TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Surgery
    DivisionSurgery-Pediatric Surgery Div

    Collapse Research 
    Collapse research activities and funding
    R21CA106513     (YANG, JIANHUA)Sep 13, 2005 - Aug 31, 2007
    Analysis of a Novel Secreted Protein in Neuroblastoma
    Role: Principal Investigator

    R01NS072420     (YANG, JIANHUA)Mar 1, 2011 - Feb 29, 2016
    DUSP26: A Novel Therapeutic Target in Neuroblastoma
    Role: Principal Investigator

    R21NS085467     (YANG, JIANHUA)Sep 15, 2013 - Aug 31, 2016
    Targeting TAK1 in Neuroblastoma
    Role: Principal Investigator

    R21NS094654     (YANG, JIANHUA)Jun 1, 2016 - Apr 30, 2019
    Role: Principal Investigator

    R01NS118008     (YANG, JIANHUA)Aug 15, 2020 - May 31, 2025
    CAMKV Kinase Signaling in Neuroblastoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chilamakuri R, Rouse DC, Yu Y, Kabir AS, Muth A, Yang J, Lipton JM, Agarwal S. BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy. Transl Oncol. 2022 Jan; 15(1):101272. PMID: 34823094.
      Citations: 1     
    2. Huang Y, Qi L, Kogiso M, Du Y, Braun FK, Zhang H, Huang LF, Xiao S, Teo WY, Lindsay H, Zhao S, Baxter P, Su JMF, Adesina A, Yang J, Brabetz S, Kool M, Pfister SM, Chintagumpala M, Perlaky L, Wang Z, Zhou Y, Man TK, Li XN. Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion. Adv Sci (Weinh). 2021 12; 8(23):e2101923. PMID: 34719887.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Wang W, Wang X, Rajaei M, Youn JY, Zafar A, Deokar H, Buolamwini JK, Yang J, Foster JH, Zhou J, Zhang R. Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action. Cancers (Basel). 2020 Dec 05; 12(12). PMID: 33291373.
      Citations: 4     
    4. Qi L, Kogiso M, Du Y, Zhang H, Braun FK, Huang Y, Teo WY, Lindsay H, Zhao S, Baxter P, Zhao X, Yu L, Liu Z, Zhang X, Su JM, Adesina A, Yang J, Chintagumpala M, Perlaky L, Tsz-Kwong Man C, Lau CC, Li XN. Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors. Cancer Lett. 2020 11 28; 493:197-206. PMID: 32891713.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Zhang H, Qi L, Du Y, Huang LF, Braun FK, Kogiso M, Zhao Y, Li C, Lindsay H, Zhao S, Injac SG, Baxter PA, Su JM, Stephan C, Keller C, Heck KA, Harmanci A, Harmanci AO, Yang J, Klisch TJ, Li XN, Patel AJ. Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma. Cancers (Basel). 2020 Jun 05; 12(6). PMID: 32517016.
      Citations: 4     
    6. Li H, Yu Y, Zhao Y, Wu D, Yu X, Lu J, Chen Z, Zhang H, Hu Y, Zhai Y, Su J, Aheman A, De Las Casas A, Jin J, Xu X, Shi Z, Woodfield SE, Vasudevan SA, Agarwal S, Yan Y, Yang J, Foster JH. Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling. Cancer Lett. 2019 08 10; 457:129-141. PMID: 31100410.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Yu Y, Zhao Y, Fan Y, Chen Z, Li H, Lu J, Guo K, Woodfield SE, Vasudevan SA, Yang J, Nuchtern JG. Inhibition of Ubiquitin-Specific Protease 14 Suppresses Cell Proliferation and Synergizes with Chemotherapeutic Agents in Neuroblastoma. Mol Cancer Ther. 2019 06; 18(6):1045-1056. PMID: 30962318.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Wang F, Zhou S, Qi D, Xiang SH, Wong ET, Wang X, Fonkem E, Hsieh TC, Yang J, Kirmani B, Shabb JB, Wu JM, Wu M, Huang JH, Yu WH, Wu E. Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells. J Am Chem Soc. 2019 02 27; 141(8):3613-3622. PMID: 30689374.
      Citations: 11     Fields:    Translation:HumansCells
    9. Wang Q, Gao X, Yu T, Yuan L, Dai J, Wang W, Chen G, Jiao C, Zhou W, Huang Q, Cui L, Zhang P, Moses RE, Yang J, Chen F, Fu J, Xiao J, Li L, Dang Y, Li X. REG? Controls Hippo Signaling and Reciprocal NF-?B-YAP Regulation to Promote Colon Cancer. Clin Cancer Res. 2018 04 15; 24(8):2015-2025. PMID: 29437787.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    10. Guan S, Lu J, Zhao Y, Yu Y, Li H, Chen Z, Shi Z, Liang H, Wang M, Guo K, Chen X, Sun W, Bieerkehazhi S, Xu X, Sun S, Agarwal S, Yang J. MELK is a novel therapeutic target in high-risk neuroblastoma. Oncotarget. 2018 Jan 05; 9(2):2591-2602. PMID: 29416794.
      Citations: 11     Fields:    
    11. Chen Z, Zhao Y, Yu Y, Pang JC, Woodfield SE, Tao L, Guan S, Zhang H, Bieerkehazhi S, Shi Y, Patel R, Vasudevan SA, Yi JS, Muscal JA, Xu GT, Yang J. Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo. Oncotarget. 2017 Nov 28; 8(61):104090-104103. PMID: 29262623.
      Citations: 12     Fields:    
    12. Sun W, Rojas Y, Wang H, Yu Y, Wang Y, Chen Z, Rajapakshe K, Xu X, Huang W, Agarwal S, Patel RH, Woodfield S, Zhao Y, Jin J, Zhang H, Major A, Hicks MJ, Shohet JM, Vasudevan SA, Coarfa C, Yang J, Nuchtern JG. EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma. Oncotarget. 2017 Nov 07; 8(55):94780-94792. PMID: 29212266.
      Citations: 4     Fields:    
    13. Lu J, Guan S, Zhao Y, Yu Y, Woodfield SE, Zhang H, Yang KL, Bieerkehazhi S, Qi L, Li X, Gu J, Xu X, Jin J, Muscal JA, Yang T, Xu GT, Yang J. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. Cancer Lett. 2017 08 01; 400:61-68. PMID: 28455243.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    14. Li H, Wang Y, Chen Z, Lu J, Pan J, Yu Y, Zhao Y, Zhang H, Hu T, Liu Q, Yang J. Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo. Oncotarget. 2017 Jan 24; 8(4):5874-5884. PMID: 27564113.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    15. Mao X, Chen Z, Zhao Y, Yu Y, Guan S, Woodfield SE, Vasudevan SA, Tao L, Pang JC, Lu J, Zhang H, Zhang F, Yang J. Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma. Oncotarget. 2017 Jan 03; 8(1):1555-1568. PMID: 27902463.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    16. Bieerkehazhi S, Chen Z, Zhao Y, Yu Y, Zhang H, Vasudevan SA, Woodfield SE, Tao L, Yi JS, Muscal JA, Pang JC, Guan S, Zhang H, Nuchtern JG, Li H, Li H, Yang J. Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling. Oncotarget. 2017 Jan 03; 8(1):1469-1480. PMID: 27903968.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    17. Chen Z, Wang L, Yao D, Yang T, Cao WM, Dou J, Pang JC, Guan S, Zhang H, Yu Y, Zhao Y, Wang Y, Xu X, Shi Y, Patel R, Zhang H, Vasudevan SA, Liu S, Yang J, Nuchtern JG. Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. Sci Rep. 2016 12 19; 6:38011. PMID: 27991505.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Lu J, Guan S, Zhao Y, Yu Y, Wang Y, Shi Y, Mao X, Yang KL, Sun W, Xu X, Yi JS, Yang T, Yang J, Nuchtern JG. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. 2016 Dec 13; 7(50):82757-82769. PMID: 27764791.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    19. Guan S, Zhao Y, Lu J, Yu Y, Sun W, Mao X, Chen Z, Xu X, Pan J, Sun S, Yang J. Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis. Oncotarget. 2016 Nov 15; 7(46):75914-75925. PMID: 27713150.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Li H, Chen Z, Hu T, Wang L, Yu Y, Zhao Y, Sun W, Guan S, Pang JC, Woodfield SE, Liu Q, Yang J. Novel proteasome inhibitor ixazomib sensitizes neuroblastoma cells to doxorubicin treatment. Sci Rep. 2016 Sep 30; 6:34397. PMID: 27687684.
      Citations: 13     Fields:    
    21. Chen Z, Wang Z, Pang JC, Yu Y, Bieerkehazhi S, Lu J, Hu T, Zhao Y, Xu X, Zhang H, Yi JS, Liu S, Yang J. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep. 2016 07 05; 6:29090. PMID: 27378523.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    22. Han X, Liu Z, Zhao L, Wang F, Yu Y, Yang J, Chen R, Qin L. Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR-Cas9 System. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8561-5. PMID: 27258939.
      Citations: 8     Fields:    Translation:HumansCells
    23. Wang Y, Wang L, Guan S, Cao W, Wang H, Chen Z, Zhao Y, Yu Y, Zhang H, Pang JC, Huang SL, Akiyama Y, Yang Y, Sun W, Xu X, Shi Y, Zhang H, Kim ES, Muscal JA, Lu F, Yang J. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016 Jan 20; 6:19423. PMID: 26786851.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    24. Shi Y, Ma IT, Patel RH, Shang X, Chen Z, Zhao Y, Cheng J, Fan Y, Rojas Y, Barbieri E, Chen Z, Yu Y, Jin J, Kim ES, Shohet JM, Vasudevan SA, Yang J. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 06; 6:e1841. PMID: 26247726.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    25. Zhang H, Dou J, Yu Y, Zhao Y, Fan Y, Cheng J, Xu X, Liu W, Guan S, Chen Z, shi Y, Patel R, Vasudevan SA, Zage PE, Zhang H, Nuchtern JG, Kim ES, Fu S, Yang J. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling. Apoptosis. 2015 Jan; 20(1):50-62. PMID: 25425103.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    26. Sun W, Quan C, Huang Y, Ji W, Yu L, Li X, Zhang Y, Zheng Z, Zou H, Li Q, Xu P, Feng Y, Li L, Zhang Y, Cui Y, Jia X, Meng X, Zhang C, Jin Y, Bai J, Yu J, Yu Y, Yang J, Fu S. Constitutive ERK1/2 activation contributes to production of double minute chromosomes in tumour cells. J Pathol. 2015 Jan; 235(1):14-24. PMID: 25214430.
      Citations: 9     Fields:    Translation:HumansCells
    27. Cheng J, Fan YH, Xu X, Zhang H, Dou J, Tang Y, Zhong X, Rojas Y, Yu Y, Zhao Y, Vasudevan SA, Zhang H, Nuchtern JG, Kim ES, Chen X, Lu F, Yang J. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014 Feb 20; 5:e1079. PMID: 24556694.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    28. Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Xu X, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung JU, Li X, Xu G, Yang J. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014 Feb 10; 211(2):313-28. PMID: 24493797.
      Citations: 85     Fields:    Translation:AnimalsCells
    29. Fan Y, Ge N, Wang X, Sun W, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, Leung E, Lu YJ, Gray JW, Schiff R, Hilsenbeck SG, Osborne CK, Yang J, Zhang H. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. J Pathol. 2014 Jan; 232(1):75-86. PMID: 24122835.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    30. Fan YH, Cheng J, Vasudevan SA, Dou J, Zhang H, Patel RH, Ma IT, Rojas Y, Zhao Y, Yu Y, Zhang H, Shohet JM, Nuchtern JG, Kim ES, Yang J. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013 Oct 17; 4:e867. PMID: 24136231.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    31. Fan Y, Cheng J, Vasudevan SA, Patel RH, Liang L, Xu X, Zhao Y, Jia W, Lu F, Zhang H, Nuchtern JG, Kim ES, Yang J. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy. Apoptosis. 2013 Oct; 18(10):1224-34. PMID: 23700229.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    32. Fan Y, Mao R, Yang J. NF-?B and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 2013 Mar; 4(3):176-85. PMID: 23483479.
      Citations: 197     Fields:    Translation:HumansCells
    33. Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 01; 339(6119):590-5. PMID: 23287719.
      Citations: 121     Fields:    Translation:HumansCells
    34. Liang L, Fan Y, Cheng J, Cheng D, Zhao Y, Cao B, Ma L, An L, Jia W, Su X, Yang J, Zhang H. TAK1 ubiquitination regulates doxorubicin-induced NF-?B activation. Cell Signal. 2013 Jan; 25(1):247-54. PMID: 22981905.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    35. Zhao Y, Liang L, Fan Y, Sun S, An L, Shi Z, Cheng J, Jia W, Sun W, Mori-Akiyama Y, Zhang H, Fu S, Yang J. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cell Signal. 2012 Nov; 24(11):2197-204. PMID: 22750291.
      Citations: 27     Fields:    Translation:HumansCells
    36. Fan Y, Shi Y, Liu S, Mao R, An L, Zhao Y, Zhang H, Zhang F, Xu G, Qin J, Yang J. Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFa-induced NF-?B activation via mediating TAK1 degradation. Cell Signal. 2012 Jul; 24(7):1381-9. PMID: 22406003.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    37. Zhang X, Berger FG, Yang J, Lu X. USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J. 2011 Jun 01; 30(11):2177-89. PMID: 21522127.
      Citations: 71     Fields:    Translation:AnimalsCells
    38. Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, Zhang H, Lu XB, Fu SB, Yang J. USP4 targets TAK1 to downregulate TNFa-induced NF-?B activation. Cell Death Differ. 2011 Oct; 18(10):1547-60. PMID: 21331078.
      Citations: 71     Fields:    Translation:HumansCells
    39. Fan Y, Yu Y, Mao R, Zhang H, Yang J. TAK1 Lys-158 but not Lys-209 is required for IL-1ß-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-?B activation. Cell Signal. 2011 Apr; 23(4):660-5. PMID: 21130870.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    40. Shi Z, Cai Z, Sanchez A, Zhang T, Wen S, Wang J, Yang J, Fu S, Zhang D. A novel Toll-like receptor that recognizes vesicular stomatitis virus. J Biol Chem. 2011 Feb 11; 286(6):4517-24. PMID: 21131352.
      Citations: 65     Fields:    Translation:AnimalsCells
    41. Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol. 2011 Jan; 13(1):14-27. PMID: 21075780.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    42. Mao R, Fan Y, Mou Y, Zhang H, Fu S, Yang J. TAK1 lysine 158 is required for TGF-ß-induced TRAF6-mediated Smad-independent IKK/NF-?B and JNK/AP-1 activation. Cell Signal. 2011 Jan; 23(1):222-7. PMID: 20837137.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    43. Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM, Donehower LA, Nuchtern JG, Yang J. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010 Sep 02; 29(35):4938-46. PMID: 20562916.
      Citations: 28     Fields:    Translation:HumansCells
    44. Sun W, Yang J. Molecular basis of lysophosphatidic acid-induced NF-?B activation. Cell Signal. 2010 Dec; 22(12):1799-803. PMID: 20471472.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    45. Sun W, Wang H, Zhao X, Yu Y, Fan Y, Wang H, Wang X, Lu X, Zhang G, Fu S, Yang J. Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. J Biol Chem. 2010 Jul 09; 285(28):21341-8. PMID: 20448038.
      Citations: 8     Fields:    Translation:HumansCells
    46. Sun W, Tan X, Shi Y, Xu G, Mao R, Gu X, Fan Y, Yu Y, Burlingame S, Zhang H, Rednam SP, Lu X, Zhang T, Fu S, Cao G, Qin J, Yang J. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. Cell Signal. 2010 Mar; 22(3):386-94. PMID: 19874889.
      Citations: 54     Fields:    Translation:HumansCells
    47. Sun W, Ge N, Yu Y, Burlingame S, Li X, Zhang M, Ye S, Fu S, Yang J. Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. J Biol Chem. 2010 Mar 12; 285(11):7911-8. PMID: 20068038.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    48. Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010 Feb 19; 285(8):5347-60. PMID: 20038579.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    49. Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J. Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem. 2010 Jan 08; 285(2):969-78. PMID: 19910467.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    50. Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X. Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res. 2009 Oct 15; 69(20):7960-8. PMID: 19808970.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    51. Fan Y, Mao R, Zhao Y, Yu Y, Sun W, Song P, Shi Z, Zhang D, Yvon E, Zhang H, Fu S, Yang J. Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. J Biol Chem. 2009 Oct 23; 284(43):29290-7. PMID: 19706600.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    52. Vasudevan SA, Shang X, Shang X, Chang S, Ge N, Diaz-Miron JL, Russell HV, Hicks MJ, Ludwig AD, Wesson CL, Burlingame SM, Kim ES, Khan J, Yang J, Nuchtern JG. Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. Mol Cancer Ther. 2009 Aug; 8(8):2478-89. PMID: 19671756.
      Citations: 7     Fields:    Translation:HumansCells
    53. Shang X, Burlingame SM, Okcu MF, Ge N, Russell HV, Egler RA, David RD, Vasudevan SA, Yang J, Nuchtern JG. Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Mol Cancer Ther. 2009 Aug; 8(8):2461-9. PMID: 19671766.
      Citations: 39     Fields:    Translation:HumansCells
    54. Sun W, Li H, Yu Y, Fan Y, Grabiner BC, Mao R, Ge N, Zhang H, Fu S, Lin X, Yang J. MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation. Cell Signal. 2009 Oct; 21(10):1488-94. PMID: 19465115.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B, Pass AK, Chu M, Zhang D, Lu X, Fu S, Lin X, Yang J. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal. 2009 Jan; 21(1):95-102. PMID: 18930133.
      Citations: 55     Fields:    Translation:HumansCells
    56. Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J. Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem. 2008 Sep 05; 283(36):24497-505. PMID: 18617512.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    57. Shu Q, Wong KK, Su JM, Adesina AM, Yu LT, Tsang YT, Antalffy BC, Baxter P, Perlaky L, Yang J, Dauser RC, Chintagumpala M, Blaney SM, Lau CC, Li XN. Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells. 2008 Jun; 26(6):1414-24. PMID: 18403755.
      Citations: 83     Fields:    Translation:HumansAnimals
    58. Deng Y, Yang J, McCarty M, Su B. MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1404-11. PMID: 17687003.
      Citations: 14     Fields:    Translation:AnimalsCells
    59. Vasudevan SA, Russell HV, Okcu MF, Burlingame SM, Liu ZJ, Yang J, Nuchtern JG. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. J Pediatr Surg. 2007 Jan; 42(1):148-52. PMID: 17208556.
      Citations: 7     Fields:    Translation:Humans
    60. Yang J, Wang K, Driver J, Yang J, Barron AR. The use of fullerene substituted phenylalanine amino acid as a passport for peptides through cell membranes. Org Biomol Chem. 2007 Jan 21; 5(2):260-6. PMID: 17205169.
      Citations: 7     Fields:    Translation:HumansCells
    61. Deng M, Chen WL, Takatori A, Peng Z, Zhang L, Mongan M, Parthasarathy R, Sartor M, Miller M, Yang J, Su B, Kao WW, Xia Y. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol Biol Cell. 2006 Aug; 17(8):3446-55. PMID: 16760432.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    62. Abbasi S, Lee JD, Su B, Chen X, Alcon JL, Yang J, Kellems RE, Xia Y. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem. 2006 Mar 24; 281(12):7717-26. PMID: 16415348.
      Citations: 28     Fields:    Translation:AnimalsCells
    63. Abbasi S, Su B, Kellems RE, Yang J, Xia Y. The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. J Biol Chem. 2005 Nov 04; 280(44):36737-46. PMID: 16126726.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    64. Vasudevan SA, Skoko J, Wang K, Burlingame SM, Patel PN, Lazo JS, Nuchtern JG, Yang J. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun. 2005 May 06; 330(2):511-8. PMID: 15796912.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    65. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat Immunol. 2004 Jan; 5(1):98-103. PMID: 14661019.
      Citations: 90     Fields:    Translation:AnimalsCells
    66. Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z. Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. J Biol Chem. 2003 May 09; 278(19):16797-801. PMID: 12615919.
      Citations: 8     Fields:    Translation:HumansCells
    67. Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol. 2001 Jul; 2(7):620-4. PMID: 11429546.
      Citations: 126     Fields:    Translation:AnimalsCells
    68. Su B, Cheng J, Yang J, Guo Z. MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression. J Biol Chem. 2001 May 04; 276(18):14784-90. PMID: 11278622.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    69. Cheng J, Yang J, Xia Y, Karin M, Su B. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr; 20(7):2334-42. PMID: 10713157.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    70. Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B. Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000 Mar; 24(3):309-13. PMID: 10700190.
      Citations: 83     Fields:    Translation:Animals
    71. Yang J, New L, Jiang Y, Han J, Su B. Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase. Gene. 1998 May 28; 212(1):95-102. PMID: 9661668.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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