TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address6565 Fannin - Ms BCM 620
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01HL149407     (FRANGOGIANNIS, NIKOLAOS G)Apr 3, 2020 - Mar 31, 2024
    Regulation of the TGF-beta superfamily in the remodeling and failing heart
    Role: Principal Investigator

    R01HL085440     (FRANGOGIANNIS, NIKOLAOS G)Jun 1, 2006 - Dec 31, 2025
    Resolution of inflammation in healing myocardial infarcts
    Role: Principal Investigator

    R01HL076246     (FRANGOGIANNIS, NIKOLAOS G)Apr 1, 2004 - Jan 31, 2024
    Chemokines in healing myocardial infarction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frangogiannis NG. The fate and role of the pericytes in myocardial diseases. Eur J Clin Invest. 2024 Apr 08; e14204. PMID: 38586936.
    2. Frangogiannis NG. Response by Frangogiannis to Letter Regarding Article, "Cardiac Pericytes Acquire a Fibrogenic Phenotype and Contribute to Vascular Maturation After Myocardial Infarction". Circulation. 2024 03 19; 149(12):e962-e963. PMID: 38498609.
      Citations:    Fields:    Translation:HumansCells
    3. Frangogiannis NG. TGF-? as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities. Expert Opin Ther Targets. 2024 Jan-Feb; 28(1-2):45-56. PMID: 38329809.
      Citations:    Fields:    Translation:HumansCells
    4. Frangogiannis NG. Targeting galectin-3 in myocardial infarction: a unique opportunity for biomarker-guided therapy. Cardiovasc Res. 2023 11 25; 119(15):2495-2496. PMID: 37772841; PMCID: PMC10676455.
      Citations: 1     Fields:    Translation:Humans
    5. Li R, Chen B, Kubota A, Hanna A, Humeres C, Hernandez SC, Liu Y, Ma R, Tuleta I, Huang S, Venugopal H, Zhu F, Su K, Li J, Zhang J, Zheng D, Frangogiannis NG. Protective effects of macrophage-specific integrin a5 in myocardial infarction are associated with accentuated angiogenesis. Nat Commun. 2023 Nov 20; 14(1):7555. PMID: 37985764; PMCID: PMC10662477.
      Citations:    Fields:    Translation:AnimalsCells
    6. Frangogiannis NG. Fibroblasts, myofibroblasts and cardiac arrhythmias. J Cardiovasc Aging. 2023 Oct; 3(4). PMID: 38235057; PMCID: PMC10793996.
    7. Elrod JW, Calvert JW, Qin D, Jia XF, Hanna A, Lee J, Pekson R, Frangogiannis NG, Kitsis RN. BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction. J Mol Cell Cardiol. 2023 11; 184:1-12. PMID: 37709008; PMCID: PMC10841630.
      Citations:    Fields:    Translation:Animals
    8. Alex L, Tuleta I, Hernandez SC, Hanna A, Venugopal H, Astorkia M, Humeres C, Kubota A, Su K, Zheng D, Frangogiannis NG. Cardiac Pericytes Acquire a Fibrogenic Phenotype and Contribute to Vascular Maturation After Myocardial Infarction. Circulation. 2023 09 12; 148(11):882-898. PMID: 37350296; PMCID: PMC10527624.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Frangogiannis NG. The Many Faces of NLRs in Macrophage?Biology. JACC Basic Transl Sci. 2023 May; 8(5):497-500. PMID: 37325407; PMCID: PMC10264703.
    10. Alex L, Tuleta I, Hanna A, Frangogiannis NG. Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix-Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion. J Am Heart Assoc. 2023 03 21; 12(6):e027463. PMID: 36892073; PMCID: PMC10111546.
      Citations:    Fields:    Translation:AnimalsCells
    11. Kubota A, Frangogiannis NG. Macrophages in myocardial infarction. Am J Physiol Cell Physiol. 2022 10 01; 323(4):C1304-C1324. PMID: 36094436; PMCID: PMC9576166.
    12. Li R, Frangogiannis NG. Integrins in cardiac fibrosis. J Mol Cell Cardiol. 2022 Nov; 172:1-13. PMID: 35872324.
      Citations:    Fields:    
    13. Li J, Li R, Tuleta I, Hernandez SC, Humeres C, Hanna A, Chen B, Frangogiannis NG. The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction. FASEB J. 2022 07; 36(7):e22400. PMID: 35695814; PMCID: PMC9216182.
      Citations:    Fields:    Translation:AnimalsCells
    14. Chen B, Li R, Hernandez SC, Hanna A, Su K, Shinde AV, Frangogiannis NG. Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium. J Mol Cell Cardiol. 2022 10; 171:1-15. PMID: 35780861.
      Citations:    Fields:    
    15. Venugopal H, Hanna A, Humeres C, Frangogiannis NG. Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction. Cells. 2022 04 20; 11(9). PMID: 35563692; PMCID: PMC9102016.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Humeres C, Venugopal H, Frangogiannis NG. Smad-dependent pathways in the infarcted and failing heart. Curr Opin Pharmacol. 2022 06; 64:102207. PMID: 35367786; PMCID: PMC9167749.
      Citations:    Fields:    Translation:HumansCells
    17. Frangogiannis NG. Why animal model studies are lost in translation. J Cardiovasc Aging. 2022 Apr; 2(2). PMID: 35497093; PMCID: PMC9052957.
    18. Chen B, Li R, Kubota A, Alex L, Frangogiannis NG. Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies. Sci Rep. 2022 03 16; 12(1):4542. PMID: 35296717; PMCID: PMC8927419.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Annex BH, Bristow MR, Frangogiannis NG, Kelly DP, Kontaridis MI, Libby P, Robb MacLellan W, McNamara CA, Mann DL, Pitt GS, Sipido KR. JACC: Basic to Translational Science Top Reviewers 2021: With Appreciation. JACC Basic Transl Sci. 2022 Feb; 7(2):192. PMID: 35257046; PMCID: PMC8897159.
    20. Humeres C, Shinde AV, Hanna A, Alex L, Li R, Chen B, Conway SJ, Frangogiannis NG, Hern?ndez SC. Smad7 effects on TGF-? and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure. J Clin Invest. 2022 02 01; 132(3). PMID: 34905511; PMCID: PMC8803336.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Frangogiannis NG. Transforming growth factor-? in myocardial disease. Nat Rev Cardiol. 2022 07; 19(7):435-455. PMID: 34983937.
      Citations: 5     Fields:    Translation:HumansCells
    22. Alex L, Tuleta I, Harikrishnan V, Frangogiannis NG. Validation of Specific and Reliable Genetic Tools to Identify, Label, and Target Cardiac Pericytes in Mice. J Am Heart Assoc. 2022 01 04; 11(1):e023171. PMID: 34935413; PMCID: PMC9075200.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, Kassiri Z, de Castro Br?s LE, Frantz S. Guidelines for in vivo mouse models of myocardial infarction. Am J Physiol Heart Circ Physiol. 2021 12 01; 321(6):H1056-H1073. PMID: 34623181; PMCID: PMC8834230.
      Citations: 8     Fields:    Translation:Animals
    24. Frangogiannis NG. Platelet-derived growth factor (PDGF) therapy in myocardial infarction: Challenges and opportunities. Int J Cardiol. 2021 10 15; 341:74-75. PMID: 34418517.
      Citations: 1     Fields:    Translation:Humans
    25. Tuleta I, Frangogiannis NG. Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities. Adv Drug Deliv Rev. 2021 09; 176:113904. PMID: 34331987; PMCID: PMC8444077.
      Citations: 3     Fields:    Translation:HumansAnimals
    26. Lindsey ML, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O'Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR, de Castro Br?s LE. Reperfused vs. nonreperfused myocardial infarction: when to use which model. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H208-H213. PMID: 34114891; PMCID: PMC8321810.
      Citations: 8     Fields:    Translation:Animals
    27. Hanna A, Shinde AV, Li R, Alex L, Humeres C, Balasubramanian P, Frangogiannis NG. Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension. Matrix Biol. 2021 05; 99:18-42. PMID: 34048934; PMCID: PMC8591556.
      Citations: 5     Fields:    Translation:AnimalsCells
    28. Frangogiannis NG. Cardiac fibrosis. Cardiovasc Res. 2021 05 25; 117(6):1450-1488. PMID: 33135058; PMCID: PMC8152700.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    29. Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L, Sadoshima J, Sussman MA, Taffet GE, Tanaka H, Torella D, Wang Y, Wang DW. Editors' Preamble to The Journal of Cardiovascular Aging. J Cardiovasc Aging. 2021; 1. PMID: 34327514; PMCID: PMC8318349.
    30. Tuleta I, Frangogiannis NG. Diabetic fibrosis. Biochim Biophys Acta Mol Basis Dis. 2021 04 01; 1867(4):166044. PMID: 33378699; PMCID: PMC7867637.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    31. Hanna A, Humeres C, Frangogiannis NG. The role of Smad signaling cascades in cardiac fibrosis. Cell Signal. 2021 01; 77:109826. PMID: 33160018; PMCID: PMC7727442.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    32. Frangogiannis NG. Fact and Fiction About Fibroblast to Endothelium Conversion: Semantics and Substance of Cellular Identity. Circulation. 2020 10 27; 142(17):1663-1666. PMID: 33104399; PMCID: PMC7594161.
      Citations: 3     Fields:    Translation:HumansCells
    33. Li R, Frangogiannis NG. Chemokines in cardiac fibrosis. Curr Opin Physiol. 2021 Feb; 19:80-91. PMID: 33195890; PMCID: PMC7665080.
      Citations: 8     
    34. Frangogiannis NG. The significance of COVID-19-associated myocardial injury: how overinterpretation of scientific findings can fuel media sensationalism and spread misinformation. Eur Heart J. 2020 10 14; 41(39):3836-3838. PMID: 33006608; PMCID: PMC7599034.
      Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
    35. Hanna A, Frangogiannis NG. Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure. Cardiovasc Drugs Ther. 2020 12; 34(6):849-863. PMID: 32902739; PMCID: PMC7479403.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    36. Hanna A, Shinde AV, Frangogiannis NG. Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H948-H964. PMID: 32886000; PMCID: PMC7701358.
      Citations: 11     Fields:    Translation:AnimalsCells
    37. Chen B, Frangogiannis NG. Chemokines in Myocardial Infarction. J Cardiovasc Transl Res. 2021 02; 14(1):35-52. PMID: 32415537.
      Citations: 16     Fields:    Translation:HumansAnimals
    38. Frangogiannis NG, de Castro Br?s LE. Extracellular matrix-derived peptides in tissue remodeling and fibrosis. Matrix Biol. 2020 09; 91-92:176-187. PMID: 32438055; PMCID: PMC7434701.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    39. Frangogiannis NG, Kovacic JC. Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC?Focus Seminar. J Am Coll Cardiol. 2020 05 05; 75(17):2219-2235. PMID: 32354387; PMCID: PMC7269147.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    40. Huang S, Chen B, Humeres C, Alex L, Hanna A, Frangogiannis NG. The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice. Biochim Biophys Acta Mol Cell Res. 2020 07; 1867(7):118703. PMID: 32179057; PMCID: PMC7261645.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Frangogiannis N. Transforming growth factor-? in tissue fibrosis. J Exp Med. 2020 03 02; 217(3):e20190103. PMID: 32997468; PMCID: PMC7062524.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    42. Frangogiannis NG. Monocyte subsets as predictors of adverse events in patients with atherosclerosis. Hellenic J Cardiol. 2019 Sep - Oct; 60(5):322-323. PMID: 31846698.
      Citations:    Fields:    Translation:HumansCells
    43. Frangogiannis NG. Editorial commentary: Myocardial fibrosis in genetic cardiomyopathies: A cause of dysfunction, or simply an epiphenomenon? Trends Cardiovasc Med. 2020 08; 30(6):362-363. PMID: 31653486.
      Citations:    Fields:    Translation:Humans
    44. Frangogiannis NG. How do endosomal Toll-like receptors sense and extend ischaemic myocardial injury? Cardiovasc Res. 2019 10 01; 115(12):1687-1689. PMID: 31099398; PMCID: PMC6755353.
      Citations:    Fields:    Translation:HumansCells
    45. Hanna A, Frangogiannis NG. The Role of the TGF-? Superfamily in Myocardial Infarction. Front Cardiovasc Med. 2019; 6:140. PMID: 31620450; PMCID: PMC6760019.
      Citations: 71     
    46. Frangogiannis NG. S100A8/A9 as a therapeutic target in myocardial infarction: cellular mechanisms, molecular interactions, and translational challenges. Eur Heart J. 2019 08 21; 40(32):2724-2726. PMID: 31334753; PMCID: PMC6703152.
      Citations: 7     Fields:    Translation:HumansCells
    47. Hanna A, Frangogiannis NG. The cell biological basis for primary unloading in acute myocardial infarction. Int J Cardiol. 2019 10 15; 293:45-47. PMID: 31296394.
      Citations:    Fields:    Translation:Humans
    48. Humeres C, Frangogiannis NG. Fibroblasts in the Infarcted, Remodeling, and Failing Heart. JACC Basic Transl Sci. 2019 Jun; 4(3):449-467. PMID: 31312768; PMCID: PMC6610002.
      Citations: 93     
    49. Frangogiannis NG. The Extracellular Matrix in Ischemic and Nonischemic Heart Failure. Circ Res. 2019 06 21; 125(1):117-146. PMID: 31219741; PMCID: PMC6588179.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    50. Andreadou I, Cabrera-Fuentes HA, Devaux Y, Frangogiannis NG, Gomes CPC, Hausenloy DJ, Frantz S, Guzik T, Liehn EA, Schulz R. Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities. Cardiovasc Res. 2019 06 01; 115(7):1117-1130. PMID: 30825305; PMCID: PMC6529904.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    51. Chen B, Huang S, Su Y, Wu YJ, Hanna A, Brickshawana A, Graff J, Frangogiannis NG. Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation. Circ Res. 2019 06 21; 125(1):55-70. PMID: 31092129; PMCID: PMC6681442.
      Citations: 49     Fields:    Translation:AnimalsCells
    52. Frangogiannis NG. Can Myocardial Fibrosis Be Reversed? J Am Coll Cardiol. 2019 05 14; 73(18):2283-2285. PMID: 31072571.
      Citations: 10     Fields:    Translation:HumansCells
    53. Huang S, Chen B, Su Y, Alex L, Humeres C, Shinde AV, Conway SJ, Frangogiannis NG. Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart. J Mol Cell Cardiol. 2019 07; 132:84-97. PMID: 31085202; PMCID: PMC6579679.
      Citations: 28     Fields:    Translation:AnimalsCells
    54. Alex L, Frangogiannis NG. Pericytes in the infarcted heart. Vasc Biol. 2019; 1(1):H23-H31. PMID: 32923950; PMCID: PMC7439839.
      Citations: 8     
    55. Russo I, Cavalera M, Huang S, Su Y, Hanna A, Chen B, Shinde AV, Conway SJ, Graff J, Frangogiannis NG. Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program. Circ Res. 2019 04 12; 124(8):1214-1227. PMID: 30686120; PMCID: PMC6459716.
      Citations: 49     Fields:    Translation:AnimalsCells
    56. Chen B, Brickshawana A, Frangogiannis NG. The Functional Heterogeneity of Resident Cardiac Macrophages in Myocardial InjuryCCR2+ Cells Promote Inflammation, Whereas CCR2- Cells Protect. Circ Res. 2019 01 18; 124(2):183-185. PMID: 30653429; PMCID: PMC6338423.
      Citations: 9     Fields:    Translation:HumansCells
    57. Frangogiannis NG. Protean Functions and Phenotypic Plasticity of Regulatory T Cells in Chronic Ischemic Heart Failure. Circulation. 2019 01 08; 139(2):222-225. PMID: 30615501; PMCID: PMC6326094.
      Citations: 1     Fields:    Translation:HumansCells
    58. Chen B, Huang S, Frangogiannis NG. Aging, cardiac repair and Smad3. Aging (Albany NY). 2018 09 20; 10(9):2230-2232. PMID: 30243021; PMCID: PMC6188500.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    59. Frangogiannis NG. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019 02; 65:70-99. PMID: 30056242.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    60. Alex L, Russo I, Holoborodko V, Frangogiannis NG. Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H934-H949. PMID: 30004258; PMCID: PMC6230908.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    61. Frangogiannis NG. Targeting mitochondrial calcium transport in myocardial infarction. Hellenic J Cardiol. 2018 Jul - Aug; 59(4):223-225. PMID: 29940221.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    62. Chen B, Frangogiannis NG. The Role of Macrophages in Nonischemic?Heart Failure. JACC Basic Transl Sci. 2018 Apr; 3(2):245-248. PMID: 30062210; PMCID: PMC6060201.
      Citations: 12     
    63. Frangogiannis NG. Galectin-3 in the fibrotic response: Cellular targets and molecular mechanisms. Int J Cardiol. 2018 05 01; 258:226-227. PMID: 29544937.
      Citations: 4     Fields:    Translation:Humans
    64. Huang S, Frangogiannis NG. Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges. Br J Pharmacol. 2018 05; 175(9):1377-1400. PMID: 29394499; PMCID: PMC5901181.
      Citations: 69     Fields:    Translation:HumansAnimals
    65. Kirk JA, Frangogiannis NG. Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker? Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1256-H1258. PMID: 29498533; PMCID: PMC6032078.
      Citations: 2     Fields:    Translation:Humans
    66. Shinde AV, Su Y, Palanski BA, Fujikura K, Garcia MJ, Frangogiannis NG. Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload. J Mol Cell Cardiol. 2018 04; 117:36-48. PMID: 29481819; PMCID: PMC5892840.
      Citations: 12     Fields:    Translation:AnimalsCells
    67. Alex L, Frangogiannis NG. The Cellular Origin of Activated Fibroblasts in the Infarcted and Remodeling Myocardium. Circ Res. 2018 02 16; 122(4):540-542. PMID: 29449358; PMCID: PMC5820780.
      Citations: 13     Fields:    Translation:HumansCells
    68. Frangogiannis NG. Cell therapy for peripheral artery disease. Curr Opin Pharmacol. 2018 04; 39:27-34. PMID: 29452987; PMCID: PMC6019642.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    69. Lindsey ML, Bolli R, Canty JM, Du XJ, Frangogiannis NG, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G, Frantz S, Ping P. Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol. 2018 04 01; 314(4):H812-H838. PMID: 29351451; PMCID: PMC5966768.
      Citations: 161     Fields:    Translation:AnimalsCells
    70. Shinde AV, Frangogiannis NG. Tissue transglutaminase in the pathogenesis of heart failure. Cell Death Differ. 2018 03; 25(3):453-456. PMID: 29238072; PMCID: PMC5864221.
      Citations: 4     Fields:    Translation:Humans
    71. Frangogiannis NG. Cell biological mechanisms in regulation of the post-infarction inflammatory response. Curr Opin Physiol. 2018 Feb; 1:7-13. PMID: 29552674; PMCID: PMC5851468.
      Citations: 20     
    72. Kong P, Shinde AV, Su Y, Russo I, Chen B, Saxena A, Conway SJ, Graff JM, Frangogiannis NG. Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium. Circulation. 2018 02 13; 137(7):707-724. PMID: 29229611; PMCID: PMC5812838.
      Citations: 65     Fields:    Translation:AnimalsCells
    73. Frangogiannis NG. Fibroblasts and the extracellular matrix in right ventricular disease. Cardiovasc Res. 2017 Oct 01; 113(12):1453-1464. PMID: 28957531; PMCID: PMC5852546.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    74. Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B, Adams RH. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun. 2017 09 18; 8(1):578. PMID: 28924218; PMCID: PMC5603578.
      Citations: 14     Fields:    Translation:AnimalsCells
    75. Shinde AV, Dobaczewski M, de Haan JJ, Saxena A, Lee KK, Xia Y, Chen W, Su Y, Hanif W, Kaur Madahar I, Paulino VM, Melino G, Frangogiannis NG. Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling. Cardiovasc Res. 2017 Jul 01; 113(8):892-905. PMID: 28371893; PMCID: PMC5852520.
      Citations: 13     Fields:    Translation:AnimalsCells
    76. Hanif W, Alex L, Su Y, Shinde AV, Russo I, Li N, Frangogiannis NG. Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure. Cardiovasc Pathol. 2017 Sep - Oct; 30:27-37. PMID: 28759817; PMCID: PMC5592139.
      Citations: 21     Fields:    Translation:HumansAnimals
    77. Frangogiannis NG. The extracellular matrix in myocardial injury, repair, and remodeling. J Clin Invest. 2017 May 01; 127(5):1600-1612. PMID: 28459429; PMCID: PMC5409799.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    78. Frangogiannis NG. Editor's Choice- Activation of the innate immune system in the pathogenesis of acute heart failure. Eur Heart J Acute Cardiovasc Care. 2018 Jun; 7(4):358-361. PMID: 28452231.
      Citations:    Fields:    Translation:Humans
    79. Shinde AV, Frangogiannis NG. Mechanisms of Fibroblast Activation in the Remodeling Myocardium. Curr Pathobiol Rep. 2017 Jun; 5(2):145-152. PMID: 29057165; PMCID: PMC5646705.
      Citations: 18     
    80. Frangogiannis NG. The role of transforming growth factor (TGF)-? in the infarcted myocardium. J Thorac Dis. 2017 Mar; 9(Suppl 1):S52-S63. PMID: 28446968; PMCID: PMC5383562.
      Citations: 53     
    81. Chen B, Frangogiannis NG. Immune cells in repair of the infarcted myocardium. Microcirculation. 2017 01; 24(1). PMID: 27542099.
      Citations: 30     Fields:    Translation:HumansAnimals
    82. Shinde AV, Humeres C, Frangogiannis NG. The role of a-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim Biophys Acta Mol Basis Dis. 2017 01; 1863(1):298-309. PMID: 27825850; PMCID: PMC5163362.
      Citations: 124     Fields:    Translation:AnimalsCells
    83. Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML. Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research. Circ Res. 2016 10 28; 119(10):1040-1045. PMID: 27789578; PMCID: PMC5123693.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    84. Frangogiannis NG. The Functional Pluralism of Fibroblasts in the Infarcted Myocardium. Circ Res. 2016 10 28; 119(10):1049-1051. PMID: 27789580; PMCID: PMC5123771.
      Citations: 11     Fields:    Translation:Cells
    85. Chen B, Frangogiannis NG. Macrophages in the Remodeling Failing Heart. Circ Res. 2016 09 16; 119(7):776-8. PMID: 27635078; PMCID: PMC5065930.
      Citations: 19     Fields:    Translation:Cells
    86. Frunza O, Russo I, Shinde AV, Su Y, Frangogiannis NG. Authors' Reply. Am J Pathol. 2016 Aug; 186(8):2234-2235. PMID: 27461365; PMCID: PMC4973651.
      Citations:    Fields:    
    87. Prabhu SD, Frangogiannis NG. The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res. 2016 06 24; 119(1):91-112. PMID: 27340270; PMCID: PMC4922528.
      Citations: 556     Fields:    Translation:HumansAnimalsCells
    88. Frunza O, Russo I, Saxena A, Shinde AV, Humeres C, Hanif W, Rai V, Su Y, Frangogiannis NG. Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis. Am J Pathol. 2016 05; 186(5):1114-27. PMID: 26948424; PMCID: PMC4861760.
      Citations: 36     Fields:    Translation:AnimalsCells
    89. Frangogiannis NG. Fibroblast-Extracellular Matrix Interactions in Tissue Fibrosis. Curr Pathobiol Rep. 2016 Mar; 4(1):11-18. PMID: 27171595; PMCID: PMC4860262.
      Citations: 16     
    90. Russo I, Frangogiannis NG. Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol. 2016 Jan; 90:84-93. PMID: 26705059; PMCID: PMC4718740.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    91. Saxena A, Shinde AV, Haque Z, Wu YJ, Chen W, Su Y, Frangogiannis NG. The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):223-31. PMID: 26542797; PMCID: PMC4689654.
      Citations: 8     Fields:    Translation:AnimalsCells
    92. Frangogiannis NG. Pathophysiology of Myocardial Infarction. Compr Physiol. 2015 Sep 20; 5(4):1841-75. PMID: 26426469.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
    93. Frangogiannis NG. Emerging roles for macrophages in cardiac injury: cytoprotection, repair, and regeneration. J Clin Invest. 2015 Aug 03; 125(8):2927-30. PMID: 26214519; PMCID: PMC4563767.
      Citations: 22     Fields:    Translation:AnimalsCells
    94. Saxena A, Russo I, Frangogiannis NG. Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res. 2016 Jan; 167(1):152-66. PMID: 26241027; PMCID: PMC4684426.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    95. Shinde AV, Frangogiannis NG. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium. Circ Res. 2015 Jun 19; 117(1):10-2. PMID: 26089362.
      Citations:    Fields:    Translation:HumansAnimals
    96. Frangogiannis NG. The reparative function of cardiomyocytes in the infarcted myocardium. Cell Metab. 2015 Jun 02; 21(6):797-8. PMID: 26039445.
      Citations: 7     Fields:    Translation:AnimalsCells
    97. Biernacka A, Cavalera M, Wang J, Russo I, Shinde A, Kong P, Gonzalez-Quesada C, Rai V, Dobaczewski M, Lee DW, Wang XF, Frangogiannis NG. Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. Circ Heart Fail. 2015 Jul; 8(4):788-98. PMID: 25985794; PMCID: PMC4512850.
      Citations: 57     Fields:    Translation:AnimalsCells
    98. Frangogiannis NG. Inflammation in cardiac injury, repair and regeneration. Curr Opin Cardiol. 2015 May; 30(3):240-5. PMID: 25807226; PMCID: PMC4401066.
      Citations: 73     Fields:    Translation:HumansCells
    99. Frangogiannis NG. Interleukin-1 in cardiac injury, repair, and remodeling: pathophysiologic and translational concepts. Discoveries (Craiova). 2015 Jan-Mar; 3(1). PMID: 26273700; PMCID: PMC4532433.
      Citations: 31     
    100. Frangogiannis NG. Targeting the transforming growth factor (TGF)-? cascade in the remodeling heart: benefits and perils. J Mol Cell Cardiol. 2014 Nov; 76:169-71. PMID: 25218305; PMCID: PMC4408532.
      Citations: 11     Fields:    Translation:HumansAnimals
    101. Saxena A, Dobaczewski M, Rai V, Haque Z, Chen W, Li N, Frangogiannis NG. Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1233-42. PMID: 25128167; PMCID: PMC4200341.
      Citations: 76     Fields:    Translation:AnimalsCells
    102. Saxena A, Bujak M, Frunza O, Dobaczewski M, Gonzalez-Quesada C, Lu B, Gerard C, Frangogiannis NG. CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans. Cardiovasc Res. 2014 Jul 15; 103(2):217-27. PMID: 24891401; PMCID: PMC4148609.
      Citations: 33     Fields:    Translation:AnimalsCells
    103. Cavalera M, Wang J, Frangogiannis NG. Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities. Transl Res. 2014 Oct; 164(4):323-35. PMID: 24880146; PMCID: PMC4180761.
      Citations: 94     Fields:    Translation:HumansAnimals
    104. Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. 2014 May; 11(5):255-65. PMID: 24663091; PMCID: PMC4407144.
      Citations: 467     Fields:    Translation:HumansCells
    105. Frangogiannis NG. The immune system and the remodeling infarcted heart: cell biological insights and therapeutic opportunities. J Cardiovasc Pharmacol. 2014 Mar; 63(3):185-95. PMID: 24072174; PMCID: PMC3949163.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    106. Rienks M, Papageorgiou AP, Frangogiannis NG, Heymans S. Myocardial extracellular matrix: an ever-changing and diverse entity. Circ Res. 2014 Feb 28; 114(5):872-88. PMID: 24577967.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    107. Frangogiannis NG. Contribution of extramedullary organs in myocardial inflammation and remodeling: does the spleen cause cardiac melancholy? Circ Res. 2014 Jan 17; 114(2):230-2. PMID: 24436423; PMCID: PMC4040257.
      Citations:    Fields:    Translation:AnimalsCells
    108. Cavalera M, Frangogiannis NG. Targeting the chemokines in cardiac repair. Curr Pharm Des. 2014; 20(12):1971-9. PMID: 23844733; PMCID: PMC4408530.
      Citations: 24     Fields:    Translation:HumansAnimals
    109. Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol. 2014 May; 70:74-82. PMID: 24321195; PMCID: PMC3995820.
      Citations: 200     Fields:    Translation:HumansAnimalsCells
    110. Frangogiannis NG. MicroRNAs and endothelial function: many challenges and early hopes for clinical applications. J Am Coll Cardiol. 2014 Apr 29; 63(16):1695-6. PMID: 24291271.
      Citations: 2     Fields:    Translation:HumansAnimals
    111. Kong P, Cavalera M, Frangogiannis NG. The role of thrombospondin (TSP)-1 in obesity and diabetes. Adipocyte. 2014 Jan 01; 3(1):81-4. PMID: 24575376; PMCID: PMC3917940.
      Citations: 16     Fields:    
    112. Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee DW, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis NG. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013 Dec 06; 113(12):1331-44. PMID: 24081879; PMCID: PMC4408537.
      Citations: 62     Fields:    Translation:AnimalsCells
    113. Saxena A, Chen W, Su Y, Rai V, Uche OU, Li N, Frangogiannis NG. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol. 2013 Nov 01; 191(9):4838-48. PMID: 24078695; PMCID: PMC3822582.
      Citations: 104     Fields:    Translation:Animals
    114. Kong P, Christia P, Saxena A, Su Y, Frangogiannis NG. Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol. 2013 Nov 01; 305(9):H1363-72. PMID: 23997102; PMCID: PMC3840245.
      Citations: 99     Fields:    Translation:AnimalsCells
    115. Christia P, Frangogiannis NG. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest. 2013 Sep; 43(9):986-95. PMID: 23772948; PMCID: PMC3745791.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    116. Kong P, Gonzalez-Quesada C, Li N, Cavalera M, Lee DW, Frangogiannis NG. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab. 2013 Aug 01; 305(3):E439-50. PMID: 23757408; PMCID: PMC3742854.
      Citations: 46     Fields:    Translation:AnimalsCells
    117. Christia P, Bujak M, Gonzalez-Quesada C, Chen W, Dobaczewski M, Reddy A, Frangogiannis NG. Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem. 2013 Aug; 61(8):555-70. PMID: 23714783; PMCID: PMC3724390.
      Citations: 55     Fields:    Translation:Animals
    118. Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci. 2014 Feb; 71(4):549-74. PMID: 23649149; PMCID: PMC3769482.
      Citations: 494     Fields:    Translation:HumansAnimalsCells
    119. Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG. Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2598-608. PMID: 22995519; PMCID: PMC3510666.
      Citations: 38     Fields:    Translation:AnimalsCells
    120. Chen W, Frangogiannis NG. Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta. 2013 Apr; 1833(4):945-53. PMID: 22982064; PMCID: PMC3541439.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    121. Dobaczewski M, de Haan JJ, Frangogiannis NG. The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium. J Cardiovasc Transl Res. 2012 Dec; 5(6):837-47. PMID: 22956156; PMCID: PMC3535072.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    122. Frangogiannis NG. Monomeric C-reactive protein and inflammatory injury in myocardial infarction. Cardiovasc Res. 2012 Oct 01; 96(1):4-6. PMID: 22871589; PMCID: PMC3444236.
      Citations: 2     Fields:    Translation:HumansCells
    123. Frangogiannis NG. Matricellular proteins in cardiac adaptation and disease. Physiol Rev. 2012 Apr; 92(2):635-88. PMID: 22535894; PMCID: PMC4411042.
      Citations: 179     Fields:    Translation:HumansAnimals
    124. Frangogiannis NG. Biomarkers: hopes and challenges in the path from discovery to clinical practice. Transl Res. 2012 Apr; 159(4):197-204. PMID: 22424424; PMCID: PMC4402218.
      Citations: 26     Fields:    Translation:Humans
    125. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res. 2012 Jan 06; 110(1):159-73. PMID: 22223212; PMCID: PMC3690135.
      Citations: 432     Fields:    Translation:HumansAnimalsCells
    126. Frangogiannis NG. The stromal cell-derived factor-1/CXCR4 axis in cardiac injury and repair. J Am Coll Cardiol. 2011 Nov 29; 58(23):2424-6. PMID: 22115650.
      Citations: 14     Fields:    Translation:Animals
    127. Xia Y, Dobaczewski M, Gonzalez-Quesada C, Chen W, Biernacka A, Li N, Lee DW, Frangogiannis NG. Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension. 2011 Nov; 58(5):902-11. PMID: 21947471; PMCID: PMC3199343.
      Citations: 72     Fields:    Translation:AnimalsCells
    128. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-? signaling in fibrosis. Growth Factors. 2011 Oct; 29(5):196-202. PMID: 21740331; PMCID: PMC4408550.
      Citations: 397     Fields:    Translation:HumansAnimalsCells
    129. Biernacka A, Frangogiannis NG. Aging and Cardiac Fibrosis. Aging Dis. 2011 Apr; 2(2):158-173. PMID: 21837283; PMCID: PMC3153299.
      Citations: 195     
    130. Frangogiannis NG. Stromal cell-derived factor-1-mediated angiogenesis for peripheral arterial disease: ready for prime time? Circulation. 2011 Mar 29; 123(12):1267-9. PMID: 21403099.
      Citations: 4     Fields:    Translation:HumansAnimals
    131. Dobaczewski M, Frangogiannis NG. The cellular specificity of leptin-mediated actions in the infarcted heart. Cardiovasc Res. 2011 Jan 01; 89(1):9-11. PMID: 21062917; PMCID: PMC3002876.
      Citations: 2     Fields:    Translation:AnimalsCells
    132. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF)-? signaling in cardiac remodeling. J Mol Cell Cardiol. 2011 Oct; 51(4):600-6. PMID: 21059352; PMCID: PMC3072437.
      Citations: 368     Fields:    Translation:HumansAnimalsCells
    133. Chen W, Frangogiannis NG. The role of inflammatory and fibrogenic pathways in heart failure associated with aging. Heart Fail Rev. 2010 Sep; 15(5):415-22. PMID: 20213186; PMCID: PMC2920375.
      Citations: 63     Fields:    Translation:HumansCells
    134. Dobaczewski M, Bujak M, Li N, Gonzalez-Quesada C, Mendoza LH, Wang XF, Frangogiannis NG. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res. 2010 Aug 06; 107(3):418-28. PMID: 20522804; PMCID: PMC2917472.
      Citations: 173     Fields:    Translation:AnimalsCells
    135. Dobaczewski M, Xia Y, Bujak M, Gonzalez-Quesada C, Frangogiannis NG. CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells. Am J Pathol. 2010 May; 176(5):2177-87. PMID: 20382703; PMCID: PMC2861083.
      Citations: 133     Fields:    Translation:AnimalsCells
    136. Frangogiannis NG. Syndecan-1: a critical mediator in cardiac fibrosis. Hypertension. 2010 Feb; 55(2):233-5. PMID: 20048190; PMCID: PMC2819313.
      Citations: 12     Fields:    Translation:AnimalsCells
    137. Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, Garvey ME, Frangogiannis NG, Michael LH, Chow CW, Dyck JR, Young ME. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010 Feb 19; 106(3):546-50. PMID: 20007913; PMCID: PMC3021132.
      Citations: 100     Fields:    Translation:AnimalsCells
    138. Bujak M, Dobaczewski M, Gonzalez-Quesada C, Xia Y, Leucker T, Zymek P, Veeranna V, Tager AM, Luster AD, Frangogiannis NG. Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res. 2009 Nov 06; 105(10):973-83. PMID: 19797174; PMCID: PMC2783369.
      Citations: 75     Fields:    Translation:AnimalsCells
    139. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol. 2010 Mar; 48(3):504-11. PMID: 19631653; PMCID: PMC2824059.
      Citations: 214     Fields:    Translation:HumansAnimalsCells
    140. Dobaczewski M, Frangogiannis NG. Chemokines and cardiac fibrosis. Front Biosci (Schol Ed). 2009 06 01; 1(2):391-405. PMID: 19482709; PMCID: PMC2798729.
      Citations: 43     Fields:    Translation:HumansCells
    141. Bujak M, Frangogiannis NG. The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp (Warsz). 2009 May-Jun; 57(3):165-76. PMID: 19479203; PMCID: PMC2788964.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    142. Gonzalez-Quesada C, Frangogiannis NG. Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes. Curr Atheroscler Rep. 2009 Mar; 11(2):131-8. PMID: 19228487; PMCID: PMC2787514.
      Citations: 27     Fields:    Translation:Humans
    143. Xia Y, Lee K, Li N, Corbett D, Mendoza L, Frangogiannis NG. Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol. 2009 Apr; 131(4):471-81. PMID: 19030868; PMCID: PMC2782393.
      Citations: 116     Fields:    Translation:AnimalsCells
    144. Thakker GD, Frangogiannis NG, Zymek PT, Sharma S, Raya JL, Barger PM, Taegtmeyer H, Entman ML, Ballantyne CM. Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity. Obesity (Silver Spring). 2008 Dec; 16(12):2593-600. PMID: 18833212; PMCID: PMC3049112.
      Citations: 15     Fields:    Translation:Animals
    145. Dobaczewski M, Frangogiannis NG. Chemokines in myocardial infarction: translating basic research into clinical medicine. Future Cardiol. 2008 Jul; 4(4):347-51. PMID: 19804314.
      Citations: 5     Fields:    
    146. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res. 2008 Aug; 58(2):88-111. PMID: 18620057; PMCID: PMC2642482.
      Citations: 252     Fields:    Translation:HumansAnimalsCells
    147. Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol. 2008 Jul; 173(1):57-67. PMID: 18535174; PMCID: PMC2438285.
      Citations: 129     Fields:    Translation:AnimalsCells
    148. Bujak M, Kweon HJ, Chatila K, Li N, Taffet G, Frangogiannis NG. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol. 2008 Apr 08; 51(14):1384-92. PMID: 18387441; PMCID: PMC3348616.
      Citations: 92     Fields:    Translation:AnimalsCells
    149. Huebener P, Abou-Khamis T, Zymek P, Bujak M, Ying X, Chatila K, Haudek S, Thakker G, Frangogiannis NG. CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol. 2008 Feb 15; 180(4):2625-33. PMID: 18250474.
      Citations: 88     Fields:    Translation:AnimalsCells
    150. Rao L, Ling Y, He R, Gilbert AL, Frangogiannis NG, Wang J, Nagueh SF, Khoury DS. Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1002-9. PMID: 18083892.
      Citations: 1     Fields:    Translation:Animals
    151. Frangogiannis NG. The prognostic value of monocyte chemoattractant protein-1/CCL2 in acute coronary syndromes. J Am Coll Cardiol. 2007 Nov 27; 50(22):2125-7. PMID: 18036448.
      Citations: 10     Fields:    Translation:HumansAnimals
    152. Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, Wang XF, Frangogiannis NG. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation. 2007 Nov 06; 116(19):2127-38. PMID: 17967775.
      Citations: 171     Fields:    Translation:AnimalsCells
    153. Xia Y, Frangogiannis NG. MCP-1/CCL2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy. Inflamm Allergy Drug Targets. 2007 Jun; 6(2):101-7. PMID: 17692033.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    154. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost. 2007 May; 97(5):738-47. PMID: 17479184.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    155. Frangogiannis NG, Dewald O, Xia Y, Ren G, Haudek S, Leucker T, Kraemer D, Taffet G, Rollins BJ, Entman ML. Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation. 2007 Feb 06; 115(5):584-92. PMID: 17283277.
      Citations: 125     Fields:    Translation:AnimalsCells
    156. Chatila K, Ren G, Xia Y, Huebener P, Bujak M, Frangogiannis NG. The role of the thrombospondins in healing myocardial infarcts. Cardiovasc Hematol Agents Med Chem. 2007 Jan; 5(1):21-7. PMID: 17266545.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    157. Zymek P, Nah DY, Bujak M, Ren G, Koerting A, Leucker T, Huebener P, Taffet G, Entman M, Frangogiannis NG. Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling. Cardiovasc Res. 2007 May 01; 74(2):313-22. PMID: 17188669; PMCID: PMC1924681.
      Citations: 32     Fields:    Translation:AnimalsCells
    158. Haudek SB, Xia Y, Huebener P, Lee JM, Carlson S, Crawford JR, Pilling D, Gomer RH, Trial J, Frangogiannis NG, Entman ML. Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18284-9. PMID: 17114286; PMCID: PMC1643845.
      Citations: 183     Fields:    Translation:AnimalsCells
    159. Zymek P, Bujak M, Chatila K, Cieslak A, Thakker G, Entman ML, Frangogiannis NG. The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol. 2006 Dec 05; 48(11):2315-23. PMID: 17161265.
      Citations: 91     Fields:    Translation:AnimalsCells
    160. Frangogiannis NG. The mechanistic basis of infarct healing. Antioxid Redox Signal. 2006 Nov-Dec; 8(11-12):1907-39. PMID: 17034340.
      Citations: 106     Fields:    Translation:HumansAnimals
    161. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007 May 01; 74(2):184-95. PMID: 17109837; PMCID: PMC1924687.
      Citations: 380     Fields:    Translation:HumansAnimalsCells
    162. Thakker GD, Frangogiannis NG, Bujak M, Zymek P, Gaubatz JW, Reddy AK, Taffet G, Michael LH, Entman ML, Ballantyne CM. Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2504-14. PMID: 16731644.
      Citations: 49     Fields:    Translation:Animals
    163. Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem. 2006; 13(16):1877-93. PMID: 16842199.
      Citations: 85     Fields:    Translation:HumansCells
    164. Frangogiannis NG, Entman ML. Identification of mast cells in the cellular response to myocardial infarction. Methods Mol Biol. 2006; 315:91-101. PMID: 16110151.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    165. Park TH, Nagueh SF, Khoury DS, Kopelen HA, Akrivakis S, Nasser K, Ren G, Frangogiannis NG. Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H724-31. PMID: 16183729.
      Citations: 27     Fields:    Translation:Animals
    166. Frangogiannis NG, Entman ML. Chemokines in myocardial ischemia. Trends Cardiovasc Med. 2005 Jul; 15(5):163-9. PMID: 16165012.
      Citations: 44     Fields:    Translation:HumansAnimals
    167. Frangogiannis NG, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, Winkelmann K, Michael LH, Lawler J, Entman ML. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005 Jun 07; 111(22):2935-42. PMID: 15927970.
      Citations: 146     Fields:    Translation:AnimalsCells
    168. Dewald O, Zymek P, Winkelmann K, Koerting A, Ren G, Abou-Khamis T, Michael LH, Rollins BJ, Entman ML, Frangogiannis NG. CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res. 2005 Apr 29; 96(8):881-9. PMID: 15774854.
      Citations: 285     Fields:    Translation:AnimalsCells
    169. Somasundaram P, Ren G, Nagar H, Kraemer D, Mendoza L, Michael LH, Caughey GH, Entman ML, Frangogiannis NG. Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol. 2005 Jan; 205(1):102-11. PMID: 15586361; PMCID: PMC2275298.
      Citations: 42     Fields:    Translation:AnimalsCells
    170. Frangogiannis NG, Entman ML. Targeting the chemokines in myocardial inflammation. Circulation. 2004 Sep 14; 110(11):1341-2. PMID: 15364818.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    171. Dobaczewski M, Akrivakis S, Nasser K, Michael LH, Entman ML, Frangogiannis NG. Vascular mural cells in healing canine myocardial infarcts. J Histochem Cytochem. 2004 Aug; 52(8):1019-29. PMID: 15258177.
      Citations: 19     Fields:    Translation:Animals
    172. Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol. 2004 Apr; 2(2):163-74. PMID: 15320517.
      Citations: 18     Fields:    Translation:HumansAnimals
    173. Dewald O, Ren G, Duerr GD, Zoerlein M, Klemm C, Gersch C, Tincey S, Michael LH, Entman ML, Frangogiannis NG. Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol. 2004 Feb; 164(2):665-77. PMID: 14742270; PMCID: PMC1602262.
      Citations: 184     Fields:    Translation:AnimalsCells
    174. Ren G, Dewald O, Frangogiannis NG. Inflammatory mechanisms in myocardial infarction. Curr Drug Targets Inflamm Allergy. 2003 Sep; 2(3):242-56. PMID: 14561159.
      Citations: 61     Fields:    Translation:HumansAnimals
    175. Frangogiannis NG, Mendoza LH, Ren G, Akrivakis S, Jackson PL, Michael LH, Smith CW, Entman ML. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H483-92. PMID: 12689859.
      Citations: 45     Fields:    Translation:AnimalsCells
    176. Dewald O, Frangogiannis NG, Zoerlein M, Duerr GD, Klemm C, Knuefermann P, Taffet G, Michael LH, Crapo JD, Welz A, Entman ML. Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2700-5. PMID: 12586861; PMCID: PMC151404.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    177. Shimoni S, Frangogiannis NG, Aggeli CJ, Shan K, Verani MS, Quinones MA, Espada R, Letsou GV, Lawrie GM, Winters WL, Reardon MJ, Zoghbi WA. Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy. Circulation. 2003 Feb 04; 107(4):538-44. PMID: 12566363.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    178. Fernandes LS, Conde ID, Wayne Smith C, Kansas GS, Snapp KR, Bennet N, Ballantyne C, McIntire LV, O'Brian Smith E, Klem JA, Mathew S, Frangogiannis N, Turner NA, Maresh KJ, Kleiman NS. Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting. Thromb Res. 2003; 111(3):171-7. PMID: 14678816.
      Citations: 13     Fields:    Translation:HumansCells
    179. Gersch C, Dewald O, Zoerlein M, Michael LH, Entman ML, Frangogiannis NG. Mast cells and macrophages in normal C57/BL/6 mice. Histochem Cell Biol. 2002 Jul; 118(1):41-9. PMID: 12122446.
      Citations: 49     Fields:    Translation:AnimalsCells
    180. Frangogiannis NG, Shimoni S, Chang SM, Ren G, Dewald O, Gersch C, Shan K, Aggeli C, Reardon M, Letsou GV, Espada R, Ramchandani M, Entman ML, Zoghbi WA. Active interstitial remodeling: an important process in the hibernating human myocardium. J Am Coll Cardiol. 2002 May 01; 39(9):1468-74. PMID: 11985909.
      Citations: 33     Fields:    Translation:HumansCells
    181. Frangogiannis NG, Shimoni S, Chang SM, Ren G, Shan K, Aggeli C, Reardon MJ, Letsou GV, Espada R, Ramchandani M, Entman ML, Zoghbi WA. Evidence for an active inflammatory process in the hibernating human myocardium. Am J Pathol. 2002 Apr; 160(4):1425-33. PMID: 11943726; PMCID: PMC1867231.
      Citations: 31     Fields:    Translation:HumansCells
    182. Ren G, Michael LH, Entman ML, Frangogiannis NG. Morphological characteristics of the microvasculature in healing myocardial infarcts. J Histochem Cytochem. 2002 Jan; 50(1):71-9. PMID: 11748296.
      Citations: 70     Fields:    Translation:AnimalsCells
    183. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res. 2002 Jan; 53(1):31-47. PMID: 11744011.
      Citations: 638     Fields:    Translation:HumansCells
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