154252.
      Citations: 37     Fields:    Translation:AnimalsCells
    106. Chaudry MA, James KC, Ng CT, Nicholls PJ. Anabolic and androgenic activities, in rat, of some nandrolone and androstanolone esters. J Pharm Pharmacol. 1976 Dec; 28(12):882-5. PMID: 12263.
      Citations: 2     Fields:    Translation:Animals
    107. Sanchez G, Alderete JF. The effect of host adrenalectomy on the physiology of Trypanosoma rhodesiense. Comp Biochem Physiol A Comp Physiol. 1975 Dec 01; 52(4):623-6. PMID: 1186.
      Citations: 1     Fields:    Translation:Animals
    108. Hansson B, Mannheimer C. [Treatment of ischemic wounds in the elderly by covering with pigskin heterografts]. Lakartidningen. 1975 Nov 26; 72(48):4736-7. PMID: 565.
      Citations:    Fields:    Translation:HumansAnimals
    109. Hendrickson WA, Ward KB. Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1349-56. PMID: 5.
      Citations: 6     Fields:    Translation:AnimalsCells
    110. Smith RJ, Bryant RG. Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1281-6. PMID: 3.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    111. Renaud B, Buda M, Lewis BD, Pujol JF. Effects of 5,6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat. Biochem Pharmacol. 1975 Sep 15; 24(18):1739-42. PMID: 17.
      Citations: 9     Fields:    Translation:AnimalsCells
    112. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
      Citations: 44     Fields:    Translation:AnimalsCells
    113. Ahn BK, Wist AO, Liu CC, Ko WH. Development of a miniature pH glass electrode with field-effect-transistor amplifier for biomedical applications. Med Biol Eng. 1975 May; 13(3):450-6. PMID: 563.
      Citations: 1     Fields:    
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