VIJAY K. YECHOOR

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address
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    TitleAdjunct Associate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    K08DK068391     (YECHOOR, VIJAY K)Jul 1, 2004 - Jun 30, 2009
    NIH/NIDDK
    Islet Neogenesis with Ngn3 Therapy Reverses Diabetes
    Role: Principal Investigator

    R03DK078716     (YECHOOR, VIJAY K)Jan 1, 2009 - Dec 31, 2010
    NIH/NIDDK
    Reversing Autoimmune Diabetes with Gene Therapy Induced Islet Neogenesis
    Role: Principal Investigator

    R56DK089061     (YECHOOR, VIJAY K)Jul 1, 2010 - Jun 30, 2012
    NIH/NIDDK
    Circadian Control of Islet Function
    Role: Principal Investigator

    R01DK097160     (YECHOOR, VIJAY K)Feb 1, 2014 - May 31, 2019
    NIH/NIDDK
    Circadian Clock and Beta Cell Stress Adaptation
    Role: Principal Investigator

    I01BX002678     (YECHOOR, VIJAY K)Jan 1, 2016 - Dec 31, 2019
    VA
    Tead1 - A Regulator of Quiescence and Proliferation in Pancreatic Beta Cells
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aslanoglou D, Bertera S, Sánchez-Soto M, Benjamin Free R, Lee J, Zong W, Xue X, Shrestha S, Brissova M, Logan RW, Wollheim CB, Trucco M, Yechoor VK, Sibley DR, Bottino R, Freyberg Z. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Transl Psychiatry. 2021 Feb 16; 11(1):59. PMID: 33589583.
      Citations:    Fields:    
    2. Figueiro MG, Goo YH, Hogan R, Plitnick B, Lee JK, Jahangir K, Moulik M, Yechoor VK, Paul A. Light-Dark Patterns Mirroring Shift Work Accelerate Atherosclerosis and Promote Vulnerable Lesion Phenotypes. J Am Heart Assoc. 2021 Jan 19; 10(2):e018151. PMID: 33401929.
      Citations: 1     Fields:    
    3. Xiong X, Lin Y, Lee J, Paul A, Yechoor V, Figueiro M, Ma K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2021 02 05; 521:111110. PMID: 33285245.
      Citations:    Fields:    
    4. Liu R, Xiong X, Nam D, Yechoor V, Ma K. SRF-MRTF signaling suppresses brown adipocyte development by modulating TGF-ß/BMP pathway. Mol Cell Endocrinol. 2020 09 15; 515:110920. PMID: 32603734.
      Citations: 1     Fields:    
    5. Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M. Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2020 07 01; 319(1):H89-H99. PMID: 32502376.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Yin H, Li W, Chatterjee S, Xiong X, Saha P, Yechoor V, Ma K. Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation. FASEB J. 2020 05; 34(5):6613-6627. PMID: 32212194.
      Citations: 1     Fields:    Translation:Animals
    7. Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Kühn B. Control of cytokinesis by ß-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019 10 09; 11(513). PMID: 31597755.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    8. Chatterjee S, Yin H, Li W, Lee J, Yechoor VK, Ma K. The Nuclear Receptor and Clock Repressor Rev-erba Suppresses Myogenesis. Sci Rep. 2019 03 14; 9(1):4585. PMID: 30872796.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Liu R, Jagannathan R, Li F, Lee J, Balasubramanyam N, Kim BS, Yang P, Yechoor VK, Moulik M. Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2):e0212017. PMID: 30811446.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Lee J, Ma K, Moulik M, Yechoor V. Untimely oxidative stress in ß-cells leads to diabetes - Role of circadian clock in ß-cell function. Free Radic Biol Med. 2018 05 01; 119:69-74. PMID: 29458148.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Gao H, Ho E, Balakrishnan M, Yechoor V, Yallampalli C. Decreased insulin secretion in pregnant rats fed a low protein diet. Biol Reprod. 2017 Oct 01; 97(4):627-635. PMID: 29025046.
      Citations:    Fields:    Translation:Animals
    12. Xie A, Li R, Jiang T, Yan H, Zhang H, Yang Y, Yang L, Yechoor V, Chan L, Chen W. Anti-TCRß mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice. Endocrinology. 2017 10 01; 158(10):3140-3151. PMID: 28977608.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17). PMID: 28878117.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    14. Pradhan G, Wu CS, Han Lee J, Kanikarla P, Guo S, Yechoor VK, Samson SL, Sun Y. Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R. Sci Rep. 2017 04 20; 7(1):979. PMID: 28428639.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Goo YH, Yechoor VK, Paul A. Transcriptional profiling of foam cells in response to hypercholesterolemia. Genom Data. 2016 Sep; 9:37-9. PMID: 27408807.
      Citations: 2     
    16. Goo YH, Son SH, Yechoor VK, Paul A. Transcriptional Profiling of Foam Cells Reveals Induction of Guanylate-Binding Proteins Following Western Diet Acceleration of Atherosclerosis in the Absence of Global Changes in Inflammation. J Am Heart Assoc. 2016 Apr 18; 5(4):e002663. PMID: 27091181.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. Lee J, Liu R, de Jesus D, Kim BS, Ma K, Moulik M, Yechoor V. Circadian control of ß-cell function and stress responses. Diabetes Obes Metab. 2015 Sep; 17 Suppl 1:123-33. PMID: 26332977.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    18. Nam D, Yechoor VK, Ma K. Molecular clock integration of brown adipose tissue formation and function. Adipocyte. 2016 Apr-Jun; 5(2):243-50. PMID: 27385482.
      Citations: 6     Fields:    
    19. Li R, Buras E, Lee J, Liu R, Liu V, Espiritu C, Ozer K, Thompson B, Nally L, Yuan G, Oka K, Chang B, Samson S, Yechoor V, Chan L. Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Ther. 2015 Nov; 22(11):876-82. PMID: 26172077.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. Erratum. PD-L1-Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes 2015;64:529-540. Diabetes. 2015 Jul; 64(7):2685. PMID: 26106199.
      Citations:    Fields:    
    21. Nam D, Chatterjee S, Yin H, Liu R, Lee J, Yechoor VK, Ma K. Novel Function of Rev-erba in Promoting Brown Adipogenesis. Sci Rep. 2015 Jun 10; 5:11239. PMID: 26058812.
      Citations: 13     Fields:    Translation:Animals
    22. Nam D, Guo B, Chatterjee S, Chen MH, Nelson D, Yechoor VK, Ma K. The adipocyte clock controls brown adipogenesis through the TGF-ß and BMP signaling pathways. J Cell Sci. 2015 May 01; 128(9):1835-47. PMID: 25749863.
      Citations: 23     Fields:    Translation:AnimalsCells
    23. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2015 Feb; 64(2):529-40. PMID: 25332429.
      Citations: 8     Fields:    Translation:AnimalsCells
    24. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ß-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ß-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261.
      Citations: 77     Fields:    Translation:AnimalsCells
    25. Chatterjee S, Nam D, Guo B, Kim JM, Winnier GE, Lee J, Berdeaux R, Yechoor VK, Ma K. Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci. 2013 May 15; 126(Pt 10):2213-24. PMID: 23525013.
      Citations: 24     Fields:    Translation:AnimalsCells
    26. Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655. PMID: 23516528.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Li R, Oka K, Yechoor V. Neo-islet formation in liver of diabetic mice by helper-dependent adenoviral vector-mediated gene transfer. J Vis Exp. 2012 Oct 10; (68). PMID: 23093064.
      Citations:    Fields:    Translation:AnimalsCells
    28. Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, Minze LJ, Hsueh W, Ma K. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012 Aug; 26(8):3453-63. PMID: 22611086.
      Citations: 52     Fields:    Translation:AnimalsCells
    29. Poungvarin N, Lee JK, Yechoor VK, Li MV, Assavapokee T, Suksaranjit P, Thepsongwajja JJ, Saha PK, Oka K, Chan L. Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia. 2012 Jun; 55(6):1783-96. PMID: 22382520.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    30. Chen W, Chang B, Saha P, Hartig SM, Li L, Reddy VT, Yang Y, Yechoor V, Mancini MA, Chan L. Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar; 32(6):1099-111. PMID: 22269949.
      Citations: 56     Fields:    Translation:AnimalsCells
    31. Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ß-cells. Islets. 2011 Nov-Dec; 3(6):381-8. PMID: 22045262.
      Citations: 39     Fields:    Translation:AnimalsCells
    32. Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. 2011 Dec; 52(12):2234-44. PMID: 21949050.
      Citations: 21     Fields:    Translation:AnimalsCells
    33. Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L. The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia. 2011 Oct; 54(10):2595-605. PMID: 21786021.
      Citations: 25     Fields:    Translation:AnimalsCells
    34. Yechoor V, Chan L. Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation. Mol Endocrinol. 2010 Aug; 24(8):1501-11. PMID: 20219891.
      Citations: 13     Fields:    Translation:HumansCells
    35. Yechoor V, Liu V, Paul A, Lee J, Buras E, Ozer K, Samson S, Chan L. Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. Endocrinology. 2009 Nov; 150(11):4863-73. PMID: 19819964.
      Citations: 17     Fields:    Translation:HumansAnimals
    36. Chen W, Yechoor VK, Chang BH, Li MV, March KL, Chan L. The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology. 2009 Oct; 150(10):4552-61. PMID: 19574402.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    37. Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar; 16(3):358-73. PMID: 19289082.
      Citations: 81     Fields:    Translation:AnimalsCells
    38. Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov; 16(11):1805-12. PMID: 18781141.
      Citations: 17     Fields:    Translation:AnimalsCells
    39. Paul A, Chang BH, Li L, Yechoor VK, Chan L. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res. 2008 Jun 20; 102(12):1492-501. PMID: 18483409.
      Citations: 57     Fields:    Translation:AnimalsCells
    40. Paul A, Yechoor V, Raja R, Li L, Chan L. Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice. Atherosclerosis. 2008 Oct; 200(2):257-63. PMID: 18289551.
      Citations: 4     Fields:    Translation:AnimalsCells
    41. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. PMID: 15895078.
      Citations: 79     Fields:    Translation:AnimalsCells
    42. Niendorf ER, Parker JA, Yechoor V, Garber JR, Boiselle PM. Thymic hyperplasia in thyroid cancer patients. J Thorac Imaging. 2005 Feb; 20(1):1-4. PMID: 15729115.
      Citations: 7     Fields:    Translation:Humans
    43. Yechoor V, Chan L. Gene therapy progress and prospects: gene therapy for diabetes mellitus. Gene Ther. 2005 Jan; 12(2):101-7. PMID: 15496957.
      Citations: 9     Fields:    Translation:HumansAnimals
    44. Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CR. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16525-30. PMID: 15546994.
      Citations: 46     Fields:    Translation:AnimalsCells
    45. Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Feb 10; 109(5):647-55. PMID: 14744975.
      Citations: 89     Fields:    Translation:HumansAnimals
    46. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. PMID: 14578284.
      Citations: 24     Fields:    Translation:AnimalsCells
    47. Yechoor VK, Patti ME, Saccone R, Kahn CR. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10587-92. PMID: 12149437.
      Citations: 34     Fields:    Translation:AnimalsCells
    48. Yechoor VK, Shandera WX, Rodriguez P, Cate TR. Tuberculous meningitis among adults with and without HIV infection. Experience in an urban public hospital. Arch Intern Med. 1996 Aug 12-26; 156(15):1710-6. PMID: 8694670.
      Citations: 21     Fields:    Translation:HumansCells
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