GRETCHEN DARLINGTON

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Administration

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    R01GM032111     (DARLINGTON, GRETCHEN J.)Sep 1, 1982 - Feb 28, 1993
    NIH
    ACTIVATION AND REGULATION OF HEPATIC GENES
    Role: Principal Investigator

    R13HD026431     (DARLINGTON, GRETCHEN J.)Jun 19, 1989 - May 30, 1990
    NIH
    FASEB RESEARCH CONFERENCE--CELLULAR &MOLECULAR GENETICS
    Role: Principal Investigator

    T32AG000183     (DONEHOWER, LAWRENCE A.)Sep 14, 1989 - Apr 30, 2016
    NIH
    Biology of Aging Training Grant
    Role: Co-Principal Investigator

    T32GM008307     (SHAULSKY, GAD)Jul 1, 1990 - Jun 30, 2021
    NIH
    Program in Human and Molecular Genetics
    Role: Co-Principal Investigator

    T32HG000003     (CHINAULT, ALAN CRAIG)Sep 30, 1990 - Jul 31, 1996
    NIH
    GENOMIC ANALYSIS
    Role: Co-Principal Investigator

    R01DK045285     (DARLINGTON, GRETCHEN J.)May 1, 1993 - Apr 30, 2002
    NIH
    C/EBP ALPHA REGULATION OF ADIPOSE TISSUE DIFFERENTIATION
    Role: Principal Investigator

    R13AG011559     (DARLINGTON, GRETCHEN J.)Jun 8, 1993 - Sep 30, 1993
    NIH
    SYMPOSIUM+SID--CELL CYCLE, CELL AGING, GROWTH REGULATION
    Role: Principal Investigator

    R13AG012379     (DARLINGTON, GRETCHEN J.)Aug 20, 1994 - Jul 31, 1995
    NIH
    REGULATION OF CELL AND TISSUE DIFFERENTIATION
    Role: Principal Investigator

    R01DK053045     (DARLINGTON, GRETCHEN J.)Aug 28, 1997 - Jul 31, 2006
    NIH
    C/EBP ALPHA REGULATION OF ACUTE PHASE RESPONSE IN VIVO
    Role: Principal Investigator

    R03AG017705     (DARLINGTON, GRETCHEN J.)Sep 30, 1999 - Aug 31, 2001
    NIH
    METABOLIC SIMILARITIES IN LONG LIVED MODELS
    Role: Principal Investigator

    U24DK058862     (DARLINGTON, GRETCHEN J.)Jun 25, 2001 - May 31, 2005
    NIH
    NIDDK/Baylor Biotech Center
    Role: Principal Investigator

    U01DK063588     (DARLINGTON, GRETCHEN J.)Sep 30, 2002 - Jul 31, 2006
    NIH
    Gene Expression and Discovery in Liver and Gut Stem Cel*
    Role: Principal Investigator

    R13DK076529     (DARLINGTON, GRETCHEN J.)Jul 22, 2006 - Jul 22, 2007
    NIH
    Liver Biology /Development /Disease FASEB Conference
    Role: Principal Investigator

    R01AG028865     (DARLINGTON, GRETCHEN J.)Aug 1, 2007 - Jul 31, 2013
    NIH
    Molecular Mechanisms of Longevity in Long-Lived Mice
    Role: Principal Investigator

    RC2AG036562     (DARLINGTON, GRETCHEN J.)Sep 30, 2009 - Aug 31, 2012
    NIH
    Epigenetic Changes with Age in Hematopoietic Stem Cells
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Passman AM, Low J, London R, Tirnitz-Parker JE, Miyajima A, Tanaka M, Strick-Marchand H, Darlington GJ, Finch-Edmondson M, Ochsner S, Zhu C, Whelan J, Callus BA, Yeoh GC. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells Int. 2016; 2016:5702873. PMID: 27777588.
      Citations: 3     
    2. Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 02; 16(4):426-38. PMID: 25772072.
      Citations: 56     Fields:    Translation:AnimalsCells
    3. Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 04; 15(3):350-364. PMID: 25130491.
      Citations: 109     Fields:    Translation:AnimalsCells
    4. Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014 May 01; 14(5):673-88. PMID: 24792119.
      Citations: 184     Fields:    Translation:AnimalsCells
    5. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    6. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23. PMID: 24270360.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    7. Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev. 2013 Sep; 134(9):407-15. PMID: 24007921.
      Citations: 8     Fields:    Translation:AnimalsCells
    8. Reddy AK, Hartley CJ, Pham TT, Darlington G, Entman ML, Taffet GE. Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):152-9. PMID: 23682160.
      Citations: 2     Fields:    Translation:Animals
    9. Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013 Mar; 57(3):1098-106. PMID: 23172628.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    10. Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC. Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mech Ageing Dev. 2012 Jul; 133(7):467-78. PMID: 22704917.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 04; 44(1):23-31. PMID: 22138693.
      Citations: 388     Fields:    Translation:HumansAnimalsCells
    12. Qiu Q, Hernandez JC, Dean AM, Rao PH, Darlington GJ. CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells. Stem Cells Dev. 2011 Dec; 20(12):2177-88. PMID: 21361791.
      Citations: 34     Fields:    Translation:AnimalsCells
    13. Singh P, Goode T, Dean A, Awad SS, Darlington GJ. Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver. J Gerontol A Biol Sci Med Sci. 2011 Sep; 66(9):944-56. PMID: 21719609.
      Citations: 10     Fields:    Translation:AnimalsCells
    14. Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010 Sep; 52(3):1023-32. PMID: 20564353.
      Citations: 11     Fields:    Translation:AnimalsCells
    15. Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol. 2009 Jul; 29(14):3867-80. PMID: 19398579.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    16. El-Serag HB, Nurgalieva ZZ, Mistretta TA, Finegold MJ, Souza R, Hilsenbeck S, Shaw C, Darlington G. Gene expression in Barrett's esophagus: laser capture versus whole tissue. Scand J Gastroenterol. 2009; 44(7):787-95. PMID: 19391063.
      Citations: 20     Fields:    Translation:Humans
    17. Singh P, Coskun ZZ, Goode C, Dean A, Thompson-Snipes L, Darlington G. Lymphoid neogenesis and immune infiltration in aged liver. Hepatology. 2008 May; 47(5):1680-90. PMID: 18395842.
      Citations: 28     Fields:    Translation:AnimalsCells
    18. Reddy AK, Amador-Noguez D, Darlington GJ, Scholz BA, Michael LH, Hartley CJ, Entman ML, Taffet GE. Cardiac function in young and old Little mice. J Gerontol A Biol Sci Med Sci. 2007 Dec; 62(12):1319-25. PMID: 18166681.
      Citations: 17     Fields:    Translation:Animals
    19. Ochsner SA, Strick-Marchand H, Qiu Q, Venable S, Dean A, Wilde M, Weiss MC, Darlington GJ. Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers. Stem Cells. 2007 Oct; 25(10):2476-87. PMID: 17641245.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G. Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell. 2007 Aug; 6(4):453-70. PMID: 17521389.
      Citations: 59     Fields:    Translation:AnimalsCells
    21. El-Serag HB, Nurgalieva Z, Souza RF, Shaw C, Darlington G. Is genomic evaluation feasible in endoscopic studies of Barrett's esophagus? A pilot study. Gastrointest Endosc. 2006 Jul; 64(1):17-26. PMID: 16813797.
      Citations: 5     Fields:    Translation:HumansCells
    22. Yoshida Y, Hughes DE, Rausa FM, Kim IM, Tan Y, Darlington GJ, Costa RH. C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Hepatology. 2006 Feb; 43(2):276-86. PMID: 16440369.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
      Citations: 5     Fields:    Translation:AnimalsCells
    24. Yang J, Croniger CM, Lekstrom-Himes J, Zhang P, Fenyus M, Tenen DG, Darlington GJ, Hanson RW. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem. 2005 Nov 18; 280(46):38689-99. PMID: 16166091.
      Citations: 32     Fields:    Translation:AnimalsCells
    25. Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ. A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr. 2005 Aug; 82(2):471-6. PMID: 16087995.
      Citations: 63     Fields:    Translation:HumansCellsCTClinical Trials
    26. Amador-Noguez D, Zimmerman J, Venable S, Darlington G. Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1086-100. PMID: 15925325.
      Citations: 20     Fields:    Translation:AnimalsCells
    27. Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res. 2005 Jun; 20(6):945-53. PMID: 15883634.
      Citations: 30     Fields:    Translation:HumansCTClinical Trials
    28. Amador-Noguez D, Yagi K, Venable S, Darlington G. Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell. 2004 Dec; 3(6):423-41. PMID: 15569359.
      Citations: 68     Fields:    Translation:Animals
    29. Mackey SL, Darlington GJ. CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes. J Biol Chem. 2004 Apr 16; 279(16):16206-13. PMID: 14960573.
      Citations: 5     Fields:    Translation:AnimalsCells
    30. Mackey S, Singh P, Darlington GJ. Making the liver young again. Hepatology. 2003 Dec; 38(6):1349-52. PMID: 14647042.
      Citations: 3     Fields:    Translation:AnimalsCells
    31. Akiba T, Kuroiwa N, Shimizu-Yabe A, Iwase K, Hiwasa T, Yokoe H, Kubosawa H, Kageyama R, Darlington GJ, Mori M, Tanzawa H, Takiguchi M, Dahrington GJ. Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein alpha for the expression in the parotid gland. J Biochem. 2002 Oct; 132(4):621-7. PMID: 12359078.
      Citations: 5     Fields:    Translation:Animals
    32. Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ. C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. J Biol Chem. 2002 Sep 13; 277(37):33848-56. PMID: 12105198.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    33. Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem. 2002 Jun 14; 277(24):21489-98. PMID: 11940593.
      Citations: 22     Fields:    Translation:AnimalsCells
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