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TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    Collapse Research 
    Collapse research activities and funding
    R01GM072804     (SERYSHEVA, IRINA I)Mar 11, 2005 - May 31, 2018
    Structure-function studies of IP3R channels
    Role: Principal Investigator

    R21AR063255     (SERYSHEVA, IRINA I)Mar 1, 2013 - Feb 28, 2015
    Structural Studies of RyR Channel
    Role: Principal Investigator

    R21NS106968     (SERYSHEVA, IRINA I)Feb 15, 2018 - Jan 31, 2020
    Regulation of IP3R channel in apoptosis
    Role: Principal Investigator

    R21NS108724     (BOLOTINA, VICTORIA M)Jul 15, 2018 - Jun 30, 2020
    Structure-Function of PLA2g6
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 Jan; 26(1):40-49. PMID: 30598551.
      View in: PubMed
    2. Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II. Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res. 2018 Dec; 28(12):1158-1170. PMID: 30470765.
      View in: PubMed
    3. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863.
      View in: PubMed
    4. Baker MR, Fan G, Serysheva II. Structure of IP3R channel: high-resolution insights from cryo-EM. Curr Opin Struct Biol. 2017 10; 46:38-47. PMID: 28618351.
      View in: PubMed
    5. Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D. An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife. 2017 03 29; 6. PMID: 28355133.
      View in: PubMed
    6. Serysheva II, Baker MR, Fan G. Structural Insights into IP3R Function. Adv Exp Med Biol. 2017; 981:121-147. PMID: 29594860.
      View in: PubMed
    7. Jarius S, Ringelstein M, Haas J, Serysheva II, Komorowski L, Fechner K, Wandinger KP, Albrecht P, Hefter H, Moser A, Neuen-Jacob E, Hartung HP, Wildemann B, Aktas O. Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. J Neuroinflammation. 2016 10 24; 13(1):278. PMID: 27776522.
      View in: PubMed
    8. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature. 2015 Nov 19; 527(7578):336-41. PMID: 26458101; PMCID: PMC4804758.
    9. Baker MR, Fan G, Serysheva II. Single-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous Environment. Eur J Transl Myol. 2015 Jan 07; 25(1):4803. PMID: 26913144.
      View in: PubMed
    10. Baker MR, Fan G, Serysheva II. Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Eur J Transl Myol. 2015; 25(1):35-48. PMID: 25844145.
      View in: PubMed
    11. Jarius S, Scharf M, Begemann N, Stöcker W, Probst C, Serysheva II, Nagel S, Graus F, Psimaras D, Wildemann B, Komorowski L. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. J Neuroinflammation. 2014 Dec 11; 11:206. PMID: 25498830; PMCID: PMC4300617.
    12. Serysheva II. Toward a high-resolution structure of IP3R channel. Cell Calcium. 2014 Sep; 56(3):125-32. PMID: 25159857; PMCID: PMC4162860.
    13. Ludtke SJ, Serysheva II. Single-particle cryo-EM of calcium release channels: structural validation. Curr Opin Struct Biol. 2013 Oct; 23(5):755-62. PMID: 23831288; PMCID: PMC3805725.
    14. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Validation of cryo-EM structure of IP3R1 channel. Structure. 2013 Jun 04; 21(6):900-9. PMID: 23707684; PMCID: PMC3696195.
    15. Popova OB, Baker MR, Tran TP, Le T, Serysheva II. Identification of ATP-binding regions in the RyR1 Ca²? release channel. PLoS One. 2012; 7(11):e48725. PMID: 23144945; PMCID: PMC3492408.
    16. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Flexible architecture of IP3R1 by Cryo-EM. Structure. 2011 Aug 10; 19(8):1192-9. PMID: 21827954; PMCID: PMC3154621.
    17. Serysheva II, Ludtke SJ. 3D Structure of IP(3) Receptor. Curr Top Membr. 2010; 66:171-89. PMID: 22353480.
      View in: PubMed
    18. Serysheva II. Preface. Curr Top Membr. 2010; 66:xv-xvi. PMID: 22353487.
      View in: PubMed
    19. Hamilton SL, Serysheva II. Ryanodine receptor structure: progress and challenges. J Biol Chem. 2009 Feb 13; 284(7):4047-51. PMID: 18927076; PMCID: PMC3837402.
    20. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707; PMCID: PMC2474495.
    21. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7451-5. PMID: 18490661; PMCID: PMC2396679.
    22. Serysheva II, Chiu W, Ludtke SJ. Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. Methods Cell Biol. 2007; 79:407-35. PMID: 17327167.
      View in: PubMed
    23. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. The pore structure of the closed RyR1 channel. Structure. 2005 Aug; 13(8):1203-11. PMID: 16084392; PMCID: PMC2983469.
    24. Serysheva II, Hamilton SL, Chiu W, Ludtke SJ. Structure of Ca2+ release channel at 14 A resolution. J Mol Biol. 2005 Jan 21; 345(3):427-31. PMID: 15581887; PMCID: PMC2978512.
    25. Serysheva II. Structural insights into excitation-contraction coupling by electron cryomicroscopy. Biochemistry (Mosc). 2004 Nov; 69(11):1226-32. PMID: 15627376.
      View in: PubMed
    26. Serysheva II, Bare DJ, Ludtke SJ, Kettlun CS, Chiu W, Mignery GA. Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. J Biol Chem. 2003 Jun 13; 278(24):21319-22. PMID: 12714606.
      View in: PubMed
    27. Baker ML, Serysheva II, Sencer S, Wu Y, Ludtke SJ, Jiang W, Hamilton SL, Chiu W. The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12155-60. PMID: 12218169; PMCID: PMC129414.
    28. Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL. Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10370-5. PMID: 12149473; PMCID: PMC124921.
    29. Pate P, Mochca-Morales J, Wu Y, Zhang JZ, Rodney GG, Serysheva II, Williams BY, Anderson ME, Hamilton SL. Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J Biol Chem. 2000 Dec 15; 275(50):39786-92. PMID: 11005820.
      View in: PubMed
    30. Hamilton SL, Serysheva I, Strasburg GM. Calmodulin and Excitation-Contraction Coupling. News Physiol Sci. 2000 Dec; 15:281-284. PMID: 11390927.
      View in: PubMed
    31. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J. 1999 Oct; 77(4):1936-44. PMID: 10512814; PMCID: PMC1300475.
    32. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W. Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol. 1996 Jun; 3(6):547-52. PMID: 8646541.
      View in: PubMed
    33. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
      View in: PubMed
    34. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Nat Struct Biol. 1995 Jan; 2(1):18-24. PMID: 7719847.
      View in: PubMed
    35. Serysheva II, Tourkin AI, Bartish IV, Poglazov BF. GTPase activity of bacteriophage T4 sheath protein. J Mol Biol. 1992 Jan 05; 223(1):23-5. PMID: 1731071.
      View in: PubMed
    36. Serysheva II, Ven'iaminov SIu, Selivanov NA, Rodikova LP, Poglazov BF. [Changes in the secondary structure bacteriophage T4 envelope protein after its polymerization]. Mol Biol (Mosk). 1990 Mar-Apr; 24(2):541-7. PMID: 2362596.
      View in: PubMed
    37. Serysheva II, Turkin AI, Bartish IV, Poglazov BF. [The effect of nucleotides on the sedimentation properties of contracted sheath of bacteriophage T4]. Dokl Akad Nauk SSSR. 1988 Nov-Dec; 303(1):245-8. PMID: 3266140.
      View in: PubMed
    38. Serysheva II, Tourkin AI, Poglazov BF. On the presence of guanosine phosphate in the tail of bacteriophage T4. J Mol Biol. 1984 Nov 05; 179(3):565-9. PMID: 6096555.
      View in: PubMed
    39. Serysheva II, Ven'iaminov SIu, Turkin AI, Rodikova LP, Selivanov NA. [Determination and identification of the nucleoside phosphate bound to bacteriophage T4 cap protein]. Dokl Akad Nauk SSSR. 1984; 275(5):1224-6. PMID: 6734418.
      View in: PubMed
    40. Gorbatova LP, Selivanova GN, Serysheva II, Turkina EV, Belous EA. [Functional role of the basal lamina proteins of bacteriophage T4]. Dokl Akad Nauk SSSR. 1979; 247(3):738-42. PMID: 477508.
      View in: PubMed
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