IRINA I. SERYSHEVA

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
Address
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    R01GM072804     (SERYSHEVA, IRINA I)Feb 24, 2010 - May 31, 2018
    NIH/NIGMS
    Structure-function studies of IP3R channels
    Role: Principal Investigator

    R21AR063255     (SERYSHEVA, IRINA I)Mar 1, 2013 - Feb 28, 2015
    NIH/NIAMS
    Structural Studies of RyR Channel
    Role: Principal Investigator

    R21NS106968     (SERYSHEVA, IRINA I)Feb 15, 2018 - Jan 31, 2020
    NIH/NINDS
    Regulation of IP3R channel in apoptosis
    Role: Principal Investigator

    R21NS108724     (BOLOTINA, VICTORIA M)Jul 15, 2018 - Jun 30, 2020
    NIH/NINDS
    Structure-Function of PLA2g6
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G. Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4). PMID: 31501195.
      Citations: 3     Fields:    
    2. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 01; 26(1):40-49. PMID: 30598551.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II. Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res. 2018 12; 28(12):1158-1170. PMID: 30470765.
      Citations: 6     Fields:    Translation:AnimalsCells
    4. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863.
      Citations: 14     Fields:    Translation:HumansCells
    5. Baker MR, Fan G, Serysheva II. Structure of IP3R channel: high-resolution insights from cryo-EM. Curr Opin Struct Biol. 2017 10; 46:38-47. PMID: 28618351.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    6. Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D. An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife. 2017 03 29; 6. PMID: 28355133.
      Citations: 25     Fields:    Translation:Cells
    7. Serysheva II, Baker MR, Fan G. Structural Insights into IP3R Function. Adv Exp Med Biol. 2017; 981:121-147. PMID: 29594860.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Jarius S, Ringelstein M, Haas J, Serysheva II, Komorowski L, Fechner K, Wandinger KP, Albrecht P, Hefter H, Moser A, Neuen-Jacob E, Hartung HP, Wildemann B, Aktas O. Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. J Neuroinflammation. 2016 10 24; 13(1):278. PMID: 27776522.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature. 2015 Nov 19; 527(7578):336-41. PMID: 26458101.
      Citations: 68     Fields:    Translation:AnimalsCells
    10. Baker MR, Fan G, Serysheva II. Single-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous Environment. Eur J Transl Myol. 2015 Jan 07; 25(1):4803. PMID: 26913144.
      Citations:    
    11. Baker MR, Fan G, Serysheva II. Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Eur J Transl Myol. 2015; 25(1):35-48. PMID: 25844145.
      Citations:    
    12. Jarius S, Scharf M, Begemann N, Stöcker W, Probst C, Serysheva II, Nagel S, Graus F, Psimaras D, Wildemann B, Komorowski L. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. J Neuroinflammation. 2014 Dec 11; 11:206. PMID: 25498830.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Serysheva II. Toward a high-resolution structure of IP3R channel. Cell Calcium. 2014 Sep; 56(3):125-32. PMID: 25159857.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Ludtke SJ, Serysheva II. Single-particle cryo-EM of calcium release channels: structural validation. Curr Opin Struct Biol. 2013 Oct; 23(5):755-62. PMID: 23831288.
      Citations: 8     Fields:    Translation:Cells
    15. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Validation of cryo-EM structure of IP3R1 channel. Structure. 2013 Jun 04; 21(6):900-9. PMID: 23707684.
      Citations: 24     Fields:    Translation:Cells
    16. Popova OB, Baker MR, Tran TP, Le T, Serysheva II. Identification of ATP-binding regions in the RyR1 Ca²? release channel. PLoS One. 2012; 7(11):e48725. PMID: 23144945.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Flexible architecture of IP3R1 by Cryo-EM. Structure. 2011 Aug 10; 19(8):1192-9. PMID: 21827954.
      Citations: 41     Fields:    Translation:AnimalsCells
    18. Serysheva II, Ludtke SJ. 3D Structure of IP(3) Receptor. Curr Top Membr. 2010; 66:171-89. PMID: 22353480.
      Citations: 6     Fields:    
    19. Serysheva II. Preface. Curr Top Membr. 2010; 66:xv-xvi. PMID: 22353487.
      Citations:    Fields:    
    20. Hamilton SL, Serysheva II. Ryanodine receptor structure: progress and challenges. J Biol Chem. 2009 Feb 13; 284(7):4047-51. PMID: 18927076.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    21. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707.
      Citations: 57     Fields:    Translation:Cells
    22. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7451-5. PMID: 18490661.
      Citations: 84     Fields:    Translation:AnimalsCells
    23. Serysheva II, Chiu W, Ludtke SJ. Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. Methods Cell Biol. 2007; 79:407-35. PMID: 17327167.
      Citations: 6     Fields:    Translation:AnimalsCells
    24. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. The pore structure of the closed RyR1 channel. Structure. 2005 Aug; 13(8):1203-11. PMID: 16084392.
      Citations: 64     Fields:    Translation:AnimalsCells
    25. Serysheva II, Hamilton SL, Chiu W, Ludtke SJ. Structure of Ca2+ release channel at 14 A resolution. J Mol Biol. 2005 Jan 21; 345(3):427-31. PMID: 15581887.
      Citations: 32     Fields:    Translation:Cells
    26. Serysheva II. Structural insights into excitation-contraction coupling by electron cryomicroscopy. Biochemistry (Mosc). 2004 Nov; 69(11):1226-32. PMID: 15627376.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Serysheva II, Bare DJ, Ludtke SJ, Kettlun CS, Chiu W, Mignery GA. Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. J Biol Chem. 2003 Jun 13; 278(24):21319-22. PMID: 12714606.
      Citations: 34     Fields:    Translation:AnimalsCells
    28. Baker ML, Serysheva II, Sencer S, Wu Y, Ludtke SJ, Jiang W, Hamilton SL, Chiu W. The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12155-60. PMID: 12218169.
      Citations: 20     Fields:    Translation:AnimalsCells
    29. Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL. Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10370-5. PMID: 12149473.
      Citations: 26     Fields:    Translation:AnimalsCells
    30. Pate P, Mochca-Morales J, Wu Y, Zhang JZ, Rodney GG, Serysheva II, Williams BY, Anderson ME, Hamilton SL. Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J Biol Chem. 2000 Dec 15; 275(50):39786-92. PMID: 11005820.
      Citations: 49     Fields:    Translation:AnimalsCells
    31. Hamilton SL, Serysheva I, Strasburg GM. Calmodulin and Excitation-Contraction Coupling. News Physiol Sci. 2000 Dec; 15:281-284. PMID: 11390927.
      Citations: 9     Fields:    
    32. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J. 1999 Oct; 77(4):1936-44. PMID: 10512814.
      Citations: 37     Fields:    Translation:Cells
    33. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W. Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol. 1996 Jun; 3(6):547-52. PMID: 8646541.
      Citations: 51     Fields:    Translation:AnimalsCells
    34. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
      Citations: 57     Fields:    Translation:Cells
    35. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Nat Struct Biol. 1995 Jan; 2(1):18-24. PMID: 7719847.
      Citations: 54     Fields:    Translation:AnimalsCells
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