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IRINA SERYSHEVA

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
Address6431 Fannin, MSB 6.102
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R21AR082833     (SERYSHEVA, IRINA I)Jul 1, 2023 - Jun 30, 2025
    NIH
    Defining architecture of EC coupling machinery in situ
    Role: Principal Investigator
    R21NS108724     (BOLOTINA, VICTORIA M)Jul 15, 2018 - Jun 30, 2021
    NIH
    Structure-Function of PLA2g6
    Role: Co-Principal Investigator
    R21NS106968     (SERYSHEVA, IRINA I)Feb 15, 2018 - Jan 31, 2021
    NIH
    Regulation of IP3R channel in apoptosis
    Role: Principal Investigator
    R21AR063255     (SERYSHEVA, IRINA I)Mar 1, 2013 - Feb 29, 2016
    NIH
    Structural Studies of RyR Channel
    Role: Principal Investigator
    R01GM072804     (SERYSHEVA, IRINA I)Mar 11, 2005 - Feb 29, 2024
    NIH
    Structure-function studies of IP3R channels
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. Publisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun. 2024 Apr 08; 15(1):3022. PMID: 38589378; PMCID: PMC11001901.
      Citations:    
    2. Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun. 2024 Mar 04; 15(1):1965. PMID: 38438382; PMCID: PMC10912198.
      Citations:    Fields:    Translation:AnimalsCells
    3. Mise K, Long J, Galvan DL, Ye Z, Fan G, Serysheva II, Moore TI, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease. Res Sq. 2023 Jun 30. PMID: 37461606; PMCID: PMC10350115.
      Citations:    
    4. Baker MR, Fan G, Arige V, Serysheva II, Yule DI. Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape. Cell Calcium. 2023 09; 114:102770. PMID: 37393815; PMCID: PMC10529787.
      Citations: 2     Fields:    Translation:Cells
    5. Hryc CF, Mallampalli VKPS, Bovshik EI, Azinas S, Fan G, Serysheva II, Sparagna GC, Baker ML, Mileykovskaya E, Dowhan W. Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun. 2023 05 15; 14(1):2783. PMID: 37188665; PMCID: PMC10185535.
      Citations:    Fields:    Translation:Animals
    6. Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A. Author Correction: Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Cell Mol Immunol. 2022 Dec 06. PMID: 36471115.
      Citations:    Fields:    
    7. Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II. Conformational motions and ligand-binding underlying gating and regulation in IP3R channel. Nat Commun. 2022 11 14; 13(1):6942. PMID: 36376291; PMCID: PMC9663519.
      Citations: 4     Fields:    Translation:Cells
    8. Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A. Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Cell Mol Immunol. 2023 01; 20(1):11-25. PMID: 36302985; PMCID: PMC9794825.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Arige V, Terry LE, Wagner LE, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI. Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2209267119. PMID: 36122240; PMCID: PMC9522344.
      Citations:    
    10. Chen M, Shi X, Yu Z, Fan G, Serysheva II, Baker ML, Luisi BF, Ludtke SJ, Wang Z. In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution. Structure. 2022 01 06; 30(1):107-113.e3. PMID: 34506732; PMCID: PMC8741639.
      Citations: 4     Fields:    Translation:Cells
    11. Baker MR, Fan G, Seryshev AB, Agosto MA, Baker ML, Serysheva II. Cryo-EM structure of type 1 IP3R channel in a lipid bilayer. Commun Biol. 2021 05 25; 4(1):625. PMID: 34035440; PMCID: PMC8149723.
      Citations: 6     Translation:AnimalsCells
    12. Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G. Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4). PMID: 31501195; PMCID: PMC7111250.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    13. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 01; 26(1):40-49. PMID: 30598551; PMCID: PMC6458597.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    14. Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II. Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res. 2018 12; 28(12):1158-1170. PMID: 30470765; PMCID: PMC6274648.
      Citations: 21     Fields:    Translation:AnimalsCells
    15. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863; PMCID: PMC5657569.
      Citations: 33     Fields:    Translation:HumansCells
    16. Baker MR, Fan G, Serysheva II. Structure of IP3R channel: high-resolution insights from cryo-EM. Curr Opin Struct Biol. 2017 10; 46:38-47. PMID: 28618351; PMCID: PMC5683905.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    17. Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D. An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife. 2017 03 29; 6. PMID: 28355133; PMCID: PMC5404916.
      Citations: 91     Fields:    Translation:Cells
    18. Serysheva II, Baker MR, Fan G. Structural Insights into IP3R Function. Adv Exp Med Biol. 2017; 981:121-147. PMID: 29594860.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Jarius S, Serysheva II, Wildemann B, Ringelstein M, Haas J, Komorowski L, Fechner K, Wandinger KP, Albrecht P, Hefter H, Moser A, Neuen-Jacob E, Hartung HP, Aktas O. Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. J Neuroinflammation. 2016 10 24; 13(1):278. PMID: 27776522; PMCID: PMC5078930.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature. 2015 Nov 19; 527(7578):336-41. PMID: 26458101; PMCID: PMC4804758.
      Citations: 100     Fields:    Translation:AnimalsCells
    21. Baker MR, Fan G, Serysheva II. Single-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous Environment. Eur J Transl Myol. 2015 Jan 07; 25(1):4803. PMID: 26913144; PMCID: PMC4748972.
      Citations: 7     
    22. Baker MR, Fan G, Serysheva II. Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Eur J Transl Myol. 2015; 25(1):35-48. PMID: 25844145; PMCID: PMC4381806.
      Citations: 11     
    23. Jarius S, Serysheva II, Wildemann B, Scharf M, Begemann N, St?cker W, Probst C, Nagel S, Graus F, Psimaras D, Komorowski L. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. J Neuroinflammation. 2014 Dec 11; 11:206. PMID: 25498830; PMCID: PMC4300617.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    24. Serysheva II. Toward a high-resolution structure of IP3R channel. Cell Calcium. 2014 Sep; 56(3):125-32. PMID: 25159857; PMCID: PMC4162860.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    25. Ludtke SJ, Serysheva II. Single-particle cryo-EM of calcium release channels: structural validation. Curr Opin Struct Biol. 2013 Oct; 23(5):755-62. PMID: 23831288; PMCID: PMC3805725.
      Citations: 9     Fields:    Translation:Cells
    26. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Validation of cryo-EM structure of IP3R1 channel. Structure. 2013 Jun 04; 21(6):900-9. PMID: 23707684; PMCID: PMC3696195.
      Citations: 26     Fields:    Translation:Cells
    27. Popova OB, Baker MR, Tran TP, Le T, Serysheva II. Identification of ATP-binding regions in the RyR1 Ca?? release channel. PLoS One. 2012; 7(11):e48725. PMID: 23144945; PMCID: PMC3492408.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Flexible architecture of IP3R1 by Cryo-EM. Structure. 2011 Aug 10; 19(8):1192-9. PMID: 21827954; PMCID: PMC3154621.
      Citations: 47     Fields:    Translation:AnimalsCells
    29. Serysheva II, Ludtke SJ. 3D Structure of IP(3) Receptor. Curr Top Membr. 2010; 66:171-89. PMID: 22353480.
      Citations: 6     Fields:    
    30. Serysheva II. Preface. Curr Top Membr. 2010; 66:xv-xvi. PMID: 22353487.
      Citations:    Fields:    
    31. Hamilton SL, Serysheva II. Ryanodine receptor structure: progress and challenges. J Biol Chem. 2009 Feb 13; 284(7):4047-51. PMID: 18927076; PMCID: PMC3837402.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    32. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707; PMCID: PMC2474495.
      Citations: 61     Fields:    Translation:Cells
    33. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7451-5. PMID: 18490661; PMCID: PMC2396679.
      Citations: 100     Fields:    Translation:AnimalsCells
    34. Serysheva II, Chiu W, Ludtke SJ. Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. Methods Cell Biol. 2007; 79:407-35. PMID: 17327167.
      Citations: 6     Fields:    Translation:AnimalsCells
    35. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. The pore structure of the closed RyR1 channel. Structure. 2005 Aug; 13(8):1203-11. PMID: 16084392; PMCID: PMC2983469.
      Citations: 66     Fields:    Translation:AnimalsCells
    36. Serysheva II, Hamilton SL, Chiu W, Ludtke SJ. Structure of Ca2+ release channel at 14 A resolution. J Mol Biol. 2005 Jan 21; 345(3):427-31. PMID: 15581887; PMCID: PMC2978512.
      Citations: 32     Fields:    Translation:Cells
    37. Serysheva II. Structural insights into excitation-contraction coupling by electron cryomicroscopy. Biochemistry (Mosc). 2004 Nov; 69(11):1226-32. PMID: 15627376.
      Citations: 11     Fields:    Translation:AnimalsCells
    38. Serysheva II, Bare DJ, Ludtke SJ, Kettlun CS, Chiu W, Mignery GA. Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. J Biol Chem. 2003 Jun 13; 278(24):21319-22. PMID: 12714606.
      Citations: 36     Fields:    Translation:AnimalsCells
    39. Baker ML, Serysheva II, Sencer S, Wu Y, Ludtke SJ, Jiang W, Hamilton SL, Chiu W. The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12155-60. PMID: 12218169; PMCID: PMC129414.
      Citations: 22     Fields:    Translation:AnimalsCells
    40. Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL. Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10370-5. PMID: 12149473; PMCID: PMC124921.
      Citations: 27     Fields:    Translation:AnimalsCells
    41. Pate P, Mochca-Morales J, Wu Y, Zhang JZ, Rodney GG, Serysheva II, Williams BY, Anderson ME, Hamilton SL. Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J Biol Chem. 2000 Dec 15; 275(50):39786-92. PMID: 11005820.
      Citations: 53     Fields:    Translation:AnimalsCells
    42. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J. 1999 Oct; 77(4):1936-44. PMID: 10512814; PMCID: PMC1300475.
      Citations: 40     Fields:    Translation:Cells
    43. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W. Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol. 1996 Jun; 3(6):547-52. PMID: 8646541.
      Citations: 55     Fields:    Translation:AnimalsCells
    44. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
      Citations: 62     Fields:    Translation:Cells
    45. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Nat Struct Biol. 1995 Jan; 2(1):18-24. PMID: 7719847.
      Citations: 54     Fields:    Translation:AnimalsCells
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