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JAKE A. KUSHNER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Endocrinology/Metabolism
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    K08DK064101     (KUSHNER, JAKE ALDEN)Sep 30, 2003 - Sep 29, 2008
    NIH/NIDDK
    Cyclin D2 Regulation Of Islet Growth
    Role: Principal Investigator

    R03DK078546     (KUSHNER, JAKE ALDEN)Jul 1, 2007 - Jun 30, 2009
    NIH/NIDDK
    p130 Regulation of Islet Growth
    Role: Principal Investigator

    R01DK081469     (KUSHNER, JAKE ALDEN)Sep 30, 2008 - Jun 30, 2014
    NIH/NIDDK
    Bone Morphogenic Proteins as Novel Regulators of Beta Cell Growth
    Role: Principal Investigator

    R01AG040110     (KUSHNER, JAKE ALDEN)Sep 1, 2011 - Aug 31, 2016
    NIH/NIA
    Cell Lineage and Homeostasis of Pancreatic Beta Cells in the Aged
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hallberg SJ, Dockter NE, Kushner JA, Athinarayanan SJ. Improving the scientific rigour of nutritional recommendations for adults with type 2 diabetes: A comprehensive review of the American Diabetes Association guideline-recommended eating patterns. Diabetes Obes Metab. 2019 Apr 03. PMID: 30941880.
      View in: PubMed
    2. Danne T, Cariou B, Buse JB, Garg SK, Rosenstock J, Banks P, Kushner JA, McGuire DK, Peters AL, Sawhney S, Strumph P. Improved Time in Range and Glycemic Variability With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: A Pooled Analysis of 24-Week Continuous Glucose Monitoring Data From the inTandem Program. Diabetes Care. 2019 May; 42(5):919-930. PMID: 30833371.
      View in: PubMed
    3. Lam CJ, Rankin MM, King KB, Wang MC, Shook BC, Kushner JA. Glucagon Receptor Antagonist-Stimulated a-Cell Proliferation Is Severely Restricted With Advanced Age. Diabetes. 2019 May; 68(5):963-974. PMID: 30833466.
      View in: PubMed
    4. Danne T, Garg S, Peters AL, Buse JB, Mathieu C, Pettus JH, Alexander CM, Battelino T, Ampudia-Blasco FJ, Bode BW, Cariou B, Close KL, Dandona P, Dutta S, Ferrannini E, Fourlanos S, Grunberger G, Heller SR, Henry RR, Kurian MJ, Kushner JA, Oron T, Parkin CG, Pieber TR, Rodbard HW, Schatz D, Skyler JS, Tamborlane WV, Yokote K, Phillip M. International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors. Diabetes Care. 2019 Jun; 42(6):1147-1154. PMID: 30728224.
      View in: PubMed
    5. Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H. The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice. Front Immunol. 2019; 10:68. PMID: 30774629.
      View in: PubMed
    6. Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA. Low-Level Insulin Content Within Abundant Non-ß Islet Endocrine Cells in Long-standing Type 1 Diabetes. Diabetes. 2019 Mar; 68(3):598-608. PMID: 30552110.
      View in: PubMed
    7. Kohn JR, Hilliard ME, Lyons SK, Fox KA, Kushner JA. Identifying and addressing gaps in reproductive health education for adolescent girls with type 1 diabetes. PLoS One. 2018; 13(11):e0206102. PMID: 30399169.
      View in: PubMed
    8. Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H. CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. PLoS One. 2018; 13(9):e0203952. PMID: 30226884.
      View in: PubMed
    9. Danne T, Cariou B, Banks P, Brandle M, Brath H, Franek E, Kushner JA, Lapuerta P, McGuire DK, Peters AL, Sawhney S, Strumph P. HbA1c and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study. Diabetes Care. 2018 Sep; 41(9):1981-1990. PMID: 29937431.
      View in: PubMed
    10. Buse JB, Garg SK, Rosenstock J, Bailey TS, Banks P, Bode BW, Danne T, Kushner JA, Lane WS, Lapuerta P, McGuire DK, Peters AL, Reed J, Sawhney S, Strumph P. Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study. Diabetes Care. 2018 Sep; 41(9):1970-1980. PMID: 29937430.
      View in: PubMed
    11. Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA. Highly Proliferative a-Cell-Related Islet Endocrine Cells in Human Pancreata. Diabetes. 2018 04; 67(4):674-686. PMID: 29326366.
      View in: PubMed
    12. Cox AR, Kushner JA. Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal ß-Cell Development. Diabetes. 2017 11; 66(11):2738-2740. PMID: 29061659.
      View in: PubMed
    13. Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, Fulcher GR, Pozzilli P, Gesty-Palmer D, Lapuerta P, Simó R, Danne T, McGuire DK, Kushner JA, Peters A, Strumph P. Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes. N Engl J Med. 2017 12 14; 377(24):2337-2348. PMID: 28899222.
      View in: PubMed
    14. Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA. ß Cells Persist in T1D Pancreata Without Evidence of Ongoing ß-Cell Turnover or Neogenesis. J Clin Endocrinol Metab. 2017 08 01; 102(8):2647-2659. PMID: 28323930.
      View in: PubMed
    15. Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA. Incretin Therapies Do Not Expand ß-Cell Mass or Alter Pancreatic Histology in Young Male Mice. Endocrinology. 2017 06 01; 158(6):1701-1714. PMID: 28323942.
      View in: PubMed
    16. O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA, Atkinson MA. Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? Diabetes. 2017 06; 66(6):1443-1452. PMID: 28533295.
      View in: PubMed
    17. Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. 2017 01; 60(1):35-38. PMID: 27785529.
      View in: PubMed
    18. Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA. Resolving Discrepant Findings on ANGPTL8 in ß-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS One. 2016; 11(7):e0159276. PMID: 27410263.
      View in: PubMed
    19. Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, Orange JS. Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas Children's Hospital. J Pediatr. 2016 05; 172:5-6.e5. PMID: 27112081.
      View in: PubMed
    20. Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA. Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage. Diabetologia. 2016 06; 59(6):1231-41. PMID: 27003683.
      View in: PubMed
    21. Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY. Type I interferons mediate pancreatic toxicities of PERK inhibition. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15420-5. PMID: 26627716.
      View in: PubMed
    22. Ackerman KG, Lee B, Kushner JA. Dissatisfaction with maintenance of certification in academic pediatrics. Pediatr Res. 2016 Feb; 79(2):240-2. PMID: 26421351.
      View in: PubMed
    23. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050.
      View in: PubMed
    24. Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA. Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes. PLoS One. 2015; 10(6):e0129809. PMID: 26057531.
      View in: PubMed
    25. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA. Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia. 2015 Jul; 58(7):1523-31. PMID: 25917759.
      View in: PubMed
    26. Kushner JA, MacDonald PE, Atkinson MA. Stem cells to insulin secreting cells: two steps forward and now a time to pause? Cell Stem Cell. 2014 Nov 06; 15(5):535-6. PMID: 25517460.
      View in: PubMed
    27. Elahi D, Mirmira RG, Kushner JA. Editorial: in praise of scientific review officers. Mol Endocrinol. 2014 Jul; 28(7):987-8. PMID: 24983311.
      View in: PubMed
    28. Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014 Jun 19; 157(7):1577-90. PMID: 24949970.
      View in: PubMed
    29. Hicks KA, Kushner JA, Heptulla R, Ham JN. Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy. J Pediatr Endocrinol Metab. 2014 Jan; 27(1-2):135-8. PMID: 23959658.
      View in: PubMed
    30. Kushner JA. The role of aging upon ß cell turnover. J Clin Invest. 2013 Mar; 123(3):990-5. PMID: 23454762.
      View in: PubMed
    31. Rankin MM, Wilbur CJ, Rak K, Shields EJ, Granger A, Kushner JA. ß-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes. 2013 May; 62(5):1634-45. PMID: 23349489.
      View in: PubMed
    32. Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, Bradfield JP, Hakonarson H, Grant SF, Pu WT, Kushner JA. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. PMID: 24284823.
      View in: PubMed
    33. Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol. 2012 Dec; 32(24):5129-39. PMID: 23071091.
      View in: PubMed
    34. Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell. 2012 Nov 09; 48(3):353-64. PMID: 23022383.
      View in: PubMed
    35. Kushner JA. Development. Esophageal stem cells, where art thou? Science. 2012 Aug 31; 337(6098):1051-2. PMID: 22936766.
      View in: PubMed
    36. Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4a initiates cell cycle entry, but is not sufficient to promote ß-cell expansion in human islets. Mol Endocrinol. 2012 Sep; 26(9):1590-602. PMID: 22798294.
      View in: PubMed
    37. Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, Kushner JA, Rimm DL, Herold KC. Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes. 2011 Mar; 60(3):876-83. PMID: 21307078.
      View in: PubMed
    38. Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM, Kim GJ, Virgilio C, Granger A, Zhou D, Long SH, Schiffman AB, Kushner JA. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp. 2010 Dec 07; (46). PMID: 21178965.
      View in: PubMed
    39. Rankin MM, Kushner JA. Aging induces a distinct gene expression program in mouse islets. Islets. 2010 Nov-Dec; 2(6):345-52. PMID: 21099336.
      View in: PubMed
    40. Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA. Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem. 2010 Dec 17; 285(51):40050-9. PMID: 20943662.
      View in: PubMed
    41. Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010 Oct; 95(10):E234-9. PMID: 20660050.
      View in: PubMed
    42. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3. PMID: 20085728.
      View in: PubMed
    43. Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb; 151(2):741-7. PMID: 20032056.
      View in: PubMed
    44. Granger A, Kushner JA. Cellular origins of beta-cell regeneration: a legacy view of historical controversies. J Intern Med. 2009 Oct; 266(4):325-38. PMID: 19765178.
      View in: PubMed
    45. He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, Diehl JA, Kushner JA. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009 Nov; 23(11):1865-75. PMID: 19628581.
      View in: PubMed
    46. Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009 Jun; 58(6):1365-72. PMID: 19265026.
      View in: PubMed
    47. Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol. 2009 Jan; 174(1):276-86. PMID: 19095950.
      View in: PubMed
    48. Akirav E, Kushner JA, Herold KC. Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes. 2008 Nov; 57(11):2883-8. PMID: 18971435.
      View in: PubMed
    49. Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, Kushner JA, Jackson TL, Morrison SJ. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature. 2007 Sep 13; 449(7159):238-42. PMID: 17728714.
      View in: PubMed
    50. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov; 148(11):5136-44. PMID: 17673522.
      View in: PubMed
    51. Podcheko A, Northcott P, Bikopoulos G, Lee A, Bommareddi SR, Kushner JA, Farhang-Fallah J, Rozakis-Adcock M. Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol. 2007 Sep; 27(18):6484-96. PMID: 17636024.
      View in: PubMed
    52. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell. 2007 May; 12(5):817-26. PMID: 17488631.
      View in: PubMed
    53. Ablamunits V, Sherry NA, Kushner JA, Herold KC. Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci. 2007 Apr; 1103:19-32. PMID: 17376841.
      View in: PubMed
    54. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes. 2006 Dec; 55(12):3238-45. PMID: 17130466.
      View in: PubMed
    55. Kushner JA. Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle. 2006 Feb; 5(3):234-7. PMID: 16410729.
      View in: PubMed
    56. Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem. 2005 Nov 25; 280(47):39388-93. PMID: 16170201.
      View in: PubMed
    57. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes. 2005 Sep; 54(9):2557-67. PMID: 16123343.
      View in: PubMed
    58. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005 May; 25(9):3752-62. PMID: 15831479.
      View in: PubMed
    59. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8. PMID: 15689562.
      View in: PubMed
    60. Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Oct; 114(7):908-16. PMID: 15467829.
      View in: PubMed
    61. Pawlak DB, Kushner JA, Ludwig DS. Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet. 2004 Aug 28-Sep 3; 364(9436):778-85. PMID: 15337404.
      View in: PubMed
    62. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004 Jan; 53(1):61-6. PMID: 14693698.
      View in: PubMed
    63. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003 Aug 06; 23(18):7084-92. PMID: 12904469.
      View in: PubMed
    64. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest. 2002 May; 109(9):1193-201. PMID: 11994408.
      View in: PubMed
    65. Corbett TH, Panchapor C, Polin L, Lowichik N, Pugh S, White K, Kushner J, Meyer J, Czarnecki J, Chinnukroh S, Edelstein M, LoRusso P, Heilbrun L, Horwitz JP, Grieshaber C, Perni R, Wentland M, Coughlin S, Elenbaas S, Philion R, Rake J. Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin. Invest New Drugs. 1999; 17(1):17-27. PMID: 10555119.
      View in: PubMed
    66. Mellon SH, Kushner JA, Vaisse C. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA Cell Biol. 1991 Jun; 10(5):339-47. PMID: 1863358.
      View in: PubMed
    67. Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O. Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 06; 347(6288):76-80. PMID: 2168520.
      View in: PubMed
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